Dynamic high performance liquid chromatography on chiral stationary phases. Low temperature separation of the interconverting enantiomers of diazepam, flunitrazepam, prazepam and tetrazepam

Journal of Chromatography A

Volumn 1363, Issue , 2014, Pages 144-149

  Sabia, Rocchina ^a   Ciogli, Alessia ^a   Pierini, Marco ^a   Gasparrini, Francesco ^a   Villani, Claudio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Conformational enantiomers; Diazepam; Dynamic chromatography; Enantiomerization energy barriers; HPLC on chiral stationary phases; Low temperature HPLC

Indexed keywords

ACTIVATION ENERGY; CHROMATOGRAPHIC ANALYSIS; CONFORMATIONS; ENANTIOMERS; FREE ENERGY; GROUND STATE; RATE CONSTANTS; SEPARATION; STEREOCHEMISTRY; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; TEMPERATURE;

CHIRAL STATIONARY PHASIS; DIAZEPAM; DYNAMIC CHROMATOGRAPHY; ENANTIOMERIZATION; LOW TEMPERATURES;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

DIAZEPAM; FLUNITRAZEPAM; PRAZEPAM; TETRAZEPAM; BENZODIAZEPINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHIRAL CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; DYNAMICS; ENANTIOMER; ENERGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; LOW TEMPERATURE PROCEDURES; ROOM TEMPERATURE; SEPARATION TECHNIQUE; SIMULATION; STOCHASTIC MODEL; COLD; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; STEREOISOMERISM;

BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLD TEMPERATURE; DIAZEPAM; FLUNITRAZEPAM; MAGNETIC RESONANCE SPECTROSCOPY; PRAZEPAM; STEREOISOMERISM;

EID: 84908098588     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.07.097     Document Type: Article

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