Direct resolution, characterization, and stereospecific binding properties of an atropisomeric 1,4-benzodiazepine

Chirality

Volumn 9, Issue 5-6, 1997, Pages 495-505

  Salvadori, Piero ^a   Bertucci, Carlo ^a   Ascoli, Giorgio ^a   Uccello Barretta, Gloria ^a   Rossi, Elena ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Atropisomeric benzodiazepine; Chiral HPLC; Circular dichroism; HSA; Preparative HPLC; Stereo selective receptor binding; Stereochemistry; Stereoselective protein binding

Indexed keywords

7 CHLORO 1,3 DIHYDRO 1 (1,1 DIMETHYLETHYL) 5 (2 FLUOROPHENYL) 2H 1,4 BENZODIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; DIAZEPAM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHIRALITY; CIRCULAR DICHROISM; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY;

BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CELL MEMBRANE; CIRCULAR DICHROISM; DIAZEPAM; FLUNITRAZEPAM; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; RECEPTORS, GABA-A; SERUM ALBUMIN; STEREOISOMERISM;

EID: 0030930229     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:5/6<495::AID-CHIR16>3.0.CO;2-J     Document Type: Article

References (4)

1. Tallman, J.F., Paul, S.M., Skolnick, P., Gallagher, D.W. Receptors for the age of anxiety: Pharmacology of the benzodiazepines. Science 207:274-281, 1980.
2. Lader, M. Benzodiazepines, the opium of the masses? Neuroscience 3:153-165, 1978.
3. a. Squires, R.F., Braestrup, C. Benzodiazepine receptors in rat brain. Nature 266:732-734, 1977.
4. b. Moehler, H., Okada, T. Benzodiazepine receptor demonstration in the central nervous system. Science 198:849-851, 1977.