Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition

Stem Cells

Volumn 32, Issue 10, 2014, Pages 2605-2615

  Speakman, Christopher M ^a   Domke, Tanja C E ^a   Wongpaiboonwattana, Wikrom ^a   Sanders, Kelly ^a   Mudaliar, Manikhandan ^a,b   Van Aalten, Daan M F ^a   Barton, Geoffrey J ^a   Stavridis, Marios P ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cell differentiation; Embryonic stem cells; O GlcNAc; Oligonucleotide microarrays; Post translational protein modification; Signal transduction

Indexed keywords

FIBROBLAST GROWTH FACTOR 5; HYDROLASE; N ACETYLGLUCOSAMINE; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX1; DIMETHYL SULFOXIDE; N ACETYLGLUCOSAMINYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DNA METHYLATION; DOWN REGULATION; EMBRYO; EMBRYOID BODY; EMBRYONIC STEM CELL; EPIGENETIC REPRESSION; GENE EXPRESSION; GENE REPRESSION; GENETIC ASSOCIATION; HISTONE MODIFICATION; MOUSE; NONHUMAN; PROTEIN MODIFICATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; GLYCOSYLATION; METABOLISM; PHOSPHORYLATION;

ACETYLGLUCOSAMINE; ANIMALS; CELL DIFFERENTIATION; DIMETHYL SULFOXIDE; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; GLYCOSYLATION; MICE; N-ACETYLGLUCOSAMINYLTRANSFERASES; PHOSPHORYLATION; TRANSCRIPTION, GENETIC;

EID: 84908097697     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1761     Document Type: Article

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