Monocyte-derived dendritic cells from HLA-B27+ axial spondyloarthritis (SpA) patients display altered functional capacity and deregulated gene expression

Arthritis Research and Therapy

Volumn 16, Issue 4, 2014, Pages

  Talpin, Alice ^a,b   Costantino, Félicie ^a,b,c   Bonilla, Nelly ^d   Leboime, Ariane ^c   Letourneur, Franck ^d   Jacques, Sébastien ^d   Dumont, Florent ^d   Amraoui, Sonia ^d   Dutertre, Charles Antoine ^e   Garchon, Henri Jean ^a,b,c   Breban, Maxime ^a,b,c   Chiocchia, Gilles ^a,b  

^a INSERM U 987   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^c Genetics Division Ambroise Paré Hospital AP HP   (France)

^d INSTITUT COCHIN   (France)

^e DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA B27 ANTIGEN; INTERLEUKIN 4; METALLOPROTEINASE; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

ADAMTS15 GENE; ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL STIMULATION; CITED2 GENE; CLINICAL ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FUNCTIONAL STATUS; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC CORRELATION; HUMAN; HUMAN CELL; MALE; MICROARRAY ANALYSIS; MONOCYTE; REAL TIME POLYMERASE CHAIN REACTION; SPONDYLARTHRITIS; TRANSCRIPTOMICS; WNT SIGNALING PATHWAY; CYTOLOGY; DNA MICROARRAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MIXED LYMPHOCYTE CULTURE; SPONDYLOARTHROPATHY;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HLA-B27 ANTIGEN; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MIDDLE AGED; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; SPONDYLARTHROPATHIES; TRANSCRIPTOME;

EID: 84908090672     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-014-0417-0     Document Type: Article

References (42)

1. Costantino F, Talpin A, Said-Nahal R, Goldberg M, Henny J, Chiocchia G, Garchon H-J, Zins M, Breban M: Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort.Ann Rheum Dis 2013:. doi:10.1136/annrheumdis-2013-204436..
2. Smith JA, Barnes MD, Hong D, DeLay ML, Inman RD, Colbert RA. Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation. Arthritis Rheum 2008, 58:1640-1649. 10.1002/art.23512, 18512784.
3. Gu J, Wei Y-L, Wei JCC, Huang F, Jan M-S, Centola M, Frank MB, Yu D. Identification of RGS1 as a candidate biomarker for undifferentiated spondylarthritis by genome-wide expression profiling and real-time polymerase chain reaction. Arthritis Rheum 2009, 60:3269-3279. 10.1002/art.24968, 19877080.
4. Duan R, Leo P, Bradbury L, Brown MA, Thomas G. Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS. Ann Rheum Dis 2010, 69:1724-1729. 10.1136/ard.2009.111690, 19643760.
5. Assassi S, Reveille JD, Arnett FC, Weisman MH, Ward MM, Agarwal SK, Gourh P, Bhula J, Sharif R, Sampat K, Mayes MD, Tan FK. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. J Rheumatol 2011, 38:87-98. 10.3899/jrheum.100469, 20952467.
6. Pimentel-Santos FM, Ligeiro D, Matos M, Mourão AF, Costa J, Santos H, Barcelos A, Godinho F, Pinto P, Cruz M, Fonseca JE, Guedes-Pinto H, Branco JC, Brown MA, Thomas GP. Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects. Arthritis Res Ther 2011, 13:R57. 10.1186/ar3309, 21470430.
7. Sharma SM, Choi D, Planck SR, Harrington CA, Austin CR, Lewis JA, Diebel TN, Martin TM, Smith JR, Rosenbaum JT. Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles. Arthritis Res Ther 2009, 11:R168. 10.1186/ar2855, 19900269.
8. Breban M, Hacquard-Bouder C, Falgarone G. Animal models of HLA-B27-associated diseases. Curr Mol Med 2004, 4:31-40. 10.2174/1566524043479347, 15011957.
9. Hacquard-Bouder C, Falgarone G, Bosquet A, Smaoui F, Monnet D, Ittah M, Breban M. Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondylarthropathy. Arthritis Rheum 2004, 50:1624-1635. 10.1002/art.20211, 15146433.
10. Hacquard-Bouder C, Chimenti M-S, Giquel B, Donnadieu E, Fert I, Schmitt A, André C, Breban M. Alteration of antigen-independent immunologic synapse formation between dendritic cells from HLA-B27-transgenic rats and CD4+ T cells: selective impairment of costimulatory molecule engagement by mature HLA-B27. Arthritis Rheum 2007, 56:1478-1489. 10.1002/art.22572, 17469106.
11. Glatigny S, Fert I, Blaton MA, Lories RJ, Araujo LM, Chiocchia G, Breban M. Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats. Arthritis Rheum 2012, 64:110-120. 10.1002/art.33321, 21905004.
12. Utriainen L, Firmin D, Wright P, Cerovic V, Breban M, McInnes I, Milling S. Expression of HLA-B27 causes loss of migratory dendritic cells in a rat model of spondylarthritis. Arthritis Rheum 2012, 64:3199-3209. 10.1002/art.34561, 22674414.
13. Araujo L, Fert I, Jouhault Q, Labroquère K, Andrieu M, Chiocchia G, Breban M: Increased production of interleukin-17 over interleukin-10 by regulatory T cells implicates ICOS molecule in experimental spondyloarthritis.Arthritis Rheum 2014, :. doi:10.1002/art.38737..
14. Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J, Braun J, Chou CT, Collantes-Estevez E, Dougados M, Huang F, Gu J, Khan MA, Kirazli Y, Maksymowych WP, Mielants H, Sørensen IJ, Ozgocmen S, Roussou E, Valle-Oñate R, Weber U, Wei J, Sieper J. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 2009, 68:777-783. 10.1136/ard.2009.108233, 19297344.
15. Dutertre C-A, Amraoui S, DeRosa A, Jourdain J-P, Vimeux L, Goguet M, Degrelle S, Feuillet V, Liovat A-S, Müller-Trutwin M, Decroix N, Deveau C, Meyer L, Goujard C, Loulergue P, Launay O, Richard Y, Hosmalin A. Pivotal role of M-DC8+ monocytes from viremic HIV-infected patients in TNFα overproduction in response to microbial products. Blood 2012, 120:2259-2268. 10.1182/blood-2012-03-418681, 22802339.
16. Gautier L, Cope L, Bolstad BM, Irizarry RA. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004, 20:307-315. 10.1093/bioinformatics/btg405, 14960456.
17. Dai M, Wang P, Boyd AD, Kostov G, Athey B, Jones EG, Bunney WE, Myers RM, Speed TP, Akil H, Watson SJ, Meng F. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucl Acids Res 2005, 33:e175-e175. 10.1093/nar/gni179, 16284200.
18. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004, 3:Article 3.
19. : Genomatix- NGS Data Analysis & Personalized Medicine. ,: []., https://www.genomatix.de/
20. Plessy C, Desbois L, Fujii T, Carninci P. Population transcriptomics with single-cell resolution: a new field made possible by microfluidics: a technology for high throughput transcript counting and data-driven definition of cell types. Bioessays 2013, 35:131-140. 10.1002/bies.201200093, 23281054.
21. Fert I, Cagnard N, Glatigny S, Letourneur F, Jacques S, Smith JA, Colbert RA, Taurog JD, Chiocchia G, Araujo LM, Breban M. Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis. Arthritis Rheum 2014, 66:841-851. 10.1002/art.38318.
22. Zhu J, Yu DTY. Matrix metalloproteinase expression in the spondyloarthropathies. Curr Opin Rheumatol 2006, 18:364-368. 10.1097/01.bor.0000231904.04548.09, 16763456.
23. Maksymowych WP, Landewé R, Conner-Spady B, Dougados M, Mielants H, van der Tempel H, Poole AR, Wang N, van der Heijde D. Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis. Arthritis Rheum 2007, 56:1846-1853. 10.1002/art.22589, 17530713.
24. Mattey DL, Packham JC, Nixon NB, Coates L, Creamer P, Hailwood S, Taylor GJ, Bhalla AK. Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis. Arthritis Res Ther 2012, 14:R127. 10.1186/ar3857, 22640827.
25. Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank SMV, Edwards DR, Parker AE, Clark IM. Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum 2004, 50:131-141. 10.1002/art.11433, 14730609.
26. Bragança J, Swingler T, Marques FIR, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S. Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. J Biol Chem 2002, 277:8559-8565. 10.1074/jbc.M110850200, 11744733.
27. Lou X, Sun S, Chen W, Zhou Y, Huang Y, Liu X, Shan Y, Wang C. Negative feedback regulation of NF-κB action by CITED2 in the nucleus. J Immunol 2011, 186:539-548. 10.4049/jimmunol.1001650, 21098220.
28. Goodman RH, Smolik S. CBP/p300 in cell growth, transformation, and development. Genes Dev 2000, 14:1553-1577. 10887150.
29. Bai L, Merchant JL. A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. FEBS Lett 2007, 581:5904-5910. 10.1016/j.febslet.2007.11.072, 18054336.
30. Lee JY, Taub PJ, Wang L, Clark A, Zhu LL, Maharam ER, Leong DJ, Ramcharan M, Li Z, Liu Z, Ma Y-Z, Sun L, Zaidi M, Majeska RJ, Sun HB. Identification of CITED2 as a negative regulator of fracture healing. Biochem Biophys Res Commun 2009, 387:641-645. 10.1016/j.bbrc.2009.07.029, 19607804.
31. Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J 2011, 25:182-191. 10.1096/fj.10-164277, 20826544.
32. Goldring SR, Goldring MB. Eating bone or adding it: the Wnt pathway decides. Nat Med 2007, 13:133-134. 10.1038/nm0207-133, 17290270.
33. Laine CM, Joeng KS, Campeau PM, Kiviranta R, Tarkkonen K, Grover M, Lu JT, Pekkinen M, Wessman M, Heino TJ, Nieminen-Pihala V, Aronen M, Laine T, Kröger H, Cole WG, Lehesjoki A-E, Nevarez L, Krakow D, Curry CJR, Cohn DH, Gibbs RA, Lee BH, Mäkitie O. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N Engl J Med 2013, 368:1809-1816. 10.1056/NEJMoa1215458, 23656646.
34. Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 2005, 102:3324-3329. 10.1073/pnas.0408742102, 15728361.
35. Franck H, Meurer T, Hofbauer LC. Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis. J Rheumatol 2004, 31:2236-2241. 15517638.
36. Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, Wang Y-C, Pulendran B. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 2010, 329:849-853. 10.1126/science.1188510, 20705860.
37. Nishita M, Yoo SK, Nomachi A, Kani S, Sougawa N, Ohta Y, Takada S, Kikuchi A, Minami Y. Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. J Cell Biol 2006, 175:555-562. 10.1083/jcb.200607127, 17101698.
38. Nomachi A, Nishita M, Inaba D, Enomoto M, Hamasaki M, Minami Y. Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J Biol Chem 2008, 283:27973-27981. 10.1074/jbc.M802325200, 18667433.
39. Dhaenens M, Fert I, Glatigny S, Haerinck S, Poulain C, Donnadieu E, Hacquard-Bouder C, André C, Elewaut D, Deforce D, Breban M. Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability. Arthritis Rheum 2009, 60:2622-2632. 10.1002/art.24780, 19714626.
40. Johnson K, Hashimoto S, Lotz M, Pritzker K, Terkeltaub R. Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa. Am J Pathol 2001, 159:149-163. 10.1016/S0002-9440(10)61682-3, 11438463.
41. Hoppe B, Häupl T, Skapenko A, Ziemer S, Tauber R, Salama A, Schulze-Koops H, Burmester G-R, Dörner T. Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation. Ann Rheum Dis 2012, 71:1163-1169. 10.1136/annrheumdis-2011-200738, 22267327.
42. Sarraj B, Ludányi K, Glant TT, Finnegan A, Mikecz K. Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis. J Immunol 2006, 177:1932-1940. 10.4049/jimmunol.177.3.1932, 16849507.