DOCK2 is critical for CD8+TCR- graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells

Stem Cells

Volumn 32, Issue 10, 2014, Pages 2732-2743

  Wen, Yujie ^a   Elliott, Mary J ^a   Huang, Yiming ^a   Miller, Thomas O ^a   Corbin, Deborah R ^a   Hussain, Lala Rukh ^a   Ratajczak, Mariusz Z ^a   Fukui, Yoshinori ^b   Ildstad, Suzanne T ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

DOCK2; Facilitating cells; Hematopoietic stem cells; Regulatory T cells

Indexed keywords

CD8 ANTIGEN; DEDICATOR OF CYTOKINESIS 2; INTERLEUKIN 10; PROTEIN; UNCLASSIFIED DRUG; DOCK2 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL HOMING; CELL MIGRATION; CELL SURVIVAL; CELLS; CONTROLLED STUDY; CYTOKINESIS; ENGRAFTMENT; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBINOPATHY; IN VITRO STUDY; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; STEM CELL; TRANSPLANTATION TOLERANCE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL MOTION; CYTOLOGY; DOWN REGULATION; METABOLISM; STEM CELL NICHE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELL SURVIVAL; DOWN-REGULATION; GTPASE-ACTIVATING PROTEINS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE, INBRED C57BL; MODELS, BIOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; STEM CELL NICHE; T-LYMPHOCYTES, REGULATORY;

EID: 84908089368     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1780     Document Type: Article

References (47)

1. Li HW, Sykes M. Emerging concepts in haematopoietic cell transplantation. Nat Rev Immunol 2012;12:403-416.
2. Tyndall A. Successes and failures of stem cell transplantation in autoimmune diseases. Hematology 2011;2011:280-284.
3. Leventhal J, Abecassis M, Miller J et al. Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: Durable chimerism predicts outcome. Transplantation 2013;95:169-176.
4. Leventhal J, Abecassis M, Miller J et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012;4: 124-128.
5. Kawai T, Sachs DH, Sykes M et al. HLAmismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2013;368:1850-1852.
6. Kawai T, Cosimi AB, Spitzer TR et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008;358:353-361.
7. Scandling JD, Busque S, Dejbakhsh-Jones S et al. Tolerance and withdrawal of immuno- suppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant 2012;12:1133-1145.
8. Scandling JD, Busque S, Shizuru JA et al. Induced immune tolerance for kidney transplantation. N Engl J Med 2011;365:1359-1360.
9. Kaufman CL, Colson YL, Wren SM et al. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 1994;84:2436-2446.
10. Rezzoug F, Huang Y, Tanner MK et al. TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function. J Immunol 2008;180:49-57.
11. Huang Y, Fugier-Vivier IJ, Miller T et al. Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: Are they a component of diabetes pathogenesis? Diabetes 2008;57:2360-2370.
12. Grimes HL, Schanie CL, Huang Y et al. Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes. Exp Hematol 2004;32:946-954.
13. Schuchert MJ, Wright RD, Colson YL. Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD81 bone marrow subpopulation that promotes allogeneic stem cell engraftment. Nat Med 2000;6:904-909.
14. Gandy KL, Domen J, Aguila H et al. CD81TCR1 and CD81TCR2 cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 1999;11:579-590.
15. Adams GB, Chabner KT, Foxall RB et al. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 2003;101:45-51.
16. Bridenbaugh S, Kenins L, Bouliong-Pillai E et al. Clinical stem-cell sources contain CD81CD31 T-cell receptor-negative cells that facilitate bone marrow repopulation with hematopoietic stem cells. Blood 2008;111: 1735-1738.
17. Fugier-Vivier IJ, Rezzoug F, Huang Y et al. Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J Exp Med 2005;201:373-383.
18. Yaroslavskiy B, Colson Y, Ildstad S et al. Addition of a bone marrow "facilitating cell" population increases stem cell-derived cobblestone area formation in impaired longterm bone marrow culture stroma. Exp Hematol 1998;26:604-611.
19. Huang Y, Bozulic LD, Miller T et al. CD8a1 plasmacytoid precursor DCs induce antigen-specific regulatory T cells that enhance HSC engraftment in vivo. Blood 2011;117:2494-2505.
20. Li XC, Strom TB. A rare find-cells that improve bone marrow transplantation. Nat Med 2000;6:866-867.
21. Reif K, Cyster J. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol 2002;12:368-373.
22. Fukui Y, Hashimoto O, Sanui T et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 2001;412:826-831.
23. Gotoh K, Tanaka Y, Nishikimi A et al. Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells. Blood 2008;111:2973-2976.
24. Kunisaki Y, Nishikimi A, Tanaka Y et al. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol 2006;174:647-652.
25. Bustin SA, Benes V, Garson J et al. The need for transparency and good practices in the qPCR literature. Nat Methods 2013;10: 1063-1067.
26. Bustin SA, Benes V, Garson JA et al. The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments. Clin Chem 2009;55:611-622.
27. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using realtime quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001;25:402-408.
28. Schmittgen TD, Livak KJ. Analyzing realtime PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-1108.
29. Parish CR, Glidden MH, Quah BJ et al. Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation. Curr Protoc Immunol 2009;Chapter 4:Unit4.
30. Maeda M, Hasegawa H, Hyodo T et al. ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. Mol Biol Cell 2011;22:3840-3852.
31. Rajeevan MS, Vernon SD, Taysavang N et al. Validation of array-based gene expression profiles by real-time (kinetic) RT-PCR. J Mol Diagn 2001;3:26-31.
32. Ippagunta SK, Malireddi RK, Shaw PJ et al. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol 2011; 12:1010-1016.
33. Taylor KN, Shinde-Patil VR, Cohick E et al. Induction of FoxP31CD41251 regulatory T cells following hemopoietic stem cell transplantation: Role of bone marrowderived facilitating cells. J Immunol 2007; 179:2153-2162.
34. Taylor KN, Laszkowska M, Cohick E et al. Induction of FoxP31CD41CD251 regulatory T cells by a bone marrow population distinct from plasmacytoid-DC. Cell Immunol 2008; 251:43-49.
35. Lutz MB. Therapeutic potential of semimature dendritic cells for tolerance induction. Front Immunol 2012;3:123.
36. Kushwah R, Hu J. Role of dendritic cells in the induction of regulatory T cells. Cell Biosci 2011;1:20.
37. Wood KJ, Bushell A, Hester J. Regulatory immune cells in transplantation. Nat Rev Immunol 2012;12:417-430.
38. Jin JO, Han X, Yu Q. Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. J Autoimmun 2013;40:28-44.
39. Fujisaki J, Wu J, Carlson AL et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 2011;474:216-219.
40. Nishikimi A, Uruno T, Duan X et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol 2012;19:488-497.
41. Sugiyama T, Kohara H, Noda M et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-988.
42. Chow A, Lucas D, Hidalgo A et al. Bone marrow CD1691 macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 2011;208:261-271.
43. Kunisaki Y, Frenette PS. The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion. Nat Med 2012;18:864-865.
44. Andolfi G, Fousteri G, Rossetti M et al. Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD41 T cells. Mol Ther 2012;20: 1778-1790.
45. Gagliani N, Jofra T, Stabilini A et al. Antigen- specific dependence of Tr1-cell therapy in preclinical models of islet transplant. Diabetes 2010;59:433-439.
46. Burrell BE, Nakayama Y, Xu J et al. Regulatory T cell induction, migration, and function in transplantation. J Immunol 2012;189: 4705-4711.
47. Gotoh K, Tanaka Y, Nishikimi A et al. Selective control of type I IFN induction by the Rac activator DOCK2 during TLRmediated plasmacytoid dendritic cell activation. J Exp Med 2010;207:721-730.