Prognostic value of cardiac troponin in patients with chronic kidney disease without suspected acute coronary syndrome: A systematic review and meta-analysis

Annals of Internal Medicine

Volumn 161, Issue 7, 2014, Pages 491-501

  Michos, Erin D ^a   Wilson, Lisa M ^b   Yeh, Hsin Chieh ^b   Berger, Zackary ^b   Suarez Cuervo, Catalina ^b   Stacy, Sylvie R ^c   Bass, Eric B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN I; TROPONIN T; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CORONARY ARTERY DISEASE; DIALYSIS; FOLLOW UP; HUMAN; KIDNEY GRAFT; META ANALYSIS; PREVALENCE; PROGNOSIS; PROTEIN BLOOD LEVEL; REVIEW; SYSTEMATIC REVIEW; BLOOD; CARDIOVASCULAR DISEASES; MORTALITY; RENAL INSUFFICIENCY, CHRONIC; RENAL REPLACEMENT THERAPY; RISK;

ACUTE CORONARY SYNDROME; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; HUMANS; PROGNOSIS; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; RISK; TROPONIN I; TROPONIN T;

EID: 84908087046     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M14-0743     Document Type: Review

References (121)

1. Jaffe AS. Chasing troponin: how low can you go if you can see the rise? [Editorial]. J Am Coll Cardiol. 2006;48:1763-4. [PMID: 17084246]
2. National Institute of Diabetes and Digestive and Kidney Diseases. United States Renal Data System: 2011 USRDS Annual Data Report. Volume Two: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health; 2011. Accessed at www.usrds.org/2011/pdf/v2-00-intro-11.pdf on 7 July 2014.
3. Khan IA, Wattanasuwan N, Mehta NJ, Tun A, Singh N, Singh HK, et al. Prognostic value of serum cardiac troponin I in ambulatory patients with chronic renal failure undergoing long-term hemodialysis: a two-year outcome analysis. J Am Coll Cardiol. 2001;38:991-8. [PMID: 11583870]
4. Diris JH, Hackeng CM, Kooman JP, Pinto YM, Hermens WT, van Dieijen- Visser MP. Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients. Circulation. 2004;109:23-5. [PMID: 14691043]
5. Ellis K, Dreisbach AW, Lertora JL. Plasma elimination of cardiac troponin I in end-stage renal disease. South Med J. 2001;94:993-6. [PMID: 11702827]
6. Wang AY, Lai KN. Use of cardiac biomarkers in end-stage renal disease. J Am Soc Nephrol. 2008;19:1643-52. [PMID: 18322158] doi:10.1681/ASN .2008010012
7. Newby LK, Jesse RL, Babb JD, Christenson RH, De Fer TM, Diamond GA, et al. ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevations: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2012;60:2427-63. [PMID: 23154053] doi: 10.1016/j.jacc.2012.08.969
8. Wayand D, Baum H, Schätzle G, Schärf J, Neumeier D. Cardiac troponin T and I in end-stage renal failure. Clin Chem. 2000;46:1345-50. [PMID: 10973864]
9. Goicoechea M, de Vinuesa SG, Gómez-Campderá F, Luño J. Predictive cardiovascular risk factors in patients with chronic kidney disease (CKD). Kidney Int Suppl. 2005:S35-8. [PMID: 15613066]
10. Goicoechea M, Garca de Vinuesa S, Gómez-Campderá F, Gutierrez MJ, Blanco P, Amann R, et al. Clinical significance of cardiac troponin T levels in chronic kidney disease patients: predictive value for cardiovascular risk. Am J Kidney Dis. 2004;43:846-53. [PMID: 15112175]
11. Khan NA, Hemmelgarn BR, Tonelli M, Thompson CR, Levin A. Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis. Circulation. 2005;112:3088-96. [PMID: 16286604]
12. Iliou MC, Fumeron C, Benoit MO, Tuppin P, Calonge VM, Moatti N, et al. Prognostic value of cardiac markers in ESRD: Chronic Hemodialysis and New Cardiac Markers Evaluation (CHANCE) study. Am J Kidney Dis. 2003; 42:513-23. [PMID: 12955679]
13. Roche. FDA clears new intended uses for Roche Diagnostics Troponin T Test. Trade News. 24 May 2004.
14. Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52:377-84. [PMID: 9764259]
15. Berkman ND, Lohr KN, Ansari M, McDonagh M, Balk E, Whitlock E, et al. Grading the Strength of a Body of Evidence When Assessing Health Care Interventions for the Effective Health Care Program of the Agency for Healthcare Research and Quality: An Update. In: Agency for Healthcare Research and Quality. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. AHRQ publication no. 10(11)-EHC063-EF. Rockville, MD: Agency for Healthcare Research and Quality; 2012.
16. Cornell JE, Mulrow CD, Localio R, Stack CB, Meibohm AR, Guallar E, et al. Random-effects meta-analysis of inconsistent effects: a time for change. Ann Intern Med. 2014;160:267-70. [PMID: 24727843] doi:10.7326/M13-2886
17. Hardy RJ, Thompson SG. A likelihood approach to meta-analysis with random effects. Stat Med. 1996;15:619-29. [PMID: 8731004]
18. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60. [PMID: 12958120]
19. Geerse DA, van Berkel M, Vogels S, Kooman JP, Konings CJ, Scharnhorst V. Moderate elevations of high-sensitivity cardiac troponin I and B-type natriuretic peptide in chronic hemodialysis patients are associated with mortality. Clin Chem Lab Med. 2013;51:1321-8. [PMID: 23241607] doi:10.1515/cclm-2012-0305
20. Artunc F, Mueller C, Breidthardt T, Twerenbold R, Peter A, Thamer C, et al. Sensitive troponins-which suits better for hemodialysis patients? Associated factors and prediction of mortality. PLoS One. 2012;7:e47610. [PMID: 23077650] doi:10.1371/journal.pone.0047610
21. Kalaji FR, Albitar S. Predictive value of cardiac troponin T and I in hemodialysis patients. Saudi J Kidney Dis Transpl. 2012;23:939-45. [PMID: 22982904] doi:10.4103/1319-2442.100868
22. Hasegawa M, Ishii J, Kitagawa F, Kanayama K, Takahashi H, Ozaki Y, et al. Prognostic value of highly sensitive troponin T on cardiac events in patients with chronic kidney disease not on dialysis. Heart Vessels. 2013;28:473-9. [PMID: 22914904] doi:10.1007/s00380-012-0273-2
23. deFilippi C, Seliger SL, Kelley W, Duh SH, Hise M, Christenson RH, et al. Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome. Clin Chem. 2012;58:1342-51. [PMID: 22791885] doi:10.1373/clinchem.2012.185322
24. Scheven L, de Jong PE, Hillege HL, Lambers Heerspink HJ, van Pelt LJ, Kootstra JE, et al; PREVEND Study Group. High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate. Eur Heart J. 2012;33:2272-81. [PMID: 22740385]
25. Gaiki MR, DeVita MV, Michelis MF, Panagopoulos G, Rosenstock JL. Troponin I as a prognostic marker of cardiac events in asymptomatic hemodialysis patients using a sensitive troponin I assay. Int Urol Nephrol. 2012;44: 1841-5. [PMID: 22311387] doi:10.1007/s11255-012-0128-x
26. Shroff GR, Akkina SK, Miedema MD, Madlon-Kay R, Herzog CA, Kasiske BL. Troponin I levels and postoperative myocardial infarction following renal transplantation. Am J Nephrol. 2012;35:175-80. [PMID: 22286592] doi: 10.1159/000335679
27. Holden RM, Beseau D, Booth SL, Adams MA, Garland JS, Morton RA, et al. FGF-23 is associated with cardiac troponin T and mortality in hemodialysis patients. Hemodial Int. 2012;16:53-8. [PMID: 22099949] doi:10.1111/j.1542- 4758.2011.00630.x
28. McMurray JJ, Uno H, Jarolim P, Desai AS, de Zeeuw D, Eckardt KU, et al. Predictors of fatal and nonfatal cardiovascular events in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia: an analysis of the Trial to Reduce cardiovascular Events with Aranesp (darbepoetin-alfa) Therapy (TREAT). Am Heart J. 2011;162:748-755.e3. [PMID: 21982669] doi:10.1016/ j.ahj.2011.07.016
29. Hallén J, Madsen L, Ladefoged S, Fagerland MW, Serebruany VL, Agewall S, et al. Incremental value of a combination of cardiac troponin T, N-terminal pro-brain natriuretic peptide and C-reactive protein for prediction of mortality in end-stage renal disease. Scand J Urol Nephrol. 2011;45:151-8. [PMID: 21091090] doi:10.3109/00365599.2010.529819
30. Codognotto M, Piccoli A, Zaninotto M, Mion MM, Ruzza L, Barchita A, et al. Effect of a dialysis session on the prognostic values of NT-proBNP, troponins, endothelial damage and inflammation biomarkers. J Nephrol. 2010;23: 465-71. [PMID: 20540041]
31. McGill D, Talaulikar G, Potter JM, Koerbin G, Hickman PE. Over time, high-sensitivity TnT replaces NT-proBNP as the most powerful predictor of death in patients with dialysis-dependent chronic renal failure. Clin Chim Acta. 2010;411:936-9. [PMID: 20298685] doi:10.1016/j.cca.2010.03.004
32. Hickman PE, McGill DA, Talaulikar G, Hiremagalur B, Bromley J, Rahman A, et al. Prognostic efficacy of cardiac biomarkers for mortality in dialysis patients. Intern Med J. 2009;39:812-8. [PMID: 20233242] doi:10.1111/j.1445- 5994.2009.01846.x
33. Claes K, Bammens B, Evenepoel P, Kuypers D, Coosemans W, Darius T, et al. Troponin I is a predictor of acute cardiac events in the immediate postoperative renal transplant period. Transplantation. 2010;89:341-6. [PMID: 20145526] doi:10.1097/TP.0b013e3181bc405e
34. Orea-Tejeda A, Sánchez-González LR, Castillo-Martínez L, Valdespino- Trejo A, Sánchez-Santillán RN, Keirns-Davies C, et al. Prognostic value of cardiac troponin T elevation is independent of renal function and clinical findings in heart failure patients. Cardiol J. 2010;17:42-8. [PMID: 20104456]
35. Kostrubiec M, Labyk A, Pedowska-Wloszek J, Pacho S, Wojciechowski A, Jankowski K, et al. Assessment of renal dysfunction improves troponin-based short-term prognosis in patients with acute symptomatic pulmonary embolism. J Thromb Haemost. 2010;8:651-8. [PMID: 20088923] doi:10.1111/j.1538-7836.2010.03762.x
36. Petrovic D, Stojimirovic BB. Cardiac troponins: outcome predictors in hemodialysis patients. J Artif Organs. 2009;12:258-63. [PMID: 20035399] doi:10.1007/s10047-009-0472-5
37. Chrysochou C, Manzoor S, Wright J, Roberts SA, Wood G, McDowell G, et al. Role of renal function and cardiac biomarkers (NT-proBNP and troponin) in determining mortality and cardiac outcome in atheromatous renovascular disease. Kidney Blood Press Res. 2009;32:373-9. [PMID: 19887825] doi:10.1159/ 000254337
38. Bagheri N, Taziki O, Falaknazi K. C-reactive protein, cardiac troponin T and low albumin are predictors of mortality in hemodialysis patients. Saudi J Kidney Dis Transpl. 2009;20:789-93. [PMID: 19736474]
39. Hickson LJ, Hickson LT, El-Zoghby ZM, Lorenz EC, Stegall MD, Jaffe AS, et al. Patient survival after kidney transplantation: relationship to pretransplant cardiac troponin T levels. Am J Transplant. 2009;9:1354-61. [PMID: 19459818] doi:10.1111/j.1600-6143.2009.02636.x
40. Roberts MA, Hare DL, Macmillan N, Ratnaike S, Sikaris K, Ierino FL. Serial increased cardiac troponin T predicts mortality in asymptomatic patients treated with chronic haemodialysis. Ann Clin Biochem. 2009;46:291-5. [PMID: 19454539] doi:10.1258/acb.2009.008213
41. Trapé J, Pérez A, Naval I, Escudero J, Comerma I, Sans A, et al. NTproBNP in haemodialysis patients: a preliminary study. Scand J Clin Lab Invest. 2008;68:415-20. [PMID: 19172698] doi:10.1080/00365510701813088
42. Sahinarslan A, Güz G, Okyay K, Mutluay R, Yalçin R, Bali M, et al. Prognostic value of troponin T and homocysteine in patients with end-stage renal disease. Turk Kardiyol Dern Ars. 2008;36:382-7. [PMID: 19155641]
43. Kang EW, Na HJ, Hong SM, Shin SK, Kang SW, Choi KH, et al. Prognostic value of elevated cardiac troponin I in ESRD patients with sepsis. Nephrol Dial Transplant. 2009;24:1568-73. [PMID: 19145004] doi:10.1093/ndt/ gfn730
44. Hocher B, Kalk P, Godes M, Liefeldt L, Ziebig R, Stasch JP, et al. Genderdependent impact of risk factors for cardiovascular and non-cardiovascular mortality in end-stage renal disease patients on haemodialysis. Kidney Blood Press Res. 2008;31:360-6. [PMID: 19023219] doi:10.1159/000173718
45. Hickson LJ, Cosio FG, El-Zoghby ZM, Gloor JM, Kremers WK, Stegall MD, et al. Survival of patients on the kidney transplant wait list: relationship to cardiac troponin T. Am J Transplant. 2008;8:2352-9. [PMID: 18785956] doi: 10.1111/j.1600-6143.2008.02395.x
46. Han SH, Choi HY, Kim DK, Moon SJ, Lee JE, Yoo TH, et al. Elevated cardiac troponin T predicts cardiovascular events in asymptomatic continuous ambulatory peritoneal dialysis patients without a history of cardiovascular disease. Am J Nephrol. 2009;29:129-35. [PMID: 18719346] doi:10.1159/000151634
47. Helleskov Madsen L, Ladefoged S, Hildebrandt P, Atar D. Comparison of four different cardiac troponin assays in patients with end-stage renal disease on chronic haemodialysis. Acute Card Care. 2008;10:173-80. [PMID: 18608043] doi:10.1080/17482940802100279
48. Katerinis I, Nguyen QV, Magnin JL, Descombes E. Cardiac findings in asymptomatic chronic hemodialysis patients with persistently elevated cardiac troponin I levels. Ren Fail. 2008;30:357-62. [PMID: 18569907] doi:10.1080/ 08860220801947355
49. Connolly GM, Cunningham R, McNamee PT, Young IS, Maxwell AP. Troponin T is an independent predictor of mortality in renal transplant recipients. Nephrol Dial Transplant. 2008;23:1019-25. [PMID: 18065785]
50. Satyan S, Light RP, Agarwal R. Relationships of N-terminal pro-Bnatriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients. Am J Kidney Dis. 2007; 50:1009-19. [PMID: 18037101]
51. Brunet P, Oddoze C, Paganelli F, Indreies M, Faure V, Opris-Saveanu A, et al. Cardiac troponins I and T in hemodialysis patients without acute coronary syndrome. Int J Cardiol. 2008;129:205-9. [PMID: 17662483]
52. Sommerer C, Beimler J, Schwenger V, Heckele N, Katus HA, Giannitsis E, et al. Cardiac biomarkers and survival in haemodialysis patients. Eur J Clin Invest. 2007;37:350-6. [PMID: 17461980]
53. Wang AY, Lam CW, Wang M, Chan IH, Goggins WB, Yu CM, et al. Prognostic value of cardiac troponin T is independent of inflammation, residual renal function, and cardiac hypertrophy and dysfunction in peritoneal dialysis patients. Clin Chem. 2007;53:882-9. [PMID: 17395709]
54. Lamb EJ, Kenny C, Abbas NA, John RI, Webb MC, Price CP, et al. Cardiac troponin I concentration is commonly increased in nondialysis patients with CKD: experience with a sensitive assay. Am J Kidney Dis. 2007;49:507-16. [PMID: 17386318]
55. Feringa HH, Bax JJ, de Jonge R, Elhendy A, van Domburg RT, Dunkelgrun M, et al. Impact of glomerular filtration rate on minor troponin T elevations for risk assessment in patients undergoing operation for abdominal aortic aneurysm or lower extremity arterial obstruction. Am J Cardiol. 2006;98:1515-8. [PMID: 17126662]
56. Kanwar M, Hashem M, Rosman H, Kamalakannan D, Cheema A, Ali A, et al. Usefulness of clinical evaluation, troponins, and C-reactive protein in predicting mortality among stable hemodialysis patients. Am J Cardiol. 2006;98: 1283-7. [PMID: 17056347]
57. Wang AY, Lam CW, Yu CM, Wang M, Chan IH, Lui SF, et al. Troponin T, left ventricular mass, and function are excellent predictors of cardiovascular congestion in peritoneal dialysis. Kidney Int. 2006;70:444-52. [PMID: 16871255]
58. Vichairuangthum K, Leowattana W, Ong-Ajyooth L, Pokum S. The relationship between serum concentration of cardiac troponin I in chronic renal failure patients and cardiovascular events. J Med Assoc Thai. 2006;89:714-20. [PMID: 16756060]
59. Havekes B, van Manen JG, Krediet RT, Boeschoten EW, Vandenbroucke JP, Dekker FW; NECOSAD Study Group. Serum troponin T concentration as a predictor of mortality in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis. 2006;47:823-9. [PMID: 16632021]
60. Sharma R, Gaze DC, Pellerin D, Mehta RL, Gregson H, Streather CP, et al. Ischemia-modified albumin predicts mortality in ESRD. Am J Kidney Dis. 2006;47:493-502. [PMID: 16490629]
61. Sharma R, Gaze DC, Pellerin D, Mehta RL, Gregson H, Streather CP, et al. Cardiac structural and functional abnormalities in end stage renal disease patients with elevated cardiac troponin T. Heart. 2006;92:804-9. [PMID: 16216854]
62. Conway B, McLaughlin M, Sharpe P, Harty J. Use of cardiac troponin T in diagnosis and prognosis of cardiac events in patients on chronic haemodialysis. Nephrol Dial Transplant. 2005;20:2759-64. [PMID: 16188899]
63. Abbas NA, John RI, Webb MC, Kempson ME, Potter AN, Price CP, et al. Cardiac troponins and renal function in nondialysis patients with chronic kidney disease. Clin Chem. 2005;51:2059-66. [PMID: 16166165]
64. Troyanov S, Ly QH, Schampaert E, Ammann H, Lalumière G, Madore F, et al. Diagnostic specificity and prognostic value of cardiac troponins in asymptomatic chronic haemodialysis patients: a three year prospective study [Letter]. Heart. 2005;91:1227-8. [PMID: 16103574]
65. Sharma R, Pellerin D, Gaze DC, Shah JS, Streather CP, Collinson PO, et al. Dobutamine stress echocardiography and cardiac troponin T for the detection of significant coronary artery disease and predicting outcome in renal transplant candidates. Eur J Echocardiogr. 2005;6:327-35. [PMID: 15985387]
66. Hojs R, Ekart R, Hojs Fabjan T, Balon BP, Gorenjak M. Cardiac troponin T (cTnT) in hemodialysis patients with asymptomatic and symptomatic atherosclerosis. Arch Med Res. 2005;36:367-71. [PMID: 15950076]
67. Duman D, Tokay S, Toprak A, Duman D, Oktay A, Ozener IC, et al. Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients. Nephrol Dial Transplant. 2005;20:962-7. [PMID: 15741207]
68. Abaci A, Ekici E, Oguzhan A, Tokgoz B, Utas C. Cardiac troponins T and I in patients with end-stage renal disease: the relation with left ventricular mass and their prognostic value. Clin Cardiol. 2004;27:704-9. [PMID: 15628116]
69. Fernández-Reyes MJ, Mon C, Heras M, Guevara P, Garcia MC, Sanchez R, et al. Predictive value of troponin T levels for ischemic heart disease and mortality in patients on hemodialysis. J Nephrol. 2004;17:721-7. [PMID: 15593041]
70. Bozbas H, Korkmaz ME, Atar I, Eroglu S, Ozin B, Yildirir A, et al. Serum levels of cardiac enzymes before and after renal transplantation. Clin Cardiol. 2004;27:559-62. [PMID: 15553307]
71. Ie EH, Klootwijk PJ, Weimar W, Zietse R. Significance of acute versus chronic troponin T elevation in dialysis patients. Nephron Clin Pract. 2004;98: c87-92. [PMID: 15528943]
72. Hussein M, Mooij J, Roujouleh H, Al Shenawi O. Cardiac troponin-I and its prognostic significance in a dialysis population. Hemodial Int. 2004;8:332-7. [PMID: 19379438] doi:10.1111/j.1492-7535.2004.80406.x
73. Apple FS, Murakami MM, Pearce LA, Herzog CA. Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death. Clin Chem. 2004;50:2279-85. [PMID: 15364888]
74. Boulier A, Jaussent I, Terrier N, Maurice F, Rivory JP, Chalabi L, et al. Measurement of circulating troponin Ic enhances the prognostic value of C-reactive protein in haemodialysis patients. Nephrol Dial Transplant. 2004;19: 2313-8. [PMID: 15252159]
75. Hung SY, Hung YM, Fang HC, Yeh JH, Hung GC, Wu CJ, et al. Cardiac troponin I and creatine kinase isoenzyme MB in patients with intradialytic hypotension. Blood Purif. 2004;22:338-43. [PMID: 15218282]
76. Kertai MD, Boersma E, Klein J, Van Urk H, Bax JJ, Poldermans D. Long-term prognostic value of asymptomatic cardiac troponin T elevations in patients after major vascular surgery. Eur J Vasc Endovasc Surg. 2004;28:59-66. [PMID: 15177233]
77. Hocher B, Ziebig R, Krause R, Asmus G, Neumayer HH, Liefeldt L, et al. Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease. Circulation. 2004;109:2266-8. [PMID: 15136497]
78. Roberts MA, Fernando D, Macmillan N, Proimos G, Bach LA, Power DA, et al. Single and serial measurements of cardiac troponin I in asymptomatic patients on chronic hemodialysis. Clin Nephrol. 2004;61:40-6. [PMID: 14964456]
79. Hocher B, Ziebig R, Altermann C, Krause R, Asmus G, Richter CM, et al. Different impact of biomarkers as mortality predictors among diabetic and nondiabetic patients undergoing hemodialysis. J Am Soc Nephrol. 2003;14:2329-37. [PMID: 12937310]
80. Wood GN, Keevil B, Gupta J, Foley R, Bubtana A, McDowell G, et al. Serum troponin T measurement in patients with chronic renal impairment predicts survival and vascular disease: a 2 year prospective study. Nephrol Dial Transplant. 2003;18:1610-5. [PMID: 12897102]
81. Choy JB, Armstrong PW, Ulan RA, Campbell PM, Gourishankar S, Prosser CI, et al. Do cardiac troponins provide prognostic insight in hemodialysis patients? Can J Cardiol. 2003;19:907-11. [PMID: 12876611]
82. deFilippi C, Wasserman S, Rosanio S, Tiblier E, Sperger H, Tocchi M, et al. Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis. JAMA. 2003;290:353-9. [PMID: 12865376]
83. Peetz D, Schütt S, Sucké B, Faldum A, Wandel E, Hafner G, et al. Prognostic value of troponin T, troponin I, and CK-MBmass in patients with chronic renal failure. Med Klin (Munich). 2003;98:188-92. [PMID: 12715142]
84. Beciani M, Tedesco A, Violante A, Cipriani S, Azzarito M, Sturniolo A, et al. Cardiac troponin I (2nd generation assay) in chronic haemodialysis patients: prevalence and prognostic value. Nephrol Dial Transplant. 2003;18:942-6. [PMID: 12686669]
85. Scott B, Deman A, Peeters P, Van den Branden C, Stolear JC, Van Camp G, et al. Cardiac troponin T and malondialdehyde modified plasma lipids in haemodialysis patients. Nephrol Dial Transplant. 2003;18:737-42. [PMID: 12637643]
86. Farkouh ME, Robbins MJ, Zafar MU, Shimbo D, Davidson KW, Puttappa R, et al. Association between troponin I levels and mortality in stable hemodialysis patients. Am J Med. 2003;114:224-6. [PMID: 12637137]
87. Löwbeer C, Stenvinkel P, Pecoits-Filho R, Heimbürger O, Lindholm B, Gustafsson SA, et al. Elevated cardiac troponin T in predialysis patients is associated with inflammation and predicts mortality. J Intern Med. 2003;253:153-60. [PMID: 12542555]
88. Apple FS, Murakami MM, Pearce LA, Herzog CA. Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation. 2002;106:2941-5. [PMID: 12460876]
89. Löwbeer C, Gutierrez A, Gustafsson SA, Norrman R, Hulting J, Seeberger A. Elevated cardiac troponin T in peritoneal dialysis patients is associated with CRP and predicts all-cause mortality and cardiac death. Nephrol Dial Transplant. 2002;17:2178-83. [PMID: 12454230]
90. Yakupoglu U, Ozdemir FN, Arat Z, Haberal A, Agca E, Bilgin N. Can troponin-I predict cardiovascular mortality due to myocardial injury in hemodialysis patients? Transplant Proc. 2002;34:2033-4. [PMID: 12270303]
91. Mallamaci F, Zoccali C, Parlongo S, Tripepi G, Benedetto FA, Cutrupi S, et al. Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis. 2002;40:68-75. [PMID: 12087563]
92. Deegan PB, Lafferty ME, Blumsohn A, Henderson IS, McGregor E. Prognostic value of troponin T in hemodialysis patients is independent of comorbidity. Kidney Int. 2001;60:2399-405. [PMID: 11737616]
93. Ishii J, Nomura M, Okuma T, Minagawa T, Naruse H, Mori Y, et al. Risk stratification using serum concentrations of cardiac troponin T in patients with end-stage renal disease on chronic maintenance dialysis. Clin Chim Acta. 2001; 312:69-79. [PMID: 11580911]
94. Lang K, Schindler S, Forberger C, Stein G, Figulla HR. Cardiac troponins have no prognostic value for acute and chronic cardiac events in asymptomatic patients with end-stage renal failure. Clin Nephrol. 2001;56:44-51. [PMID: 11499658]
95. Ooi DS, Zimmerman D, Graham J, Wells GA. Cardiac troponin T predicts long-term outcomes in hemodialysis patients. Clin Chem. 2001;47:412-7. [PMID: 11238290]
96. Dierkes J, Domröse U, Westphal S, Ambrosch A, Bosselmann HP, Neumann KH, et al. Cardiac troponin T predicts mortality in patients with end-stage renal disease. Circulation. 2000;102:1964-9. [PMID: 11034946]
97. Porter GA, Norton T, Bennett WM. Long term follow up of the utility of troponin T to assess cardiac risk in stable chronic hemodialysis patients. Clin Lab. 2000;46:469-76. [PMID: 11034532]
98. Heeschen C, Deu A, Langenbrink L, Goldmann BU, Hamm CW. Analytical and diagnostic performance of troponin assays in patients suspicious for acute coronary syndromes. Clin Biochem. 2000;33:359-68. [PMID: 11018687]
99. Ooi DS, Veinot JP, Wells GA, House AA. Increased mortality in hemodialyzed patients with elevated serum troponin T: a one-year outcome study. Clin Biochem. 1999;32:647-52. [PMID: 10638948]
100. Stolear JC, Georges B, Shita A, Verbeelen D. The predictive value of cardiac troponin T measurements in subjects on regular haemodialysis. Nephrol Dial Transplant. 1999;14:1961-7. [PMID: 10462278]
101. Roppolo LP, Fitzgerald R, Dillow J, Ziegler T, Rice M, Maisel A. A comparison of troponin T and troponin I as predictors of cardiac events in patients undergoing chronic dialysis at a Veteran's Hospital: a pilot study. J Am Coll Cardiol. 1999;34:448-54. [PMID: 10440158]
102. Möckel M, Schindler R, Knorr L, Müller C, Heller G Jr, Störk TV, et al. Prognostic value of cardiac troponin T and I elevations in renal disease patients without acute coronary syndromes: a 9-month outcome analysis. Nephrol Dial Transplant. 1999;14:1489-95. [PMID: 10383013]
103. Musso P, Cox I, Vidano E, Zambon D, Panteghini M. Cardiac troponin elevations in chronic renal failure: prevalence and clinical significance. Clin Biochem. 1999;32:125-30. [PMID: 10211629]
104. Porter GA, Norton T, Bennett WB. Troponin T, a predictor of death in chronic haemodialysis patients. Eur Heart J. 1998;19 Suppl N:N34-7. [PMID: 9857937]
105. Morton AR, Collier CP, Ali N, Dagnone LE. Cardiac troponin I in patients receiving renal replacement therapy. ASAIO J. 1998;44:M433-5. [PMID: 9804466]
106. Martin GS, Becker BN, Schulman G. Cardiac troponin-I accurately predicts myocardial injury in renal failure. Nephrol Dial Transplant. 1998;13:1709-12. [PMID: 9681716]
107. Apple FS, Sharkey SW, Hoeft P, Skeate R, Voss E, Dahlmeier BA, et al. Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: a 1-year outcomes analysis. Am J Kidney Dis. 1997;29:399-403. [PMID: 9041216]
108. Wang AY, Lam CW, Chan IH, Wang M, Lui SF, Sanderson JE. Sudden cardiac death in end-stage renal disease patients: a 5-year prospective analysis. Hypertension. 2010;56:210-6. [PMID: 20606110] doi:10.1161 /HYPERTENSIONAHA.110.151167
109. Svensson M, Gorst-Rasmussen A, Schmidt EB, Jorgensen KA, Christensen JH. NT-pro-BNP is an independent predictor of mortality in patients with end-stage renal disease. Clin Nephrol. 2009;71:380-6. [PMID: 19356370]
110. Ilva T, Lassus J, Siirilä-Waris K, Melin J, Peuhkurinen K, Pulkki K, et al. Clinical significance of cardiac troponins I and T in acute heart failure. Eur J Heart Fail. 2008;10:772-9. [PMID: 18599345] doi:10.1016/j.ejheart .2008.06.009
111. Le Goff C, Bovy C, Aldenhoff MC, Krzesinski JM, Chapelle JP. Threeyear prognostic interest of cardiac troponin T (cTnT) and amino-terminal pro- B-natriuretic peptide (NT-proBNP) in hemodialyzed patients. Immuno-Analyse & Biologie Spécialisée. 2008;23:12-8.
112. Quiroga B, Verdalles U, Reque J, García de Vinuesa S, Goicoechea M, Luño J. Cardiovascular events and mortality in chronic kidney disease (stages I-IV). Nefrologia. 2013;33:539-45. [PMID: 23897186] doi:10.3265/ Nefrologia.pre2013.May.11895
113. Assa S, Gansevoort RT, Westerhuis R, Kobold AC, Voors AA, de Jong PE, et al. Determinants and prognostic significance of an intra-dialysis rise of cardiac troponin I measured by sensitive assay in hemodialysis patients. Clin Res Cardiol. 2013;102:439-45. [PMID: 23397594] doi:10.1007/s00392-013-0551-8
114. Wolley M, Stewart R, Curry E, Davidson J, White H, Pilmore H. Variation in and prognostic importance of troponin T measured using a highsensitivity assay in clinically stable haemodialysis patients. Clin Kidney J. 2013; 6:402-9. doi:10.1093/ckj/sfs122
115. Levin A, Rigatto C, Barrett B, Madore F, Muirhead N, Holmes D, et al; CanPREDDICT Investigators. Biomarkers of inflammation, fibrosis, cardiac stretch and injury predict death but not renal replacement therapy at 1 year in a Canadian chronic kidney disease cohort. Nephrol Dial Transplant. 2014;29: 1037-47. [PMID: 24371297] doi:10.1093/ndt/gft479
116. Farshid A, Pathak R, Shadbolt B, Arnolda L, Talaulikar G. Diastolic function is a strong predictor of mortality in patients with chronic kidney disease. BMC Nephrol. 2013;14:280. [PMID: 24359445] doi:10.1186/1471-2369-14-280
117. Bayes-Genis A, Zamora E, de Antonio M, Galán A, Vila J, Urrutia A, et al. Soluble ST2 serum concentration and renal function in heart failure. J Card Fail. 2013;19:768-75. [PMID: 24263122] doi:10.1016/j.cardfail.2013.09.005
118. Alam A, Palumbo A, Mucsi I, Barré PE, Sniderman AD. Elevated troponin I levels but not low grade chronic inflammation is associated with cardiacspecific mortality in stable hemodialysis patients. BMC Nephrol. 2013;14:247. [PMID: 24206774] doi:10.1186/1471-2369-14-247
119. Hassan HC, Howlin K, Jefferys A, Spicer ST, Aravindan AN, Suryanarayanan G, et al. High-sensitivity troponin as a predictor of cardiac events and mortality in the stable dialysis population. Clin Chem. 2014;60:389-98. [PMID: 24185551] doi:10.1373/clinchem.2013.207142
120. Vestergaard P, Mosekilde L. Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism. BMJ. 2003;327:530-4. [PMID: 12958111]
121. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al; American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108:2154-69. [PMID: 14581387]