Elevated cardiac troponin T in predialysis patients is associated with inflammation and predicts mortality

Journal of Internal Medicine

Volumn 253, Issue 2, 2003, Pages 153-160

  Löwbeer, Christian ^c   Stenvinkel, P ^c   Pecoits Filho, R ^a   Heimburger O ^c   Lindholm, B ^a   Gustafsson, S A ^b   Seeberger, A ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ST GÖRAN S HOSPITAL   (Sweden)

^c Box 1550 ^*

Author keywords

C reactive protein; Cardiac troponin T; Chronic renal disease; Inflammation; Interleukin 6; Predialysis; Survival

Indexed keywords

BIOCHEMICAL MARKER; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 6; TROPONIN T;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DIALYSIS; FEMALE; HUMAN; INFLAMMATION; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MORTALITY; PERITONEAL DIALYSIS; PRIORITY JOURNAL; PROGNOSIS; REGRESSION ANALYSIS; SURVIVAL RATE;

EID: 0037318642     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2003.01069.x     Document Type: Article

References (39)

1. Ritz E, Koch M. Morbidity and mortality due to hypertension in patients with renal failure. Am J Kidney Dis 1993; 21 (5 Suppl. 2): 113-8.
2. Lindahl B, Venge P, Wallentin L. Relation between troponin T and the risk of subsequent cardiac events in unstable coronary artery disease. The FRISC study group. Circulation 1996; 93: 1651-7.
3. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined - a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000; 36: 959-69.
4. Watnick S, Perazella MA. Cardiac troponins: utility in renal insufficiency and end-stage renal disease. Semin Dial 2002; 15: 66-70.
5. Frankel WL, Herold DA, Ziegler TW, Fitzgerald RL. Cardiac troponin T is elevated in asymptomatic patients with chronic renal failure. Am J Clin Pathol 1996; 106: 118-23.
6. Ooi DS, House AA. Cardiac troponin T in hemodialyzed patients. Clin Chem 1998; 44: 1410-6.
7. Iliou MC, Fumeron C, Benoit MO et al. Factors associated with increased serum levels of cardiac troponins T and I in chronic haemodialysis patients: Chronic Haemodialysis New Cardiac Markers Evaluation (CHANCE) Study. Nephrol Dial Transplant 2001; 16: 1452-8.
8. Lowbeer C, Ottosson-Seeberger A, Gustafsson SA, Norrman R, Hulting J, Gutierrez A. Increased cardiac troponin T and endothelin-1 concentrations in dialysis patients may indicate heart disease. Nephrol Dial Transplant 1999; 14: 1948-55.
9. Porter GA, Norton T, Bennett WM. Long term follow up of the utility of troponin T to assess cardiac risk in stable chronic hemodialysis patients. Clin Laboratory 2000; 46: 469-76.
10. Ooi DS, Veinot JP, Wells GA, House AA. Increased mortality in hemodialyzed patients with elevated serum troponin T: a one-year outcome study. Clin Biochem 1999; 32: 647-52.
11. Ooi DS, Zimmerman D, Graham J, Wells GA. Cardiac troponin T predicts long-term outcomes in hemodialysis patients. Clin Chem 2001; 47: 412-7.
12. Dierkes J, Domrose U, Westphal S et al. Cardiac troponin T predicts mortality in patients with end-stage renal disease. Circulation 2000; 102: 1964-9.
13. Deegan PB, Lafferty ME, Blumsohn A, Henderson IS, McGregor E. Prognostic value of troponin T in hemodialysis patients is independent of comorbidity. Kidney Int 2001; 60: 2399-405.
14. Mockel M, Schindler R, Knorr L et al. Prognostic value of cardiac troponin T and I elevations in renal disease patients without acute coronary syndromes: a 9-month outcome analysis. Nephrol Dial Transplant 1999; 14: 1489-95.
15. Lang K, Schindler S, Forberger C, Stein G, Figulla HR. Cardiac troponins have no prognostic value for acute and chronic cardiac events in asymptomatic patients with end-stage renal failure. Clin Nephrol 2001; 56: 44-51.
16. Koukkunen H, Penttila K, Kemppainen A et al. C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris. Ann Med 2001; 33: 37-47.
17. Stolear JC, Georges B, Shita A, Verbeelen D. The predictive value of cardiac troponin T measurements in subjects on regular haemodialysis. Nephrol Dial Transplant 1999; 14: 1961-7.
18. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 1999; 55: 648-58.
19. Iseki K, Tozawa M, Yoshi S, Fukiyama K. Serum C-reactive (CRP) and risk of death in chronic dialysis patients. Nephrol Dial Transpl 1999; 14: 1956-60.
20. Yeun JY, Levine RA, Mantadilok V, Kaysen GA. C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 2000; 35: 469-76.
21. Stenvinkel P, Heimburger O, Paultre F et al. Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 1999; 55: 1899-911.
22. Willging S, Keller F, Steinbach G. Specificity of cardiac troponins I and T in renal disease. Clin Chem Laboratory Med 1998; 36: 87-92.
23. McLaurin MD, Apple FS, Voss EM, Herzog CA, Sharkey SW. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clin Chem 1997; 43: 976-82.
24. Haller C, Zehelein J, Remppis A, Muller-Bardorff M, Katus HA. Cardiac troponin T in patients with end-stage renal disease: absence of expression in truncal skeletal muscle. Clin Chem 1998; 44: 930-8.
25. Ricchiuti V, Voss EM, Ney A, Odland M, Anderson PA, Apple FS, Cardiac troponin T isoforms expressed in renal diseased skeletal muscle will not cause false-positive results by the second generation cardiac troponin T assay by Boehringer Mannheim. Clin Chem 1998; 44:1919-24.
26. Haller C, Stevanovich A, Katus HA. Are cardiac troponins reliable serodiagnostic markers of cardiac ischaemia in end-stage renal disease? Nephrol Dial Transplant 1996; 11: 941-4.
27. Amann K, Breitbach M, Ritz E, Mall G. Myocyte/capillary mismatch in the heart of uremic patients. J Am Soc Nephrol 1998; 9: 1018-22.
28. Amann K, Ritz E. Cardiac disease in chronic uremia: pathophysiology. Adv Ren Replace Ther 1997; 4: 212-24.
29. Wu AH, Feng YJ. Biochemical differences between cTnT and cTnI and their significance for diagnosis of acute coronary syndromes. Eur Heart J 1998; 19 (Suppl. N): N25-9.
30. Ridker PM, Cushman M, Stampfer MJ, Russell PT, Hennekens CH. Inflammation, aspirin and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-9.
31. Harris TB, Ferrucci L, Tracy RP et al. Association of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 1999; 106: 506-12.
32. Bologa RM, Levine DM, Parker TS et al. Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients. Am J Kidney Dis 1998; 32: 107-14.
33. Griselli M, Herbert J, Hutchinson WL et al. C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction. J Exp Med 1999; 190: 1733-40.
34. Haubitz M, Brunkhorst R. C-reactive protein and chronic Chlamydia pneumoniae infection - long term predictors for cardiovascular disease and survival in patients on peritoneal dialysis. Nephrol Dial Transplant 2001; 16: 809-15.
35. Noh H, Lee SW, Kang SW et al. Serum C-reactive protein: a predictor of mortality in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 1998; 18: 387-94.
36. Mazzone A, De Servi S, Mazzucchelli I et al. Increased concentrations of inflammatory mediators in unstable angina: correlation with serum troponin T. Heart 2001; 85: 571-5.
37. Biasucci LM, Liuzzo G, Fantuzzi G et al. Increasing levels of interleukin (IL) -1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Circulation 1999; 99: 2079-84.
38. Heeschen C, Deu A, Langenbrink L, Goldmann BU, Hamm CW. Analytical and diagnostic performance of troponin assays in patients suspicious for acute coronary syndromes. Clin Biochem 2000; 33: 359-68.
39. Koch M, Kutkuhn B, Trenkwalder E et al. Apolipoprotein B, fibrinogen. HDL cholesterol, and apolipoprotein (a) phenotypes predict coronary artery disease in hemodialysis patients. J Am Soc Nephrol 1997; 8: 1889-98.