Multiobjective optimization on antiplatelet effects of three components combination by quantitative composition-activity relationship modeling and weighted-sum method

Chemical Biology and Drug Design

Volumn 84, Issue 5, 2014, Pages 513-521

  Huang, Yi ^a   Jiang, Wei ^a   Xiao, Yang ^b   Wang, Yi ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Antiplatelet aggregation; Quantitative composition activity relationship; Traditional chinese medicine; Weighted sum method; Xue Fu Zhu Yu Tang

Indexed keywords

ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; COLLAGEN; ANTITHROMBOCYTIC AGENT; DRUG COMBINATION; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; MALE; METHODOLOGY; MULTIOBJECTIVE OPTIMIZATION; NONHUMAN; PLATELET AGGREGATION ASSAY; QUANTITATIVE COMPOSITION ACTIVITY RELATIONSHIP MODELING; WEIGHTED SUM METHOD; ANIMAL; CHEMISTRY; DRUG COMBINATION; DRUG SCREENING; PROCEDURES; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RABBIT; REPRODUCIBILITY;

CITRUS MAXIMA;

ADENOSINE DIPHOSPHATE; ANIMALS; ARACHIDONIC ACID; COLLAGEN; DRUG COMBINATIONS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; MALE; PLATELET AGGREGATION INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RABBITS; REPRODUCIBILITY OF RESULTS;

EID: 84908066119     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12338     Document Type: Article

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