Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles

International Journal of Pharmaceutics

Volumn 407, Issue 1-2, 2011, Pages 53-62

  Shin, Sangmun ^a   Choi, Du Hyung ^b   Truong, Nguyen Khoa Viet ^a   Kim, Nam Ah ^b   Chu, Kyung Rok ^b   Jeong, Seong Hoon ^b  

^a Inje University   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

Drug releases; Matrix tablet; Response surface methodology; Robust design; swelling

Indexed keywords

CITRIC ACID; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; SILICON DIOXIDE; TERAZOSIN;

ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; GELATION; HUMAN; HYDROPHILICITY; KINETICS; MATRIX TABLET; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; TIME SERIES ANALYSIS;

DELAYED-ACTION PREPARATIONS; EXCIPIENTS; GELS; MODELS, STATISTICAL; PRAZOSIN; STEARIC ACIDS; TABLETS; TIME FACTORS;

EID: 79952296416     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.01.013     Document Type: Article

References (30)

1. Alderman, D.A., 1984. A review of cellulose ethers in hydrophilic matrices for oral controlled release dosage forms. Int. J. Pharm. 5, 1-9.
2. Bloomfield, M.S., Butler, W.C., 2000. Robustness testing, using experimental design, of a flow-through dissolution method for a product where the actives have markedly differing solubility properties. Int. J. Pharm. 206, 55-61.
3. Campos-Aldrete, M.E., Villafuerte-Robles, L., 1997. Influence of the viscosity degree and the particle size of HPMC onmetronidazole release from matrix tablets. Eur. J. Pharm. Biopharm. 43, 173-178.
4. Cho, B.R., Shin, S.M., Choi, Y., Kovach, J., 2009. Development of a multidisciplinary optimization process for designing optimal pharmaceutical formulations with constrained experimental regions. Int. J. Adv. Manuf. Tech. 44, 841-853.
5. Chopra, S., Patil, G.V., Motwani, S.K., 2007. Release modulating hydrophilic matrix systems of losartan potassium: optimization of formulation using statistical experimental design. Eur. J. Pharm. Biopharm. 66, 73-82.
6. Conti, S., Maggi, L., Segale, L., Ochoa Machiste, E., Conte, U., Grenier, P., Vergnault, G., 2007. Matrices containing NaCMC and HPMC 2 Swelling and release mechanism studies. Int. J. Pharm. 333, 143-151.
7. Davis, S.S., Hardy, J.G., Fera, J.W., 1986. Alimentary tract and pancreas: transit of pharmaceutical dosage forms through the small intestine. Gut 27, 886-892. (Pubitemid 16044258)
8. Ebube, N.K., Jones, A.B., 2004. Sustained release of acetaminophen from heterogeneous mixture of two hydrophilic non-ionic cellulose ether polymers. Int. J. Pharm. 272, 19-27.
9. El-Malah, Y., Nazzal, S., 2006. Hydrophilic matrices: application of Placket-Burman screening design to model the effect of POLTOX-carbopol blends on drug release. Int. J. Pharm. 309, 163-170.
10. Ford, J.L., Mitchell, K., Rowe, P., Armstrong, D.J., Elliott, P.N.C., Rostron, C., Hogan, J.E., 1991. Mathematical modeling of drug release from hydroxypropylmethylcellulose matrices: effect of temperature. Int. J. Pharm. 71, 95-104.
11. Furlanetto, S., Cirri, M., Maestrelli, F., Corti, G., Mura, P., 2006. Study of formulation variables influencing the drug release rate from matrix tablets by experimental design. Eur. J. Pharm. Biopharm. 62, 77-84.
12. Gao, P., Skoug, J.W., Nixon, P.R., Ju, T.R., Stemm, N.L., Sung, K.C., 1996. Swelling of hydroxypropylmethylcellulose matrix tablets Mechanistic study of the influence of formulation variables on matrix performance and drug release. J. Pharm. Sci. 85, 732-740.
13. Juarez, H., Rico, G., Villafuerte, L., 2001. Influence of admixed carboxymethylcellulose on release of 4-aminopyridine from hydroxypropyl methylcellulose matrix tablets. Int. J. Pharm. 216, 115-125.
14. Khan, G.M., Jiabi, Z., 1998. Formulation and in vitro evaluation of ibuprofen-carbopol 974P-NF controlled release matrix tablets III: influence of co-excipients n release rate of the drug. J. Control. Release 54, 185-190. (Pubitemid 28342697)
15. Kincl, M., Turk, S., Vrečer, F., 2005. Application of experimental design methodology in development and optimization of drug release method. Int. J. Pharm. 291, 39-49.
16. Madhusudan Rao, Y., Krishna Veni, J., Jayasagar, G., 2001. Formulation and evaluation of dichlorofenac sodium using hydrophilic matrices. Drug. Dev. Ind. Pharm. 27, 759-766.
17. Mitchell, K., Ford, J.L., Armstrong, D.J., Elliott, P.N.C., Rostron, C., Hogan, J.E., 1993. The influence of concentration on the release of drugs from gel and matrices containing Methocel. Int. J. Pharm. 100, 155-163.
18. Montgomery, D.C., 2001. Design and Analysis of Experiments. John Wiley & Sons Inc.
19. Neau, S.H., Howard, M.A., Claudius, J.S., Howard, D.R., 1999. The effect of aqueous solubility of xanthine derivates on the release mechanism from ethylcellulose matrix tablets. Int. J. Pharm. 179, 97-105.
20. Nerurkar, J., Jun, H.W., Price, J.C., Park, M.O., 2005. Controlled release matrix tablet of ibuprofen using cellulose ethers and carrageenans: effect of formulation factors on dissolution rate. Eur. J. Pharm. Biopharm. 61, 56-68.
21. Park, J.S., Shim, J.Y., Truong, N.K.V., Park, J.S., Shin, S., Choi, Y.W., Lee, J., Yoon, J.H., Jeong, S.H., 2010. A pharma-robust design method to investigate the effect of PEG and PEO on matrix tablets. Int. J. Pharm. 393, 79-87.
22. Pham, A.T., Lee, P.I., 1994. Probing the mechanism of drug release from hydroxypropylmethyl cellulose matrices. Pharm. Res. 11, 1379-1385.
23. Rao, K.V.R., Devi, K.P., Buri, P., 1990. Influence of molecular size and water solubility of the solute on its release from swelling and erosion controlled polymeric matrices. J. Control. Release 12, 133-141. (Pubitemid 20123878)
24. Sako, K., Nakashima, H., Sawada, T., Fukui, M., 1996. Relationship between gelation rate of controlled-release acetaminophen tablets containing polyethylene oxide and colonic drug release in dogs. Pharm. Res. 13, 594-598.
25. Scheffé, H., 1958. Experiments with mixtures. J. R. Statist. Soc. B 20, 334-360.
26. Shin, S.M., Cho, B.R., 2009. Studies on a Bi-objective robust design optimization problem. IIE Trans. 41, 957-968.
27. Shin, S.M., Cho, B.R., 2005. Bias-specified robust design optimization and an analytical solutions. Comput. Ind. Eng. 48, 129-148.
28. Siepmann, J., Streubel, A., Peppas, N.A., 2002. Understanding and prediction drug delivery from hydrophilic matrix tablets using the sequential layer model. Pharm. Res. 19, 306-313.
29. Skpoug, J.W., Borin, M.T., Fleishaker, J.C., Cooper, A.M., 1991. In vitro and in vivo evaluation of whole and half tablets of sustained release adinazolam mesylate. Pharm. Res. 8, 1482-1488.
30. Vining, G.G., Myers, R.H., 1990. Combining taguchi and response surface philosophies: a dual response approach. J. Qual. Technol. 22, 38-45.