Ginseng (Panax quinquefolius) and licorice (Glycyrrhiza uralensis) root extract combinations increase hepatocarcinoma cell (Hep-G2) viability

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Popovich, David G ^a   Yeo, Shi Yun ^a   Zhang, Wei ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GINSENG EXTRACT; GINSENOSIDE; GLYCYRRHIZA URALENSIS EXTRACT; GLYCYRRHIZIC ACID; LACTATE DEHYDROGENASE;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PHASE; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CELL STRAIN HEPG2; CELL SURVIVAL; CELL VIABILITY; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME RELEASE; GINSENG; GLYCYRRHIZA URALENSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOBOLOGRAPHIC ANALYSIS; LC 50; LIVER CELL CARCINOMA; PANAX QUINQUEFOLIUS; PLANT ROOT; PLOTS AND CURVES; PRIORITY JOURNAL;

EID: 79959201798     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nep074     Document Type: Article

References (32)

1. Shi J., Chu F. Z., The ABC of Traditional Chinese Medicine 1987 2nd Hong Kong Hai Feng
2. Barnes P. M., Powell-Griner E., McFann K., Nahin R. L., Complementary and alternative medicine use among adults: United States, 2002 Advance Data 2004 343 1 19
3. Chung W. T., Lee S. H., Kim J. D., Sung N. S., Hwang B., Lee S. Y., Yu C. Y., Lee H. Y., Effect of the extracts from Glycyrrhiza uralensis Fisch on the growth characteristics of human cell lines: anti-tumor and immune activation activities Cytotechnology 2001 37 1 55 64 (Pubitemid 34816971)
4. Wang Z. Y., Nixon D. W., Licorice and cancer Nutrition and Cancer 2001 39 1 1 11 (Pubitemid 32880942)
5. Popovich D. G., Kitts D. D., Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line Archives of Biochemistry and Biophysics 2002 406 1 8 (Pubitemid 35191710)
6. Kitts D. D., Popovich D. G., Watson D., Ginseng Performance Functional Foods 2003 New York, NY, USA Woodhead Publishing 78 92
7. Chan H.-T., Chan C., Ho J. W., Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells Toxicology 2003 188 2-3 211 217 (Pubitemid 36588901)
8. Wu X., Zhang L., Gurley E., Studer E., Shang J., Wang T., Wang C., Yan M., Jiang Z., Hylemon P. B., Sanyal A. J., Pandak W. M. Jr., Zhou H., Prevention of free fatty acid-induced hepatic lipotoxicity by 18 -glycyrrhetinic acid through lysosomal and mitochondrial pathways Hepatology 2008 47 6 1905 1915 (Pubitemid 351945558)
9. Wu Y.-T., Shen C., Yin J., Yu J.-P., Meng Q., Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid Phytotherapy Research 2006 20 8 640 645
10. Shibata S., A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice Yakugaku Zasshi 2000 120 10 849 862
11. Hawthorne S., Gallagher S., Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells Journal of Pharmacy and Pharmacology 2008 60 661 666 (Pubitemid 351589055)
12. Hsieh T.-C., Lu X., Chea J., Wu J. M., Prevention and management of prostate cancer using PC-SPES: a scientific perspective Journal of Nutrition 2002 132 111 3513S 3517S (Pubitemid 35315829)
13. Vuksan V., Stavro M. P., Sievenpiper J. L., Koo V. Y., Wong E., Beljan-Zdravkovic U., American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation Journal of the American College of Nutrition 2000 19 738 744 (Pubitemid 32065739)
14. Vuksan V., Stavro M. P., Sievenpiper J. L., Beljan-Zdravkovic U., Leiter L. A., Josse R. G., Xu Z., Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes Diabetes Care 2000 23 9 1221 1226
15. Scaglione F., Ferrara F., Dugnani S., Falchi M., Santoro G., Fraschini F., Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer Drugs under Experimental and Clinical Research 1990 16 10 537 542
16. Scaglione F., Cattaneo G., Alessandria M., Cogo R., Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold Drugs under Experimental and Clinical Research 1996 22 65 72 (Pubitemid 26305775)
17. Liu W. K., Xu S. X., Che C. T., Anti-proliferative effect of ginseng saponins on human prostate cancer cell line Life Sciences 2000 67 11 1297 1306 (Pubitemid 30640817)
18. Popovich D. G., Kitts D. D., Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, (Int-407 and Caco-2) Canadian Journal of Physiology and Pharmacology 2004 82 3 183 190 (Pubitemid 38621691)
19. Adams L. S., Seeram N. P., Hardy M. L., Carpenter C., Heber D., Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines Evidence-Based Complementary and Alternative Medicine 2006 3 1 117 124 (Pubitemid 43999659)
20. Popovich D. G., Kitts D. D., Generation of ginsenosides Rg3 and Rh2 from North American ginseng Phytochemistry 2004 65 3 337 344 (Pubitemid 38147347)
21. Zhang W., Popovich D. G., Effect of soyasapogenol A and soyasapogenol B concentrated extracts on Hep-G2 cell proliferation and apoptosis Journal of Agricultural and Food Chemistry 2008 56 8 2603 2608 (Pubitemid 351685198)
22. Tallarida R. J., Drug Synergism and Dose-Effect Data Analysis 2000 New York, NY, USA Chapman Hall/CRC
23. Tallarida R. J., Porreca F., Cowan A., Statistical analysis of drug-drug and site-site interactions with isobolograms Life Sciences 1989 45 11 947 961 (Pubitemid 19251921)
24. Huang K. C., The Pharmacology of Chinese Herbs 1998 Boca Raton, Fla, USA CRC Press
25. Ye F., Xui L., Yi J., Zhang W., Zhang D. Y., Anticancer activity of Scutellaria baicalensis and its potential mechanism Journal of Alternative and Complementary Medicine 2002 8 5 567 572 (Pubitemid 35291591)
26. Hsieh T. C., Wijeratne E. K., Liang J. Y., Gunatilaka A. L., Wu J. M., Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens Biochemical and Biophysical Research Community 2005 337 224 231 (Pubitemid 41393783)
27. Popov A. M., Comparative study of cytotoxic and hemolytic effects of triterpenoids isolated from Ginseng and Sea cucumber Izvestiya Rossiiskoi Akademii NaukSeriya Biologicheskaya 2002 2 155 164
28. Jo E.-H., Kim S.-H., Ra J.-C., Kim S.-R., Cho S.-D., Jung J.-W., Yang S.-R., Park J.-S., Hwang J.-W., Aruoma O. I., Kim T.-Y., Lee Y.-S., Kang K.-S., Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells Cancer Letters 2005 230 2 239 247 (Pubitemid 41612467)
29. Lee Y., Chung E., Youl Lee K., Hee Lee Y., Huh B., Lee S. K., Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor Molecular and Cellular Endocrinology 1997 133 2 135 140 (Pubitemid 27491526)
30. Ahn K.-S., Kim J.-H., Oh S.-R., Min B.-S., Kinjo J., Lee H.-K., Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1 Biological and Pharmaceutical Bulletin 2002 25 8 1105 1107 (Pubitemid 39663242)
31. Lee C.-H., Park S.-W., Kim Y. S., Kang S. S., Kim J. A., Lee S. H., Lee S.-M., Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice Biological and Pharmaceutical Bulletin 2007 30 10 1898 1904 (Pubitemid 47607779)
32. Nakamura T., Fujii T., Ichihara A., Enzyme leakage due to change of membrane permeability of primary cultured rat hepatocytes treated with various hepatotoxins and its prevention by glycyrrhizin Cell Biology and Toxicology 1985 1 285 295 (Pubitemid 16257883)