Buccal acetaminophen provides fast analgesia: Two randomized clinical trials in healthy volunteers

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 1621-1627

  Pickering, Gisèle ^a,b,c   Macian, Nicolas ^a   Libert, Frédéric ^a,b   Cardot, J Michel ^a   Coissard, Séverine ^a   Perovitch, Philippe ^d   Maury, Marc ^d   Dubray, Claude ^a,b,c  

^a UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^b INSERM   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d Unither Pharamceuticals   (France)

Author keywords

Healthy volunteer; Pain; Transmucosal delivery

Indexed keywords

PARACETAMOL;

ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BITTER TASTE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG RESPONSE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PAIN THRESHOLD; RANDOMIZED CONTROLLED TRIAL; SATISFACTION; STIMULUS RESPONSE; ADULT; ANALGESIA; BLOOD; BUCCAL DRUG ADMINISTRATION; CLINICAL TRIAL; DOSE RESPONSE; PAIN; PAIN MEASUREMENT; TIME;

ACETAMINOPHEN; ADMINISTRATION, BUCCAL; ADULT; ANALGESIA; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HEALTHY VOLUNTEERS; HUMANS; MALE; PAIN; PAIN MEASUREMENT; TIME FACTORS;

EID: 84908062115     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S63476     Document Type: Article

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