Paracetamol and opioid pathways: A pilot randomized clinical trial

Fundamental and Clinical Pharmacology

Volumn 27, Issue 3, 2013, Pages 339-345

  Pickering, Gisèle ^a,b,c   Moustafa, Fares ^a   Desbrandes, Stephanie ^a   Michel Cardot, J ^a   Roux, Delphine ^a   Dubray, Claude ^a,b,c  

^a UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^b INSERM   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

Author keywords

Cerebral evoked potentials; Pain; Paracetamol

Indexed keywords

NALOXONE; OPIATE RECEPTOR; PARACETAMOL; PLACEBO;

ADULT; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EVOKED RESPONSE; HUMAN; HUMAN EXPERIMENT; MALE; PAIN; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STIMULUS RESPONSE; VOLUNTEER;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; ANALYSIS OF VARIANCE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EVOKED POTENTIALS; HUMANS; INJECTIONS, INTRAVENOUS; MALE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; PILOT PROJECTS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84877815115     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2011.01010.x     Document Type: Article

References (38)

1. Pelissier T., Alloui A., Paeile C., Eschalier A.Evidence of a central antinociceptive effect of paracetamol involving spinal 5HT3 receptors. Neuroreport (1995) 6 1546-1548.
2. Alloui A., Chassaing C., Schmidt J. et al.Acetaminophen exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats. Eur. J. Pharmacol. (2002) 443 71-77.
3. Tjolsen A., Lund A., Hole K.Antinociceptive effect of acetaminophen in rats is partly dependent on spinal serotonergic systems. Eur. J. Pharmacol. (1991) 193 193-201.
4. Pini L.A., Sandrini M., Vitale G.The antinociceptive action of acetaminophen is associated with changes in the serotonergic system in the rat brain. Eur. J. Pharmacol. (1996) 308 31-40.
5. Bonnefont J., Chapuy E., Clottes E., Alloui A., Eschalier A.Spinal 5-HT1A receptors differentially influence nociceptive processing according to the nature of the noxious stimulus in rats: effect of WAY-100635 on the antinociceptive activities of paracetamol, venlafaxine and 5-HT. Pain (2005) 114 482-490.
6. Flower R.J., Vane J.R.Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature (1972) 240 410-411.
7. Mallet C., Daulhac L., Bonnefont J. et al.Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain (2008) 139 190-200.
8. Sandrini M., Vitale G., Ruggieri V., Pini L.Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats. Inflamm. Res. (2007) 56 139-142.
9. Pini L.A., Vitale G., Ottani A., Sandrini M.Naloxone-reversible antinociception by paracetamol in the rat. JPET (1997) 280 934-940.
10. Raffa R.B., Stone D.J. Jr, Tallarida R.J.Discovery of "self-synergistic" spinal/supraspinal antinociception produced by acetaminophen (paracetamol). J. Pharmacol. Exp. Ther. (2000) 295 291-294.
11. Raffa R.B., Walker E.A., Sterious S.N.Opioid receptors and paracetamol (acetaminophen). Eur. J. Pharmacol. (2004) 503 209-210.
12. Vanegas H., Tortorici V.Opioidergic effects of nonopioid analgesics on the central nervous system. Cell. Mol. Neurobiol. (2002) 22 655-661.
13. Rezende R.M., França D.S., Menezes G.B., dos Reis W.G., Bakhle Y.S., Francischi J.N.Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. Br. J. Pharmacol. (2008) 153 760-768.
14. Miranda H.F., Prieto J.C., Puig M.M., Pinardi G.Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain. Pharmacol. Biochem. Behav. (2008) 88 481-486.
15. Smith H.S.Potential analgesic mechanisms of acetaminophen. Pain Physician (2009) 12 269-280.
16. Pickering G., Loriot M.A., Libert F., Eschalier A., Beaune P., Dubray C.Acetaminophen : first evidence of a central serotonergic mechanism of action in humans. Clin. Pharmacol. Ther. (2006) 79 371-378.
17. Pickering G., Estève V., Loriot M.A., Eschalier A., Dubray C.Acetaminophen reinforces descending inhibitory pain pathways. Clin. Pharmacol. Ther. (2008) 84 47-51.
18. Willer J.C., Roby A., Le Bars D.Psychophysical and electrophysiological approaches to the pain-relieving effects of heterotopic nociceptive stimuli. Brain (1984) 107 1095-1112.
19. Price D.D., McHaffie J.G.Effects of heterotopic conditioning stimuli on first and second pain: a psychophysical evaluation in humans. Pain (1988) 34 245-252.
20. Talbot J.D., Duncan G.H., Bushnell M.C.Effects of diffuse noxious inhibitory controls (DNICs) on the sensory-discriminative dimension of pain perception. Pain (1989) 36 231-238.
21. Millan M.J.Descending control of pain. Prog. Neurobiol. (2002) 66 355-474.
22. Wen Y.R., Wang C.C., Yeh G. et al.DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and a2-adrenergic receptors. J. Biomed. Sci. (2010) 17 19.
23. Willer J.C., Le Bars D., De Broucker T.Diffuse noxious inhibitory controls in man: involvement of an opioidergic link. Eur. J. Pharmacol. (1990) 182 347-355.
24. Julien N., Marchand S.Endogenous pain inhibitory systems activated by spatial summation are opioid-mediated. Neurosci. Lett. (2006) 401 256-260.
25. Dowling J., Isbister G.K., Kirkpatrick C.M.J., Naidoo D., Graudins A.Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers. Ther. Drug Monit. (2008) 30 490-496.
26. Pelissier T., Alloui A., Caussade F. et al.Acetaminophen exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence. J. Pharmacol. Exp. Ther. (1996) 278 8-14.
27. Granovsky Y., Matre D., Sokolik A., Lorenz J., Casey K.L.Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis. Pain (2005) 115 238-247.
28. Tousignant-Laflamme Y., Pagéa S., Goffaux P., Marchand S.An experimental model to measure excitatory and inhibitory pain mechanisms in humans. Brain Res. (2008) 1230 73-79.
29. Benedetti F.The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain (1996) 64 535-543.
30. Herrero J.F., Headley P.M.Reversal by naloxone of the spinal antinociceptive actions of a systemically-administered NSAID. Br. J. Pharmacol. (1996) 118 968-972.
31. Bertolini A., Ferrari A., Ottani A., Guerzoni S., Tacchi R., Leone S.Paracetamol: new vistas of an old drug. CNS Drug Rev. (2006) 12 250-275.
32. Graham G.G., Scott K.F.Mechanism of action of acetaminophen. Am. J. Ther. (2005) 12 46-55.
33. Ruggieri V., Vitale G., Pini L.A., Sandrini M.Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoylphenolamine (AM404) in the rat: comparison with paracetamol Naunyn-Schmiedeberg's. Arch. Pharmacol. (2008) 377 219-229.
34. Schoffelmeer A.N., Hogenboom F., Wardeh G., De Vries T.J.Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core. Neuropharmacology (2006) 51 773-781.
35. Björkman R.Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta Anaesthesiol. Scand. Suppl. (1995) 103 1-44.
36. Bonnefont J., Daulhac L., Etienne M. et al.Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system. Mol. Pharmacol. (2007) 71 407-415.
37. Duman E.N., Kesim M., Kadioglu M., Yaris E., Kalyoncu N.I., Erciyes N.Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain. J. Pharmacol. Sci. (2004) 94 161-165.
38. Abbott F.V., Hellemans K.G.Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects. Behav. Brain Res. (2000) 112 177-186.