RT-PCR-based cytochrome P450 expression profile of oral tissue samples

Journal of Clinical Pharmacy and Therapeutics

Volumn 32, Issue 5, 2007, Pages 445-448

  Sarikaya, D ^a   Chiba, I ^a   Bilgen, C ^b   Kamatakii, T ^b   Topcu, Z ^c  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c EGE UNIVERSITY   (Turkey)

Author keywords

Cytochrome P450; Drug metabolizing enzymes; Oral buccal tissue

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A3; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; MESSENGER RNA; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER; MOUTH CANCER; MOUTH MUCOSA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE HOMOGENATE;

AGED; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION PROFILING; HUMANS; ISOENZYMES; LIVER; MIDDLE AGED; MOUTH MUCOSA; ORGAN SPECIFICITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34548620758     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2007.00841.x     Document Type: Article

References (16)

1. Nelson DR, Koymans L, Kamataki T et al. (1996) Cytochrome P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1 42.
2. Agundez JA (2004) Cytochrome P450 gene polymorphism and cancer. Current Drug Metabolism, 5, 211 224.
3. Nakajima M, Yokoi T (2005) Cancer pharmacogenomics: achievements in basic research. International Journal of Clinical Oncology, 10, 14 19.
4. Gonzales FJ (1992) Human cytochrome P450: problems and prospects. Trends in Pharmacological Sciences, 13, 346 352.
5. Hukkanen J, Mantyla M, Kangas L et al. (1998) Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. Pharmacology and Toxicology, 82, 93 97.
6. Vondracek M, Xi Z, Larsson P et al. (2001) Cytochrome P450 expression and related metabolism in human buccal mucosa. Carcinogenesis, 22, 481 488.
7. Guengerich FP, Shimada T (1998) Activation of procarcinogens by human cytochrome P450 enzymes. Mutation Research, 400, 201 213.
8. Ding X, Kaminsky LS (2003) Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Review of Pharmacology and Toxicology, 43, 149 173.
9. Erbengi T (1985) "Histoloji", 1. Basim. Istanbul: Tip Dizisi.
10. Topcu Z, Chiba I, Fujieda M et al. (2002) CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. Carcinogenesis, 23, 595 598.
11. T.C. Saǧlik Bakanliǧi Kanserle Savaş Dairesi Başkanliǧi (2002 Kanserle Savaş Politikasi ve Kanser Verileri (1995-1999). Yayin No: 618, Ankara.
12. O'Connell J (2002) "RT-PCR protocols". Totowa, NJ, USA: Humana Press.
13. Hukkanen J, Lassila A, Paivarinta K et al. (2000) Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. American Journal of Respiratory Cell and Molecular Biology, 22, 360 366.
14. Sato M, Sato T, Izumo T et al. (1999) Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. Carcinogenesis, 20, 1927 1931.
15. Guengerich FP, Shimada T (1991) Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chemical Research Toxicology, 4, 391 407.
16. Macfarlane GJ, Zheng JR, Marshall P et al. (1995) Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies. European Journal of Cancer. Part B, Oral Oncology, 31 (B 181 187.