CDR-H3 diversity is not required for antigen recognition by synthetic antibodies

Journal of Molecular Biology

Volumn 425, Issue 4, 2013, Pages 803-811

  Persson, Helena ^a   Ye, Wei ^a   Wernimont, Amy ^b   Adams, Jarrett J ^a   Koide, Akiko ^c   Koide, Shohei ^c   Lam, Robert ^b   Sidhu, Sachdev S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MaRS Centre   (Canada)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

affinity; antibody library; phage display; protein engineering; specificity

Indexed keywords

ALANINE; RECOMBINANT ANTIBODY;

ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

EID: 84873408836     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.11.037     Document Type: Article

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