-
1
-
-
79960653221
-
The late phase of sepsis is characterized by an increased microbiological burden and death rate.
-
Otto GP, Sossdorf M, Claus RA, Rödel J, Menge K, Reinhart K, Bauer M, Riedemann NC: The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care 2011, 15:R183..
-
(2011)
Crit Care
, vol.15
, pp. R183
-
-
Otto, G.P.1
Sossdorf, M.2
Claus, R.A.3
Rödel, J.4
Menge, K.5
Reinhart, K.6
Bauer, M.7
Riedemann, N.C.8
-
2
-
-
0038578608
-
Novel strategies for the treatment of sepsis
-
Riedemann NC, Guo R-F, Ward PA. Novel strategies for the treatment of sepsis. Nat Med 2003, 9:517-524. 10.1038/nm0503-517, 12724763.
-
(2003)
Nat Med
, vol.9
, pp. 517-524
-
-
Riedemann, N.C.1
Guo, R.-F.2
Ward, P.A.3
-
3
-
-
84874256945
-
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
-
Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013, 13:260-268. 10.1016/S1473-3099(13)70001-X, 23427891.
-
(2013)
Lancet Infect Dis
, vol.13
, pp. 260-268
-
-
Hotchkiss, R.S.1
Monneret, G.2
Payen, D.3
-
4
-
-
0028957549
-
Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group
-
7884952
-
Abraham E, Wunderink R, Silverman H, Perl TM, Nasraway S, Levy H, Bone R, Wenzel RP, Balk R, Allred R. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 1995, 273:934-941. 10.1001/jama.1995.03520360048038, 7884952.
-
(1995)
JAMA
, vol.273
, pp. 934-941
-
-
Abraham, E.1
Wunderink, R.2
Silverman, H.3
Perl, T.M.4
Nasraway, S.5
Levy, H.6
Bone, R.7
Wenzel, R.P.8
Balk, R.9
Allred, R.10
-
5
-
-
0023252009
-
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
-
3306374
-
Bone RC, Fisher CJ, Clemmer TP, Slotman GJ, Metz CA, Balk RA. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987, 317:653-658. 10.1056/NEJM198709103171101, 3306374.
-
(1987)
N Engl J Med
, vol.317
, pp. 653-658
-
-
Bone, R.C.1
Fisher, C.J.2
Clemmer, T.P.3
Slotman, G.J.4
Metz, C.A.5
Balk, R.A.6
-
6
-
-
84255194001
-
Immunosuppression in patients who die of sepsis and multiple organ failure
-
22187279
-
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306:2594-2605. 10.1001/jama.2011.1829, 22187279.
-
(2011)
JAMA
, vol.306
, pp. 2594-2605
-
-
Boomer, J.S.1
To, K.2
Chang, K.C.3
Takasu, O.4
Osborne, D.F.5
Walton, A.H.6
Bricker, T.L.7
Jarman, S.D.8
Kreisel, D.9
Krupnick, A.S.10
Srivastava, A.11
Swanson, P.E.12
Green, J.M.13
Hotchkiss, R.S.14
-
7
-
-
84888325490
-
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
-
24232462
-
Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013, 13:862-874. 10.1038/nri3552, 24232462.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 862-874
-
-
Hotchkiss, R.S.1
Monneret, G.2
Payen, D.3
-
8
-
-
84874017991
-
Immunotherapy - a potential new way forward in the treatment of sepsis
-
Payen D, Monneret G, Hotchkiss R: Immunotherapy - a potential new way forward in the treatment of sepsis. Crit Care 2013, 17:118..
-
(2013)
Crit Care
, vol.17
, pp. 118
-
-
Payen, D.1
Monneret, G.2
Hotchkiss, R.3
-
9
-
-
77953635470
-
Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism
-
20483771
-
Unsinger J, Kazama H, McDonough JS, Griffith TS, Hotchkiss RS, Ferguson TA. Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol 2010, 184:6766-6772. 10.4049/jimmunol.0904054, 20483771.
-
(2010)
J Immunol
, vol.184
, pp. 6766-6772
-
-
Unsinger, J.1
Kazama, H.2
McDonough, J.S.3
Griffith, T.S.4
Hotchkiss, R.S.5
Ferguson, T.A.6
-
10
-
-
66349131288
-
Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis
-
19448210
-
Torgersen C, Moser P, Luckner G, Mayr V, Jochberger S, Hasibeder WR, Dünser MW. Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis. Anesth Analg 2009, 108:1841-1847. 10.1213/ane.0b013e318195e11d, 19448210.
-
(2009)
Anesth Analg
, vol.108
, pp. 1841-1847
-
-
Torgersen, C.1
Moser, P.2
Luckner, G.3
Mayr, V.4
Jochberger, S.5
Hasibeder, W.R.6
Dünser, M.W.7
-
11
-
-
84891655634
-
The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
-
24185508
-
Singer M. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 2014, 5:66-72. 10.4161/viru.26907, 24185508.
-
(2014)
Virulence
, vol.5
, pp. 66-72
-
-
Singer, M.1
-
12
-
-
35349002164
-
Powering up failed organs
-
17914124
-
Singer M. Powering up failed organs. Am J Respir Crit Care Med 2007, 176:733-734. 10.1164/rccm.200707-964ED, 17914124.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 733-734
-
-
Singer, M.1
-
13
-
-
36448993710
-
Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis
-
18074472
-
Belikova I, Lukaszewicz AC, Faivre V, Damoisel C, Singer M, Payen D. Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med 2007, 35:2702-2708. 10.1097/01.CCM.0000295593.25106.C4, 18074472.
-
(2007)
Crit Care Med
, vol.35
, pp. 2702-2708
-
-
Belikova, I.1
Lukaszewicz, A.C.2
Faivre, V.3
Damoisel, C.4
Singer, M.5
Payen, D.6
-
14
-
-
0037142987
-
Association between mitochondrial dysfunction and severity and outcome of septic shock
-
Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M. Association between mitochondrial dysfunction and severity and outcome of septic shock. The Lancet 2002, 360:219-223. 10.1016/S0140-6736(02)09459-X.
-
(2002)
The Lancet
, vol.360
, pp. 219-223
-
-
Brealey, D.1
Brand, M.2
Hargreaves, I.3
Heales, S.4
Land, J.5
Smolenski, R.6
Davies, N.A.7
Cooper, C.E.8
Singer, M.9
-
15
-
-
77956635947
-
Sepsis and endothelial permeability
-
20818861
-
Lee WL, Slutsky AS. Sepsis and endothelial permeability. N Engl J Med 2010, 363:689-691. 10.1056/NEJMcibr1007320, 20818861.
-
(2010)
N Engl J Med
, vol.363
, pp. 689-691
-
-
Lee, W.L.1
Slutsky, A.S.2
-
16
-
-
79959407347
-
Broken barriers: a new take on sepsis pathogenesis.
-
Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL: Broken barriers: a new take on sepsis pathogenesis. Sci Transl Med 2011, 3:88ps25..
-
(2011)
Sci Transl Med
, vol.3
, pp. 8825
-
-
Goldenberg, N.M.1
Steinberg, B.E.2
Slutsky, A.S.3
Lee, W.L.4
-
17
-
-
77951836880
-
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.
-
London NR, Zhu W, Bozza FA, Smith MCP, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY: Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med 2010, 2:23ra19..
-
(2010)
Sci Transl Med
, vol.2
-
-
London, N.R.1
Zhu, W.2
Bozza, F.A.3
Smith, M.C.P.4
Greif, D.M.5
Sorensen, L.K.6
Chen, L.7
Kaminoh, Y.8
Chan, A.C.9
Passi, S.F.10
Day, C.W.11
Barnard, D.L.12
Zimmerman, G.A.13
Krasnow, M.A.14
Li, D.Y.15
-
18
-
-
80055021582
-
The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.
-
Kümpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park J-K, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N: The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care 2011, 15:R261..
-
(2011)
Crit Care
, vol.15
, pp. R261
-
-
Kümpers, P.1
Gueler, F.2
David, S.3
Slyke, P.V.4
Dumont, D.J.5
Park, J.-K.6
Bockmeyer, C.L.7
Parikh, S.M.8
Pavenstadt, H.9
Haller, H.10
Shushakova, N.11
-
19
-
-
33745081608
-
Comparison of two fluid-management strategies in acute lung injury
-
Heart N, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, DeBoisblanc B, Connors AF, Hite RD, Harabin AL. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006, 354:2564-2575. 10.1056/NEJMoa062200.
-
(2006)
N Engl J Med
, vol.354
, pp. 2564-2575
-
-
Heart, N.1
Wiedemann, H.P.2
Wheeler, A.P.3
Bernard, G.R.4
Thompson, B.T.5
Hayden, D.6
DeBoisblanc, B.7
Connors, A.F.8
Hite, R.D.9
Harabin, A.L.10
-
20
-
-
79251546295
-
Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
-
20975548
-
Boyd JH, Forbes J, Nakada T-A, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 2011, 39:259-265. 10.1097/CCM.0b013e3181feeb15, 20975548.
-
(2011)
Crit Care Med
, vol.39
, pp. 259-265
-
-
Boyd, J.H.1
Forbes, J.2
Nakada, T.-A.3
Walley, K.R.4
Russell, J.A.5
-
21
-
-
84904257142
-
ALBIOS Study Investigators: Albumin replacement in patients with severe sepsis or septic shock.
-
Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V, Fiore G, Latini R, Gattinoni L, ALBIOS Study Investigators: Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 2014, 371:84..
-
(2014)
N Engl J Med
, vol.371
, pp. 84
-
-
Caironi, P.1
Tognoni, G.2
Masson, S.3
Fumagalli, R.4
Pesenti, A.5
Romero, M.6
Fanizza, C.7
Caspani, L.8
Faenza, S.9
Grasselli, G.10
Iapichino, G.11
Antonelli, M.12
Parrini, V.13
Fiore, G.14
Latini, R.15
Gattinoni, L.16
-
23
-
-
70349469854
-
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial
-
19590022
-
Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk H-D. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009, 180:640-648. 10.1164/rccm.200903-0363OC, 19590022.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 640-648
-
-
Meisel, C.1
Schefold, J.C.2
Pschowski, R.3
Baumann, T.4
Hetzger, K.5
Gregor, J.6
Weber-Carstens, S.7
Hasper, D.8
Keh, D.9
Zuckermann, H.10
Reinke, P.11
Volk, H.-D.12
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