Immunotherapy - a potential new way forward in the treatment of sepsis

Critical Care

Volumn 17, Issue 1, 2013, Pages

  Payen, Didier ^a   Monneret, Guillaume ^b,c   Hotchkiss, Richard ^d  

^a HÔPITAL LARIBOISIÈRE   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 7; PROGRAMMED DEATH 1 LIGAND 1; THYMOSIN ALPHA1;

ADAPTIVE IMMUNITY; HUMAN; IMMUNE DEFICIENCY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOTHERAPY; INNATE IMMUNITY; NOTE; PATIENT CARE; PRIORITY JOURNAL; SEPSIS;

EID: 84874017991     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc12490     Document Type: Note

References (15)

1. Wu J, Zhou L, Liu J, Ma G, Kou Q, He Z, Chen J, Ou-Yang B, Chen M, Li Y, Wu X, Gu B, Chen L, Zou Z, Qiang X, Chen Y, Lin A, Zhang G, Guan X. The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial. Crit Care 2013, 17:R8. 10.1186/cc11932, 23327199.
2. Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC, Surviving Sepsis Campaign The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010, 38:367-374. 10.1097/CCM.0b013e3181cb0cdc, 20035219, Surviving Sepsis Campaign.
3. Cohen J, Opal S, Calandra T. Sepsis studies need new direction. Lancet Infect Dis 2012, 12:503-505. 10.1016/S1473-3099(12)70136-6, 22742624.
4. Serafino A, Pierimarchi P, Pica F, Andreola F, Gaziano R, Moroni N, Zonfrillo M, Sinibaldi-Vallebona P, Garaci E. Thymosin alpha1 as a stimulatory agent of innate cell-mediated immune response. Ann N Y Acad Sci 2012, 1270:13-20. 10.1111/j.1749-6632.2012.06707.x, 23050812.
5. Munoz C, Carlet J, Fitting C, Misset B, Blériot J, Cavaillon J-M. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991, 88:1747-1754. 10.1172/JCI115493, 295719, 1939659.
6. Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306:2594-2605. 10.1001/jama.2011.1829, 3361243, 22187279.
7. Monneret G, Venet F. A rapidly progressing lymphocyte exhaustion after severe sepsis. Crit Care 2012, 16:140. 10.1186/cc11416, 22824381.
8. Lukaszewicz AC, Grienay M, Resche-Rigon M, Pirracchio R, Faivre V, Boval B, Payen D. Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction. Crit Care Med 2009, 37:2746-2752. 10.1097/CCM.0b013e3181ab858a, 19707128.
9. Fumeaux T, Pugin J. Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock. Am J Respir Crit Care Med 2002, 166:1475-1482. 10.1164/rccm.200203-217OC, 12406851.
10. Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohe J, Lepape A, Ayala A, Monneret G. Increased circulating regulatory T cells (CD4(+)CD25(+)CD127(-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2009, 35:678-686. 10.1007/s00134-008-1337-8, 2789433, 18946659.
11. Belikova I, Lukaszewicz AC, Faivre V, Damoisel C, Singer M, Payen D. Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med 2007, 35:2702-2708. 10.1097/01.CCM.0000295593.25106.C4, 18074472.
12. Carson WF, Cavassani KA, Dou Y, Kunkel SL. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011, 6:273-283. 10.4161/epi.6.3.14017, 3092675, 21048427.
13. Docke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997, 3:678-681. 10.1038/nm0697-678, 9176497.
14. Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk HD. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009, 180:640-648. 10.1164/rccm.200903-0363OC, 19590022.
15. Venet F, Foray AP, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G. IL-7 restores lymphocyte functions in septic patients. J Immunol 2012, 189:5073-5081. 10.4049/jimmunol.1202062, 23053510.