The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis

Journal of Biological Chemistry

Volumn 289, Issue 42, 2014, Pages 29030-29043

  Chorba, John S ^a   Shokat, Kevan M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHYSIOLOGY; PROTEINS;

ALLOSTERIC MODULATORS; CATALYTIC DOMAINS; DOMINANT NEGATIVE; PROTEIN SECRETION; RECOGNITION SEQUENCE; SMALL MOLECULES; SPECIFIC SUBSTRATES; SUBSTRATE SPECIFICITY;

PROTEOLYSIS;

PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; PCSK9 PROTEIN, HUMAN; PROTEIN BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SPECIFICITY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; ATHEROSCLEROSIS; BINDING SITE; CHEMISTRY; GENE EXPRESSION REGULATION; HEART DISEASE; HEK293 CELL LINE; HUMAN; HYPERCHOLESTEROLEMIA; METABOLISM; MUTAGENESIS; MUTATION; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN TRANSPORT;

ALLOSTERIC SITE; ATHEROSCLEROSIS; CATALYTIC DOMAIN; GENE EXPRESSION REGULATION; HEART DISEASES; HEK293 CELLS; HUMANS; HYPERCHOLESTEROLEMIA; MUTAGENESIS; MUTATION; PHENOTYPE; PROPROTEIN CONVERTASES; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEOLYSIS; SERINE ENDOPEPTIDASES;

EID: 84908053090     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.594861     Document Type: Article

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