Serial low doses of sorafenib enhance therapeutic efficacy of adoptive T cell therapy in a murine model by improving tumor microenvironment

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Chuang, Hui Yen ^a   Chang, Ya Fang ^a   Liu, Ren Shyan ^b   Hwang, Jeng Jong ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; DEATH RECEPTOR; GRANZYME B; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; KYNURENINE; MONOCYTE CHEMOTACTIC PROTEIN 1; SORAFENIB; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN; VASCULOTROPIN; CARBANILAMIDE DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; NICOTINAMIDE;

ADOPTIVE T CELL THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL KILLING; CELL SURVIVAL; CELL THERAPY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; IC50; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LYMPHOMA; LYMPHOMA CELL LINE; MALE; MOUSE; MYELOID DERIVED SUPPRESSIVE CELL; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR MICROENVIRONMENT; TUMOR VOLUME; ADOPTIVE IMMUNOTHERAPY; ANALOGS AND DERIVATIVES; ANIMAL; CELL MOTION; CELL PROLIFERATION; DISEASE MODEL; DRUG ADMINISTRATION; DRUG EFFECTS; IMMUNOLOGY; PROCEDURES; TRANSGENIC MOUSE; TUMOR CELL LINE;

MURINAE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; IMMUNOSUPPRESSIVE AGENTS; IMMUNOTHERAPY, ADOPTIVE; LYMPHOMA; MICE; MICE, TRANSGENIC; NIACINAMIDE; PHENYLUREA COMPOUNDS; TUMOR MICROENVIRONMENT;

EID: 84908047017     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109992     Document Type: Article

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