Combined modality immunotherapy and chemotherapy: A new perspective

Cancer Immunology, Immunotherapy

Volumn 57, Issue 10, 2008, Pages 1523-1529

  Ramakrishnan, Rupal ^a   Antonia, Scott ^a   Gabrilovich, Dmitry I ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; CYCLOPHOSPHAMIDE; CYTOCHROME P450 1B1; DENDRITIC CELL VACCINE; DOCETAXEL; DOXORUBICIN; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; PACLITAXEL; PROSTATE SPECIFIC ANTIGEN; PROTEIN P53; RETINOIC ACID; VIRUS VECTOR;

CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER SURVIVAL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONFERENCE PAPER; CYTOLYSIS; DRUG EFFECT; DRUG MECHANISM; GAMMA IRRADIATION; HUMAN; IMMUNE RESPONSE; KIDNEY CARCINOMA; LUNG CANCER; LUNG SMALL CELL CANCER; LYMPHOCYTE ACTIVATION; MONOTHERAPY; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN TARGETING; T LYMPHOCYTE; TREATMENT RESPONSE; TUMOR SUPPRESSOR GENE; UNSPECIFIED SIDE EFFECT; VIRUS RECOMBINANT;

ANIMALS; ANTINEOPLASTIC AGENTS; CANCER VACCINES; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; HUMANS; NEOPLASMS;

EID: 48149096721     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-008-0531-4     Document Type: Conference Paper

References (60)

1. B Almand JI Clark E Nikitina J van Beynen NR English SC Knight DP Carbone DI Gabrilovich 2001 Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer J Immunol 166 678 689
2. LA Amos J Lowe 1999 How taxol stabilises microtubule structure Chem Biol 6 R65 69
3. SJ Antonia N Mirza I Fricke A Chiappori P Thompson N Williams G Bepler G Simon W Janssen JH Lee K Menander S Chada DI Gabrilovich 2006 Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer Clin Cancer Res 12 878 887
4. L Apetoh F Ghiringhelli A Tesniere M Obeid C Ortiz A Criollo G Mignot MC Maiuri E Ullrich P Saulnier H Yang S Amigorena B Ryffel FJ Barrat P Saftig F Levi R Lidereau C Nogues JP Mira A Chompret V Joulin F Clavel-Chapelon J Bourhis F Andre S Delaloge T Tursz G Kroemer L Zitvogel 2007 Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy Nat Med 13 1050 1059
5. PM Arlen JL Gulley C Parker L Skarupa M Pazdur D Panicali P Beetham KY Tsang DW Grosenbach J Feldman SM Steinberg E Jones C Chen J Marte J Schlom W Dahut 2006 A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer Clin Cancer Res 12 1260 1269
6. M Berndtsson Y Konishi A Bonni M Hagg M Shoshan S Linder AM Havelka 2005 Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis FEBS Lett 579 3090
7. SM Bodner JD Minna SM Jensen D D'Amico D Carbone T Mitsudomi J Fedorko DL Buchhagen MM Nau AF Gazdar 1992 Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation Oncogene 7 743 749
8. N Casares MO Pequignot A Tesniere F Ghiringhelli S Roux N Chaput E Schmitt A Hamai S Hervas-Stubbs M Obeid F Coutant D Metivier E Pichard P Aucouturier G Pierron C Garrido L Zitvogel G Kroemer 2005 Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death J Exp Med 202 1691 1701
9. G Chong M Morse 2005 Combining cancer vaccines with chemotherapy Expert Opin Pharmacother 6 2813 2820
10. S Coral L Sigalotti M Altomonte A Engelsberg F Colizzi I Cattarossi E Maraskovsky E Jager B Seliger M Maio 2002 5-aza-2′-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications Clin Cancer Res 8 2690 2695
11. J Crown M O'Leary 2000 The taxanes: an update Lancet 355 1176 1178
12. A Doyle WJ Martin K Funa A Gazdar D Carney SE Martin I Linnoila F Cuttitta J Mulshine P Bunn 1985 Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer J Exp Med 161 1135 1151
13. LA Emens EM Jaffee 2005 Leveraging the activity of tumor vaccines with cytotoxic chemotherapy Cancer Res 65 8059 8064
14. M Friberg R Jennings M Alsarraj S Dessureault A Cantor M Extermann AL Mellor DH Munn SJ Antonia 2002 Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection Int J Cancer 101 151 155
15. DI Gabrilovich 2007 Combination of chemotherapy and immunotherapy for cancer: a paradigm revisited Lancet Oncol 8 2 3
16. JG Gribben DP Ryan R Boyajian RG Urban ML Hedley K Beach P Nealon U Matulonis S Campos TD Gilligan PG Richardson B Marshall D Neuberg LM Nadler 2005 Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy Clin Cancer Res 11 4430 4436
17. S Hopkins-Donaldson A Ziegler S Kurtz C Bigosch D Kandioler C Ludwig U Zangemeister-Wittke R Stahel 2003 Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation Cell Death Differ 10 356 364
18. Y Huang MS Sheikh AJ Fornace Jr NJ Holbrook 1999 Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells Oncogene 18 3431 3439
19. C Huisman CG Ferreira LE Broker JA Rodriguez EF Smit PE Postmus FA Kruyt G Giaccone 2002 Paclitaxel triggers cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460 Clin Cancer Res 8 596 606
20. T Ishida S Chada M Stipanov S Nadaf FI Ciernik DI Gabrilovich DP Carbone 1999 Dendritic cells transduced with wild-type p53 gene elicit potent anti-tumour immune responses Clin Exp Immunol 117 244 251
21. E Jones M Dahm-Vicker AK Simon A Green F Powrie V Cerundolo A Gallimore 2002 Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice Cancer Immun 2 1
22. HJ Ko YJ Kim YS Kim WS Chang SY Ko SY Chang S Sakaguchi CY Kang 2007 A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model Cancer Res 67 7477 7486
23. S Kusmartsev F Cheng B Yu Y Nefedova E Sotomayor R Lush D Gabrilovich 2003 All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination Cancer Res 63 4441 4449
24. R Li T Moudgil HJ Ross HM Hu 2005 Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim Cell Death Differ 12 292 303
25. G Liu KL Black JS Yu 2006 Sensitization of malignant glioma to chemotherapy through dendritic cell vaccination Expert Rev Vaccines 5 233 247
26. J-PH Machiels RT Reilly LA Emens AM Ercolini RY Lei D Weintraub FI Okoye EM Jaffee 2001 Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice Cancer Res 61 3689 3697
27. C Melani S Sangaletti FM Barazzetta Z Werb MP Colombo 2007 Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma Cancer Res 67 11438 11446
28. N Mirza M Fishman I Fricke M Dunn AM Neuger TJ Frost RM Lush S Antonia DI Gabrilovich 2006 All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients Cancer Res 66 9299 9307
29. AJ Muller JB DuHadaway PS Donover E Sutanto-Ward GC Prendergast 2005 Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy Nat Med 11 312 319
30. DH Munn AL Mellor 2007 Indoleamine 2, 3-dioxygenase and tumor-induced tolerance J Clin Invest 117 1147 1154
31. S Nagaraj V Pisarev L Kinarsky S Sherman C Muro-Cacho DC Altieri DI Gabrilovich 2007 Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors J Immunother 30 169 179
32. P Nava-Parada G Forni KL Knutson LR Pease E Celis 2007 Peptide vaccine given with a toll-like receptor agonist is effective for the treatment and prevention of spontaneous breast tumors Cancer Res 67 1326 1334
33. Y Nefedova M Fishman S Sherman X Wang AA Beg DI Gabrilovich 2007 Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells Cancer Res 67 11021 11028
34. EY Nikitina S Chada C Muro-Cacho B Fang R Zhang JA Roth DI Gabrilovich 2002 An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53 Gene Ther 9 345 352
35. EY Nikitina JI Clark J Van Beynen S Chada AK Virmani DP Carbone DI Gabrilovich 2001 Dendritic cells transduced with full-length wild-type p53 generate antitumor cytotoxic T lymphocytes from peripheral blood of cancer patients Clin Cancer Res 7 127 135
36. EY Nikitina DI Gabrilovich 2001 Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: approach to treatment of advanced stage cancer Int J Cancer 94 825 833
37. R Nimmanapalli CL Perkins M Orlando E O'Bryan D Nguyen KN Bhalla 2001 Pretreatment with paclitaxel enhances Apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein Levels Cancer Res 61 759 763
38. M Obeid A Tesniere F Ghiringhelli GM Fimia L Apetoh JL Perfettini M Castedo G Mignot T Panaretakis N Casares D Metivier N Larochette P van Endert F Ciccosanti M Piacentini L Zitvogel G Kroemer 2007 Calreticulin exposure dictates the immunogenicity of cancer cell death Nat Med 13 54 61
39. R Ofir R Seidman T Rabinski M Krup V Yavelsky Y Weinstein M Wolfson 2002 Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent Cell Death Differ 9 636 642
40. S Onizuka I Tawara J Shimizu S Sakaguchi T Fujita E Nakayama 1999 Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody Cancer Res 59 3128 3133
41. SJ Park CH Wu JD Gordon X Zhong A Emami AR Safa 2004 Taxol induces caspase-10-dependent apoptosis J Biol Chem 279 51057 51067
42. RM Pitti SA Marsters DA Lawrence M Roy FC Kischkel P Dowd A Huang CJ Donahue SW Sherwood DT Baldwin PJ Godowski WI Wood AL Gurney KJ Hillan RL Cohen AD Goddard D Botstein A Ashkenazi 1998 Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer Nature 396 699 703
43. SA Rosenberg JC Yang NP Restifo 2004 Cancer immunotherapy: moving beyond current vaccines Nat Med 10 909 915
44. UA Sartorius PH Krammer 2002 Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines Int J Cancer 97 584 592
45. JH Schiller S Adak D Cella RF DeVore 3rd DH Johnson 2001 Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593-a phase III trial of the Eastern Cooperative Oncology Group J Clin Oncol 19 2114 2122
46. J Schlom PM Arlen JL Gulley 2007 Cancer vaccines: moving beyond current paradigms Clin Cancer Res 13 3776 3782
47. N Shivapurkar J Reddy H Matta UG Sathyanarayana CX Huang S Toyooka JD Minna PM Chaudhary AF Gazdar 2002 Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification Oncogene 21 8510 8514
48. RK Srivastava CY Sasaki JM Hardwick DL Longo 1999 Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription J Exp Med 190 253 265
49. S-Y Sun P Yue J-Y Zhou Y Wang H-R Choi Kim R Lotan G Sheng Wu 2001 Overexpression of Bcl2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells Biochem Biophys Res Commun 280 788
50. E Suzuki V Kapoor AS Jassar LR Kaiser SM Albelda 2005 Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity Clin Cancer Res 11 6713 6721
51. Y Tong W Song RG Crystal 2001 Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors Cancer Res 61 7530 7535
52. I Viard-Leveugle S Veyrenc LE French C Brambilla E Brambilla 2003 Frequent loss of Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma J Pathol 201 268 277
53. F Vikhanskaya S Vignati P Beccaglia C Ottoboni P Russo M D'Incalci M Broggini 1998 Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis Exp Cell Res 241 96 101
54. B Wang J He C Liu LJ Chang 2006 An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens Vaccine 24 3477 3489
55. CJ Wheeler A Das G Liu JS Yu KL Black 2004 Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination Clin Cancer Res 10 5316 5326
56. T Wieder F Essmann A Prokop K Schmelz K Schulze-Osthoff R Beyaert B Dorken PT Daniel 2001 Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3 Blood 97 1378 1387
57. YD Yoo JK Park JY Choi KH Lee YK Kang CS Kim SW Shin YH Kim JS Kim 1998 CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells Clin Cancer Res 4 3063 3068
58. B Yu S Kusmartsev F Cheng M Paolini Y Nefedova E Sotomayor D Gabrilovich 2003 Effective combination of chemotherapy and dendritic cell administration for the treatment of advanced-stage experimental breast cancer Clin Cancer Res 9 285 294
59. B Zhang NA Bowerman JK Salama H Schmidt MT Spiotto A Schietinger P Yu YX Fu RR Weichselbaum DA Rowley DM Kranz H Schreiber 2007 Induced sensitization of tumor stroma leads to eradication of established cancer by T cells J Exp Med 204 49 55
60. B Zhang T Karrison DA Rowley H Schreiber 2008 IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers J Clin Invest 118 1398 1404