Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling

ACS Chemical Biology

Volumn 9, Issue 10, 2014, Pages 2318-2325

  Nakagawa, Akito ^a   Lui, Francine E ^a   Wassaf, Dina ^b   Yefidoff Freedman, Revital ^a   Casalena, Dominick ^b   Palmer, Michelle A ^b   Meadows, Jacqueline ^c   Mozzarelli, Andrea ^d   Ronda, Luca ^d   Abdulmalik, Osheiza ^e   Bloch, Kenneth D ^a   Safo, Martin K ^c   Zapol, Warren M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d UNIVERSITY OF PARMA   (Italy)

^e CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; 5 HYDROXYMETHYLFURFURAL; ANTISICKLING AGENT; CARBOXYHEMOGLOBIN; DI[5 (2,3 DIHYDRO 1,4 BENZODIOXIN 2 YL) 4H 1,2,4 TRIAZOL 3 YL]DISULFIDE; HEMOGLOBIN; HEMOGLOBIN S; N ETHYLMALEIMIDE; OXYGEN; TETRAMER; UNCLASSIFIED DRUG; BIS(5-(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)-4H-1,2,4-TRIAZOL-3-YL)DISULFIDE; DISULFIDE; MOLECULAR LIBRARY; TRIAZOLE DERIVATIVE;

ADULT; ALLOSTERISM; ARTICLE; BINDING ASSAY; BINDING SITE; CHEMICAL STRUCTURE; COVALENT BOND; CROSS LINKING; CRYSTAL STRUCTURE; DEOXYGENATION; DRUG IDENTIFICATION; ERYTHROCYTE; HEMOLYSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPOXIA; MICROARRAY ANALYSIS; MOLECULE; NORMAL HUMAN; OXYGEN AFFINITY; OXYGEN TENSION; PATHOPHYSIOLOGY; POLYMERIZATION; SICKLE CELL; SICKLE CELL ANEMIA; X RAY CRYSTALLOGRAPHY; ANOXIA; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PROTEIN CONFORMATION;

ANEMIA, SICKLE CELL; ANOXIA; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; ERYTHROCYTES; HEMOGLOBIN, SICKLE; HEMOGLOBINS; HEMOLYSIS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR STRUCTURE; OXYGEN; PROTEIN CONFORMATION; SMALL MOLECULE LIBRARIES; TRIAZOLES;

EID: 84908037773     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500230b     Document Type: Article

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