Ligand discovery using small-molecule microarrays

Methods in Molecular Biology

Volumn 803, Issue , 2012, Pages 249-263

  Casalena, Dominick E ^a   Wassaf, Dina ^a   Koehler, Angela N ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

FK506; FKBP12; Isocyanate; Ligand discovery; Rapamycin; Small molecule microarrays

Indexed keywords

FK 506 BINDING PROTEIN; ISOCYANIC ACID DERIVATIVE; LIGAND;

ARTICLE; BIOCATALYSIS; CHEMISTRY; METABOLISM; METHODOLOGY; MICROARRAY ANALYSIS; MOLECULAR LIBRARY; PROTEIN BINDING; SURFACE PROPERTY;

BIOCATALYSIS; ISOCYANATES; LIGANDS; MICROARRAY ANALYSIS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; SURFACE PROPERTIES; TACROLIMUS BINDING PROTEIN 1A;

EID: 82355188164     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-364-6_17     Document Type: Article

References (15)

1. Vegas, A. J., Fuller, J. H., and Koehler, A. N. (2008) Small-molecule microarrays as tools in ligand discovery, Chem Soc Rev 37, 1385-1394.
2. Astle, J. M., Simpson, L.S., Huang, Y., Reddy, M.M., Wilson, R., Connell, S., Wilson, J., Kodadek, T. (2010) Seamless bead to microarray screening: rapid identification of the highest affinity protein ligands from large combinatorial libraries, Chem Biol 7, 38-45.
3. Kwon, S. J., Lee, M. Y., Ku, B., Sherman, D. H., and Dordick, J. S. (2007) Highthroughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction, ACS Chem Biol 2, 419-425. (Pubitemid 350001563)
4. Uttamchandani, M., Lee, W. L., Wang, J., and Yao, S. Q. (2007) Quantitative inhibitor fingerprinting of metalloproteases using small molecule microarrays, J Am Chem Soc 129, 13110-13117. (Pubitemid 350058351)
5. Vegas, A. J., Bradner, J. E., Tang, W., McPherson, O. M., Greenberg, E. F., Koehler, A. N., and Schreiber, S. L. (2007) Fluorousbased small-molecule microarrays for the discovery of histone deacetylase inhibitors, Angew Chem Int Ed Engl 46, 7960-7964. (Pubitemid 350033466)
6. Urbina, H. D., Debaene, F., Jost, B., Bole-Feysot, C., Mason, D. E., Kuzmic, P., Harris, J. L., and Winssinger, N. (2006) Self-assembled small-molecule microarrays for protease screening and profiling, Chembiochem 7, 1790-1797. (Pubitemid 44748665)
7. Koehler, A. N., Shamji, A. F., and Schreiber, S. L. (2003) Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis, J Am Chem Soc 125, 8420-8421. (Pubitemid 36858396)
8. Stanton, B. Z., Peng, L. F., Maloof, N., Nakai, K., Wang, X., Duffner, J. L., Taveras, K. M., Hyman, J. M., Lee, S. W., Koehler, A. N., Chen, J. K., Fox, J. L., Mandinova, A., and Schreiber, S. L. (2009) A small molecule that binds Hedgehog and blocks its signaling in human cells, Nat Chem Biol 5, 154-156.
9. Labuda, L. P., Pushechnikov, A., and Disney, M. D. (2009) Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron, ACS Chem Biol 4, 299-307.
10. Duffner, J. L., Clemons, P. A., and Koehler, A. N. (2007) A pipeline for ligand discovery using small-molecule microarrays, Curr Opin Chem Biol 11, 74-82. (Pubitemid 46216129)
11. Uttamchandani, M., Wang, J., and Yao, S. Q. (2006) Protein and small molecule microarrays: powerful tools for high-throughput proteomics, Mol Biosyst 2, 58-68.
12. Kohn, M., Wacker, R., Peters, C., Schroder, H., Soulere, L., Breinbauer, R., Niemeyer, C. M., and Waldmann, H. (2003) Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays, Angew Chem Int Ed Engl 42, 5830-5834. (Pubitemid 38029590)
13. Bradner, J. E., McPherson, O. M., Mazitschek, R., Barnes-Seeman, D., Shen, J. P., Dhaliwal, J., Stevenson, K. E., Duffner, J. L., Park, S. B., Neuberg, D. S., Nghiem, P., Schreiber, S. L., and Koehler, A. N. (2006) A robust small-molecule microarray platform for screening cell lysates, Chem Biol 13, 493-504. (Pubitemid 43729507)
14. Bradner, J. E., McPherson, O. M., and Koehler, A. N. (2006) A method for the covalent capture and screening of diverse small molecules in a microarray format, Nature Protocols 1, 2344-2352.
15. Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y., and Osada, H. (2009) Structureaffinity relationship study of bleomycins and Shble protein by use of a chemical array, Chembiochem 10, 845-852. 2