PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Bernard, Jamie J ^a   Lou, You Rong ^a   Peng, Qing Yun ^a   Li, Tao ^a   Lu, Yao Ping ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4,5 DIHYDRO 6 METHYL 5 OXO 4 PROPYL 1,2,4 TRIAZOLO[1,5 A]PYRIMIDINE; 3 ISOBUTYL 8 METHOXYMETHYL 1 METHYLXANTHINE; 9 (2 HYDROXY 3 NONYL)ADENINE; CAFFEINE; CILOSTAMIDE; CYCLIC GMP; DIPYRIDAMOLE; PHOSPHODIESTERASE INHIBITOR; SPLEEN EXONUCLEASE; T 0156; UNCLASSIFIED DRUG; ZAPRINAST; 9-(2-HYDROXY-3-NONYL)ADENINE; ADENINE; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2; PHOSPHODIESTERASE IV INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; EPIDERMIS CELL; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN FUNCTION; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; SUNBURN; ULTRAVIOLET B RADIATION; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOGENESIS; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; EPIDERMIS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROCEDURES; RADIATION RESPONSE; SKIN NEOPLASMS; ULTRAVIOLET RADIATION;

ADENINE; ANIMALS; APOPTOSIS; CAFFEINE; CARCINOGENESIS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2; DISEASE MODELS, ANIMAL; EPIDERMIS; FEMALE; MICE; MOLECULAR TARGETED THERAPY; NUCLEOTIDES, CYCLIC; PHOSPHODIESTERASE 4 INHIBITORS; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 84908032811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109862     Document Type: Article

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