The effect of substituent, degree of acetylation and positioning of the cationic charge on the antibacterial activity of quaternary chitosan derivatives

Marine Drugs

Volumn 12, Issue 8, 2014, Pages 4635-4658

  Sahariah, Priyanka ^a   Gaware, Vivek S ^a,b   Lieder, Ramona ^c   Jónsdóttir, Sigríour ^a   Hjálmarsdóttir, Martha Á ^a   Sigurjonsson, Olafur E ^c,d   Másson, Már ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

^b PCI Biotech AS   (Norway)

^c LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^d REYKJAVIK UNIVERSITY   (Iceland)

Author keywords

Antibacterial activity; Pyridiniumyl derivatives; Quaternary ammoniumyl; Silyl chitosan; Structure activity relationship (SAR); Trimethyl chitosan (TMC)

Indexed keywords

ANTIINFECTIVE AGENT; CHITOSAN DERIVATIVE; N (2 (1 PYRIDINIUMYL)ACETYL) CHITOSAN CHLORIDE; N (2 (N,N,N TRIMETHYLAMMONIUMYL)ACETYL) CHITOSAN CHLORIDE; N (6 (1 PYRIDINIUMYL)HEXANOYL) CHITOSAN CHLORIDE; N (6 (N,N,N TRIMETHYLAMMONIUMYL)HEXANOYL) CHITOSAN CHLORIDE; N,N,N TRIMETHYL CHITOSAN CHLORIDE; UNCLASSIFIED DRUG; CATION; CHITOSAN; POLYMER;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CATIONIC CHARGE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG ACETYLATION; DRUG SYNTHESIS; ERYTHROCYTE; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; HEMOLYSIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; MINIMUM LETHAL CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; PROTON CORRELATION SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; ACETYLATION; CHEMISTRY; DRUG EFFECTS;

ACETYLATION; ANTI-BACTERIAL AGENTS; CATIONS; CHITOSAN; ESCHERICHIA COLI; MOLECULAR WEIGHT; POLYMERS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908031970     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12084635     Document Type: Article

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