메뉴 건너뛰기




Volumn 120, Issue 20, 2014, Pages 3122-3130

Treating advanced hepatocellular carcinoma: How to get out of first gear

Author keywords

Angiogenic; Cabozantinib; Doxorubicin; Everolimus; Hepatocellular carcinoma; Pegylated arginine deiminase (ADI PEG 20); Sorafenib; Targeted therapy; Tivantinib; Tremelimumab

Indexed keywords

ARGININE; AZD 8055; BEVACIZUMAB; BRIVANIB; CABOZANTINIB; DOXORUBICIN; EMIBETUZUMAB; ERLOTINIB; EVEROLIMUS; FORETINIB; GOLVATINIB; LINIFANIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; ONARTUZUMAB; PEGARGIMINASE; PROTEIN KINASE B; RAMUCIRUMAB; REGORAFENIB; SCATTER FACTOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TICILIMUMAB; TIVANTINIB; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE;

EID: 84908030968     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28850     Document Type: Review
Times cited : (30)

References (76)
  • 1
    • 33748760593 scopus 로고    scopus 로고
    • Liver-directed therapies for hepatocellular carcinoma
    • Arciero CA, Sigurdson ER. Liver-directed therapies for hepatocellular carcinoma. J Natl Compr Canc Netw. 2006;4:768-774.
    • (2006) J Natl Compr Canc Netw. , vol.4 , pp. 768-774
    • Arciero, C.A.1    Sigurdson, E.R.2
  • 5
    • 27144557565 scopus 로고    scopus 로고
    • A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
    • Yeo W, Mok TS, Zee B, et al. A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J Natl Cancer Inst. 2005;97:1532-1538.
    • (2005) J Natl Cancer Inst. , vol.97 , pp. 1532-1538
    • Yeo, W.1    Mok, T.S.2    Zee, B.3
  • 6
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-390.
    • (2008) N Engl J Med. , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 7
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
    • (2009) Lancet Oncol. , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 9
  • 10
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell. 2011;146:873-887.
    • (2011) Cell. , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 11
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182-1186.
    • (1971) N Engl J Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 12
    • 0031778206 scopus 로고    scopus 로고
    • Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: Possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver
    • El-Assal ON, Yamanoi A, Soda Y, et al. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology. 1998;27:1554-1562.
    • (1998) Hepatology. , vol.27 , pp. 1554-1562
    • El-Assal, O.N.1    Yamanoi, A.2    Soda, Y.3
  • 13
    • 0035132143 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: A prospective study
    • Poon RT, Ng IO, Lau C, et al. Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann Surg. 2001;233:227-235.
    • (2001) Ann Surg. , vol.233 , pp. 227-235
    • Poon, R.T.1    Ng, I.O.2    Lau, C.3
  • 14
    • 0043163428 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
    • Chao Y, Li CP, Chau GY, et al. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol. 2003;10:355-362.
    • (2003) Ann Surg Oncol. , vol.10 , pp. 355-362
    • Chao, Y.1    Li, C.P.2    Chau, G.Y.3
  • 15
    • 84908021518 scopus 로고    scopus 로고
    • Systemic therapy for advanced hepatocellaur carcinoma
    • Harding JJ, Abou-Alfa GK. Systemic therapy for advanced hepatocellaur carcinoma. Chin Clin Oncol. 2013;2:1-14.
    • (2013) Chin Clin Oncol. , vol.2 , pp. 1-14
    • Harding, J.J.1    Abou-Alfa, G.K.2
  • 16
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
    • (2004) Cancer Res. , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 17
    • 1442335098 scopus 로고    scopus 로고
    • Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma
    • Wiesenauer CA, Yip-Schneider MT, Wang Y, Schmidt CM. Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. J Am Coll Surg. 2004;198:410-421.
    • (2004) J Am Coll Surg. , vol.198 , pp. 410-421
    • Wiesenauer, C.A.1    Yip-Schneider, M.T.2    Wang, Y.3    Schmidt, C.M.4
  • 18
    • 84859880607 scopus 로고    scopus 로고
    • Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma
    • Llovet JM, Pena CE, Lathia CD, et al. Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin Cancer Res. 2012;18:2290-2300.
    • (2012) Clin Cancer Res. , vol.18 , pp. 2290-2300
    • Llovet, J.M.1    Pena, C.E.2    Lathia, C.D.3
  • 19
    • 84866391058 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial
    • Bruix J, Raoul JL, Sherman M, et al. Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial. J Hepatol. 2012;57:821-829.
    • (2012) J Hepatol. , vol.57 , pp. 821-829
    • Bruix, J.1    Raoul, J.L.2    Sherman, M.3
  • 20
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24:4293-4300.
    • (2006) J Clin Oncol. , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 21
    • 65349096880 scopus 로고    scopus 로고
    • Selection of patients with hepatocellular carcinoma for sorafenib
    • Abou-Alfa GK. Selection of patients with hepatocellular carcinoma for sorafenib. J Natl Compr Canc Netw. 2009;7:397-403.
    • (2009) J Natl Compr Canc Netw. , vol.7 , pp. 397-403
    • Abou-Alfa, G.K.1
  • 22
    • 84891915708 scopus 로고    scopus 로고
    • Sunitinib versus sorafenib in advanced hepatocellular cancer: Results of a randomized phase III trial
    • Cheng AL, Kang YK, Lin DY, et al. Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial. J Clin Oncol. 2013;31:4067-4075.
    • (2013) J Clin Oncol. , vol.31 , pp. 4067-4075
    • Cheng, A.L.1    Kang, Y.K.2    Lin, D.Y.3
  • 23
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • Fujimoto A, Totoki Y, Abe T, et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet. 2012; 44:760-764.
    • (2012) Nat Genet. , vol.44 , pp. 760-764
    • Fujimoto, A.1    Totoki, Y.2    Abe, T.3
  • 24
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard C, Amaddeo G, Imbeaud S, et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet. 2012; 44:694-698.
    • (2012) Nat Genet. , vol.44 , pp. 694-698
    • Guichard, C.1    Amaddeo, G.2    Imbeaud, S.3
  • 25
    • 84866868120 scopus 로고    scopus 로고
    • Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma
    • Huang J, Deng Q, Wang Q, et al. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat Genet. 2012;44:1117-1121.
    • (2012) Nat Genet. , vol.44 , pp. 1117-1121
    • Huang, J.1    Deng, Q.2    Wang, Q.3
  • 26
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S, Rickman DS, de Reynies A, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology. 2007;45:42-52.
    • (2007) Hepatology. , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    De Reynies, A.3
  • 27
    • 84866532501 scopus 로고    scopus 로고
    • Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib
    • Lachenmayer A, Alsinet C, Savic R, et al. Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. Clin Cancer Res. 2012;18:4997-5007.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4997-5007
    • Lachenmayer, A.1    Alsinet, C.2    Savic, R.3
  • 28
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein
    • Giambartolomei S, Covone F, Levrero M, Balsano C. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein. Oncogene. 2001;20:2606-2610.
    • (2001) Oncogene. , vol.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3    Balsano, C.4
  • 29
    • 72549086826 scopus 로고    scopus 로고
    • New aspects of an anti-tumour drug: Sorafenib efficiently inhibits HCV replication
    • Himmelsbach K, Sauter D, Baumert TF, Ludwig L, Blum HE, Hildt E. New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication. Gut. 2009;58:1644-1653.
    • (2009) Gut. , vol.58 , pp. 1644-1653
    • Himmelsbach, K.1    Sauter, D.2    Baumert, T.F.3    Ludwig, L.4    Blum, H.E.5    Hildt, E.6
  • 30
    • 84890274647 scopus 로고    scopus 로고
    • Brivanib versus sorafenib as firstline therapy in patients with unresectable, advanced hepatocellular carcinoma: Results from the randomized phase III BRISK-FL study
    • Johnson PJ, Qin S, Park JW, et al. Brivanib versus sorafenib as firstline therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J Clin Oncol. 2013;31:3517-3524.
    • (2013) J Clin Oncol. , vol.31 , pp. 3517-3524
    • Johnson, P.J.1    Qin, S.2    Park, J.W.3
  • 31
    • 84885894561 scopus 로고    scopus 로고
    • Phase III trial of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC)
    • ) [abstract] Page. Abstract 249
    • Cainap C, Qin S, Huang WT, et al. Phase III trial of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC) [abstract]. J Clin Oncol. 2012;30(suppl 34):Page. Abstract 249.
    • (2012) J Clin Oncol. , vol.30
    • Cainap, C.1    Qin, S.2    Huang, W.T.3
  • 32
    • 79953325932 scopus 로고    scopus 로고
    • Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
    • Park JW, Finn RS, Kim JS, et al. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res. 2011;17:1973-1983.
    • (2011) Clin Cancer Res. , vol.17 , pp. 1973-1983
    • Park, J.W.1    Finn, R.S.2    Kim, J.S.3
  • 33
    • 84885587718 scopus 로고    scopus 로고
    • Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: Results from the randomized phase III BRISK-PS study
    • Llovet JM, Decaens T, Raoul JL, et al. Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. J Clin Oncol. 2013;31:3509-3516.
    • (2013) J Clin Oncol. , vol.31 , pp. 3509-3516
    • Llovet, J.M.1    Decaens, T.2    Raoul, J.L.3
  • 34
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel AB, Cohen EI, Ocean A, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol. 2008;26:2992-2998.
    • (2008) J Clin Oncol. , vol.26 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3
  • 35
    • 84890287907 scopus 로고    scopus 로고
    • A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer
    • Zhu AX, Finn RS, Mulcahy M, et al. A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer. Clin Cancer Res. 2013;19:6614-6623.
    • (2013) Clin Cancer Res. , vol.19 , pp. 6614-6623
    • Zhu, A.X.1    Finn, R.S.2    Mulcahy, M.3
  • 36
    • 64649083367 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301
    • Miller AA, Murry DJ, Owzar K, et al. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. J Clin Oncol. 2009;27:1800-1805.
    • (2009) J Clin Oncol. , vol.27 , pp. 1800-1805
    • Miller, A.A.1    Murry, D.J.2    Owzar, K.3
  • 37
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007; 356:115-124.
    • (2007) N Engl J Med. , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 38
    • 84869075481 scopus 로고    scopus 로고
    • Constitutional genetic variants as predictors of antiangiogenic therapy outcome in renal cell carcinoma
    • Rodriguez-Antona C, Garcia-Donas J. Constitutional genetic variants as predictors of antiangiogenic therapy outcome in renal cell carcinoma. Pharmacogenomics. 2012;13:1621-1633.
    • (2012) Pharmacogenomics. , vol.13 , pp. 1621-1633
    • Rodriguez-Antona, C.1    Garcia-Donas, J.2
  • 39
    • 84902537135 scopus 로고    scopus 로고
    • VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: The ALICE-1 study
    • [published online ahead of print February 8, 2014]
    • Scartozzi M, Faloppi L, Svegliati Baroni G, et al. VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: the ALICE-1 study [published online ahead of print February 8, 2014]. Int J Cancer. doi: 10.1002/ijc. 28772.]
    • Int J Cancer
    • Scartozzi, M.1    Faloppi, L.2    Svegliati Baroni, G.3
  • 40
    • 81255160848 scopus 로고    scopus 로고
    • Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: A multicentre, observational, prospective study
    • Garcia-Donas J, Esteban E, Leandro-Garcia LJ, et al. Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study. Lancet Oncol. 2011;12:1143-1150.
    • (2011) Lancet Oncol. , vol.12 , pp. 1143-1150
    • Garcia-Donas, J.1    Esteban, E.2    Leandro-Garcia, L.J.3
  • 41
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
    • Santoro A, Rimassa L, Borbath I, et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol. 2013;14:55-63.
    • (2013) Lancet Oncol. , vol.14 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 42
    • 84872600260 scopus 로고    scopus 로고
    • A Phase-1b study of tivantinib (ARQ 197) in adult patients with hepatocellular carcinoma and cirrhosis
    • Santoro A, Simonelli M, Rodriguez-Lope C, et al. A Phase-1b study of tivantinib (ARQ 197) in adult patients with hepatocellular carcinoma and cirrhosis. Br J Cancer. 2013;108:21-24.
    • (2013) Br J Cancer. , vol.108 , pp. 21-24
    • Santoro, A.1    Simonelli, M.2    Rodriguez-Lope, C.3
  • 43
    • 84872301160 scopus 로고    scopus 로고
    • SEARCH: A phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC)
    • Abstract LBA2
    • Zhu A, Rosmorduc O, Evans J, Ross P, Santoro A, Carrilho FJ, et al. SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC). Ann Oncol 2012;23(Suppl 9):ixe1-ixe30. Abstract LBA2.
    • (2012) Ann Oncol , vol.23 , pp. ixe1-ixe30
    • Zhu, A.1    Rosmorduc, O.2    Evans, J.3    Ross, P.4    Santoro, A.5    Carrilho, F.J.6
  • 44
    • 84865107387 scopus 로고    scopus 로고
    • Erlotinib and sorafenib in an orthotopic rat model of hepatocellular carcinoma
    • Sieghart W, Pinter M, Dauser B, et al. Erlotinib and sorafenib in an orthotopic rat model of hepatocellular carcinoma. J Hepatol. 2012; 57:592-599.
    • (2012) J Hepatol. , vol.57 , pp. 592-599
    • Sieghart, W.1    Pinter, M.2    Dauser, B.3
  • 45
    • 34548077118 scopus 로고    scopus 로고
    • Phase i targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
    • Duran I, Hotte SJ, Hirte H, et al. Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors. Clin Cancer Res. 2007;13:4849-4857.
    • (2007) Clin Cancer Res. , vol.13 , pp. 4849-4857
    • Duran, I.1    Hotte, S.J.2    Hirte, H.3
  • 46
    • 77949695492 scopus 로고    scopus 로고
    • Phase i combination of sorafenib and erlotinib therapy in solid tumors: Safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort
    • Quintela-Fandino M, Le Tourneau C, Duran I, et al. Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort. Mol Cancer Ther. 2010;9:51-760.
    • (2010) Mol Cancer Ther. , vol.9 , pp. 51-760
    • Quintela-Fandino, M.1    Le Tourneau, C.2    Duran, I.3
  • 47
    • 34047245311 scopus 로고    scopus 로고
    • Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1
    • Alavi AS, Acevedo L, Min W, Cheresh DA. Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1. Cancer Res. 2007;67:2766-2772.
    • (2007) Cancer Res. , vol.67 , pp. 2766-2772
    • Alavi, A.S.1    Acevedo, L.2    Min, W.3    Cheresh, D.A.4
  • 48
    • 33748063941 scopus 로고    scopus 로고
    • Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance
    • McCubrey JA, Steelman LS, Abrams SL, et al. Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul. 2006;46:249-279.
    • (2006) Adv Enzyme Regul. , vol.46 , pp. 249-279
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3
  • 49
    • 78650247661 scopus 로고    scopus 로고
    • Sorafenib modulates the gene expression of multi-drug resistance mediating ATP-binding cassette proteins in experimental hepatocellular carcinoma
    • Hoffmann K, Franz C, Xiao Z, et al. Sorafenib modulates the gene expression of multi-drug resistance mediating ATP-binding cassette proteins in experimental hepatocellular carcinoma. Anticancer Res. 2010;30:4503-4508.
    • (2010) Anticancer Res. , vol.30 , pp. 4503-4508
    • Hoffmann, K.1    Franz, C.2    Xiao, Z.3
  • 50
    • 60449093312 scopus 로고    scopus 로고
    • Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: Results from a phase i extension trial
    • Richly H, Schultheis B, Adamietz IA, et al. Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial. Eur J Cancer. 2009;45: 579-587.
    • (2009) Eur J Cancer. , vol.45 , pp. 579-587
    • Richly, H.1    Schultheis, B.2    Adamietz, I.A.3
  • 51
    • 78349298645 scopus 로고    scopus 로고
    • Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
    • Abou-Alfa GK, Johnson P, Knox JJ, et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA. 2010;304:2154-2160.
    • (2010) JAMA , vol.304 , pp. 2154-2160
    • Abou-Alfa, G.K.1    Johnson, P.2    Knox, J.J.3
  • 52
    • 0035947770 scopus 로고    scopus 로고
    • Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
    • Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol. 2001;153:1023-1034.
    • (2001) J Cell Biol. , vol.153 , pp. 1023-1034
    • Wang, R.1    Ferrell, L.D.2    Faouzi, S.3    Maher, J.J.4    Bishop, J.M.5
  • 53
    • 35148864569 scopus 로고    scopus 로고
    • In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells
    • Salvi A, Arici B, Portolani N, Giulini SM, De Petro G, Barlati S. In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells. Int J Oncol. 2007;31:451-460.
    • (2007) Int J Oncol. , vol.31 , pp. 451-460
    • Salvi, A.1    Arici, B.2    Portolani, N.3    Giulini, S.M.4    De Petro, G.5    Barlati, S.6
  • 54
    • 65549097632 scopus 로고    scopus 로고
    • MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells
    • Salvi A, Sabelli C, Moncini S, et al. MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells. FEBS J. 2009;276:2966-2982.
    • (2009) FEBS J. , vol.276 , pp. 2966-2982
    • Salvi, A.1    Sabelli, C.2    Moncini, S.3
  • 55
    • 27744557794 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vectormediated NK4 gene therapy
    • Heideman DA, Overmeer RM, van Beusechem VW, et al. Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vectormediated NK4 gene therapy. Cancer Gene Ther. 2005;12:954-962.
    • (2005) Cancer Gene Ther. , vol.12 , pp. 954-962
    • Heideman, D.A.1    Overmeer, R.M.2    Van Beusechem, V.W.3
  • 56
    • 84878398940 scopus 로고    scopus 로고
    • Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma
    • Ogunwobi OO, Puszyk W, Dong HJ, Liu C. Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma. PLoS One. 2013;8:e63765.
    • (2013) PLoS One. , vol.8
    • Ogunwobi, O.O.1    Puszyk, W.2    Dong, H.J.3    Liu, C.4
  • 57
    • 84861535274 scopus 로고    scopus 로고
    • Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    • Huynh H, Ong R, Soo KC. Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Angiogenesis. 2012;15:59-70.
    • (2012) Angiogenesis. , vol.15 , pp. 59-70
    • Huynh, H.1    Ong, R.2    Soo, K.C.3
  • 58
    • 84872549428 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT)
    • Page. Abstract 4007
    • Verslype C, Cohn AL, Kelley RK, et al. Activity of cabozantinib (XL184) in hepatocellular carcinoma: results from a phase II randomized discontinuation trial (RDT). J Clin Oncol. 2012; VOL (suppl):Page. Abstract 4007.
    • (2012) J Clin Oncol.
    • Verslype, C.1    Cohn, A.L.2    Kelley, R.K.3
  • 59
    • 84875657918 scopus 로고    scopus 로고
    • Expression and prognostic value of VEGFR-2, PDGFR-beta, and c-Met in advanced hepatocellular carcinoma
    • Chu JS, Ge FJ, Zhang B, et al. Expression and prognostic value of VEGFR-2, PDGFR-beta, and c-Met in advanced hepatocellular carcinoma. J Exp Clin Cancer Res. 2013;32:16.
    • (2013) J Exp Clin Cancer Res. , vol.32 , pp. 16
    • Chu, J.S.1    Ge, F.J.2    Zhang, B.3
  • 60
    • 0027954225 scopus 로고
    • C-met mRNA overexpression in human hepatocellular carcinoma
    • Boix L, Rosa JL, Ventura F, et al. c-met mRNA overexpression in human hepatocellular carcinoma. Hepatology. 1994;19:88-91.
    • (1994) Hepatology. , vol.19 , pp. 88-91
    • Boix, L.1    Rosa, J.L.2    Ventura, F.3
  • 61
    • 0027967963 scopus 로고
    • Expression of the c-met protooncogene in human hepatocellular carcinoma
    • Suzuki K, Hayashi N, Yamada Y, et al. Expression of the c-met protooncogene in human hepatocellular carcinoma. Hepatology. 1994; 20:1231-1236.
    • (1994) Hepatology. , vol.20 , pp. 1231-1236
    • Suzuki, K.1    Hayashi, N.2    Yamada, Y.3
  • 62
    • 0030857813 scopus 로고    scopus 로고
    • Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas
    • Kiss A, Wang NJ, Xie JP, Thorgeirsson SS. Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas. Clin Cancer Res. 1997;3: 1059-1066.
    • (1997) Clin Cancer Res. , vol.3 , pp. 1059-1066
    • Kiss, A.1    Wang, N.J.2    Xie, J.P.3    Thorgeirsson, S.S.4
  • 63
    • 0030951358 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma
    • Ueki T, Fujimoto J, Suzuki T, Yamamoto H, Okamoto E. Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma. Hepatology. 1997;25:619-623.
    • (1997) Hepatology. , vol.25 , pp. 619-623
    • Ueki, T.1    Fujimoto, J.2    Suzuki, T.3    Yamamoto, H.4    Okamoto, E.5
  • 64
    • 61949226823 scopus 로고    scopus 로고
    • Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma
    • Ke AW, Shi GM, Zhou J, et al. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma. Hepatology. 2009;49:491-503.
    • (2009) Hepatology. , vol.49 , pp. 491-503
    • Ke, A.W.1    Shi, G.M.2    Zhou, J.3
  • 65
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest. 2006;116:1582-1595.
    • (2006) J Clin Invest. , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 66
    • 84877848587 scopus 로고    scopus 로고
    • Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition
    • Katayama R, Aoyama A, Yamori T, et al. Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition. Cancer Res. 2013;73:3087-3096.
    • (2013) Cancer Res. , vol.73 , pp. 3087-3096
    • Katayama, R.1    Aoyama, A.2    Yamori, T.3
  • 67
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • 1983e1971-1911
    • Villanueva A, Chiang DY, Newell P, et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology. 2008;135: 1972-1983, 1983e1971-1911.
    • (2008) Gastroenterology. , vol.135 , pp. 1972-1983
    • Villanueva, A.1    Chiang, D.Y.2    Newell, P.3
  • 68
    • 0036792124 scopus 로고    scopus 로고
    • Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo
    • Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA. Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res. 2002;62:5443-5450.
    • (2002) Cancer Res. , vol.62 , pp. 5443-5450
    • Ensor, C.M.1    Holtsberg, F.W.2    Bomalaski, J.S.3    Clark, M.A.4
  • 69
    • 3042744030 scopus 로고    scopus 로고
    • Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: Results from phase I/II studies
    • Izzo F, Marra P, Beneduce G, et al. Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies. J Clin Oncol. 2004;22:1815-1822.
    • (2004) J Clin Oncol. , vol.22 , pp. 1815-1822
    • Izzo, F.1    Marra, P.2    Beneduce, G.3
  • 70
    • 77952316981 scopus 로고    scopus 로고
    • Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma
    • Glazer ES, Piccirillo M, Albino V, et al. Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol. 2010;28:2220-2226.
    • (2010) J Clin Oncol. , vol.28 , pp. 2220-2226
    • Glazer, E.S.1    Piccirillo, M.2    Albino, V.3
  • 71
    • 77957245576 scopus 로고    scopus 로고
    • A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
    • Yang TS, Lu SN, Chao Y, et al. A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients. Br J Cancer. 2010;103:954-960.
    • (2010) Br J Cancer. , vol.103 , pp. 954-960
    • Yang, T.S.1    Lu, S.N.2    Chao, Y.3
  • 72
    • 84873736254 scopus 로고    scopus 로고
    • Immunotherapy of hepatocellular carcinoma: Unique challenges and clinical opportunities
    • Pardee AD, Butterfield LH. Immunotherapy of hepatocellular carcinoma: unique challenges and clinical opportunities. Oncoimmunology. 2012;1:48-55.
    • (2012) Oncoimmunology. , vol.1 , pp. 48-55
    • Pardee, A.D.1    Butterfield, L.H.2
  • 73
    • 84879141840 scopus 로고    scopus 로고
    • A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
    • Sangro B, Gomez-Martin C, de la Mata M, et al. A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C. J Hepatol. 2013;59:81-88.
    • (2013) J Hepatol. , vol.59 , pp. 81-88
    • Sangro, B.1    Gomez-Martin, C.2    De La Mata, M.3
  • 74
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C, et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med. 2009;206:1327-1337.
    • (2009) J Exp Med. , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3
  • 75
    • 84867495878 scopus 로고    scopus 로고
    • RECIST: No longer the sharpest tool in the oncology clinical trials toolbox - Point
    • discussion 5150
    • Sharma MR, Maitland ML, Ratain MJ. RECIST: no longer the sharpest tool in the oncology clinical trials toolbox - point. Cancer Res. 2012;72:5145-5149; discussion 5150.
    • (2012) Cancer Res. , vol.72 , pp. 5145-5149
    • Sharma, M.R.1    Maitland, M.L.2    Ratain, M.J.3
  • 76
    • 83855160927 scopus 로고    scopus 로고
    • Comparison of tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST in patients treated with sorafenib for hepatocellular carcinoma
    • Edeline J, Boucher E, Rolland Y, et al. Comparison of tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST in patients treated with sorafenib for hepatocellular carcinoma. Cancer. 2012;118:147-156.
    • (2012) Cancer. , vol.118 , pp. 147-156
    • Edeline, J.1    Boucher, E.2    Rolland, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.