메뉴 건너뛰기




Volumn 12, Issue 12, 2005, Pages 954-962

Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy

Author keywords

Angiogenesis; c MET; Hepatocyte growth factor; Invasion; Tumor growth

Indexed keywords

CYTOKINE RECEPTOR ANTAGONIST; PROTEIN; PROTEIN NK4; UNCLASSIFIED DRUG;

EID: 27744557794     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700856     Document Type: Article
Times cited : (36)

References (46)
  • 2
    • 0037407437 scopus 로고    scopus 로고
    • The promise of gene therapy in gastrointestinal and liver diseases
    • Prieto J, Herraiz M, Sangro B, et al. The promise of gene therapy in gastrointestinal and liver diseases. Gut. 2003; 52(Suppl 2):49-54.
    • (2003) Gut , vol.52 , Issue.2 SUPPL. , pp. 49-54
    • Prieto, J.1    Herraiz, M.2    Sangro, B.3
  • 3
    • 0031583998 scopus 로고    scopus 로고
    • HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor
    • Date K, Matsumoto K, Shimura H, et al. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett. 1997;420:1-6.
    • (1997) FEBS Lett , vol.420 , pp. 1-6
    • Date, K.1    Matsumoto, K.2    Shimura, H.3
  • 4
    • 0034547912 scopus 로고    scopus 로고
    • HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice
    • Kuba K, Matsumoto K, Date K, et al. HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Res. 2000;60:6737-6743.
    • (2000) Cancer Res , vol.60 , pp. 6737-6743
    • Kuba, K.1    Matsumoto, K.2    Date, K.3
  • 5
    • 0032506703 scopus 로고    scopus 로고
    • Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor
    • Date K, Matsumoto K, Kuba K, et al. Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor. Oncogene. 1998;17: 3045-3054.
    • (1998) Oncogene , vol.17 , pp. 3045-3054
    • Date, K.1    Matsumoto, K.2    Kuba, K.3
  • 6
    • 0032713122 scopus 로고    scopus 로고
    • Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells
    • Jiang WG, Hiscox SE, Parr C, et al. Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells. Clin Cancer Res. 1999;5:3695-3703.
    • (1999) Clin Cancer Res , vol.5 , pp. 3695-3703
    • Jiang, W.G.1    Hiscox, S.E.2    Parr, C.3
  • 7
    • 0037850880 scopus 로고    scopus 로고
    • NK4 (HGF-antagonist/ angiogenesis inhibitor) in cancer biology and therapeutics
    • Matsumoto K, Nakamura T. NK4 (HGF-antagonist/ angiogenesis inhibitor) in cancer biology and therapeutics. Cancer Sci. 2003;94:321-327.
    • (2003) Cancer Sci , vol.94 , pp. 321-327
    • Matsumoto, K.1    Nakamura, T.2
  • 8
    • 0036171069 scopus 로고    scopus 로고
    • Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy
    • Maemondo M, Narumi K, Saijo Y, et al. Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy. Mol Ther. 2002;5:177-185.
    • (2002) Mol Ther , vol.5 , pp. 177-185
    • Maemondo, M.1    Narumi, K.2    Saijo, Y.3
  • 9
    • 0036021906 scopus 로고    scopus 로고
    • Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas
    • Hirao S, Yamada Y, Koyama F, et al. Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas. Cancer Gene Ther. 2002;9:700-707.
    • (2002) Cancer Gene Ther , vol.9 , pp. 700-707
    • Hirao, S.1    Yamada, Y.2    Koyama, F.3
  • 10
    • 0036345115 scopus 로고    scopus 로고
    • Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer
    • Maehara N, Nagai E, Mizumoto K, et al. Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer. Clin Exp Metastasis. 2002;19:417-426.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 417-426
    • Maehara, N.1    Nagai, E.2    Mizumoto, K.3
  • 11
    • 0036789558 scopus 로고    scopus 로고
    • Intraperitoneal injection of adenovirus-media ted NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice
    • Saimura M, Nagai E, Mizumoto K, et al. Intraperitoneal injection of adenovirus-media ted NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice. Cancer Gene Ther. 2002;9:799-806.
    • (2002) Cancer Gene Ther , vol.9 , pp. 799-806
    • Saimura, M.1    Nagai, E.2    Mizumoto, K.3
  • 12
    • 7444226277 scopus 로고    scopus 로고
    • Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4
    • Heideman DAM, van Beusechem VW, Bloemena E, et al. Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4. J Gene Med. 2004;6:317-327.
    • (2004) J Gene Med , vol.6 , pp. 317-327
    • Heideman, D.A.M.1    Van Beusechem, V.W.2    Bloemena, E.3
  • 13
    • 20844441418 scopus 로고    scopus 로고
    • Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression
    • Fujiwara H, Kubota T, Amaike H, et al. Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression. Cancer Gene Ther. 2005; 12:206-216.
    • (2005) Cancer Gene Ther , vol.12 , pp. 206-216
    • Fujiwara, H.1    Kubota, T.2    Amaike, H.3
  • 14
    • 4444267635 scopus 로고    scopus 로고
    • Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice
    • Ueda K, Iwahashi M, Matsuura I, et al. Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice. Eur J Cancer. 2004;40: 2135-2142.
    • (2004) Eur J Cancer , vol.40 , pp. 2135-2142
    • Ueda, K.1    Iwahashi, M.2    Matsuura, I.3
  • 15
    • 3242715129 scopus 로고    scopus 로고
    • Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres
    • Kushibiki T, Matsumoto K, Nakamura T, Tabata Y. Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres. Pharm Res. 2004;21:1109-1118.
    • (2004) Pharm Res , vol.21 , pp. 1109-1118
    • Kushibiki, T.1    Matsumoto, K.2    Nakamura, T.3    Tabata, Y.4
  • 16
    • 2942560880 scopus 로고    scopus 로고
    • Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model
    • Tanaka T, Shimura H, Sasaki T, et al. Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model. Cancer Gene Ther. 2004; 11:431-440.
    • (2004) Cancer Gene Ther , vol.11 , pp. 431-440
    • Tanaka, T.1    Shimura, H.2    Sasaki, T.3
  • 17
    • 2942555478 scopus 로고    scopus 로고
    • Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
    • Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T. Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Ther. 2004;11:419-430.
    • (2004) Cancer Gene Ther , vol.11 , pp. 419-430
    • Wen, J.1    Matsumoto, K.2    Taniura, N.3    Tomioka, D.4    Nakamura, T.5
  • 18
    • 0141925943 scopus 로고    scopus 로고
    • Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4
    • Brockmann MA, Papadimitriou A, Brandt M, et al. Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4. Clin Cancer Res. 2003;9:4578-4585.
    • (2003) Clin Cancer Res , vol.9 , pp. 4578-4585
    • Brockmann, M.A.1    Papadimitriou, A.2    Brandt, M.3
  • 19
    • 0038505656 scopus 로고    scopus 로고
    • The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo
    • Davies G, Mason MD, Martin TA, et al. The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo. Int J Cancer. 2003;106:348-354.
    • (2003) Int J Cancer , vol.106 , pp. 348-354
    • Davies, G.1    Mason, M.D.2    Martin, T.A.3
  • 20
    • 0041887145 scopus 로고    scopus 로고
    • Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist
    • Martin TA, Parr C, Davies G, et al. Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis. 2003;24:1317-1323.
    • (2003) Carcinogenesis , vol.24 , pp. 1317-1323
    • Martin, T.A.1    Parr, C.2    Davies, G.3
  • 21
    • 0000312502 scopus 로고    scopus 로고
    • Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues
    • Luo YQ, Wu MC, Cong WM. Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues. World J Gastroenterol. 1999;5:119-121.
    • (1999) World J Gastroenterol , vol.5 , pp. 119-121
    • Luo, Y.Q.1    Wu, M.C.2    Cong, W.M.3
  • 22
    • 0033867263 scopus 로고    scopus 로고
    • u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma
    • Tavian D, De Petro G, Benetti A, et al. u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma. Int J Cancer. 2000;87:644-649.
    • (2000) Int J Cancer , vol.87 , pp. 644-649
    • Tavian, D.1    De Petro, G.2    Benetti, A.3
  • 23
    • 0033065805 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
    • Okano J, Shiota G, Kawasaki H. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. Liver. 1999; 19:151-159.
    • (1999) Liver , vol.19 , pp. 151-159
    • Okano, J.1    Shiota, G.2    Kawasaki, H.3
  • 24
    • 0031022607 scopus 로고    scopus 로고
    • Expression of HGF, its receptor c-met, c-myc and albumin in cirrhotic and neoplastic human liver tissue
    • Ljubimova JY, Petrovic LM, Wilson SE, et al. Expression of HGF, its receptor c-met, c-myc and albumin in cirrhotic and neoplastic human liver tissue. J Histochem Cytochem. 1997; 45:79-87.
    • (1997) J Histochem Cytochem , vol.45 , pp. 79-87
    • Ljubimova, J.Y.1    Petrovic, L.M.2    Wilson, S.E.3
  • 25
    • 0030951358 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor and its receptor c-met protooncogene in hepatocellular carcinoma
    • Ueki T, Fujimoto J, Suzuki T, et al. Expression of hepatocyte growth factor and its receptor c-met protooncogene in hepatocellular carcinoma. Hepatology. 1997;25: 619-623.
    • (1997) Hepatology , vol.25 , pp. 619-623
    • Ueki, T.1    Fujimoto, J.2    Suzuki, T.3
  • 26
    • 0029910845 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers
    • Sakata H, Takayama H, Sharp R, et al. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ.. 1996;7:1513-1523.
    • (1996) Cell Growth Differ , vol.7 , pp. 1513-1523
    • Sakata, H.1    Takayama, H.2    Sharp, R.3
  • 27
    • 85047696179 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine
    • Horiguchi N, Takayama H, Toyoda M, et al. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Oncogene. 2002;21:1791-1799.
    • (2002) Oncogene , vol.21 , pp. 1791-1799
    • Horiguchi, N.1    Takayama, H.2    Toyoda, M.3
  • 28
    • 0026046210 scopus 로고
    • Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines
    • Tajima H, Matsumoto K, Nakamura T. Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines. FEBS Lett. 1991;291:229-232.
    • (1991) FEBS Lett , vol.291 , pp. 229-232
    • Tajima, H.1    Matsumoto, K.2    Nakamura, T.3
  • 29
    • 0026599602 scopus 로고
    • Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells
    • Shiota G, Rhoads DB, Wang TC, et al. Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA. 1992;89:373-377.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 373-377
    • Shiota, G.1    Rhoads, D.B.2    Wang, T.C.3
  • 30
    • 0026551914 scopus 로고
    • Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells
    • Miyazaki M, Gohda E, Tsuboi S, et al. Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells. Cell Biol Int Rep. 1992;16: 145-154.
    • (1992) Cell Biol Int Rep , vol.16 , pp. 145-154
    • Miyazaki, M.1    Gohda, E.2    Tsuboi, S.3
  • 31
    • 0030683506 scopus 로고    scopus 로고
    • Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: Evidence for a role of hepatocyte growth factor
    • Neaud V, Faouzi S, Guirouilh J, et al. Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor. Hepatology. 1997;26:1458-1466.
    • (1997) Hepatology , vol.26 , pp. 1458-1466
    • Neaud, V.1    Faouzi, S.2    Guirouilh, J.3
  • 32
    • 0028965029 scopus 로고
    • Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine
    • Liu ML, Mars WM, Michalopoulos GK. Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine. Carcinogenesis. 1995;16:841-843.
    • (1995) Carcinogenesis , vol.16 , pp. 841-843
    • Liu, M.L.1    Mars, W.M.2    Michalopoulos, G.K.3
  • 33
    • 0029670654 scopus 로고    scopus 로고
    • Inhibitory effect of hepatocyte growth factor on metastasis of hepatocellular carcinoma in transgenic mice
    • Shiota G, Kawasaki H, Nakamura T, et al. Inhibitory effect of hepatocyte growth factor on metastasis of hepatocellular carcinoma in transgenic mice. Res Commun Mol Pathol Pharmacol. 1996;91:33-39.
    • (1996) Res Commun Mol Pathol Pharmacol , vol.91 , pp. 33-39
    • Shiota, G.1    Kawasaki, H.2    Nakamura, T.3
  • 34
    • 0029793097 scopus 로고    scopus 로고
    • Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model
    • Santoni-Rugiu E, Preisegger KH, Kiss A, et al. Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc Natl Acad Sci USA. 1996;93:9577-9582.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9577-9582
    • Santoni-Rugiu, E.1    Preisegger, K.H.2    Kiss, A.3
  • 35
    • 0028910237 scopus 로고
    • Maintenance of vascular endothelial cell-specific properties after immortalization with an amphotrophic replication-deficient retrovirus containing human papilloma virus 16 E6/E7 DNA
    • Fontijn R, Hop C, Brinkman HJ, et al. Maintenance of vascular endothelial cell-specific properties after immortalization with an amphotrophic replication-deficient retrovirus containing human papilloma virus 16 E6/E7 DNA. Exp Cell Res. 1995;216:199-207.
    • (1995) Exp Cell Res , vol.216 , pp. 199-207
    • Fontijn, R.1    Hop, C.2    Brinkman, H.J.3
  • 36
    • 0034868238 scopus 로고    scopus 로고
    • Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma
    • Heideman DAM, Snijders PJF, Bloemena E, et al. Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma. J. Pathol. 2001;194:428-435.
    • (2001) J Pathol , vol.194 , pp. 428-435
    • Heideman, D.A.M.1    Snijders, P.J.F.2    Bloemena, E.3
  • 37
    • 0029778863 scopus 로고    scopus 로고
    • Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines
    • Borset M, Lien E, Espevik T, et al. Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. J Biol Chem. 1996;271: 24655-24661.
    • (1996) J Biol Chem , vol.271 , pp. 24655-24661
    • Borset, M.1    Lien, E.2    Espevik, T.3
  • 38
    • 0030690583 scopus 로고    scopus 로고
    • Met and hepatocyte growth factor/scatter factor expression in human gliomas
    • Koochekpour S, Jeffers M, Rulong S, et al. Met and hepatocyte growth factor/scatter factor expression in human gliomas. Cancer Res. 1997;57:5391-5398.
    • (1997) Cancer Res , vol.57 , pp. 5391-5398
    • Koochekpour, S.1    Jeffers, M.2    Rulong, S.3
  • 39
    • 0036006814 scopus 로고    scopus 로고
    • Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition
    • Maulik G, Shrikhande A, Kijima T, et al. Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine Growth Factor Rev. 2002;13:41-59.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 41-59
    • Maulik, G.1    Shrikhande, A.2    Kijima, T.3
  • 40
    • 0037286698 scopus 로고    scopus 로고
    • HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model
    • Nakabayashi M, Morishita R, Nakagami H, et al. HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model. Diabetologia. 2003;46:115-123.
    • (2003) Diabetologia , vol.46 , pp. 115-123
    • Nakabayashi, M.1    Morishita, R.2    Nakagami, H.3
  • 41
    • 0034731366 scopus 로고    scopus 로고
    • Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells
    • Kuba K, Matsumoto K, Ohnishi K, et al. Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells. Biochem Biophys Res Commun. 2000;279:846-852.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 846-852
    • Kuba, K.1    Matsumoto, K.2    Ohnishi, K.3
  • 42
    • 0033926002 scopus 로고    scopus 로고
    • Replicative adenoviruses for cancer therapy
    • Alemany R, Balague C, Curiel DT. Replicative adenoviruses for cancer therapy. Nat Biotechnol. 2000;18:723-727.
    • (2000) Nat Biotechnol , vol.18 , pp. 723-727
    • Alemany, R.1    Balague, C.2    Curiel, D.T.3
  • 43
    • 0034077666 scopus 로고    scopus 로고
    • Replication-selective adenoviruses as oncolytic agents
    • Heise C, Kirn DH. Replication-selective adenoviruses as oncolytic agents. J Clin Invest.. 2000;105:847-851.
    • (2000) J Clin Invest , vol.105 , pp. 847-851
    • Heise, C.1    Kirn, D.H.2
  • 44
    • 0034688181 scopus 로고    scopus 로고
    • Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus
    • Motoi F, Sunamura M, Ding L, et al. Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus. Hum Gene Ther. 2000;11: 223-235.
    • (2000) Hum Gene Ther , vol.11 , pp. 223-235
    • Motoi, F.1    Sunamura, M.2    Ding, L.3
  • 45
    • 3042820799 scopus 로고    scopus 로고
    • Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer
    • Maemondo M, Saijo Y, Narumi K, et al. Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer. Cancer Res. 2004;64:4611-4620.
    • (2004) Cancer Res , vol.64 , pp. 4611-4620
    • Maemondo, M.1    Saijo, Y.2    Narumi, K.3
  • 46
    • 0032482939 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy
    • Folkman J. Antiangiogenic gene therapy. Proc Natl Acad Sci USA. 1998;95:9065-9066.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9065-9066
    • Folkman, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.