Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells

Biochimie

Volumn 106, Issue , 2014, Pages 157-166

  Laafi, Jihane ^a   Homedan, Chadi ^a,b   Jacques, Caroline ^a   Gueguen, Naig ^b,f   Schmitt, Caroline ^c,d,e   Puy, Hervé ^c,d,e   Reynier, Pascal ^b,f   Carmen Martinez, Maria ^a   Malthièry, Yves ^a,b  

^a UNIVERSITÉ D'ANGERS   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f CNRS   (France)

Author keywords

5 Aminolevulinic acid; Energetic dysfunctions; Mitochondria; Oxidative phosphorylation; Oxidative stress; Respiratory chain

Indexed keywords

AMINOLEVULINIC ACID; ANTIOXIDANT; CITRATE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOFUSIN 2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTOPORPHYRIN; TRANSCRIPTION FACTOR NRF1; UNCOUPLING PROTEIN 2; ADENOSINE TRIPHOSPHATE; DNA BINDING PROTEIN; ION CHANNEL; METALLOPORPHYRIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; MN(III) 5,10,15,20-TETRAKIS(N-METHYLPYRIDINIUM-2-YL)PORPHYRIN; ND5 PROTEIN, HUMAN; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; TFAM PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; BIOENERGY; BIOGENESIS; CELL CULTURE; CELL FUNCTION; CELL VIABILITY; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC CODE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; LEAD POISONING; LIVER CELL CARCINOMA; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NECROSIS; NORMAL HUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PORPHYRIA; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY CHAIN; RNA EXTRACTION; UPREGULATION; WESTERN BLOTTING; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; LIVER TUMOR; METABOLISM; MITOCHONDRION; OXYGEN CONSUMPTION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATE; AMINOLEVULINIC ACID; ANTIOXIDANTS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; GENE EXPRESSION; HEP G2 CELLS; HUMANS; ION CHANNELS; LIVER NEOPLASMS; METALLOPORPHYRINS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDANTS; OXYGEN CONSUMPTION; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 84908025350     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.08.014     Document Type: Article

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