5-Aminolevulinic acid-based photodynamic therapy: Principles and experimental research

Photochemistry and Photobiology

Volumn 65, Issue 2, 1997, Pages 235-251

  Peng, Qian ^a   Berg, Kristian ^a   Moan, Johan ^a   Kongshaug, Magne ^a   Nesland, Jahn M ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0031080041     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1997.tb08549.x     Document Type: Conference Paper

References (234)

1. Leibovici, L., N. Schoenfeld, H. A. Yehoshua, R. Mamet, E. Rakowski, A. Shindel and A. Atsmon (1988) Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer. Cancer 62, 2297-2300.
2. Schoenfeld, N., O. Epstein, M. Lahav, R. Mamet, M. Shaklai and A. Atsmon (1988) The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders. Cancer Lett. 43, 43-48.
3. Kondo, M., N. Hirota, T. Takaoka and M. Kajiwara (1993) Heme-biosynthetic enzyme activities and porphyrin accumulation in normal liver and hepatoma cell line of rats. Cell Biol. Toxicol. 9, 95-105.
4. Dailey, H. A. and A. Smith (1984) Differential interaction of porphyrins used in photoradiation therapy with ferrochelatase. Biochem. J. 223, 441-445.
5. Smith, A. (1987) Mechanisms of toxicity of photoactivated artificial porphyrins. Role of porphyrin-protein interactions. Ann. N.Y. Acad. Sci. 514, 309-322.
6. El-Sharabasy, M. M. H., A. M. El-Wassel, M. M. Hafez and S. A. Salim (1992) Porphyrin metabolism in some malignant diseases. Br. J. Cancer 65, 409-412.
7. van Hillegersberg, R., J. W. Van den Berg, W. J. Kort, O. T. Terpstra and J. H. Wilson (1992) Selective accumulation of endogenously produced porphyrins in a liver metastasis model in rats. Gastroenterology 103, 647-651.
8. Kennedy, J. C., R. H. Pettier and D. C. Pross (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principle and present clinical experience. J. Photochem. Photobiol. B Biol. 6, 143-148.
9. Kennedy, J. C. and R. H. Pottier (1992) Endogenous protoporphyrin IX, a clinical useful photosensitizer for photodynamic therapy. J. Photochem. Photobiol. B Biol. 14, 275-292.
10. Malik, Z. and H. Lugaci (1987) Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins. Br. J. Cancer 56, 589-595.
11. Peng, Q., J. F. Evensen, C. Rimington and J. Moan (1987) A comparison of different photosensitizing dyes with respect to uptake by C3H-tumors and tissues of mice. Cancer Lett. 36, 1-10.
12. Warloe, T., Q. Peng, H. Heyerdahl, J. Moan, H. B. Steen and K.-E. Giercksky (1995) Photodynamic therapy with 5-aminolevulinic acid induced porphyrins and DMSO/EDTA for basal cell carcinoma. In 5th International Photodynamic Association Biennial Meeting, Vol. 2371 (Edited by D. A. Cortese), pp. 226-235. Proc. SPIE. Bellingham, Washington.
13. Kriegmair, M., R. Baumgartner, R. Knuechel, H. Stepp, F. Hofstadter and A. Hofstetter (1996) Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. J. Urol. 155, 105-110.
14. Regula, J., A. J. MacRobert, A. Gorchein, G. A. Buonaccorsi, S. M. Thorpe, G. M. Spencer, A. R. W. Hatfield and S. G. Bown (1995) Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumors using 5 aminolaevulinic acid induced protoporphyrin IX - a pilot study. Gut 36, 67-75.
15. Huber, R. M., F. Gamarra, A. Leberig, H. Stepp, K. Rick and R. Baumgartner (1996) Inhaled 5-aminolevulinic acid (ALA) for photodynamic diagnosis and early detection of bronchial tumors: first experience in patients. Abstract book of 6th IPA meeting, Melbourne, Australia.
16. Goff, B. A., R. Bachor, N. Kollias and T. Hasan (1992) Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless quinea pigs. J. Photochem. Photobiol. B Biol. 15, 239-251.
17. Warloe, T., Q. Peng, H. B. Steen and K.-E. Giercksky (1992) Localization of porphyrins in human basal cell carcinoma and normal skin tissue induced by topical application of 5-aminolevulinic acid. In Photodynamic Therapy and Biomedical Lasers (Edited by P. Spinelli, M. Dal Fante and R. Marchesini), pp. 454-458. Elsevier, Amsterdam.
18. Gaullier, J. M., K. Berg, Q. Peng, H. Anholt, P. K. Selbo and J. Moan (1997) The use of esters of 5-aminolevulinic acid to improve photodynamic therapy on cells in culture. Cancer Res. (In press)
19. Peng, Q., T. Warloe, J. Moan, H. Heyerdahl, H. B. Steen, K.-E. Giercksky and J. M. Nesland (1995) ALA derivative-induced protoporphyrin IX build-up and distribution in human nodular basal cell carcinoma. Photochem. Photobiol. 61, 82S.
20. Peng, Q., J. Moan, T. Warloe, V. Iani, H. B. Steen, A. Bjørseth and J. M. Nesland (1996) Build-up of esterified aminolevulinic-acid-derivative-induced porphyrin fluorescence in normal mouse skin. J. Photochem. Photobiol. B Biol. 34, 95-96.
21. Cotter, P. D., H. A. Drabkin, T. Varkony, D. I. Smith and D. F. Bishop (1995) Assignment of the human housekeeping delta-aminolevulinate synthase gene (ALAS1) to chromosome band 3p21.1 by PCR analysis of somatic cell hybrids. Cytogenet. Cell Genet. 69, 207-208.
22. Cox T. C., M. J. Bawden, N. G. Abraham, S. S. Bottomley, B. K. May, E. Baker, L. Z. Chen and G. R. Sutherland (1990) Erythroid 5-aminolevulinate synthase is located on the X chromosome. Am. J. Hum. Genet. 46, 107-111.
23. Conboy, J. G., T. C. Cox, S. S. Bottomley, M. J. Bawden and B. K. May (1992) Human erythroid 5-aminolevulinate synthase. Gene structure and species-specific differences in alternative RNA splicing. J. Biol. Chem. 267, 18753-18758.
24. Ferreira, G. C. and H. A. Dailey (1993) Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization. J. Biol. Chem. 268, 584-590.
25. May, B. K. and M. J. Bawden (1989) Control of heme biosynthesis in animals. Semin. Hematol. 26, 150-156.
26. Scotto, A. W., L. F. Chang and D. S. Beattie (1983) The characterization and submitochondrial localization of delta-aminolevulinic acid synthase and an associated amidase in rat liver mitochondria using an improved assay for both enzymes. J. Biol. Chem. 258, 81-90.
27. Guo, G. G., M. Gu and J. D. Etlinger (1994) 240-kDa proteasome inhibitor (CF-2) is identical to delta-aminolevulinic acid dehydratase. J. Biol. Chem. 269, 12399-12402.
28. Norton, B., W. G. Lanyon, M. R. Moore, M. Porteous, G. R. Youngs and J. M. Connor (1993) Evidence for involvement of a second genetic locus on chromosome 11q in porphyrin metabolism. Hum. Genet. 91, 576-578.
29. Xu, W., C. A. Kozak and R. J. Desnick (1995) Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7. Genomics 26, 556-562.
30. Moore, M. R., K. E. L. McColl, C. Rimington and A. Goldberg. (1987) Disorders of Porphyrin Metabolism. Plenum Press, New York.
31. Smith, A. G. and J. E. Francis (1979) Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase. Biochem. J. 183, 455-458.
32. De Verneuil, H., B. Grandchamp, C. Foubert, D. Weil, V. C. N'Guyen, M. S. Gross, S. Sassa and Y. Nordmann (1984) Assignment of the gene for uroporphyrinogen decarboxylase to human chromosome 1 by somatic cell hybridization and specific enzyme immunoassay. Hum. Genet. 66, 202-205.
33. Romeo, P. H., N. Raich, A. Dubart, D. Beaupain, M. Pryor, J. Kushner, M. Cohen-Solal and M. Goossens (1986) Molecular cloning and nucleotide sequence of a complete human uroporphyrinogen decarboxylase cDNA. J. Biol. Chem. 261, 9825-9831.
34. Elder, G. H. and J. O. Evans (1978) Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria. Biochem. J. 172, 345-347.
35. Grandchamp, B., N. Phung and Y. Nordmann (1978) The mitochondrial localization of coproporphyrinogen III oxidase. Biochem. J. 176, 97-102.
36. Akthar, M. (1991) Mechanisms and stereochemistry of the enzymes involved in the convesion of uroporphyrinogen III into haem. In Biosynthesis of Tetrapyrroles (Edited by P. M. Jordan), pp. 67-100. Elsevier, Amsterdam.
37. Grandchamp, B., D. Weil, Y. Nordmann, N. Van Cong, H. De Verneuil, C. Foubert and M. S. Gross (1983) Assignment of the human coproporphyrinogen oxidase to chromosome. Hum. Genet. 64, 180-183.
38. Battle, A. M. d., A. Benson and C. Rimington (1965) Purification and properties of coproporphyrinogenase. Biochem. J. 97, 731-740.
39. Ferreira, G. C., T. L. Andrew, S. W. Karr and H. A. Dailey (1988) Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex. J. Biol. Chem. 263, 3835-3839.
40. Rossi, E., K. A. Costin and P. Garcia-Webb (1988) Ferrochelatase activity in human lymphocytes, as quantified by a new high-performance liquid-chromatographic method. Clin. Chem. 34, 2481-2485.
41. Ferreira, G. C., R. Franco, S. G. Lloyd, A. S. Pereira, I. Moura, J. J. Moura and B. H. Huynh (1994) Mammalian ferrochelatase, a new addition to the metalloenzyme family. J. Biol. Chem. 269, 7062-7065.
42. Punekar, N. S. and R. S. Gokhale (1991) Factors influencing the stability of heme and ferrochelatase: role of oxygen. Biotechnol. Appl. Biochem. 14, 21-29.
43. Bottomley, S. S. and U. Muller-Eberhard (1988) Pathophysiology of heme synthesis. Semin. Hematol. 25, 282-302.
44. Rossi, E., P. V. Attwood, P. Garcia-Webb and K. A. Costin (1990) Inhibition of human lymphocyte ferrochelatase activity by hemin. Biochim. Biophys. Acta 1038, 375-381.
45. Wolfson, S. J., A. Bartczak and J. R. Bloomer (1979) Effect of endogenous heme generation on delta-aminolevulinic acid synthase activity in rat liver mitochondria. J. Biol. Chem. 254, 3543-3546.
46. Sassa, S. and A. Kappas (1981) Genetic, metabolic and biochemical aspects of the porphyrias. In Advances in Human Genetics (Edited by H. Harris and K. Hirshhorn), pp. 121-231. Plenum Press, New York.
47. Williams, M., J. Van der Zee and J. Van Steveninck (1992) Toxic dark effects of protoporphyrin on the cytochrome P-450 system in rat liver microsomes. Biochem. J. 288, 155-159.
48. Braidotti, G., I. A. Borthwick and B. K. May (1993) Identification of regulatory sequences in the gene for 5-aminolevulinate synthase from rat. J. Biol. Chem. 268, 1109-1117.
49. Hamilton, J. W., W. J. Bernent, P. R. Sinclair, J. F. Sinclair, J. A. Alcedo and K. E. Wetterhahn (1991) Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription. Arch. Biochem. Biophys. 289, 387-392.
50. Drew, P. D. and I. Z. Ades (1989) Regulation of the stability of chicken embryo liver delta-aminolevulinate synthase mRNA by hemin. Biochem. Biophys. Res. Commun. 162, 102-107.
51. Cable, E. E., J. A. Pepe, N. C. Karamitsios, R. W. Lambrecht and H. L. Bonkovsky (1994) Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94, 649-654.
52. Yamamoto, M., S. Kure, J. D. Engel and K. Hiraga (1988) Structure, turnover, and heme-mediated suppression of the level of mRNA encoding rat liver delta-aminolevulinate synthase. J. Biol. Chem. 263, 15973-15979.
53. May, B. K., S. C. Dogra, T. J. Sadlon, C. R. Bhasker, T. C. Cox and S. S. Bottomley (1995) Molecular regulation of heme biosynthesis in higher vertebrates. Prog. Nucleic Acid Res. Mol. Biol. 51, 1-51.
54. Borthwick, I. A., G. Srivastava, A. R. Day, B. A. Pirola, M. A. Snoswell, B. K. May and W. H. Elliott (1985) Complete nucleotide sequence of hepatic 5-aminolaevulinate synthase precursor. Eur. J. Biochem. 150, 481-484.
55. Yamauchi, K., N. Hayashi and G. Kikuchi (1980) Translocation of delta-aminolevulinate synthase from the cytosol to the mitochondria and its regulation by hemin in the rat liver. J. Biol. Chem. 255, 1746-1751.
56. Hayashi, N., N. Watanabe and G. Kikuchi (1983) Inhibition by hemin of in vitro translocation of chicken liver delta-aminolevulinate synthase into mitochondria. Biochem. Biophys. Res. Commun. 115, 700-706.
57. Lathrop, J. T. and M. P. Timko (1993) Regulation by heme of mitochondrial protein transport through a conserved amino acid motif. Science 259, 522-525.
58. Igarashi, J., N. Hayashi and G. Kikuchi (1976) Delta-aminolevulinate synthetases in the liver cytosol fraction and mitochondria of mice treated with allylisopropylacetamide and 3,5-dicarbethoxyl-1,4-dihydrocollidine. J. Biochem. (Tokyo) 80, 1091-1099.
59. Berry, J. P. (1996) The role of lysosomes in the selective concentration of mineral elements. A microanalytical study. Cell. Mol. Biol. 42, 395-411.
60. Melefors, O., B. Goossen, H. E. Johansson, R. Stripecke, N. K. Gray and M. W. Hentze (1993) Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells. J. Biol. Chem. 268, 5974-5978.
61. Ferreira, G. C. (1995) Ferrochelatase binds the iron-responsive element present in the erythroid 5-aminolevulinate synthase mRNA. Biochem. Biophys. Res. Commun. 214, 875-878.
62. Shoji, W., Y. Ohmori and M. Obinata (1993) c-Myc selectively regulates the latent period and erythroid-specific genes in murine erythroleukemia cell differentiation. Jpn. J. Cancer Res. 84, 885-892.
63. Urban-Grimal, D. and R. Labbe-Bois (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol. Gen. Genet. 183, 85-92.
64. Theil, E. C. (1994) Iron regulatory elements (IREs): a family of mRNA non-coding sequences. Biochem. J. 304, 1-11.
65. Guo, B., Y. Yu and E. A. Leibold (1994) Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J. Biol. Chem. 269, 24252-24260.
66. Guo, B., J. D. Phillips, Y. Yu and E. A. Leibold (1995) Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J. Biol. Chem. 270, 21645-21651.
67. Mascotti, D. P., D. Rup and R. E. Thach (1995) Regulation of iron metabolism: translational effects mediated by iron, heme, and cytokines. Annu. Rev. Nutr. 15, 239-261.
68. Ward, J. H., I. Jordan, J. P. Kushner and J. Kaplan (1984) Heme regulation of HeLa cell transferrin receptor number. J. Biol. Chem. 259, 13235-13240.
69. Goessling, L. S., S. Daniels-McQueen, M. Bhattacharyya-Pakrasi, J. J. Lin and R. E. Thach (1992) Enhanced degradation of the ferritin repressor protein during induction of ferritin messenger RNA translation. Science 256, 670-673.
70. Chen, J. J. and I. M. London (1995) Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase. Trends Biochem. Sci. 20, 105-108.
71. Thorstensen, K. and I. Romslo (1990) The role of transferrin in the mechanism of cellular iron uptake. Biochem. J. 271, 1-9.
72. Applegate, L. A., P. Luscher and R. M. Tyrrell (1991) Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res. 51, 974-978.
73. Rublevskaya, I. and M. D. Maines (1994) Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes. J. Biol. Chem. 269, 26390-26395.
74. Vile, G. F. and R. M. Tyrrell (1993) Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J. Biol. Chem. 268, 14678-14681.
75. Smith, A., J. Alam, P. V. Escriba and W. T. Morgan (1993) Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin. J. Biol. Chem. 268, 7365-7371.
76. Basu-Modak, S. and R. M. Tyrrell (1993) Singlet oxygen: a primary effector in the ultraviolet A/near-visible light induction of the human heme oxygenase gene. Cancer Res. 53, 4505-4510.
77. Bressoud, D., V. Jomini and R. M. Tyrrell (1992) Dark induction of haem oxygenase messenger RNA by haematoporphyrin derivative and zinc phthalocyanine; agents for photodynamic therapy. J. Photochem. Photobiol. B Biol. 14, 311-318.
78. Elliott, T. (1993) Transport of 5-aminolevulinic acid by the dipeptide permease in Salmonella typhimurium. J. Bacteriol. 175, 325-331.
79. Verkamp, E., V. M. Backman, J. M. Bjornsson, D. Soll and G. Eggertsson (1993) The periplasmic dipeptide permease system transports 5-aminolevulinic acid in Escherichia coli. J. Bacteriol. 175, 1452-1456.
80. Bermudez Moretti, M., S. Correa Garcia, C. Stella, E. Ramos and A. M. Batlle (1993) Delta-aminolevulinic acid transport in Saccharomyces cerevisiae. Int. J. Biochem. 25, 1917-1924.
81. Bermudez Moretti, M., S. R. Correa Garcia, M. S. Chianelli, E. H. Ramos, J. R. Mattoon and A. Batlle (1995) Evidence that 4-aminobutyric acid and 5-aminolevulinic acid share a common transport system into Saccharomyces cerevisiae. Int. J. Biochem. Cell Biol. 27, 169-173.
82. Princ, F. G., A. A. Juknat and A. M. Batlle (1994) Porphyrinogenesis in rat cerebellum. Effect of high delta-aminolevulinic acid concentration. Gen. Pharmacol. 25, 761-766.
83. Shedlofsky, S. I., P. R. Sinclair, H. L. Bonkovsky, J. F. Healey, A. T. Swim and J. M. Robinson (1987) Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450. Biochem. J. 248, 229-236.
84. Hermes-Lima, M., R. F. Castilho, V. G. Valle, E. J. Bechara and A. E. Vercesi (1992) Calcium-dependent mitochondrial oxidative damage promoted by 5-aminolevulinic acid. Biochim. Biophys. Acta 1180, 201-206.
85. Monteiro, H. P., D. S. Abdalla, A. Faljoni-Alario and E. J. Bechara (1986) Generation of active oxygen species during coupled autoxidation of oxyhemoglobin and delta-aminolevulinic acid. Biochim. Biophys. Acta 881, 100-106.
86. Monteiro, H. P., D. S. Abdalla, O. Augusto and E. J. Bechara (1989) Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinopathies. Arch. Biochem. Biophys. 271, 206-216.
87. Hermes-Lima, M., V. G. Valle, A. E. Vercesi and E. J. Bechara (1991) Damage to rat liver mitochondria promoted by delta-aminolevulinic acid-generated reactive oxygen species: connections with acute intermittent porphyria and lead-poisoning. Biochim. Biophys. Acta 1056, 57-63.
88. Navone N. M., S. G. Afonso, C. F. Polo and A. M. Batlle (1992) Uroporphyrinogen decarboxylase from mouse mammary carcinoma and liver of normal and tumor-bearing mouse. Comp. Biochem. Physiol. [B] 102, 87-92.
89. 2+ ions. Biochim. Biophys. Acta 1225, 259-263.
90. Fraga, C. G., J. Onuki, F. Lucesoli, E. J. Bechara and P. Di Mascio (1994) 5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2′-deoxyguanosine in DNA. Carcinogenesis 15, 2241-2244.
91. Oteiza, P. I. and E. J. Bechara (1993) 5-aminolevulinic acid induces lipid peroxidation in cardiolipin-rich liposomes. Arch. Biochem. Biophys. 305, 282-287.
92. Oteiza, P. I., C. G. Kleinman, M. Demasi and E. J. Bechara (1995) 5-Aminolevulinic acid induces iron release from ferritin. Arch. Biochem. Biophys. 316, 607-611.
93. Berg, K., H. Anholt, Ø. Been and J. Moan (1996) The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolevulinic acid-treated cells. Br. J. Cancer 74, 688-697.
94. Fiedler, D. M., P. M. Eckl and B. Krammer (1996) Does δ-aminolaevulinic acid induce genotoxic effects? J. Photochem. Photobiol. 33, 39-44.
95. He, D., E. Karas, S. Sassa and H. W. Lim (1993) Porphyrin synthesis by murine epidermal cells. Skin Pharmacol. 6, 20-25.
96. Schoenfeld, N., R. Mamet, Y. Nordenberg, M. Shafran, T. Babushkin and Z. Malik (1994) Protoporphyrin biosynthesis in melanoma B16 cells stimulated by 5-aminolevulinic acid and chemical inducers: characterization of photodynamic inactivation. Int. J. Cancer 56, 106-112.
97. Iinuma, S., S. S. Farshi, B. Ortel and T. Hasan (1994) A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin [published erratum appears in Br. J. Cancer 1994 Dec;70(6):1283], Br. J. Cancer 70, 21-28.
98. Ratcliffe, S. L. and E. K. Matthews (1995) Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands. Br. J. Cancer 71, 300-305.
99. Rebeiz, N., C. C. Rebeiz, S. Arkins, K. W. Kelley and C. A. Rebeiz (1992) Photodestruction of tumor cells by induction of endogenous accumulation of protoporphyrin IX: enhancement by 1,10-phenanthroline. Photochem. Photobiol. 55, 431-435.
100. He, D., S. Behar, N. Nomura, S. Sassa and H. W. Lim (1995) The effect of ALA and radiation on porphyrin/heme biosynthesis in endothelial cells. Photochem. Photobiol. 61, 656-661.
101. He, D., S. Sassa and H. W. Lim (1993) Effect of UVA and blue light on porphyrin biosynthesis in epidermal cells. Photochem. Photobiol. 57, 825-829.
102. Been, Ø., Q. Peng, K. Berg and J. Moan (1992) Photosensitisation of tumor cells in vitro and in vivo using endogenous porphyrins induced with exogenous 5-aminolevulinic acid. In Photodynamic Therapy and Biomedical Lasers (Edited by P. Spinelli, M. Dal Fante and R. Marchesini), pp. 521-525. Elsevier, Amsterdam.
103. Malik, Z., B. Ehrenberg and A. Faraggi (1989) Inactivation of erythrocytic, lymphocytic and myelocytic leukemic cells by photoexcitation of endogenous porphyrins. J. Photochem. Photobiol. B Biol. 4, 195-205.
104. Dietel, W., K. Bolsen, E. Dickson, C. Fritsch, R. Pottier and R. Wendenburg (1996) Formation of water-soluble porphyrins and protoporphyrin IX in 5-aminolevulinic-acid-incubated carcinoma cells. J. Photochem. Photobiol. B Biol. 33, 225-231.
105. Navone, N. M., A. L. Frisardi, E. R. Resnik, A. M. d. C. Battle and C. F. Polo (1988) Porphyrin biosynthesis in human breast cancer. Preliminary mimetic in vitro studies. Med. Sci. Res. 16, 61-62.
106. Durko, I. and A. Juhasz (1990) Effects of two microtubule-depolymerizing drugs, vincristine and vinblastine, on porphyrin production by primary neural tissue cultures. Neurochem. Res. 15, 1135-1139.
107. Walters, R. T., T. G. Gribble and H. C. Schartz (1963) Synthesis of haem in normal and leukemic leukocytes. Nature 197, 1213-1214.
108. Navone, N. M., C. F. Polo, A. L. Frisardi, N. E. Andrade and A. M. Battle (1990) Heme biosynthesis in human breast cancer - mimetic "in vitro" studies and some heme enzymic activity levels. Int. J. Biochem. 22, 1407-1411.
109. Riesenberg, R., C. Fuchs and M. Kriegmair (1996) Photodynamic effects of 5-aminolevulinic acid-induced porphyrin on human bladder carcinoma cells in vitro. Eur. J. Cancer [A] 32A, 328-334.
110. Uberriegler, K. P., E. Banieghbal and B. Krammer (1995) Subcellular damage kinetics within co-cultivated WI38 and VA13-transformed WI38 human fibroblasts following 5-aminolevulinic acid-induced protoporphyrin IX formation. Photochem. Photobiol. 62, 1052-1057.
111. Steinbach, P., H. Weingandt, R. Baumgartner, M. Kriegmair, F. Hofstadter and R. Knuchel (1995) Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to 5-aminolevulinic acid. Photochem. Photobiol. 62, 887-895.
112. Schick, E., R. Kaufmann, A. Ruck, A. Hainzl and W. H. Boehncke (1995) Influence of activation and differentiation of cells on the effectiveness of photodynamic therapy. Acta Dermato-Venereol. 75, 276-279.
113. Elder, G. H. (1982) Enzymatic defects in porphyria: an overview. Semin. Liver Dis. 2, 87-99.
114. Berg, K., Z. Luksiene, J. Moan and L. W. Ma (1995) Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX. Radiat. Res. 142, 340-346.
115. Shevchuk, I., V. Chekulayev, J. Moan and K. Berg (1996) Effects of lodinamine and levamisole on 5-aminolevulinic acid-induced photochemotherapy. Int. J. Cancer. 67, 791-799.
116. Gaullier, J. M., M. Geze, R. Santus, T. Sa e Melo, J. C. Maziere, M. Bazin, P. Morliere and L. Dubertret (1995) Subcellular localization of and photosensitization by protoporphyrin IX in human keratinocytes and fibroblasts cultivated with 5-aminolevulinic acid. Photochem. Photobiol. 62, 114-122.
117. Fukuda, H., A. M. Batlle and P. A. Riley (1993) Kinetics of porphyrin accumulation in cultured epithelial cells exposed to ALA. Int. J. Biochem. 25, 1407-1410.
118. Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
119. Knuechel, R., P. Keng, F. Hofstaedter, V. Langmuir, R. M. Sutherland and D. P. Penney (1990) Differentiation patterns in two-/and three-dimensional culture systems of human squamous carcinoma cell lines. Am. J. Pathol. 137, 725-736.
120. Rosales, C., V. O'Brien, L. Kornberg and R. Juliano (1995) Signal transduction by cell adhesion receptors. Biochim. Biophys. Acta 1242, 77-98.
121. Raghow, R. (1994) The role of extracellular matrix in postinflammatory wound healing and fibrosis. FASEB J. 8, 823-831.
122. Washbrook, R., H. Fukuda, A. Batlle and P. Riley (1996) Stimulation of tetrapyrrole synthesis in mammalian epithelial cells in culture by exposure to aminolevulinic acid. Br. J. Cancer. (In press)
123. Hanania, J. and Z. Malik (1992) The effect of EDTA and serum on endogenous porphyrin accumulation and photodynamic sensitization of human K562 leukemic cells. Cancer Lett. 65, 127-131.
124. Granick, S., P. Sinclair, S. Sassa and G. Grieninger (1975) Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. J. Biol. Chem. 250, 9215-9225.
125. Laskey, J. D., P. Ponka and H. M. Schulman (1986) Control of heme synthesis during Friend cell differentiation: role of iron and transferrin. J. Cell Physiol. 129, 185-192.
126. Rittenhouse-Diakun, K., H. Van Leengoed, J. Morgan, E. Hryhorenko, G. Paszkiewicz, J. E. Whitaker and A. R. Oseroff (1995) The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA). Photochem. Photobiol. 61, 523-528.
127. Lim, H. W., S. Behar and D. He (1994) Effect of porphyrin and irradiation on heme biosynthetic pathway in endothelial cells. Photodermatol. Photoimmunol. Photomed. 10, 17-21.
128. Ortel, B., A. Tanew and H. Honigsmann (1993) Lethal photosensitization by endogenous porphyrins of PAM cells - modification by desferrioxamine. J. Photochem. Photobiol. B Biol. 17, 273-278.
129. Brodie, C., G. Siriwardana, J. Lucas, R. Schleicher, N. Terada, A. Szepesi, E. Gelfand and P. Seligman (1993) Neuroblastoma sensitivity to growth inhibition by desferrioxamine: evidence for a block in G1 phase of the cell cycle. Cancer Res. 53, 3968-3975.
130. Christensen, T. and J. Moan (1979) Photodynamic inactivation of synchronized human cells in vitro in the presence of hematoporphyrin. Cancer Res. 39, 3735-3737.
131. Donfrancesco, A., G. Deb, L. De Sio, R. Cozza and A. Castellano (1996) Role of deferoxamine in tumor therapy. Acta Haematol. 95, 66-69.
132. Donfrancesco, A., G. Deb, C. Dominici, D. Pileggi, M. A. Castello and L. Helson (1990) Effects of a single course of deferoxamine in neuroblastoma patients. Cancer Res. 50, 4929-4930.
133. Olivieri, N. F., G. Koren, D. Matsui, P. P. Liu, L. Blendis, R. Cameron, R. A. McClelland and D. M. Templeton (1992) Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. Blood 79, 2741-2748.
134. Bentur, Y., M. McGuigan and G. Koren (1991) Deferoxamine (desferrioxamine). New toxicities for an old drug. Drug Safety 6, 37-46.
135. Afonso, S. G., S. Chinarro, J. J. Munoz, R. E. De Salamanca and A. M. Batlle (1990) Photodynamic and non-photodynamic action of several porphyrins on the activity of some heme-enzymes. J. Enzyme Inhib. 3, 303-310.
136. Afonso, S. G., S. Chinarro, R. E. De Salamanca and A. M. Batlle (1991) Further evidence on the photodynamic and the novel non-photodynamic inactivation of uroporphyrinogen decarboxylase by uroporphyrin I. J. Enzyme Inhib. 5, 225-233.
137. Batlle, A. M., R. E. De Salamanca, S. Chinarro, S. G. Afonso, and A. M. Stella (1986) Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins. Int. J. Biochem. 18, 143-147.
138. Afonso, S. G., C. F. Polo, R. E. De Salamanca and A. Batlle (1996) Mechanistic studies on uroporphyrin I-induced photoinactivation of some heme-enzymes. Int. J. Biochem. Cell Biol. 28, 415-420.
139. Briggs, D. W., L. W. Condie, R. M. Sedman and T. R. Tephly (1976) Delta-aminolevulinic acid synthetase in the heart. J. Biol. Chem. 251, 4996-5001.
140. De Matteis, F. and A. Gibbs (1972) Stimulation of liver 5-aminolaevulinate synthetase by drugs and its relevance to drug-induced accumulation of cytochrome P-450. Studies with phenylbutazone and 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Biochem. J. 126, 1149-1160.
141. Afonso, S. G., C. F. Polo, N. M. Navone, E. S. Vazquez, A. M. Buzaleh, E. Schoua and A. M. Batlle (1990) In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway. Gen. Pharmacol. 21, 423-426.
142. Ebert, P. S., I. Wars and D. N. Buell (1976) Erythroid differentiation in cultured Friend leukemia cells treated with metabolic inhibitors. Cancer Res. 36, 1809-1813.
143. Iwasa, F., R. A. Galbraith and S. Sassa (1988) Effects of dimethyl sulphoxide on the synthesis of plasma proteins in the human hepatoma HepG2. Induction of an acute-phase-like reaction. Biochem. J. 253, 927-930.
144. Rutherford, T., G. G. Thompson and M. R. Moore (1979) Heme biosynthesis in Friend erythroleukemia cells: control by ferrochelatase. Proc. Natl. Acad. Sci. USA 76, 833-836.
145. Fujita, H., M. Yamamoto, T. Yamagami, N. Hayashi, T. R. Bishop, H. De Verneuil, T. Yoshinaga, S. Shibahara, R. Morimoto and S. Sassa (1991) Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells. Biochim. Biophys. Acta 1090, 311-316.
146. Fukuda, Y., H. Fujita, S. Taketani and S. Sassa (1993) Dimethyl sulphoxide and haemin induce ferrochelatase mRNA by different mechanisms in murine erythroleukaemia cells. Br. J. Haematol. 83, 480-484.
147. Ma, L. W., J. Moan, K. Berg, Q. Peng and H. B. Steen (1993) Potentiation of photodynamic therapy by mitomycin C in cultured human colon adenocarcinoma cells. Radiat. Res. 134, 22-28.
148. Caron, R. M. and J. W. Hamilton (1995) Preferential effects of the chemotherapeutic DNA crosslinking agent mitomycin C on inducible gene expression in vivo. Environ. Mol. Mutagen. 25, 4-11.
149. Kawasaki, N., K. Morimoto, T. Tanimoto and T. Hayakawa (1996) Control of hemoglobin synthesis in erythroid differentiating K562 cells. 1. Role of iron in erythroid cell heme synthesis. Arch. Biochem. Biophys. 328, 289-294.
150. Malik, Z., S. D. Chitayat and Y. Langzam (1988) Hemin dependent morphological maturation and endogenous porphyrin synthesis by K562 leukemic cells. Cancer Lett. 41, 203-209.
151. Cable, E. E., J. A. Pepe, S. E. Donohue, R. W. Lambrecht and H. L. Bonkovsky (1994) Effects of mifepristone (RU-486) on heme metabolism and cytochromes P-450 in cultured chick embryo liver cells, possible implications for acute porphyria. Eur. J. Biochem. 225, 651-657.
152. Ward, A. J. and E. K. Matthews (1996) Cytotoxic, nuclear, and growth inhibitory effects of photodynamic drugs on pancreatic carcinoma cells. Cancer Lett. 102, 39-47.
153. Moan, J. and K. Berg (1991) The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem. Photobiol. 53, 549-553.
154. Malik, Z., M. Dishi and Y. Garini (1996) Fourier transform multipixel spectroscopy and spectral imaging of protoporphyrin in single melanoma cells. Photochem. Photobiol. 63, 608-614.
155. Schothorst, A. A., D. Suurmond and J. S. Ploem (1977) In vitro studies on the protoporphyrin uptake and photosensitivity of normal skin fibroblasts and fibroblasts from patients with erythropoietic protoporphyria. J. Invest. Dermatol. 69, 551-557.
156. 3H]-PK 11195 binding to platelets. Neuroreport 5, 1093-1096.
157. Gederaas, O. S., K. Thorstensen and I. Romslo (1996) The effect of brief illumination on intracellular free calcium concentration in cells with 5-aminolevulinic acid-induced protoporphyrin IX synthesis. Scand. J. Clin. Invest. (In press)
158. Casas, A., H. Fukuda and A. M. del C. Batlle (1996) Potentiation of the 5-aminolevulinic acid-based photodynamic therapy with cyclophosphamide. Cancer Biochem. Biophys. (In press)
159. Noodt, B. B., K. Berg, T. Stokke, Q. Peng and J. M. Nesland (1996) Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX. Br. J. Cancer 74, 22-29.
160. Scott, J. J. (1955) The metabolism of d-aminolevulinic acid. In Ciba Foundation Symposium on Porphyrin Biosynthesis and Metabolism (Edited by G. E. W. Wolstenholme and E. C. P. Millar), pp. 43-62. J. and A. Churchill, Ltd, London.
161. Gorchein, A. and R. Webber (1987) δ-Aminolevulinic acid in plasma, cerebrospinal fluid, saliva and erythrocytes: studies in normal, uraemic and porphyric subjects. Clin. Sci. 72, 103-112.
162. Buttery, J., S. Stuart and P. R. Pannall (1995) An improved direct method for the measurement of urinary δ-aminolevulinic acid. Clin. Chem. 28, 477-480.
163. Lamola, A. A., I. Asher, U. Muller-Eberhard and M. B. PohFitzpatrick (1981) Fluorimetric study of the binding of protoporphyrin to haemopexin and albumin. Biochem. J. 196, 693-698.
164. Kongshaug, M., J. Moan and S. B. Brown (1989) The distribution of porphyrins with different tumor localizing ability among plasma proteins. Br. J. Cancer 59, 184-188.
165. Goldberg, A. and C. Rimington (1962) In Diseases of porphyrin metabolism. Charles C. Thomas, Springfield, IL.
166. Egger, N. G., M. Motamedi, M. Pow-Sang, E. Orihuela and K. E. Anderson
167. Rimington, C. and W. H. Lockwood (1968) The excretion of porphyrin-peptide conjugates in porphyria variegata. Clin. Sci. 35, 211-247.
168. Peng, Q., J. Moan, T. Warloe, J. M. Nesland and C. Rimington (1992) Distribution and photosensitizing efficiency of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma. Int. J. Cancer 52, 433-443.
169. Bedwell, J., A. J. MacRobert, D. Phillips and S. G. Bown (1992) Fluorescence distribution and photodynamic effect of ALA-induced PPIX in the DMH rat colonie tumor model. Br. J. Cancer 65, 818-824.
170. Fukuda, H., A. Casas, F. Chueke, S. Paredes and A. M. C. Batlle (1993) Photodynamic action of endogenously synthesized porphyrins from aminolevulinic acid, using a new model for assaying the effectiveness of tumoral cell killing. Int. J. Biochem. 25, 1395-1398.
171. Hua, Z., S. L. Gibson, T. H. Foster and R. Hilf (1995) Effectiveness of delta-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo. Cancer Res. 55, 1723-1731.
172. Henderson, B. W., L. Vaughan, D. A. Bellnier, H. van Leengoed, P. G. Johnson and A. R. Oseroff (1995) Photosensitization of murine tumor, vasculature and skin by using 5-aminolevulinic acid-induced porphyrin. Photochem. Photobiol. 62, 780-789.
173. Loh, C. S., A. J. MacRobert, J. Regula and S. G. Bown (1993) Oral vs. i.v. administration of 5-ALA. Br. J. Cancer 68, 41-51.
174. Xu, S., I. Aravind, M. A. C. Becker, J. D. Wiltshire, H. F. Haberman, Z. Chen and A. A. Gaspari (1995) Endogenous porphyrins in murine skin and transplanted PAM-212 squamous cell carcinoma tissues after injection of δ-aminolevulinic acid. Chin. Med. J. (Engl.) 108, 286-290.
175. 6, Photofrin and ALA-induced protoporphyrin IX in a colon carcinoma model. Br. J. Cancer 73, 937-944.
176. El-Far, M., M. Ghoneim and E. Ibraheim (1990) Biodistribution and selective in vivo tumor localization of endogenous porphyrins induced and stimulated by 5-aminolevulinic acid: a newly developed technique. J. Tumor Marker Oncol. 5, 27-34.
177. van Hillegersberg, R., J. M. Hekking-Weijma, J. H. P. Wilson, A. Edixhoven-Bosdijk and W. J. Kort (1995) Adjuvant intraoperative photodynamic therapy diminished the rate of local recurrence in a rat mammary tumor model. Br. J. Cancer 71, 733-737.
178. Regula, J., B. Ravi, J. Bedwell, A. J. MacRobert and S. G. Bown (1994) Photodynamic therapy using 5-aminolevulinic acid for experimental pancreatic cancer-prolonged animal survival. Br. J. Cancer 70, 248-254.
179. Lofgren, L. A., A. M. Ronn, M. Nouri, C. J. Lee, D. Yoo and B. M. Steinberg (1995) Efficacy of intravenous δ-aminolevulinic acid photodynamic therapy on rabbit papillomas. Br. J. Cancer 72, 857-864.
180. Lilge, L., M. C. Olivo, S. W. Schatz, J. A. MaGuire, M. S. Patterson and B. C. Wilson (1996) The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy. Br. J. Cancer 73, 332-343.
181. Abels, C., P. Heil, M. Dellian, G. E. H. Kuhnle, R. Baumgartner and A. E. Goetz (1994) In vivo kinetics and spectra of 5-aminolevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster. Br. J. Cancer 70, 826-833.
182. Fukuda, H., S. Paredes and A. M. C. Batlle (1992) Tumor-localizing properties of porphyrins. In vivo studies using free and liposome encapsulated aminolevulinic acid. Comp. Biochem. Physiol. 102B, 433-436.
183. Fukuda, H., S. Paredes, A. Casas, F. Chuekes and A. M. C. Batlle (1992) Potential of liposome-entrapped aminolevulinic acid in cancer therapy. Effect of prior injection of empty liposomes and different routes of administration. Cancer J. 5, 295-299.
184. Cubeddu, R., G. Canti, P. Taroni and G. Valentini (1995) δ-Aminolevulinic acid induced fluorescence in tumor-bearing mice. J. Photochem. Photobiol. B Biol. 30, 23-27.
185. Sroka, R., W. Reyer, L. Gossner, T. Sassy, S. Stocker and R. Baumgartner (1996) Pharmacokinetics of 5-aminolevulinic acid-induced porphyrins in tumour-bearing mice. J. Photochem. Photobiol. B Biol. 34, 13-19.
186. Loh, C. S., D. Vernon, A. J. MacRobert, J. Bedwell, S. G. Bown and S. B. Brown (1993) Endogenous porphyrin distribution induced by 5-aminolevulinic acid in the tissue layers of the gastrointestinal tract. J. Photochem. Photobiol. B Biol. 20, 47-54.
187. Sardesai, V. M., J. Waldman and J. M. Orten (1964) A comparative study of porphyrin biosynthesis in different tissues. Blood 24, 178-186.
188. Peng, Q., T. Warloe, J. Moan, H. Steen, K.-E. Giercksky and J. M. Nesland (1993) Localization of ALA-induced porphyrins in normal and malignant tissues of mice, dogs and patients. Conference on photosensitization and photochemotherapy of cancer. Abstract book, pp. S4, March 16-17, 1993, Oslo.
189. Sima, A. A. F., J. C. Kennedy, D. Blakeslee and D. M. Robertson (1981) Experimental porphyric neuropathy: a preliminary report. Can. J. Neurol. Sci. 8, 105-114.
190. Anderson, K. E., G. S. Drummond, U. Freddara, M. Sardana and S. Sassa (1981) Porphyrogenic effects and induction of heme oxygenase in vivo by δ-aminolevulinic acid. Biochim. Biophys. Acta 676, 289-299.
191. Brooker, J. D., G. Strivastava, B. K. May and W. H. Elliot (1982) Radiochemical assay for 5-aminolevulinic acid synthase. Enzyme 28, 109-119.
192. Malik, Z. and M. Djaldetti (1979) 5-Aminolevulinic acid stimulation of derivative, and hemoglobin synthesis by uninduced Friend erythroleukemic cells. Cell Differ. 8, 223-233.
193. Conder, L. H., S. I. Woodard and H. A. Dailey (1991) Multiple mechanisms for the regulation of heme synthesis during erythroid cell differentiation. Possible role for coproporphyrinogen oxidase. Biochem. J. 275(Pt. 2), 321-326.
194. Malik, Z., G. Kostenich, L. Roitman, B. Ehrenberg and A. Orenstein (1995) Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice. J. Photochem. Photobiol. B Biol. 28, 213-218.
195. Peng, Q., J. Moan, V. Iani and J. M. Nesland (1996) Effect of desferrioxamine on production of ALA-induced protoporphyrin IX in normal mouse skin. Proc. SPIE 2625, 51-57.
196. Rebeiz N., S. Arkins, C. A. Rebeiz, J. Simon, J. F. Zachary, and K. W. Kelley (1996) Induction of tumor necrosis by δ-aminolevulinic acid and 1,10-phenanthroline photodynamic therapy. Cancer Res. 56, 339-344.
197. Margaron, P., R. W. Boyle, R. Ouellet, T. L. Nguyen and J. E. van Lier (1992) Photodynamic therapy with topical phthalocyanine formulations on intradermally transplanted EMT-6 tumors in Balb/c mice. In Photodynamic Therapy and Biomedical Lasers (Edited by P. Spinelli, M. Dal Fante and R. Marchesini), pp. 850-854. Elsevier, Amsterdam.
198. Orth, K., König, K., Genze, F. and A. Rück (1994) Photodynamic therapy of experimental colonie tumours with 5-aminolevulinic acid-induced endogenous porphyrins. J. Cancer Res. Clin. Oncol. 120, 657-661.
199. Cairnduff, F., D. J. H. Roberts, B. Dixon and S. B. Brown (1995) Response of a rodent fibrosarcoma to photodynamic therapy using 5-aminolevulinic acid or polyhaematoporphyrin. Int. J. Radiat. Biol. 67, 93-99.
200. van der Veen, N., H. van Leengoed and W. M. Star (1994) In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations. Br. J. Cancer 70, 867-872.
201. Messmann, H., P. Mikvy, G. Buonaccorsi, C. L. Davies, A. J. MacRobert and S. G. Bown (1995) Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies. Br. J. Cancer 72, 589-594.
202. Star, W. M, H. P. A. Marijnissen, A. E. van den Berg-Blok, J. A. C. Versteeg, K. A. P. Franken and H. S. Reinhold (1986) Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo sandwich observation chambers. Cancer Res. 46, 2532-2540.
203. Peng, Q. and J. Moan (1995) Correlation of distribution of sulphonated aluminum phthalocyanines with their photodynamic effect in tumour and skin of mice bearing CaD2 mammary carcinoma. Br. J. Cancer 72, 565-574.
204. Peng, Q., J. Moan, L. W. Ma and J. M. Nesland (1995) Uptake, localization and photodynamic effect of meso-tetra(hydroxyphenyl)porphine and its corresponding chlorin in normal and tumor tissues of mice bearing mammary carcinoma. Cancer Res. 55, 2620-2626.
205. Schmidt, H. G., R. H. Riddell, B. Walther, D. B. Skinner and J. F. Riemann (1985) Dysplasia in Barrett's esophagus. J. Cancer Res. Clin. Oncol. 110, 145-152
206. Miros, M., P. Kerlin and N. Walker (1991) Only patients with dysplasia progressed to adenocarcinoma in Barrett's oesophagus. Gut 32, 1441-1446.
207. Hameeteman, W., G. N. J. Tytgat, H. J. Houthoff and J. G. van den Tweel (1989) Barrett's esophagus: development of dysplasia and adenocarcinoma. Gastroenterology 96, 1249-1256.
208. Ming, S. C., A. Bajtai, P. Correa, K. Elster, O. H. Javi et al. (1984) Gastric dysplasia. Significance and pathological criteria. Cancer 54, 1794-1801.
209. Morson, B. C., L. H. Sobin, E. Grundmann, A. Johansen, T. Nagayo and A. Serk-Hanssen (1980) Precancerous conditions and epithelial dysplasia in the stomach. J. Clin. Pathol. 33, 711-721.
210. Rice, T. W., G. W. Falk, E. Achkar and R. E. Petras (1993) Surgical management of high-grade dysplasia in Barrett's esophagus. Am. J. Gastroenterol. 88, 1832-1836.
211. Loh, C. S., J. Bedwell, A. J. MacRobert, N. Krasner, D. Phillips and S. G. Bown (1992) Photodynamic therapy of the normal stomach: a comparative study between di-sulphonated aluminum phthalocyanine and 5-aminolevulinic acid. Br. J. Cancer 66, 452-462.
212. Loh, C. S., A. J. MacRobert, G. Buonaccorsi, N. Krasner and S. G. Bown (1996) Mucosal ablation using photodynamic therapy for the treatment of dysplasia: an experimental study in the normal rat stomach. Gut 38, 71-78.
213. Kleemann, D., A. J. MacRobert, T. Mentzel, P. M. Speigh and S. G. Bown (1996) Photodynamic therapy on the normal rabbit larynx with phthalocyanine and 5-aminolevulinic acid induced protoporphyrin IX photosensitisation. Br. J. Cancer 74, 49-58.
214. Schneider, D., H. F. Schellhas, T. A. Wessler, I. W. Chen and B. C. Moulton (1988) Endometrial ablation by DHE photoradiation therapy in estrogen treated ovariectomized rats. Colposcopy & Gynecol. Laser Surg. 4, 73-77
215. Bhatta, N., R. Anderson, T. Flotte, I. Schiff, T. Hasan and N. S. Nishioka (1992) Endometrial ablation by means of photodynamic therapy with Photofrin II. Am. J. Obstet. Gynecol. 167, 1856-1863.
216. Chapman, J. A., Y. Tadir, B. J. Tromberg et al. (1993) Effect of administration route and estrogen manipulation on endometrial uptake of Photofrin. Am. J. Obstet. Gynecol. 168, 685-692.
217. Manyal, M. J., L. M. Nelson and D. Solomon (1989) Photodynamic therapy of rabbit endometrium transplants: a model for treatment of endometriosis. Fertil. Steril. 52, 140-145.
218. Petrucco, O. M., M. Sathenanden, M. F. Petrucco et al. (1990) Ablation of endometriotic implants in rabbits by hematoporphyrin derivative photoradiation therapy using the gold vapor laser. Laser Surg. Med. 10, 344-348.
219. Yang, J. Z., D. A. van Vugt, J. C. Kennedy and R. L. Reid (1993) Intrauterine 5-aminolevulinic acid induces selective fluorescence and photodynamic ablation of the rat endometrium. Photochem. Photobiol. 57, 803-807.
220. Judd, M. D., J. Bedwell, A. J. MacRobert and S. G. Bown (1992) Comparison of the distribution of phthalocyanine and ALA-induced porphyrin sensitisers within the rabbit uterus. In Photodynamic Therapy and Biomedical Lasers (Edited by P. Spinelli, M. Dal Fante and R. Marchesini), pp. 322-326. Elsevier, Amsterdam.
221. Wyss, P., B. J. Trombery, M. T. Wyss, T. Krasieva, M. Schell, M. W. Berns and Y. Tadir (1994) Photodynamic destruction of endometrial tissue with topical 5-aminolevulinic acid in rats and rabbits. Am. J. Obstet. Gynecol. 171, 1176-1183.
222. Gannon, M. J., N. Johnson, D. J. H. Roberts, J. A. Holroyd, D. I. Vernon, S. B. Brown and R. J. Liford (1995) Photosensitization of the endometrium with topical 5-aminolevulinic acid. Am. J. Obstet. Gynecol. 173, 1826-1828.
223. Yang, J. Z., D. A. van Vugt, J. C. Kennedy and R. L. Reid (1993) Evidence of lasting functional destruction of the rat endometrium after 5-aminolevulinic acid-induced photodynamic ablation: prevention of implantation. Am. J. Obstet. Gynecol. 168, 995-1001.
224. Yang, J. Z., P. A. Greer, D. A. van Vugt and R. L. Reid (1995) Treatment with 5-aminolevulinic acid and photoactivating light causes destruction of preimplantation mouse embryos. Fertil. Steril. 63, 1088-1093.
225. Yang, J. Z., J. P. van Dijk-Smith, D. A. van Vugt, J. C. Kennedy and R. L. Reid (1996) Fluorescence and photosensitization of experimental endometriosis in the rat after systemic 5-aminolevulinic acid administration: a potential new approach to the diagnosis and treatment of endometriosis. Am. J. Obstet. Gynecol. 174, 154-160.
226. Fehr, M. K., L. O. Svaasand, B. J. Tromberg, P. Ngo and M. W. Berns (1996) Differential cell photosensitivity in photodynamic therapy of the rat endometrium. Proc. SPIE 2625, 58-69.
227. Grant, W. E., P. M. Speight, A. J. MacRobert, C. Hopper and S. G. Bown (1994) Photodynamic therapy of normal rat arteries after photosensitisation using disulphonated aluminum phthalocyanine and 5-aminolevulinic acid. Br. J. Cancer 70, 72-78.
228. Grant, W. E., G. Buonaccorsi, P. M. Speight, A. J. MacRobert, C. Hopper and S. G. Bown (1995) The effect of photodynamic therapy on the mechanical integrity of normal rabbit carotid arteries. Laryngoscope 105, 867-871.
229. Nyamekye, I., S. Anglin, J. McEwan, A. J. MacRobert, S. G. Bown, C. Bishop and M. A. Mchir (1995) Photodynamic therapy of normal and balloon-injured rat carotid arteries using 5-aminolevulinic acid. Circulation 91, 417-425.
230. Henderson, B. W. (1990) Probing the effects of photodynamic therapy through in vivo-in vitro methods. In Photodynamic Therapy of Neoplastic Disease, Vol. I (Edited by D. Kessel), pp. 169-188. CRC Press, Boca Raton, FL.
231. Roberts, D. J. H., F. Cairnduff, I. Driver, B. Dixon and S. B. Brown (1994) Tumor vascular shutdown following photodynamic therapy based on polyhaematoporphyrin or 5-aminolevulinic acid. Int. J. Oncol. 5, 763-768.
232. Leveckis, J., N. J. Brown and M. W. R. Reed (1995) The effect of aminolevulinic acid-induced protoporphyrin IX-mediated photodynamic therapy on the cremaster muscle microcirculation in vivo. Br. J. Cancer 12, 1113-1119.
233. Brun, A. and S. Sandberg (1991) Mechanisms of photosensitivity in porphyric patients with special emphasis on erythropoietic protoporphyria. J. Photochem. Photobiol. B Biol. 10, 285-302.
234. Batlle, A. M. del C. (1993) Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis. J. Photochem. Photobiol. B Biol. 20, 5-22.