A20-an omnipotent protein in the liver: Prometheus myth resolved?

Advances in Experimental Medicine and Biology

Volumn 809, Issue , 2014, Pages 117-139

  da Silva, Cleide Goncalves ^a   Cervantes, Jesus Revuelta ^a   Studer, Peter ^a   Ferran, Christiane ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A20 PROTEIN; CYTOKINE; GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; SIGNAL PEPTIDE; TNFAIP3 PROTEIN, HUMAN;

ACUTE LIVER FAILURE; ANTIAPOPTOTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; BODY MASS; CAUSE OF DEATH; CHRONIC LIVER DISEASE; DRUG MECHANISM; ENZYME ACTIVATION; FULMINANT HEPATIC FAILURE; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GLUCOSE METABOLISM; HUMAN; INSULIN SIGNALING; KNOCKOUT MOUSE; LIPID METABOLISM; LIVER CELL; LIVER FIBROSIS; LIVER GRAFT; LIVER PROTECTION; LIVER REGENERATION; LIVER RESECTION; LIVER TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPERFUSION INJURY; TOXIC HEPATITIS; ACUTE DISEASE; ANIMAL; CHRONIC DISEASE; DISEASE MODEL; LIVER; LIVER DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; LIVER DISEASES; LIVER REGENERATION; NUCLEAR PROTEINS;

EID: 84908022745     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-1-4939-0398-6_8     Document Type: Chapter

References (124)

1. Ramadori G, Moriconi F, Malik I, Dudas J. Physiology and pathophysiology ofliver int1ammation, damage and repair. J Physiol Pharmacol2008; 59(Suppll):107-17; PMID:18802219.
2. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
3. Madeira VM. Overview of mitochondrial bioenergetics. Methods Mol Bioi 2012; 810: 1-6; PMID:22057557; http://dx.doi.org/lO.1007/978-1-61779-382-0_1.
4. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
5. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
6. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
7. Lee WM. Acute liver failure. N EnglJ Med 1993; 329: 1862-72; PMID:8305063; http://dx.doi.org/lO.l056/NEJM199312163292508.
8. Neuberger J. Prediction of survival for patients with fulminant hepatic failure. Hepatology 2005; 41: 19-22; PMID: 15690476; http://dx.doi.org/l 0.1 002/hep.20562.
9. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
10. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
11. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
12. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
13. Carithers RLJ Jr.; American Association for the Study of Liver Diseases. Liver transplantation. Liver Transpl2000; 6:122-35; PMID:I0648593; http://dx.doi.org/lO.1002/1t.500060122.
14. Bonham CA, Gerber DA, Grewal H. Live donor transplantation: Strategies for expanding the adult organ donor pool. Conference report. 2001; 1st Annual Winter Symposium: Living donor adult-to-adult transplantation of the kidney and liver(Ponta Vedra Beach Florida).
15. Goss JA, Shackleton CR, McDiarmid SV, Maggard M, Swenson K, Seu P, Vargas J, Martin M, Ament M, Brill J, et al. Long-term results of pediatric liver transplantation: an analysis of 569 transplants. Ann Surg 1998; 228:411-20; PMID:9742924; http://dx.doi.org/l0.l097/00000658-199809000-00014.
16. Lo CM, Fan ST, Chan JK, Wei W, Lo RJ, Lai CL. Minimum graft volume for successful adult-to-adult living donor liver transplantation for fulminant hepatic failure. Transplantation 1996; 62:696-8; PMID:8830841; http://dx.doi.orgIl0.l097/00007890-199609150-00029.
17. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
18. Rauen U, Polzar B, Stephan H, Mannherz HG, de Groot H. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. F ASEB J 1999; 13: 155-68; PMID:9872940.
19. Schauer RJ, Bilzer M, Kalmuk S, Gerbes AL, Leiderer R, Schildberg FW, Messmer K. Microcirculatory failure after rat liver transplantation is related to Kupffer cell-derived oxidant stress but not involved in early graft dysfunction. Transplantation 2001; 72: 1692-9; PMID: 11726835; http://dx.doi. org/l0.l 097/00007890-200111270-00022.
20. Casillas-Ramirez A, Mosbah TB, Ramalho F, Rose-Catafau J, Peralta C. Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation. Life Sci 2006; 79:1881-94; PMTD: 16828807; http://dx.doi.org/10.1016/j.lfs.2006.06.024.
21. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
22. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
23. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
24. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276:60-6; PMlD:9082986; http://dx.doi.org/10.1126/science.276.5309.60.
25. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
26. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
27. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
28. Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, Lambris JD. The proinflammatory mediators C3a and C5a are essential for liver regeneration. 1 Exp Med 2003; 198:913-23; PMTD:12975457; http://dx.doi.org/10.1084/jem.20030374.
29. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
30. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology 2006; 130: 1886-900; PMlD: 16697751; http://dx.doi.org/I 0.1 053/j.gastro.2006.0 1.038.
31. Seki E, Tsutsui H, Timuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology 2005; 41:443-50; PMTD:15723296; http://dx.doi.org/10.1002/hep.20603.
32. Taub R, Greenbaum LE, Peng Y. Transcriptional regulatory signals define cytokine-dependent and-independent pathways in liver regeneration. Semin Liver Dis 1999; 19: 117-27; PMID: I 0422195; http://dx.doi.org/l 0.1 055/s-2007-1007104.
33. Heim MH, Gamboni G, Beglinger C, Gyr K. Specific activation of AP-I but not Stat3 in regenerating liver in mice. Eur 1 Clin Invest 1997; 27:948-55; PMlD:9395792; http://dx.doi.org/l0.1046/j.1365-2362.1 997.2100770.x.
34. Yamada Y, Kirillova I, Peschon 11, Fausto N. Initiation ofliver growth by tumornecrosis factor: deficient liver regeneration in mice lacking type T tumor necrosis factor receptor. Proc Natl Acad Sci USA 1997; 94: 1441-6; PMID:9037072; http://dx.doi.org/10.1073/pnas.94.4.1441.
35. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
36. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
37. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
38. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
39. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
40. Blindenbacher A, Wang X, Langer I, Savino R, Terracciano L, Heim MH. Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology 2003; 38:674-82; PMTD: 12939594; http://dx.doi.org/I 0.1 053/jhep.2003.50378.
41. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
42. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
43. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
44. Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol 2000; 18: 143-64; PMID: 10837055; http://dx.doi.orgIl0.1146/annurev.immuno1.l8.1.143.
45. Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A. Cytokine-inducible SH2 protein-3 (CIS3/S0CS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells 1999; 4:339-51; PMID: 10421843; http://dx.doi.orgIl0.1046/j.1365-2443.1999.00263.x.
46. Croker BA, Krebs DL, Zhang JG, Wormald S, Willson T A, Stanley EG, Robb L, Greenhalgh CJ, Forster I, Clausen BE, et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 2003; 4:540-5; PMID: 12754505; http://dx.doi.orgIl0.1038/ni931.
47. Lang R, Pauleau AL, Parganas E, Takahashi Y, Mages J, Ihle IN, Rutschman R, Murray PJ. SOCS3 regulates the plasticity of gp 130 signaling. Nat Immunol 2003; 4:546-50; PMID: 12754506; http://dx.doi.orgll 0.1 038/ni932.
48. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 2003; 4:551-6; PMID:12754507; http://dx.doi.org/l0.l038/ni938.
49. Diehl AM, Rai R. Review: regulation ofliverregeneration by pro-inflammatory cytokines. J Gastroenterol Hepatol 1996; II:466-70; PMID:8743919; http://dx.doi.org/10.llll/j.1440-1746.1996.tb00292.x.
50. White P, Brestelli IE, Kaestner KH, Greenbaum LE. Identification of transcriptional networks during liver regeneration. J BioI Chern 2005; 280:3715-22; PMID:15546871; http://dx.doi.orgIl0.l074/jbc. M410844200.
51. Li W, Liang X, Leu n, Kovalovich K, Ciliberto G, Taub R. Global changes in interleukin-6-dependent gene expression patterns in mouse livers after partial hepatectomy. Hepatology 2001; 33:1377-86; PMID: 11391526; http://dx.doi.org/l0.l053/jhep.2001.24431.
52. Guo F, Nian H, Zhang H, Huang L, Tang Y, Xiao X, He D. Proteomic analysis of the transition trom quiescent to proliferating stages in rat liver hepatectomy model. Proteomics 2006; 6:3075-86; PMID: 16619303; http://dx.doi.orgIl0.1002/pmic.200500322.
53. LeeGH, Merlino G, Fausto N. Development ofliver tumors in transforming growth factor alpha transgenic mice. Cancer Res 1992; 52:5162-70; PMID:1327502.
54. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
55. Schmidt C, Bladt F, Goedecke S, Brinkmann Y, Zschiesche W, Sharpe M, Gherardi E, Birchmeier C. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995; 373:699-702; PMID:7854452; http://dx.doi.org/l0.l038/373699aO.
56. BreitkopfK, Godoy P, Ciuclan L, Singer MV, Dooley S. TGF-beta/Smad signaling in the injured liver. Z Gastroenterol 2006; 44:57-66; PMID: 16397841; http://dx.doi.orgIl0.1055/s-2005-858989.
57. Macias-Silva M, Li W, Leu n, Crissey MA, Taub R. Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration. J BioI Chern 2002; 277:28483-90; PMID:12023281; http://dx.doi.orgIl0.l074/jbc.M202403200.
58. Zhong Z, Tsukada S, Rehman H, et al. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Feb 2010;16(2):181-190.
59. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
60. Busuttil RW. How safe are donors in adult-to-adult living related liver transplantation? Liver Transpl 2002; 8: 121-2; PMID: 11862587; http://dx.doi.org/IO.1053/jlts.2002.31736.
61. Emond JC, Freeman RB Jr., Renz JF, Yersiz H, Rogiers X, Busuttil RW. Optimizing the use of donated cadaver livers: analysis and policy development to increase the application of split-liver transplantation. Liver Transpl 2002; 8:863-72; PMIO: 12360426; http://dx.doi.org/10.1053/jlts.2002.34639.
62. Ghobrial RM, Saab S, Lassman C, Lu DS, Raman S, Limanond P, Kunder G, Marks K, Amersi F, Anselmo D, et al. Donor and recipient outcomes in right lobe adult living donor liver transplantation. Liver Transpl 2002; 8:901-9; PMID: 12360431; http://dx.doi.orgIl0.1053/jlts.2002.35548.
63. Liang TB, Man K, Kin-Wah Lee T, Hong-Teng Tsui S, Lo CM, Xu X, Zheng SS, Fan ST, Wong J. Distinct intragraft response pattern in relation to graft size in liver transplantation. Transplantation 2003; 75:673-8; PMTD:12640308; http://dx.doi.orgIl0.l097/01.TP.0000048490.24429.89.
64. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. Liverregeneration is suppressed in small-for-size liver grafts after transplantation: involvementofc-Jun N-terminal kinase, cyclin 01, and defective energy supply. Transplantation 2006; 82:241-50; PMID:16858288; http://dx.doi.orgl I 0.1 097/0 l.tp.0000228867.98158.d2.
65. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
66. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
67. Opipari A W Jr., Boguski MS, Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Bioi Chern 1990; 265:14705-8; PMID:2118515.
68. Opipari A W Jr., Hu HM, Yabkowitz R, Dixit VM. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Bioi Chern 1992; 267: 12424-7; PMID: 1618749.
69. Sarma V, Lin Z, Clark L, Rust BM, Tewari M, Noelle RJ, Dixit VM. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Bioi Chern 1995; 270:12343-6; PMTD:7539000; http://dx.doi.orgIl0.l074/jbc.270.21.12343.
70. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
71. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
72. Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C. A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets. J Exp Med 1999; 190: 1135-46; PMTD: 10523611; http://dx.doi.orgIl0.l084/jem.190.8.1135.
73. Dixit VM, Green S, Sarma V, Holzman LB, WolfFW, O' Rourke K, Ward PA, Prochownik EV, Marks RM. Tumor necrosis factor-alpha induction of no vel gene products in human endothelial cells including a macrophage-specific chemotaxin. J Bioi Chern 1990; 265:2973-8; PMID:2406243.
74. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
75. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
76. Laherty CD, Perkins ND, Dixit VM. Human T cell leukemia virus type TTax and phorbol12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B. J Bioi Chem 1993; 268:5032-9; PMID:8444879.
77. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
78. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
79. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
80. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
81. da Silva CG, Maccariello ER, Wilson SW, Putheti P, Daniel S, Damrauer SM, Peterson CR, Siracuse JJ, Kaczmarek E, Ferran C. Hepatocyte growth factor preferentially activates the anti-inflammatory arm of NF-KB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation. J Cell Physiol 2012; 227: 1382-90; PMTD:21618526; http://dx.doi.orgIl0.l002/jcp.22851.
82. Evans PC, Kilshaw PJ. Tnterleukin-13 protects endothelial cells from apoptosis and activation: association with the protective genes A20 and AI. Transplantation 2000; 70:928-34; PMID:11014646; http://dx.doi.org/l 0.1 097/00007890-200009270-000 I O.
83. Daniel S, Arvelo MB, Patel VI, Longo CR, Shrikhande G, Shukri T, Mahiou J, Sun DW, Mottley C, Grey ST, et al. A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood 2004; 104:2376-84; PMTD: 15251990; http://dx.doi.orgIl0.1182/blood-2003-02-0635.
84. Patel VI, Daniel S, Longo CR, Shrikhande GV, Scali ST, Czismadia E, Groft CM, Shukri T, Motley-Dore C, Ramsey HE, et al. A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression ofneointimal hyperplasia. FASEB J 2006; 20:1418-30; PMlD:16816117; http://dx.doi.org/l 0.1 096/fj.05-4981 com.
85. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
86. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
87. Turer EE, Tavares RM, Mortier E, Hitotsumatsu, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med 2008; 205:451-64; PMTD:18268035; http://dx.doi.org/l0.l084/jem.20071108.
88. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
89. Lee WM. Acute liver failure. N EnglJ Med 1993; 329: I 862-72; PMlD:8305063;http://dx.doi.org/I0. 10561 NEJM199312163292508.
90. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
91. Arvelo MB, Cooper JT, Longo C, Daniel S, Grey ST, Mahiou J, Czismadia E, Abu-Jawdeh G, Ferran C. A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. Hepatology 2002; 35:535-43; PMTD:11870365; http://dx.doi.org/l0.l053/jhep.2002.31309.
92. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
93. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
94. Mignon A, Rouquet N, Fabre M, Martin S, Pages JC, Dhainaut JF, Kahn A, Briand P, Joulin V. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med 1999; 159:1308-15; PMlD:IOI94182; http://dx.doi. org/l 0.1 I 64/ajrccm. 159.4. 9712012.
95. Liu B, Jiang D, Ou Y, Hu Z, Jiang J, Lei X. An anti-intlammatory role of A20 zinc finger protein during trauma combined with endotoxin challenge. The Journal of surgical research.
96. Busuttil RW, Tanaka K. The utility of marginal donors in liver transplantation. Liver Transpl 2003; 9:651-63; PMTD:12827549; http://dx.doi.orgIl0.l053/jlts.2003.50105.
97. ClavienPA, Selzner M. Hepatic steatosis and transplantation. Liver Transpl 2002; 8:980; PMlD: 12360447; http://dx.doi.orgIl0.l053/jlts.2002.35671.
98. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
99. Sun J, Sun L, Zhang N, Lu X, Zhang H. A20 is up-regulated in primary mouse hepatocytes subjected to hypoxia and reperfusion. Cell Biochem FUllct 2012; 30:683-6; PMlD:22736257; http://dx.doi. org/l 0.1 002/cbf.2850.
100. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
101. Rakhshandehroo M, Knoch B, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. PPAR Res. 2010;2010.
102. Farrell GC. Probing Prometheus: fat fueling the fire? Hepatology 2004; 40: 1252-5; PMlD: 1555871 0; http://dx.doi.orgIl0.l002/hep.20522.
103. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
104. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
105. de Jonge J, Kurian S, Shaked A,. Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Apr 2009;9(4):758-772.
106. Longo CR, Patel VI, Shrikhande GV, Scali ST, Csizmadia E, Daniel S, Sun DW, Grey ST, Arvelo MB, Ferran C. A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p2lwafl-dependent mechanism. Hepatology 2005; 42:156-64; PMID:15962316; http://dx.doi. orgl1 0.1 002/hep.20741.
107. da Silva CG, Studer P, Skroch M, Mahiou J, Minussi DC, Peterson CR, Wilson SW, Patel VI, Ma A, Csizmadia E, et al. A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals. Hepatology 2013; 57:2014-25; PMTD:23238769; http://dx.doi. orgl1 0.1 002/hep.26197.
108. Patel VI, Daniel S, Longo CR, et al. A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression ofneointimal hyperplasia. FASEB journal: official publication ofthe Federation of American Societies for Experimental Biology. Ju12006;20(9):1418-1430.
109. Riehle KJ, Campbell JS, McMahan RS, Johnson MM, Beyer RP, Bammler TK, Fausto N. Regulation ofliverregeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med 2008; 205:91-103; PMID: 18158318; http://dx.doi.orgIl0.l 084/jem.20070820.
110. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
111. Siracuse JJ, Fisher MD, da Silva CG, Peterson CR, Csizmadia E, Moll HP, Damrauer SM, Studer P, Choi L Y, Essayagh S,. A20-mediated modulation of inflammatory and immune responses in aortic allografts and development of transplant arteriosclerosis. Transplantation 2012; 93:373-82; PMID:22245872; http://dx.doi.org/lO.l097/TP.Ob013e3182419829.
112. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
113. Daniel S, Patel VI, Shrikhande GV, Scali ST, Ramsey HE, Csizmadia E, Benhaga N, Fisher MD, Arvelo MB, Ferran C. The universal NF-kappaB inhibitor a20 protects from transplant vasculopathy by differentially affecting apoptosis in endothelial and smooth muscle cells. Transplant Proc 2006; 38:3225-7; PMID: 17175229; http://dx.doi.orgIl0.1016/j.transproceed.2006.10.167.
114. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
115. Zhang A, Zhang M, Wang Y, Xie H, Zheng S. Calcitriol prolongs recipient survival by inducing expression of zinc-finger protein A20 and inhibiting its downstream gene following rat orthotopic liver transplantation. Immunopharmacol Immunotoxicol 2006; 28:591-600; PMID:17190736; http://dx.doi.orgll 0.1 08010892397060 1067003.
116. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
117. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
118. Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV, Scali ST, Libermann T A, Bhasin MK,. A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS One 2011; 6:e 17715; PMTD:21437236; http://dx.doi.orgI10.1371/journa1.pone.0017715.
119. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
120. Xu MQ, Yao ZX. Functional changes of dendritic cells derived from allogeneic partial liver graft undergoing acute rejection in rats. World 1 Gastroenterol 2003; 9: 141-7; PMID: 12508370.
121. Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D, Gervino EV, Johnstone MT, Trischitta V, Shoelson SE, Doria A. Tag polymorphisms at the A20 (TNF AIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes 2007; 56:499-505; PMlD: 17259397; http://dx.doi.org/lO.2337/db06-0946.
122. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
123. Krebs HA. The citric acid cycle and the Szent-Gyorgyi cycle in pigeon breast muscle. Biochem J 1940; 34:775-9; PMID:16747218.
124. Graham RR, Cotsapas C, Davies L, Hackett R, Lessard C, Leon M, Burtt NP, Guiducci C, Parkin M, Gates C, et al. Genetic variants nearTNF AIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008; 40:1059-61; PMTD:19165918; http://dx.doi.org/lO.l038/ng.200.