The Universal NF-kappaB Inhibitor A20 Protects From Transplant Vasculopathy by Differentially Affecting Apoptosis in Endothelial and Smooth Muscle Cells

Transplantation Proceedings

Volumn 38, Issue 10, 2006, Pages 3225-3227

  Daniel, S ^a   Patel, V I ^a   Shrikhande, G V ^a   Scali, S T ^a   Ramsey, H E ^a   Csizmadia, E ^a   Benhaga, N ^a   Fisher, M D ^a   Arvelo, M B ^a   Ferran, C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 8; CYTOKINE; FAS ANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN A20; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CAROTID ARTERY INJURY; CELL DEATH; CELL DIVISION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; NATURAL KILLER CELL; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SMOOTH MUSCLE FIBER; TRANSPLANT VASCULOPATHY; VASCULAR DISEASE; VIRAL GENE THERAPY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CAROTID ARTERIES; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NG-NITROARGININE METHYL ESTER; RATS; TRANSPLANTATION, HOMOLOGOUS;

EID: 33845409242     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.10.167     Document Type: Article

References (17)

1. Cecka J.M. The UNOS scientific renal transplant registry. Clin Transpl 13 (1999) 1
2. Keck B.M., Bennett L.E., and Rosendale J. Worldwide thoracic organ transplantation: a report from the UNOS/ISHLT international registry for thoracic organ transplantation. Clin Transplant 13 (1999) 35
3. Behrendt D., Ganz P., and Fang J.C. Cardiac allograft vasculopathy. Curr Opin Cardiol 15 (2000) 422
4. Tullius S.G., and Tilney N.L. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 59 (1995) 2126
5. Gimbrone M.A.J. Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Card 75 (1995) 67B
6. Rekhter M.D., and Gordon D. Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques. Am J Pathol 147 (1995) 668
7. Pollman M.J., Hall J.L., and Mann M.J. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Nat Med 4 (1998) 222
8. Hayry P. New targets for the prevention of transplant vascular disease. Transplant Proc 33 (2001) 2332
9. Bach F.H., Hancock W.W., and Ferran C. Protective genes expressed in endothelial cells: a regulatory response to injury. Immunol Today 18 (1997) 483
10. Ferran C. Protective genes in the vessel wall: modulators of graft survival and function. Transplantation 82 suppl 1 (2006) S36
11. Cooper J.T., Stroka D.M., Brostjan C., and Palmetshofer. A20 blocks endothelial cell activation through a NF-κB-dependent mechanism. ??. J Biol Chem 271 (1996) 18068
12. Patel V.I., Daniel S., and Longo C.R. A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J 20 (2006) 1418
13. Kunter U., Floege J., and von J.A.S. Expression of A20 in the vessel wall of rat-kidney allografts correlates with protection from transplant arteriosclerosis. Transplantation 75 (2003) 3
14. Daniel S., Arvelo M.B., and Patel V.I. A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood 104 (2004) 2376
15. Libby P., and Pober J.S. Chronic rejection. Immunity 14 (2001) 387
16. Ferran C., Stroka D.M., and Badrichani A.Z. A20 inhibits NF-κB activation in endothelial cells without sensitizing to TNF-mediated apoptosis. Blood 91 (1998) 2249
17. Longo C.R., Arvelo M.B., and Patel V.I. A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation 108 (2003) 1113