SDF-1 inhibition targets the bone marrow niche for cancer therapy

Cell Reports

Volumn 9, Issue 1, 2014, Pages 118-128

  Roccaro, Aldo M ^a   Sacco, Antonio ^a   Purschke, Werner G ^b   Moschetta, Michele ^a   Buchner, Klaus ^b   Maasch, Christian ^b   Zboralski, Dirk ^b   Zöllner, Stefan ^b   Vonhoff, Stefan ^b   Mishima, Yuji ^a   Maiso, Patricia ^a   Reagan, Michaela R ^a   Lonardi, Silvia ^c   Ungari, Marco ^c   Facchetti, Fabio ^c   Eulberg, Dirk ^b   Kruschinski, Anna ^b   Vater, Axel ^b   Rossi, Giuseppe ^d   Klussmann, Sven ^b   Ghobrial, Irene M ^a   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b NOXXON PHARMA AG   (Germany)

^c UNIVERSITY OF BRESCIA   (Italy)

^d SPEDALI CIVILI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; BORTEZOMIB; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; COFILIN; GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; OLAPTESED PEGOL; PAXILLIN; PLERIXAFOR; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1; BORONIC ACID DERIVATIVE; CXCL12 PROTEIN, HUMAN; CXCL12 PROTEIN, MOUSE; MACROGOL DERIVATIVE; OLIGONUCLEOTIDE; PYRAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BONE MARROW CELL; BONE MARROW METASTASIS; BONE METASTASIS; CANCER GROWTH; CANCER THERAPY; CD34 SELECTION; CELL ADHESION; CELL HOMING; CLONAL CELL LINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISSOCIATION CONSTANT; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENTIATION; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MESENCHYMAL STROMA CELL; MONOCLONAL IMMUNOGLOBULINEMIA; MONOTHERAPY; MOUSE; MULTIPLE MYELOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA CELL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SOLID TUMOR; STEM CELL NICHE; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR VOLUME; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BONE MARROW; BONE MARROW CANCER; CHEMISTRY; GENE SILENCING; GENETICS; MALE; METABOLISM; METASTASIS; PATHOLOGY; SCID MOUSE; SECONDARY;

ANIMALS; BONE MARROW; BONE MARROW NEOPLASMS; BORONIC ACIDS; BORTEZOMIB; CHEMOKINE CXCL12; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MICE; MICE, SCID; MULTIPLE MYELOMA; NEOPLASM METASTASIS; OLIGONUCLEOTIDES; POLYETHYLENE GLYCOLS; PYRAZINES;

EID: 84908013351     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.08.042     Document Type: Article

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