RNA aptamers and spiegelmers: Synthesis, purification, and post-synthetic PEG conjugation

Current Protocols in Nucleic Acid Chemistry

Volumn , Issue SUPPL.46, 2011, Pages

  Hoffmann, Stefanie ^a   Hoos, Johannes ^a   Klussmann, Sven ^a   Vonhoff, Stefan ^a  

^a NOXXON PHARMA AG   (Germany)

Author keywords

Oligonucleotide PEG conjugation; Preparative RP AX HPLC purification; Solid phase RNA synthesis; Spiegelmer NOX E36

Indexed keywords

APTAMER; DICHLOROACETIC ACID; ESTER; MACROGOL; N HYDROXYSUCCINIMIDE; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID; RNA; SPIEGELMER NOX E36; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CONCENTRATION (PARAMETERS); CONJUGATION; CROSS COUPLING REACTION; DENATURATION; DEPROTECTION REACTION; DESALINATION; DOWNSTREAM PROCESSING; EVAPORATION; FREEZE DRYING; HIGH TEMPERATURE; MACROMOLECULE; MOLECULAR WEIGHT; OXIDATION; PH; PRIORITY JOURNAL; QUALITY CONTROL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RNA CAPPING; RNA CLEAVAGE; RNA PROCESSING; RNA PURIFICATION; RNA SYNTHESIS; SOLID PHASE SYNTHESIS; ULTRAFILTRATION;

EID: 84857576006     PISSN: 19349270     EISSN: 19349289     Source Type: Journal    
DOI: 10.1002/0471142700.nc0446s46     Document Type: Article

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