Maternal Aldehyde Elimination during Pregnancy Preserves the Fetal Genome

Molecular Cell

Volumn 55, Issue 6, 2014, Pages 807-817

  Oberbeck, Nina ^a   Langevin, Frédéric ^a   King, Gareth ^a   deWind, Niels ^b   Crossan, Gerry P ^a   Patel, Ketan J ^a,c  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE; ENZYME; PROTEIN ALDH1A1; PROTEIN ALDH1B1; PROTEIN ALDH2; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; FANCA PROTEIN, MOUSE; FANCONI ANEMIA GROUP A PROTEIN; ISOENZYME; RETINAL DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH DEFECT; BONE MARROW DEPRESSION; CATABOLISM; CONTROLLED STUDY; DETOXIFICATION; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; ESSENTIAL GENE; FANCA GENE; FANCONI ANEMIA; FEMALE; FETAL WELL BEING; FETUS; FETUS DEVELOPMENT; GENOMIC INSTABILITY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MALE; MOTHER; MOUSE; NEWBORN; NONHUMAN; PREGNANCY; PROTECTION; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; DISEASE MODEL; GENETICS; GENOME; HUMAN; METABOLISM; PATHOLOGY; PRENATAL DEVELOPMENT;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DNA DAMAGE; EMBRYO, MAMMALIAN; ETHANOL; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; FEMALE; GENOME; HEMATOPOIETIC STEM CELLS; HUMANS; ISOENZYMES; MICE; MICE, INBRED C57BL; PREGNANCY; RETINAL DEHYDROGENASE;

EID: 84907989251     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2014.07.010     Document Type: Article

References (44)

1. Alter B.P. Cancer in Fanconi anemia, 1927-2001. Cancer 2003, 97:425-440.
2. Alter B.P., Rosenberg P.S. VACTERL-H Association and Fanconi Anemia. Mol Syndromol 2013, 4:87-93.
3. Anderson K.V., Nüsslein-Volhard C. Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature 1984, 311:223-227.
4. Arnon J., Meirow D., Lewis-Roness H., Ornoy A. Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum. Reprod. Update 2001, 7:394-403.
5. Brooks P.J., Enoch M.A., Goldman D., Li T.K., Yokoyama A. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 2009, 6:e50.
6. Ceccaldi R., Parmar K., Mouly E., Delord M., Kim J.M., Regairaz M., Pla M., Vasquez N., Zhang Q.S., Pondarre C., et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell 2012, 11:36-49.
7. Clarkson B.D., Boyse E.A. Possible explanation of the high concoddance for acute leukaemia in monozygotic twins. Lancet 1971, 1:699-701.
8. Fowden A.L., Giussani D.A., Forhead A.J. Endocrine and metabolic programming during intrauterine development. Early Hum. Dev. 2005, 81:723-734.
9. Fowden A.L., Giussani D.A., Forhead A.J. Intrauterine programming of physiological systems: causes and consequences. Physiology (Bethesda) 2006, 21:29-37.
10. Garaycoechea J.I., Patel K.J. Why does the bone marrow fail in Fanconi anemia?. Blood 2014, 123:26-34.
11. Garaycoechea J.I., Crossan G.P., Langevin F., Daly M., Arends M.J., Patel K.J. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature 2012, 489:571-575.
12. Greaves M.F., Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat. Rev. Cancer 2003, 3:639-649.
13. Hall E.J. Scientific view of low-level radiation risks. Radiographics 1991, 11:509-518.
14. Harada S., Agarwal D.P., Goedde H.W. Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 1981, 2:982.
15. Hira A., Yabe H., Yoshida K., Okuno Y., Shiraishi Y., Chiba K., Tanaka H., Miyano S., Nakamura J., Kojima S., et al. Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood 2013, 122:3206-3209.
16. Hodskinson M.R., Silhan J., Crossan G.P., Garaycoechea J.I., Mukherjee S., Johnson C.M., Schärer O.D., Patel K.J. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol. Cell 2014, 54:472-484.
17. Jansen J.G., Langerak P., Tsaalbi-Shtylik A., van den Berk P., Jacobs H., de Wind N. Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. J.Exp. Med. 2006, 203:319-323.
18. Kamimae-Lanning A.N., Goloviznina N.A., Kurre P. Fetal origins of hematopoietic failure in a murine model of Fanconi anemia. Blood 2013, 121:2008-2012.
19. Klein Douwel D., Boonen R.A., Long D.T., Szypowska A.A., Räschle M., Walter J.C., Knipscheer P. XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol. Cell 2014, 54:460-471.
20. Klyosov A.A., Rashkovetsky L.G., Tahir M.K., Keung W.M. Possible role of liver cytosolic and mitochondrial aldehyde dehydrogenases in acetaldehyde metabolism. Biochemistry 1996, 35:4445-4456.
21. Knipscheer P., Räschle M., Smogorzewska A., Enoiu M., Ho T.V., Schärer O.D., Elledge S.J., Walter J.C. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 2009, 326:1698-1701.
22. Kutler D.I., Singh B., Satagopan J., Batish S.D., Berwick M., Giampietro P.F., Hanenberg H., Auerbach A.D. A 20-year perspective on the International Fanconi Anemia Registry (IFAR). Blood 2003, 101:1249-1256.
23. Langevin F., Crossan G.P., Rosado I.V., Arends M.J., Patel K.J. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 2011, 475:53-58.
24. Li X., Ito M., Zhou F., Youngson N., Zuo X., Leder P., Ferguson-Smith A.C. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev. Cell 2008, 15:547-557.
25. Murga M., Bunting S., Montaña M.F., Soria R., Mulero F., Cañamero M., Lee Y., McKinnon P.J., Nussenzweig A., Fernandez-Capetillo O. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat. Genet. 2009, 41:891-898.
26. Neveling K., Endt D., Hoehn H., Schindler D. Genotype-phenotype correlations in Fanconi anemia. Mutat. Res. 2009, 668:73-91.
27. Niedzwiedz W., Mosedale G., Johnson M., Ong C.Y., Pace P., Patel K.J. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol. Cell 2004, 15:607-620.
28. Nüsslein-Volhard C., Frohnhöfer H.G., Lehmann R. Determination of anteroposterior polarity in Drosophila. Science 1987, 238:1675-1681.
29. O'Shea K.S., Kaufman M.H. The teratogenic effect of acetaldehyde: implications for the study of the fetal alcohol syndrome. J.Anat. 1979, 128:65-76.
30. Pelegri F., Knaut H., Maischein H.M., Schulte-Merker S., Nüsslein-Volhard C. A mutation in the zebrafish maternal-effect gene nebel affects furrow formation and vasa RNA localization. Curr. Biol. 1999, 9:1431-1440.
31. *2 on blood acetaldehyde concentrations. Hum. Genomics 2009, 3:121-127.
32. Räschle M., Knipscheer P., Enoiu M., Angelov T., Sun J., Griffith J.D., Ellenberger T.E., Schärer O.D., Walter J.C. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 2008, 134:969-980.
33. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J.Biol. Chem. 1998, 273:5858-5868.
34. Rosado I.V., Langevin F., Crossan G.P., Takata M., Patel K.J. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Nat. Struct. Mol. Biol. 2011, 18:1432-1434.
35. Ross A.L., Simpson L.J., Sale J.E. Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1. Nucleic Acids Res. 2005, 33:1280-1289.
36. Rutschmann S., Crozat K., Li X., Du X., Hanselman J.C., Shigeoka A.A., Brandl K., Popkin D.L., McKay D.B., Xia Y., et al. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice. G3 (Bethesda) 2012, 2:499-504.
37. Stagos D., Chen Y., Brocker C., Donald E., Jackson B.C., Orlicky D.J., Thompson D.C., Vasiliou V. Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metab. Dispos. 2010, 38:1679-1687.
38. Streffer C., Shore R., Konermann G., Meadows A., Uma Devi P., Preston Withers J., Holm L.E., Stather J., Mabuchi K. Biological effects after prenatal irradiation (embryo and fetus). A report of the International Commission on Radiological Protection. Ann. ICRP 2003, 33:5-206. H R.
39. Toledo T.M., Harper R.C., Moser R.H. Fetal effects during cyclophosphamide and irradiation therapy. Ann. Intern. Med. 1971, 74:87-91.
40. van Dijk B.A., Boomsma D.I., de Man A.J. Blood group chimerism in human multiple births is not rare. Am. J. Med. Genet. 1996, 61:264-268.
41. Webster W.S., Walsh D.A., McEwen S.E., Lipson A.H. Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome. Teratology 1983, 27:231-243.
42. Yoshida A., Impraim C.C., Huang I.Y. Enzymatic and structural differences between usual and atypical human liver alcohol dehydrogenases. J.Biol. Chem. 1981, 256:12430-12436.
43. Yoshida A., Huang I.Y., Ikawa M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc. Natl. Acad. Sci. USA 1984, 81:258-261.
44. Yoshida A., Hsu L.C., Davé V. Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase. Enzyme 1992, 46:239-244.