Proteomics using mammospheres as a model system to identify proteins deregulated in breast cancer stem cells

Current Molecular Medicine

Volumn 13, Issue 3, 2013, Pages 459-463

  Li, G ^a   Zhao, F ^a,b   Cui, Y ^c  

^a ZHEJIANG SCI TECH UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c CANCER HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Mammosphere; Proteomics; Stem cell

Indexed keywords

ACTIN; ALPHA ENOLASE; CLEAVAGE STIMULATION FACTOR; FATTY ACID SYNTHASE; FK 506 BINDING PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HEAT SHOCK PROTEIN 27; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; INITIATION FACTOR 4E; KERATIN; PDZ PROTEIN; PEPTIDE ALPHA N ACETYLTRANSFERASE A; PROTEASOME; REPLICATION FACTOR A; SEPTIN; UBIQUITIN CONJUGATING ENZYME E2;

ARTICLE; BREAST CANCER; BREAST CELL; CANCER GROWTH; CANCER STEM CELL; CARCINOGENESIS; CELL STRAIN MCF 7; CELL STRUCTURE; CELL SURVIVAL; CELLULAR STRESS RESPONSE; DOWN REGULATION; HUMAN; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METASTASIS; NUCLEOTIDE SEQUENCE; PROSTATE TUMOR; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

EID: 84876231306     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652413805076759     Document Type: Article

References (22)

1. Vargo-Gogola T, Rosen JM. Modelling breast cancer: One size does not fit all. Nat Rev Cancer 2007; 7(9): 659-672.
2. Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells-- perspectives on current status and future directions: Aacr workshop on cancer stem cells. Cancer Res 2006; 66(19): 9339-9344.
3. Singh A, Settleman J. Emt, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 2010; 29(34): 4741-4751.
4. Blick T, Hugo H, Widodo E, et al. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia 2010; 15(2): 235-252.
5. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414(6859): 105-111.
6. Tang DG. Understanding cancer stem cell heterogeneity and plasticity. Cell Res 2012; 22(3): 457-472.
7. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective I dentification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100(7): 3983-3988.
8. Phillips TM, McBride WH, Pajonk F. The response of cd24(- /low)/cd44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006; 98(24): 1777-1785.
9. Yu F, Yao H, Zhu P, et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131(6): 1109-1123.
10. Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003; 17(10): 1253-1270.
11. Woodward WA, Chen MS, Behbod F, Rosen JM. On mammary stem cells. J Cell Sci 2005; 118(Pt 16): 3585-3594.
12. Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007; 1(5): 555-567.
13. Han M, Liu M, Wang Y, et al. Re-expression of miR-21 contributes to migration and invasion by inducing epithelialmesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells. Mol Cell Biochem 2012; 363(1-2): 427-436.
14. Korkaya H, Paulson A, Iovino F, Wicha MS. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008; 27(47): 6120-6130.
15. Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005; 65(13): 5506-5511.
16. Peattie DA, Harding MW, Fleming MA, et al. Expression and characterization of human fkbp52, an immunophilin that associates with the 90-kda heat shock protein and is a component of steroid receptor complexes. Proc Natl Acad Sci USA 1992; 89(22): 10974-10978.
17. Azam S, Jouvet N, Jilani A, et al. Human glyceraldehyde-3- phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme ape1. J Biol Chem 2008; 283(45): 30632-30641.
18. Lu J, Suzuki T, Lu S, Suzuki N. Involvement of glyceraldehyde-3-phosphate dehydrogenase in the x-ray resistance of hela cells. Biosci Biotechnol Biochem 2008; 72(9): 2432-2435.
19. Sasaki H, Moriyama S, Mizuno K, et al. Cten mRNA expression was correlated with tumor progression in lung cancers. Lung Cancer 2003; 40(2): 151-155.
20. Cappello F, David S, Ardizzone N, et al. Expression of heat shock proteins HSP10, HSP27, HSP60, HSP70, and HSP90 in urothelial carcinoma of urinary bladder. J Cancer Mol 2006; 2(2): 73-77.
21. Concannon CG, Gorman AM, Samali A. On the role of hsp27 in regulating apoptosis. Apoptosis 2003; 8(1): 61-70.
22. Lin JF, Xu J, Tian HY, et al. Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Int J Cancer 2007; 121(12): 2596-2605.