Inhibition of Ebola virus infection: Identification of niemann-pick C1 as the target by optimization of a chemical probe

ACS Medicinal Chemistry Letters

Volumn 4, Issue 2, 2013, Pages 239-243

  Lee, Kyungae ^a   Ren, Tao ^a   Coîté, Marceline ^b   Gholamreza, Berahman ^b   Misasi, John ^b,c   Bruchez, Anna ^b   Cunningham, James ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Ebola virus; Niemann Pick C1; photoaffinity label; small molecule inhibitor; target identification; viral entry

Indexed keywords

2 BENZYLPIPERAZINE DERIVATIVE; ADAMANTANE DIPEPTIDE; ANTIVIRUS AGENT; GLYCOPROTEIN; NIEMANN PICK C1; PIPERAZINE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; ARTICLE; CATION EXCHANGE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EBOLA VIRUS INFECTION; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; VIRUS INFECTION; VIRUS INHIBITION;

EID: 84873941669     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300370k     Document Type: Article

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