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Volumn 355, Issue 1, 2014, Pages 25-33

Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression

Author keywords

Apoptosis; Hepatocellular carcinoma; KLF9; P53 protein; Transcriptional regulation

Indexed keywords

CYCLOHEXIMIDE; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR KLF9; UNCLASSIFIED DRUG; KLF9 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; TP53 PROTEIN, HUMAN;

EID: 84907965660     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.09.022     Document Type: Article
Times cited : (65)

References (32)
  • 1
    • 0026657846 scopus 로고
    • Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene
    • Imataka H., Sogawa K., Yasumoto K., Kikuchi Y., Sasano K., Kobayashi A., et al. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 1992, 11:3663-3671.
    • (1992) EMBO J. , vol.11 , pp. 3663-3671
    • Imataka, H.1    Sogawa, K.2    Yasumoto, K.3    Kikuchi, Y.4    Sasano, K.5    Kobayashi, A.6
  • 2
    • 0037218919 scopus 로고    scopus 로고
    • Sp1- and Kruppel-like transcription factors
    • Kaczynski J., Cook T., Urrutia R. Sp1- and Kruppel-like transcription factors. Genome Biol 2003, 4:206-214.
    • (2003) Genome Biol , vol.4 , pp. 206-214
    • Kaczynski, J.1    Cook, T.2    Urrutia, R.3
  • 3
    • 78149481592 scopus 로고    scopus 로고
    • Mammalian Kruppel-like factors in health and diseases
    • McConnell B.B., Yang V.W. Mammalian Kruppel-like factors in health and diseases. Physiol. Rev 2010, 90:1337-1381.
    • (2010) Physiol. Rev , vol.90 , pp. 1337-1381
    • McConnell, B.B.1    Yang, V.W.2
  • 4
    • 0141625268 scopus 로고    scopus 로고
    • An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation
    • Fernandez-Zapico M.E., Mladek A., Ellenrieder V., Folch-Puy E., Miller L., Urrutia R. An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J. 2003, 22:4748-4758.
    • (2003) EMBO J. , vol.22 , pp. 4748-4758
    • Fernandez-Zapico, M.E.1    Mladek, A.2    Ellenrieder, V.3    Folch-Puy, E.4    Miller, L.5    Urrutia, R.6
  • 5
    • 0041736054 scopus 로고    scopus 로고
    • Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A
    • Pang Y.P., Kumar G.A., Zhang J.S., Urrutia R. Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A. FEBS Lett 2003, 548:108-112.
    • (2003) FEBS Lett , vol.548 , pp. 108-112
    • Pang, Y.P.1    Kumar, G.A.2    Zhang, J.S.3    Urrutia, R.4
  • 6
    • 63849102885 scopus 로고    scopus 로고
    • Stressor and glucocorticoid-dependent induction of the immediate early gene kruppel-like factor 9: implications for neural development and plasticity
    • Bonett R.M., Hu F., Bagamasbad P., Denver R.J. Stressor and glucocorticoid-dependent induction of the immediate early gene kruppel-like factor 9: implications for neural development and plasticity. Endocrinology 2009, 150:1757-1765.
    • (2009) Endocrinology , vol.150 , pp. 1757-1765
    • Bonett, R.M.1    Hu, F.2    Bagamasbad, P.3    Denver, R.J.4
  • 7
    • 84858048672 scopus 로고    scopus 로고
    • Kruppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis
    • Pabona J.M., Simmen F.A., Nikiforov M.A., Zhuang D., Shankar K., Velarde M.C., et al. Kruppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J. Clin. Endocrinol. Metab 2012, 97:E376-E392.
    • (2012) J. Clin. Endocrinol. Metab , vol.97 , pp. E376-E392
    • Pabona, J.M.1    Simmen, F.A.2    Nikiforov, M.A.3    Zhuang, D.4    Shankar, K.5    Velarde, M.C.6
  • 8
    • 67449163748 scopus 로고    scopus 로고
    • Nuclear receptor co-regulator Kruppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus
    • Pabona J.M., Velarde M.C., Zeng Z., Simmen F.A., Simmen R.C. Nuclear receptor co-regulator Kruppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus. J. Endocrinol 2009, 200:63-73.
    • (2009) J. Endocrinol , vol.200 , pp. 63-73
    • Pabona, J.M.1    Velarde, M.C.2    Zeng, Z.3    Simmen, F.A.4    Simmen, R.C.5
  • 9
    • 78651306412 scopus 로고    scopus 로고
    • Kruppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis
    • Pei H., Yao Y., Yang Y., Liao K., Wu J.R. Kruppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis. Cell Death Differ 2011, 18:315-327.
    • (2011) Cell Death Differ , vol.18 , pp. 315-327
    • Pei, H.1    Yao, Y.2    Yang, Y.3    Liao, K.4    Wu, J.R.5
  • 10
    • 84863572695 scopus 로고    scopus 로고
    • Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes
    • Sporl F., Korge S., Jurchott K., Wunderskirchner M., Schellenberg K., Heins S., et al. Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:10903-10908.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 10903-10908
    • Sporl, F.1    Korge, S.2    Jurchott, K.3    Wunderskirchner, M.4    Schellenberg, K.5    Heins, S.6
  • 11
    • 43549090677 scopus 로고    scopus 로고
    • Downregulation of Kruppel-like factor 9 in human colorectal cancer
    • Kang L., Lu B., Xu J., Hu H., Lai M. Downregulation of Kruppel-like factor 9 in human colorectal cancer. Pathol. Int 2008, 58:334-338.
    • (2008) Pathol. Int , vol.58 , pp. 334-338
    • Kang, L.1    Lu, B.2    Xu, J.3    Hu, H.4    Lai, M.5
  • 12
    • 79951836097 scopus 로고    scopus 로고
    • Kruppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells
    • Ying M., Sang Y., Li Y., Guerrero-Cazares H., Quinones-Hinojosa A., Vescovi A.L., et al. Kruppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells. Stem Cells 2011, 29:20-31.
    • (2011) Stem Cells , vol.29 , pp. 20-31
    • Ying, M.1    Sang, Y.2    Li, Y.3    Guerrero-Cazares, H.4    Quinones-Hinojosa, A.5    Vescovi, A.L.6
  • 13
    • 79952277505 scopus 로고    scopus 로고
    • The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective
    • Venook A.P., Papandreou C., Furuse J., de Guevara L.L. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist 2010, 15(Suppl. 4):5-13.
    • (2010) Oncologist , vol.15 , pp. 5-13
    • Venook, A.P.1    Papandreou, C.2    Furuse, J.3    de Guevara, L.L.4
  • 14
    • 33947162353 scopus 로고    scopus 로고
    • Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation
    • Kremer-Tal S., Narla G., Chen Y., Hod E., DiFeo A., Yea S., et al. Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J. Hepatol 2007, 46:645-654.
    • (2007) J. Hepatol , vol.46 , pp. 645-654
    • Kremer-Tal, S.1    Narla, G.2    Chen, Y.3    Hod, E.4    DiFeo, A.5    Yea, S.6
  • 15
    • 34249057494 scopus 로고    scopus 로고
    • KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis
    • Sirach E., Bureau C., Peron J.M., Pradayrol L., Vinel J.P., Buscail L., et al. KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis. Cell Death Differ 2007, 14:1202-1210.
    • (2007) Cell Death Differ , vol.14 , pp. 1202-1210
    • Sirach, E.1    Bureau, C.2    Peron, J.M.3    Pradayrol, L.4    Vinel, J.P.5    Buscail, L.6
  • 16
    • 84865487198 scopus 로고    scopus 로고
    • Dysregulated Kruppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma
    • e1-e2
    • Li Q., Gao Y., Jia Z., Mishra L., Guo K., Li Z., et al. Dysregulated Kruppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology 2012, 143:799-810. e1-e2.
    • (2012) Gastroenterology , vol.143 , pp. 799-810
    • Li, Q.1    Gao, Y.2    Jia, Z.3    Mishra, L.4    Guo, K.5    Li, Z.6
  • 17
    • 84891925577 scopus 로고    scopus 로고
    • The fate of Kruppel-like factor 9-positive hepatic carcinoma cells may be determined by the programmed cell death protein 5
    • Fu D.Z., Cheng Y., He H., Liu H.Y., Liu Y.F. The fate of Kruppel-like factor 9-positive hepatic carcinoma cells may be determined by the programmed cell death protein 5. Int. J. Oncol 2014, 44:153-160.
    • (2014) Int. J. Oncol , vol.44 , pp. 153-160
    • Fu, D.Z.1    Cheng, Y.2    He, H.3    Liu, H.Y.4    Liu, Y.F.5
  • 18
    • 4143069155 scopus 로고    scopus 로고
    • KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells
    • Ellenrieder V., Buck A., Harth A., Jungert K., Buchholz M., Adler G., et al. KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. Gastroenterology 2004, 127:607-620.
    • (2004) Gastroenterology , vol.127 , pp. 607-620
    • Ellenrieder, V.1    Buck, A.2    Harth, A.3    Jungert, K.4    Buchholz, M.5    Adler, G.6
  • 20
    • 0034954161 scopus 로고    scopus 로고
    • A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A
    • Zhang J.S., Moncrieffe M.C., Kaczynski J., Ellenrieder V., Prendergast F.G., Urrutia R. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Mol. Cell. Biol 2001, 21:5041-5049.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 5041-5049
    • Zhang, J.S.1    Moncrieffe, M.C.2    Kaczynski, J.3    Ellenrieder, V.4    Prendergast, F.G.5    Urrutia, R.6
  • 21
    • 84863170102 scopus 로고    scopus 로고
    • KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells
    • Mannava S., Zhuang D., Nair J.R., Bansal R., Wawrzyniak J.A., Zucker S.N., et al. KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells. Blood 2012, 119:1450-1458.
    • (2012) Blood , vol.119 , pp. 1450-1458
    • Mannava, S.1    Zhuang, D.2    Nair, J.R.3    Bansal, R.4    Wawrzyniak, J.A.5    Zucker, S.N.6
  • 22
    • 84901201313 scopus 로고    scopus 로고
    • KLF9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits AKT activation and suppresses tumor growth of prostate cancer cells
    • Shen P., Sun J., Xu G., Zhang L., Yang Z., Xia S., et al. KLF9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits AKT activation and suppresses tumor growth of prostate cancer cells. Prostate 2014, 74:946-958.
    • (2014) Prostate , vol.74 , pp. 946-958
    • Shen, P.1    Sun, J.2    Xu, G.3    Zhang, L.4    Yang, Z.5    Xia, S.6
  • 23
    • 0035860820 scopus 로고    scopus 로고
    • Kruppel-like factors: three fingers in many pies
    • Bieker J.J. Kruppel-like factors: three fingers in many pies. J. Biol. Chem 2001, 276:34355-34358.
    • (2001) J. Biol. Chem , vol.276 , pp. 34355-34358
    • Bieker, J.J.1
  • 24
    • 33646757232 scopus 로고    scopus 로고
    • The complexity of p53 stabilization and activation
    • Lavin M.F., Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ 2006, 13:941-950.
    • (2006) Cell Death Differ , vol.13 , pp. 941-950
    • Lavin, M.F.1    Gueven, N.2
  • 25
    • 0033552613 scopus 로고    scopus 로고
    • Regulation of p53 stability
    • Ashcroft M., Vousden K.H. Regulation of p53 stability. Oncogene 1999, 18:7637-7643.
    • (1999) Oncogene , vol.18 , pp. 7637-7643
    • Ashcroft, M.1    Vousden, K.H.2
  • 26
    • 0038751860 scopus 로고    scopus 로고
    • P53 downstream targets and chemosensitivity
    • Sax J.K., El-Deiry W.S. p53 downstream targets and chemosensitivity. Cell Death Differ 2003, 10:413-417.
    • (2003) Cell Death Differ , vol.10 , pp. 413-417
    • Sax, J.K.1    El-Deiry, W.S.2
  • 27
    • 0034808019 scopus 로고    scopus 로고
    • Down-regulation of beta-catenin by activated p53
    • Sadot E., Geiger B., Oren M., Ben-Ze'ev A. Down-regulation of beta-catenin by activated p53. Mol. Cell. Biol 2001, 21:6768-6781.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 6768-6781
    • Sadot, E.1    Geiger, B.2    Oren, M.3    Ben-Ze'ev, A.4
  • 28
    • 0037079250 scopus 로고    scopus 로고
    • P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells
    • Cagatay T., Ozturk M. P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells. Oncogene 2002, 21:7971-7980.
    • (2002) Oncogene , vol.21 , pp. 7971-7980
    • Cagatay, T.1    Ozturk, M.2
  • 30
    • 84856554756 scopus 로고    scopus 로고
    • An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma
    • Kim G.P., Mahoney M.R., Szydlo D., Mok T.S., Marshke R., Holen K., et al. An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma. Invest. New Drugs 2012, 30:387-394.
    • (2012) Invest. New Drugs , vol.30 , pp. 387-394
    • Kim, G.P.1    Mahoney, M.R.2    Szydlo, D.3    Mok, T.S.4    Marshke, R.5    Holen, K.6
  • 31
    • 66449131460 scopus 로고    scopus 로고
    • Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Chen K.F., Yeh P.Y., Hsu C., Hsu C.H., Lu Y.S., Hsieh H.P., et al. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J. Biol. Chem 2009, 284:11121-11133.
    • (2009) J. Biol. Chem , vol.284 , pp. 11121-11133
    • Chen, K.F.1    Yeh, P.Y.2    Hsu, C.3    Hsu, C.H.4    Lu, Y.S.5    Hsieh, H.P.6
  • 32
    • 84984548924 scopus 로고    scopus 로고
    • Bortezomib sensitizes HCC cells to CS-1008, an antihuman death receptor 5 antibody, through the inhibition of CIP2A
    • Chen K.F., Yu H.C., Liu C.Y., Chen H.J., Chen Y.C., Hou D.R., et al. Bortezomib sensitizes HCC cells to CS-1008, an antihuman death receptor 5 antibody, through the inhibition of CIP2A. Mol. Cancer Ther 2011, 10:892-901.
    • (2011) Mol. Cancer Ther , vol.10 , pp. 892-901
    • Chen, K.F.1    Yu, H.C.2    Liu, C.Y.3    Chen, H.J.4    Chen, Y.C.5    Hou, D.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.