메뉴 건너뛰기




Volumn 16, Issue 10, 2014, Pages 1341-1353

MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras

Author keywords

Carcinogenesis; Glioma; MiR 124; N Ras; R Ras

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MICRORNA 124; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; R RAS PROTEIN; RAF PROTEIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VASCULOTROPIN; DACARBAZINE; MICRORNA; MIRN124 MICRORNA, HUMAN; RAS PROTEIN; RRAS PROTEIN, HUMAN;

EID: 84907959333     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou084     Document Type: Article
Times cited : (125)

References (47)
  • 1
    • 0035559064 scopus 로고    scopus 로고
    • Current epidemiological trends and surveillance issues in brain tumors
    • Davis FG, McCarthy BJ. Current epidemiological trends and surveillance issues in brain tumors. Expert Rev Anticancer Ther. 2001;1(3):395-401.
    • (2001) Expert Rev Anticancer Ther. , vol.1 , Issue.3 , pp. 395-401
    • Davis, F.G.1    McCarthy, B.J.2
  • 2
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-996.
    • (2005) N Engl J Med. , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 3
    • 79953052206 scopus 로고    scopus 로고
    • Inhibition of PI3 K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
    • Prasad G, Sottero T, Yang X, et al. Inhibition of PI3 K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro Oncol. 2011;13(4):384-392.
    • (2011) Neuro Oncol. , vol.13 , Issue.4 , pp. 384-392
    • Prasad, G.1    Sottero, T.2    Yang, X.3
  • 4
    • 84879032241 scopus 로고    scopus 로고
    • MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma
    • Li RY, Chen LC, Zhang HY, et al. MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma. CNS Neurosci Ther. 2013;19(7):477-483.
    • (2013) CNS Neurosci Ther. , vol.19 , Issue.7 , pp. 477-483
    • Li, R.Y.1    Chen, L.C.2    Zhang, H.Y.3
  • 5
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5(7):522-531.
    • (2004) Nat Rev Genet. , vol.5 , Issue.7 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 6
    • 84860386287 scopus 로고    scopus 로고
    • Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders
    • Long JM, Lahiri DK. Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders. Exp Neurol. 2012;235(2):402-418.
    • (2012) Exp Neurol. , vol.235 , Issue.2 , pp. 402-418
    • Long, J.M.1    Lahiri, D.K.2
  • 7
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215-233.
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 8
    • 84863011293 scopus 로고    scopus 로고
    • MicroRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN
    • Zhang BG, Li JF, Yu BQ, et al. MicroRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN. Oncol Rep. 2012;27(4):1019-1026.
    • (2012) Oncol Rep. , vol.27 , Issue.4 , pp. 1019-1026
    • Zhang, B.G.1    Li, J.F.2    Yu, B.Q.3
  • 9
    • 79961065195 scopus 로고    scopus 로고
    • The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death
    • Ruan Q, Wang T, Kameswaran V, et al. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proc Natl Acad Sci U S A. 2011;108(29):12030-12035.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.29 , pp. 12030-12035
    • Ruan, Q.1    Wang, T.2    Kameswaran, V.3
  • 10
    • 84859539080 scopus 로고    scopus 로고
    • MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion
    • Zhang QQ, Xu H, Huang MB, et al. MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol. 2012;14(3):278-287.
    • (2012) Neuro Oncol. , vol.14 , Issue.3 , pp. 278-287
    • Zhang, Q.Q.1    Xu, H.2    Huang, M.B.3
  • 11
    • 84880737108 scopus 로고    scopus 로고
    • MicroRNA-124 inhibits migration and invasion by down-regulating ROCK1 in glioma
    • An L, Liu Y, Wu A, Guan Y. MicroRNA-124 inhibits migration and invasion by down-regulating ROCK1 in glioma. PLoS One. 2013;8(7):e69478.
    • (2013) PLoS One , vol.8 , Issue.7 , pp. e69478
    • An, L.1    Liu, Y.2    Wu, A.3    Guan, Y.4
  • 12
    • 84880062228 scopus 로고    scopus 로고
    • MiR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma
    • Wei J, Wang F, Kong LY, et al. MiR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res. 2013;73(13):3913-3926.
    • (2013) Cancer Res. , vol.73 , Issue.13 , pp. 3913-3926
    • Wei, J.1    Wang, F.2    Kong, L.Y.3
  • 14
    • 8844252330 scopus 로고    scopus 로고
    • Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas
    • Knobbe CB, Reifenberger J, Reifenberger G. Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas. Acta Neuropathol. 2004;108(6):467-470.
    • (2004) Acta Neuropathol. , vol.108 , Issue.6 , pp. 467-470
    • Knobbe, C.B.1    Reifenberger, J.2    Reifenberger, G.3
  • 15
    • 28644439947 scopus 로고    scopus 로고
    • R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis
    • Komatsu M, Ruoslahti E. R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat Med. 2005;11(12):1346-1350.
    • (2005) Nat Med. , vol.11 , Issue.12 , pp. 1346-1350
    • Komatsu, M.1    Ruoslahti, E.2
  • 16
    • 25144492370 scopus 로고    scopus 로고
    • EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion
    • Nakada M, Niska JA, Tran NL, et al. EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. Am J Pathol. 2005;167(2):565-576.
    • (2005) Am J Pathol. , vol.167 , Issue.2 , pp. 565-576
    • Nakada, M.1    Niska, J.A.2    Tran, N.L.3
  • 17
    • 84891846003 scopus 로고    scopus 로고
    • Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN
    • Wang XR, Luo H, Li HL, et al. Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN. Neuro Oncol. 2013;15(11):1491-1501.
    • (2013) Neuro Oncol. , vol.15 , Issue.11 , pp. 1491-1501
    • Wang, X.R.1    Luo, H.2    Li, H.L.3
  • 18
    • 84934438094 scopus 로고    scopus 로고
    • MicroRNAs in melanoma biology
    • Kunz M. MicroRNAs in melanoma biology. Adv Exp Med Biol. 2013;774:103-120.
    • (2013) Adv Exp Med Biol. , vol.774 , pp. 103-120
    • Kunz, M.1
  • 19
    • 84874626235 scopus 로고    scopus 로고
    • MiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1
    • Cimino D, De Pitta C, Orso F, et al. MiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. FASEB J. 2013;27(3):1223-1235.
    • (2013) FASEB J. , vol.27 , Issue.3 , pp. 1223-1235
    • Cimino, D.1    De Pitta, C.2    Orso, F.3
  • 20
    • 84877116748 scopus 로고    scopus 로고
    • MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
    • Halkein J, Tabruyn SP, Ricke-Hoch M, et al. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J Clin Invest. 2013;123(5):2143-2154.
    • (2013) J Clin Invest. , vol.123 , Issue.5 , pp. 2143-2154
    • Halkein, J.1    Tabruyn, S.P.2    Ricke-Hoch, M.3
  • 21
    • 84855380396 scopus 로고    scopus 로고
    • MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol
    • Han Z, Yang Q, Liu B, et al. MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol. Carcinogenesis. 2012;33(1):131-139.
    • (2012) Carcinogenesis , vol.33 , Issue.1 , pp. 131-139
    • Han, Z.1    Yang, Q.2    Liu, B.3
  • 22
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer. 2007;7(4):295-308.
    • (2007) Nat Rev Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 23
    • 34547942530 scopus 로고    scopus 로고
    • Targeting oncogenic Ras
    • Diaz-Flores E, Shannon K. Targeting oncogenic Ras. Genes Dev. 2007;21(16):1989-1992.
    • (2007) Genes Dev. , vol.21 , Issue.16 , pp. 1989-1992
    • Diaz-Flores, E.1    Shannon, K.2
  • 24
    • 0042734450 scopus 로고    scopus 로고
    • Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway
    • Cole AL, Subbanagounder G, Mukhopadhyay S, et al. Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. Arterioscler Thromb Vasc Biol. 2003;23(8):1384-1390.
    • (2003) Arterioscler Thromb Vasc Biol. , vol.23 , Issue.8 , pp. 1384-1390
    • Cole, A.L.1    Subbanagounder, G.2    Mukhopadhyay, S.3
  • 25
    • 77954022714 scopus 로고    scopus 로고
    • Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma
    • Santarpia L, Myers JN, Sherman SI, et al. Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma. Cancer. 2010;116(12):2974-2983.
    • (2010) Cancer , vol.116 , Issue.12 , pp. 2974-2983
    • Santarpia, L.1    Myers, J.N.2    Sherman, S.I.3
  • 26
    • 84874613332 scopus 로고    scopus 로고
    • Combined targeting of MEK and PI3 K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo
    • Posch C, Moslehi H, Feeney L, et al. Combined targeting of MEK and PI3 K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo. Proc Natl Acad Sci U S A. 2013;110(10):4015-4020.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.10 , pp. 4015-4020
    • Posch, C.1    Moslehi, H.2    Feeney, L.3
  • 27
    • 29144470346 scopus 로고    scopus 로고
    • Real-time quantification of microRNAs by stem-loop RT-PCR
    • Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005;33(20):e179.
    • (2005) Nucleic Acids Res. , vol.33 , Issue.20 , pp. e179
    • Chen, C.1    Ridzon, D.A.2    Broomer, A.J.3
  • 28
    • 62549130754 scopus 로고    scopus 로고
    • A PCR-based platform for microRNA expression profiling studies
    • Wang X. A PCR-based platform for microRNA expression profiling studies. RNA. 2009;15(4):716-723.
    • (2009) RNA , vol.15 , Issue.4 , pp. 716-723
    • Wang, X.1
  • 29
    • 84865151156 scopus 로고    scopus 로고
    • Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels
    • Sawada J, Urakami T, Li F, et al. Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels. Cancer Cell. 2012;22(2):235-249.
    • (2012) Cancer Cell , vol.22 , Issue.2 , pp. 235-249
    • Sawada, J.1    Urakami, T.2    Li, F.3
  • 30
    • 84867084482 scopus 로고    scopus 로고
    • The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling
    • Sandri C, Caccavari F, Valdembri D, et al. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 2012;22(10):1479-1501.
    • (2012) Cell Res. , vol.22 , Issue.10 , pp. 1479-1501
    • Sandri, C.1    Caccavari, F.2    Valdembri, D.3
  • 31
    • 84877847218 scopus 로고    scopus 로고
    • Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway
    • Li Z, Zhang Y, Ramanujan K, et al. Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway. Cancer Res. 2013;73(10):3041-3050.
    • (2013) Cancer Res. , vol.73 , Issue.10 , pp. 3041-3050
    • Li, Z.1    Zhang, Y.2    Ramanujan, K.3
  • 32
    • 84877097856 scopus 로고    scopus 로고
    • Characteristics of lung cancers harboring NRAS mutations
    • Ohashi K, Sequist LV, Arcila ME, et al. Characteristics of lung cancers harboring NRAS mutations. Clin Cancer Res. 2013;19(9):2584-2591.
    • (2013) Clin Cancer Res. , vol.19 , Issue.9 , pp. 2584-2591
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 33
    • 84879771957 scopus 로고    scopus 로고
    • Functional crosstalk between Akt/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer
    • Wang C, Cigliano A, Delogu S, et al. Functional crosstalk between Akt/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: implications for the treatment of human liver cancer. Cell Cycle. 2013;12(13):1999-2010.
    • (2013) Cell Cycle , vol.12 , Issue.13 , pp. 1999-2010
    • Wang, C.1    Cigliano, A.2    Delogu, S.3
  • 34
    • 79959712087 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3 K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
    • ChappellWH, Steelman LS, Long JM, et al. Ras/Raf/MEK/ERK and PI3 K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget. 2011;2(3):135-164.
    • (2011) Oncotarget , vol.2 , Issue.3 , pp. 135-164
    • Chappell, W.H.1    Steelman, L.S.2    Long, J.M.3
  • 35
    • 22544463087 scopus 로고    scopus 로고
    • Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
    • Dumaz N, Marais R. Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J. 2005;272(14):3491-3504.
    • (2005) FEBS J. , vol.272 , Issue.14 , pp. 3491-3504
    • Dumaz, N.1    Marais, R.2
  • 36
    • 21344456180 scopus 로고    scopus 로고
    • The RAS/RAF/MEK/ERK and PI3 K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    • Meier F, Schittek B, Busch S, et al. The RAS/RAF/MEK/ERK and PI3 K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci. 2005;10:2986-3001.
    • (2005) Front Biosci. , vol.10 , pp. 2986-3001
    • Meier, F.1    Schittek, B.2    Busch, S.3
  • 37
    • 34047132303 scopus 로고    scopus 로고
    • Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression
    • Fang J, Zhou Q, Liu LZ, et al. Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis. 2007;28(4):858-864.
    • (2007) Carcinogenesis , vol.28 , Issue.4 , pp. 858-864
    • Fang, J.1    Zhou, Q.2    Liu, L.Z.3
  • 38
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 2002;29(Suppl 616):15-18.
    • (2002) Semin Oncol. , vol.29 , pp. 15-18
    • Folkman, J.1
  • 39
    • 79953792348 scopus 로고    scopus 로고
    • Fyn is induced by Ras/PI3 K/Akt signaling and is required for enhanced invasion/migration
    • Yadav V, Denning MF. Fyn is induced by Ras/PI3 K/Akt signaling and is required for enhanced invasion/migration. Mol Carcinog. 2011;50(5):346-352.
    • (2011) Mol Carcinog , vol.50 , Issue.5 , pp. 346-352
    • Yadav, V.1    Denning, M.F.2
  • 40
    • 11244270824 scopus 로고    scopus 로고
    • Thymosin {beta} (10) inhibits angiogenesis and tumor growth by interfering with Ras function
    • Lee SH, Son MJ, Oh SH, et al. Thymosin {beta} (10) inhibits angiogenesis and tumor growth by interfering with Ras function. Cancer Res. 2005;65(1):137-148.
    • (2005) Cancer Res. , vol.65 , Issue.1 , pp. 137-148
    • Lee, S.H.1    Son, M.J.2    Oh, S.H.3
  • 41
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005;433(7027):769-773.
    • (2005) Nature , vol.433 , Issue.7027 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3
  • 42
    • 84872494254 scopus 로고    scopus 로고
    • A systematic review of microRNA in glioblastoma multiforme: Micro-modulators in the mesenchymal mode of migration and invasion
    • Moller HG, Rasmussen AP, Andersen HH, et al. A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasion. Mol Neurobiol. 2013;47(1):131-144.
    • (2013) Mol Neurobiol. , vol.47 , Issue.1 , pp. 131-144
    • Moller, H.G.1    Rasmussen, A.P.2    Andersen, H.H.3
  • 43
    • 13444283313 scopus 로고    scopus 로고
    • Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death
    • Blum R, Jacob-Hirsch J, Amariglio N, et al. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res. 2005;65(3):999-1006.
    • (2005) Cancer Res. , vol.65 , Issue.3 , pp. 999-1006
    • Blum, R.1    Jacob-Hirsch, J.2    Amariglio, N.3
  • 44
    • 84861861100 scopus 로고    scopus 로고
    • MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF
    • Zou C, Xu Q, Mao F, et al. MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF. Cell Cycle. 2012;11(11):2137-2145.
    • (2012) Cell Cycle , vol.11 , Issue.11 , pp. 2137-2145
    • Zou, C.1    Xu, Q.2    Mao, F.3
  • 45
    • 77955297403 scopus 로고    scopus 로고
    • R-Ras regulates migration through an interaction with filamin A in melanoma cells
    • Gawecka JE, Griffiths GS, Ek-Rylander B, et al. R-Ras regulates migration through an interaction with filamin A in melanoma cells. PLoS One. 2010;5(6):e11269.
    • (2010) PLoS One , vol.5 , Issue.6 , pp. e11269
    • Gawecka, J.E.1    Griffiths, G.S.2    Ek-Rylander, B.3
  • 46
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120(5):635-647.
    • (2005) Cell , vol.120 , Issue.5 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 47
    • 84860448293 scopus 로고    scopus 로고
    • Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells
    • Lang MF, Yang S, Zhao C, et al. Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. PLoS One. 2012;7(4):e36248.
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e36248
    • Lang, M.F.1    Yang, S.2    Zhao, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.