The cytochrome p450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Schuck, Robert N ^a   Zha, Weibin ^a   Edin, Matthew L ^b   Gruzdev, Artiom ^b   Vendrov, Kimberly C ^a   Miller, Tricia M ^c   Xu, Zhenghong ^a   Lih, Fred B ^b   DeGraff, Laura M ^b   Tomer, Kenneth B ^b   Jones, H Michael ^d   Makowski, Liza ^e   Huang, Leaf ^a   Poloyac, Samuel M ^c   Zeldin, Darryl C ^b   Lee, Craig R ^a  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME; CYTOCHROME P450 EPOXYGENASE; EPOXYICOSATRIENOIC ACID; OXYGENASE; UNCLASSIFIED DRUG; ARACHIDONATE EPOXYGENASE; ARACHIDONIC ACID; BIOLOGICAL MARKER; CYTOCHROME P450; EPHX2 PROTEIN, MOUSE; EPOXIDE HYDROLASE; ICOSANOID; LIPID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME SYNTHESIS; EPHX2 GENE; GENE; GENE DISRUPTION; HEPATITIS; MALE; METABOLIC REGULATION; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; ANIMAL; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; DEFICIENCY; DIET; ENZYMOLOGY; FATTY LIVER; GENE EXPRESSION REGULATION; GENETICS; HYDRODYNAMICS; INFLAMMATION; LIVER; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; ARACHIDONIC ACID; ATHEROSCLEROSIS; BIOMARKERS; CYTOCHROME P-450 ENZYME SYSTEM; DIET; EICOSANOIDS; EPOXIDE HYDROLASES; FATTY LIVER; GENE EXPRESSION REGULATION; HYDRODYNAMICS; INFLAMMATION; LIPIDS; LIVER; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE, INBRED C57BL;

EID: 84907927091     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110162     Document Type: Article

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