-
1
-
-
79951499644
-
Too many roads not taken
-
Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH (2010) Too many roads not taken. Nature 470:163–165
-
(2010)
Nature
, vol.470
, pp. 163-165
-
-
Edwards, A.M.1
Isserlin, R.2
Bader, G.D.3
Frye, S.V.4
Willson, T.M.5
Yu, F.H.6
-
2
-
-
84860371953
-
Epigenetic protein families: A new frontier for drug discovery
-
Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (2012) Epigenetic protein families: A new frontier for drug discovery. Nat Rev Drug Discov 11:384–400
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 384-400
-
-
Arrowsmith, C.H.1
Bountra, C.2
Fish, P.V.3
Lee, K.4
Schapira, M.5
-
3
-
-
0037032835
-
The protein kinase complement of the human genome. Science (New York
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (2002) The protein kinase complement of the human genome. Science (New York, NY) 298:1912–1934
-
(2002)
NY)
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
4
-
-
84871918476
-
The GPCR Network: A large-scale collaboration to determine human GPCR structure and function
-
Stevens RC, Cherezov V, Katritch V, Abagyan R, Kuhn P, Rosen H, Wüthrich K (2013) The GPCR Network: A large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov 12:25–34
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 25-34
-
-
Stevens, R.C.1
Cherezov, V.2
Katritch, V.3
Abagyan, R.4
Kuhn, P.5
Rosen, H.6
Wüthrich, K.7
-
6
-
-
67650437045
-
Large-scale structural biology of the human proteome
-
Edwards A (2009) Large-scale structural biology of the human proteome. Annu Rev Biochem 78:541–568
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 541-568
-
-
Edwards, A.1
-
7
-
-
0022977712
-
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity ofFujinami sarcoma virus P130gag-fps
-
Sadowski I, Stone JC, Pawson T (1986) A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity ofFujinami sarcoma virus P130gag-fps. Mol Cell Biol 6:4396–4408
-
(1986)
Mol Cell Biol
, vol.6
, pp. 4396-4408
-
-
Sadowski, I.1
Stone, J.C.2
Pawson, T.3
-
8
-
-
0021173703
-
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis
-
Stone JC, Atkinson T, Smith M, Pawson T (1984) Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis. Cell 37:549–558
-
(1984)
Cell
, vol.37
, pp. 549-558
-
-
Stone, J.C.1
Atkinson, T.2
Smith, M.3
Pawson, T.4
-
9
-
-
50249132542
-
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation
-
Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G et al (2008) Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell 134:793–803
-
(2008)
Cell
, vol.134
, pp. 793-803
-
-
Filippakopoulos, P.1
Kofler, M.2
Hantschel, O.3
Gish, G.D.4
Grebien, F.5
Salah, E.6
Neudecker, P.7
Kay, L.E.8
Turk, B.E.9
Superti-Furga, G.10
-
10
-
-
84871737742
-
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
-
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J et al (2012) Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 3:1288
-
(2012)
Nat Commun
, vol.3
, pp. 1288
-
-
Yu, W.1
Chory, E.J.2
Wernimont, A.K.3
Tempel, W.4
Scopton, A.5
Federation, A.6
Marineau, J.J.7
Qi, J.8
Barsyte-Lovejoy, D.9
Yi, J.10
-
11
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I et al (2010) Selective inhibition of BET bromodomains. Nature 468:1067–1073
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
-
12
-
-
84870046749
-
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragmentderived hit
-
Fish PV, Filippakopoulos P, Bish G, Brennan PE, Bunnage ME, Cook AS, Federov O, Gerstenberger BS, Jones H, Knapp S et al (2012) Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragmentderived hit. J Med Chem 55:9831–9837
-
(2012)
J Med Chem
, vol.55
, pp. 9831-9837
-
-
Fish, P.V.1
Filippakopoulos, P.2
Bish, G.3
Brennan, P.E.4
Bunnage, M.E.5
Cook, A.S.6
Federov, O.7
Gerstenberger, B.S.8
Jones, H.9
Knapp, S.10
-
13
-
-
77954954525
-
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats
-
Guetg C, Lienemann P, Sirri V, Grummt I, Hernandez-Verdun D, Hottiger MO, Fussenegger M, Santoro R (2010) The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. Embo J 29:2135–2146
-
(2010)
Embo J
, vol.29
, pp. 2135-2146
-
-
Guetg, C.1
Lienemann, P.2
Sirri, V.3
Grummt, I.4
Hernandez-Verdun, D.5
Hottiger, M.O.6
Fussenegger, M.7
Santoro, R.8
-
14
-
-
54449100397
-
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH)
-
Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA (2008) Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J Biol Chem 283:25971–25978
-
(2008)
J Biol Chem
, vol.283
, pp. 25971-25978
-
-
Hewitson, K.S.1
Holmes, S.L.2
Ehrismann, D.3
Hardy, A.P.4
Chowdhury, R.5
Schofield, C.J.6
McDonough, M.A.7
-
15
-
-
84874116695
-
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
-
James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W et al (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol 9:184–191
-
(2013)
Nat Chem Biol
, vol.9
, pp. 184-191
-
-
James, L.I.1
Barsyte-Lovejoy, D.2
Zhong, N.3
Krichevsky, L.4
Korboukh, V.K.5
Herold, J.M.6
Macnevin, C.J.7
Norris, J.L.8
Sagum, C.A.9
Tempel, W.10
-
17
-
-
77954083147
-
Development of homogeneous luminescence assays for histone demethylase catalysis and binding
-
Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield C (2010) Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Anal Biochem 404:86–93
-
(2010)
Anal Biochem
, vol.404
, pp. 86-93
-
-
Kawamura, A.1
Tumber, A.2
Rose, N.R.3
King, O.N.4
Daniel, M.5
Oppermann, U.6
Heightman, T.D.7
Schofield, C.8
-
18
-
-
78649528262
-
Quantitative highthroughputscreening identifies 8- hydroxyquinolines as cell-active histone demethylase inhibitors
-
King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P et al (2010) Quantitative highthroughputscreening identifies 8- hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One 5:e15535
-
(2010)
Plos One
, vol.5
-
-
King, O.N.1
Li, X.S.2
Sakurai, M.3
Kawamura, A.4
Rose, N.R.5
Ng, S.S.6
Quinn, A.M.7
Rai, G.8
Mott, B.T.9
Beswick, P.10
-
19
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488:404–408
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
Bantscheff, M.7
Bountra, C.8
Bridges, A.9
Diallo, H.10
-
20
-
-
84878565710
-
PFI-1—A highly selective protein interaction inhibitor targeting BET bromodomains
-
Picaud S, Da Costa D, Thanasopoulou A, Filippakopoulos P, Fish PV, Philpott M, Fedorov O, Brennan P, Bunnage ME, Owen DR et al (2013) PFI-1—A highly selective protein interaction inhibitor targeting BET bromodomains. Cancer Res 73(11):3336–3346
-
(2013)
Cancer Res
, vol.73
, Issue.11
, pp. 3336-3346
-
-
Picaud, S.1
Da Costa, D.2
Thanasopoulou, A.3
Filippakopoulos, P.4
Fish, P.V.5
Philpott, M.6
Fedorov, O.7
Brennan, P.8
Bunnage, M.E.9
Owen, D.R.10
-
21
-
-
77649224314
-
Selective inhibitors of the JMJD2 histone demethylases: Combined nondenaturing mass spectrometric screening and crystallographic approaches
-
Rose NR, Woon EC, Kingham GL, King ON, Mecinovic J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA et al (2010) Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem 53:1810–1818
-
(2010)
J Med Chem
, vol.53
, pp. 1810-1818
-
-
Rose, N.R.1
Woon, E.C.2
Kingham, G.L.3
King, O.N.4
Mecinovic, J.5
Clifton, I.J.6
Ng, S.S.7
Talib-Hardy, J.8
Oppermann, U.9
McDonough, M.A.10
-
22
-
-
79953891392
-
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors
-
Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ et al (2011) Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J Biol Chem 286:13041–13051
-
(2011)
J Biol Chem
, vol.286
, pp. 13041-13051
-
-
Tian, Y.M.1
Yeoh, K.K.2
Lee, M.K.3
Eriksson, T.4
Kessler, B.M.5
Kramer, H.B.6
Edelmann, M.J.7
Willam, C.8
Pugh, C.W.9
Schofield, C.J.10
-
23
-
-
79960493567
-
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
-
Vedadi M, Barsyte-Lovejoy D, Liu F, Rival- Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A et al (2011) A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol 7:566–574
-
(2011)
Nat Chem Biol
, vol.7
, pp. 566-574
-
-
Vedadi, M.1
Barsyte-Lovejoy, D.2
Liu, F.3
Rival- Gervier, S.4
Allali-Hassani, A.5
Labrie, V.6
Wigle, T.J.7
Dimaggio, P.A.8
Wasney, G.A.9
Siarheyeva, A.10
-
24
-
-
22244450719
-
Protein families and their evolution-a structural perspective
-
Orengo CA, Thornton JM (2005) Protein families and their evolution-a structural perspective. Annu Rev Biochem 74:867–900
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 867-900
-
-
Orengo, C.A.1
Thornton, J.M.2
-
25
-
-
40849141980
-
Structural genomics and drug discovery: All in the family
-
Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowsmith CH (2008) Structural genomics and drug discovery: All in the family. Curr Opin Chem Biol 12:32–39
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 32-39
-
-
Weigelt, J.1
McBroom-Cerajewski, L.D.2
Schapira, M.3
Zhao, Y.4
Arrowsmith, C.H.5
-
26
-
-
33750470057
-
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
-
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ Jr, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H et al (2006) Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A 103:15835–15840
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 15835-15840
-
-
Vedadi, M.1
Niesen, F.H.2
Allali-Hassani, A.3
Fedorov, O.Y.4
Finerty, P.J.5
Wasney, G.A.6
Yeung, R.7
Arrowsmith, C.8
Ball, L.J.9
Berglund, H.10
-
27
-
-
84874865318
-
Next generation sequencing in cancer research and clinical application
-
Shyr D, Liu Q (2013) Next generation sequencing in cancer research and clinical application. Biol Proced Online 15:4
-
(2013)
Biol Proced Online
, vol.15
, pp. 4
-
-
Shyr, D.1
Liu, Q.2
-
28
-
-
77952888699
-
Denovo mutations of SETBP1 cause Schinzel-Giedion syndrome
-
Hoischen A, Van Bon BW, Gilissen C, Arts P, Van Lier B, Steehouwer M, De Vries P, De Reuver R, Wieskamp N, Mortier G et al (2010) Denovo mutations of SETBP1 cause Schinzel-Giedion syndrome. Nat Genet 42:483–485
-
(2010)
Nat Genet
, vol.42
, pp. 483-485
-
-
Hoischen, A.1
Van Bon, B.W.2
Gilissen, C.3
Arts, P.4
Van Lier, B.5
Steehouwer, M.6
De Vries, P.7
De Reuver, R.8
Wieskamp, N.9
Mortier, G.10
-
29
-
-
84867252179
-
An RMND1 Mutation causes encephalopathy associated with multiple oxidative phosphorylation complex deficiencies and a mitochondrial translation defect
-
Janer A, Antonicka H, Lalonde E, Nishimura T, Sasarman F, Brown GK, Brown RM, Majewski J, Shoubridge EA (2012) An RMND1 Mutation causes encephalopathy associated with multiple oxidative phosphorylation complex deficiencies and a mitochondrial translation defect. Am J Hum Genet 91:737–743
-
(2012)
Am J Hum Genet
, vol.91
, pp. 737-743
-
-
Janer, A.1
Antonicka, H.2
Lalonde, E.3
Nishimura, T.4
Sasarman, F.5
Brown, G.K.6
Brown, R.M.7
Majewski, J.8
Shoubridge, E.A.9
-
30
-
-
78650207098
-
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
-
Lo YM, Chan KC, Sun H, Chen EZ, Jiang P, Lun FM, Zheng YW, Leung TY, Lau TK, Cantor CR et al (2010) Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2:61ra91
-
(2010)
Sci Transl Med 2:61Ra91
-
-
Lo, Y.M.1
Chan, K.C.2
Sun, H.3
Chen, E.Z.4
Jiang, P.5
Lun, F.M.6
Zheng, Y.W.7
Leung, T.Y.8
Lau, T.K.9
Cantor, C.R.10
-
31
-
-
73349110071
-
Exome sequencing identifies the cause of a mendelian disorder
-
Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA et al (2010) Exome sequencing identifies the cause of a mendelian disorder. Nat Genet 42:30–35
-
(2010)
Nat Genet
, vol.42
, pp. 30-35
-
-
Ng, S.B.1
Buckingham, K.J.2
Lee, C.3
Bigham, A.W.4
Tabor, H.K.5
Dent, K.M.6
Huff, C.D.7
Shannon, P.T.8
Jabs, E.W.9
Nickerson, D.A.10
-
32
-
-
77956642100
-
Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome
-
Ng SB, Bigham AW, Buckingham KJ, Hannibal MC, McMillin MJ, Gildersleeve HI, Beck AE, Tabor HK, Cooper GM, Mefford HC et al (2010) Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome. Nat Genet 42:790–793
-
(2010)
Nat Genet
, vol.42
, pp. 790-793
-
-
Ng, S.B.1
Bigham, A.W.2
Buckingham, K.J.3
Hannibal, M.C.4
McMillin, M.J.5
Gildersleeve, H.I.6
Beck, A.E.7
Tabor, H.K.8
Cooper, G.M.9
Mefford, H.C.10
-
33
-
-
84867214350
-
Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units
-
Saunders CJ, Miller NA, Soden SE, Dinwiddie DL, Noll A, Alnadi NA, Andraws N, Patterson ML, Krivohlavek LA, Fellis J et al (2012) Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units. Sci Transl Med 4:154ra135
-
(2012)
Sci Transl Med 4:154Ra135
-
-
Saunders, C.J.1
Miller, N.A.2
Soden, S.E.3
Dinwiddie, D.L.4
Noll, A.5
Alnadi, N.A.6
Raws, N.7
Patterson, M.L.8
Krivohlavek, L.A.9
Fellis, J.10
-
34
-
-
84863970074
-
De novo mutations in human genetic disease
-
Veltman JA, Brunner HG (2012) De novo mutations in human genetic disease. Nat Rev Genet 13:565–575
-
(2012)
Nat Rev Genet
, vol.13
, pp. 565-575
-
-
Veltman, J.A.1
Brunner, H.G.2
-
35
-
-
84868249831
-
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
-
Chaikuad A, Alfano I, Kerr G, Sanvitale CE, Boergermann JH, Triffitt JT, Von Delft F, Knapp S, Knaus P, Bullock AN (2012) Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva. J Biol Chem287:36990–36998
-
(2012)
J Biol Chem287
, pp. 36990-36998
-
-
Chaikuad, A.1
Alfano, I.2
Kerr, G.3
Sanvitale, C.E.4
Boergermann, J.H.5
Triffitt, J.T.6
Von Delft, F.7
Knapp, S.8
Knaus, P.9
Bullock, A.N.10
-
36
-
-
84860322514
-
Mutations in ISPD cause Walker- Warburg syndrome and defective glycosylation of α-dystroglycan
-
Roscioli T, Kamsteeg E-J, Buysse K, Maystadt I, Van Reeuwijk J, Van den Elzen C, Van Beusekom E, Riemersma M, Pfundt R, Vissers LELM et al (2012) Mutations in ISPD cause Walker- Warburg syndrome and defective glycosylation of α-dystroglycan. Nat enet 44:581–585
-
(2012)
Nat Enet
, vol.44
, pp. 581-585
-
-
Roscioli, T.1
Kamsteeg, E.-J.2
Buysse, K.3
Maystadt, I.4
Van Reeuwijk, J.5
Van Den Elzen, C.6
Van Beusekom, E.7
Riemersma, M.8
Pfundt, R.9
Vissers, L.10
-
37
-
-
77956181585
-
High-throughput production of human proteins for crystallization: The SGC experience
-
Savitsky P, Bray J, Cooper CD, Marsden BD, Mahajan P, Burgess-Brown NA, Gileadi O (2010) High-throughput production of human proteins for crystallization: The SGC experience. J Struct Biol 172:3–13
-
(2010)
J Struct Biol
, vol.172
, pp. 3-13
-
-
Savitsky, P.1
Bray, J.2
Cooper, C.D.3
Marsden, B.D.4
Mahajan, P.5
Burgess-Brown, N.A.6
Gileadi, O.7
-
38
-
-
39549090406
-
The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins
-
Graslund S, Sagemark J, Berglund H, Dahlgren LG, Flores A, Hammarstrom M, Johansson I, Kotenyova T, Nilsson M, Nordlund P et al (2008) The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins. Protein Expr Purif 58:210–221
-
(2008)
Protein Expr Purif
, vol.58
, pp. 210-221
-
-
Graslund, S.1
Sagemark, J.2
Berglund, H.3
Dahlgren, L.G.4
Flores, A.5
Hammarstrom, M.6
Johansson, I.7
Kotenyova, T.8
Nilsson, M.9
Nordlund, P.10
|