메뉴 건너뛰기




Volumn 58, Issue 10, 2014, Pages 6242-6250

Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drugresistant tuberculosis

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID; ANTIRETROVIRUS AGENT; EFAVIRENZ; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR PLUS RITONAVIR; STAVUDINE; ZIDOVUDINE; BENZOXAZINE DERIVATIVE; TUBERCULOSTATIC AGENT;

EID: 84907907883     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03073-14     Document Type: Article
Times cited : (33)

References (54)
  • 1
    • 0012746992 scopus 로고    scopus 로고
    • The growing burden of tuberculosis: Global trends and interactions with the HIV epidemic
    • Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C. 2003. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch. Intern. Med. 163:1009-1021. http://dx.doi.org/10.1001/archinte.163.9.1009 .
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1009-1021
    • Corbett, E.L.1    Watt, C.J.2    Walker, N.3    Maher, D.4    Williams, B.G.5    Raviglione, M.C.6    Dye, C.7
  • 3
    • 77956241959 scopus 로고    scopus 로고
    • Extensively drug-resistant tuberculosis in South Africa
    • Cox H, Ford N, McDermid C, van Cutsem G, Goemaere E. 2010. Extensively drug-resistant tuberculosis in South Africa. Lancet 376:681. http://dx.doi.org/10.1016/S0140-6736(10)61327-X .
    • (2010) Lancet , vol.376 , pp. 681
    • Cox, H.1    Ford, N.2    McDermid, C.3    Van Cutsem, G.4    Goemaere, E.5
  • 4
    • 78649494186 scopus 로고    scopus 로고
    • Epidemic levels of drug resistant tuberculosis (MDR and XDR-TB) in a high HIV prevalence setting in Khayelitsha, South Africa
    • Cox HS, McDermid C, Azevedo V, Muller O, Coetzee D, Simpson J, Barnard M, Coetzee G, van Cutsem G, Goemaere E. 2010. Epidemic levels of drug resistant tuberculosis (MDR and XDR-TB) in a high HIV prevalence setting in Khayelitsha, South Africa. PLoS One 5:el3901. http://dx.doi.org/10.1371/joumal.pone.0013901 .
    • (2010) PLoS One , vol.5 , pp. el3901
    • Cox, H.S.1    McDermid, C.2    Azevedo, V.3    Muller, O.4    Coetzee, D.5    Simpson, J.6    Barnard, M.7    Coetzee, G.8    Van Cutsem, G.9    Goemaere, E.10
  • 6
    • 33846995990 scopus 로고    scopus 로고
    • XDR tuberculosis-implications for global public health
    • Raviglione MC, Smith IM. 2007. XDR tuberculosis-implications for global public health. N. Engl. J. Med. 356:656-659. http://dx.doi.org/10.1056/NEJMp068273 .
    • (2007) N. Engl. J. Med. , vol.356 , pp. 656-659
    • Raviglione, M.C.1    Smith, I.M.2
  • 7
    • 0034766403 scopus 로고    scopus 로고
    • Pharmacokinetics of para-aminosalicylic acid granules under four dosing conditions
    • Peloquin CA, Zhu M, Adam RD, Singleton MD, Nix DE. 2001. Pharmacokinetics of para-aminosalicylic acid granules under four dosing conditions. Ann. Pharmacother. 35:1332-1338. http://dx.doi.org/10.1345/aph . 1A088.
    • (2001) Ann. Pharmacother , vol.35 , pp. 1332-1338
    • Peloquin, C.A.1    Zhu, M.2    Adam, R.D.3    Singleton, M.D.4    Nix, D.E.5
  • 8
    • 70449291474 scopus 로고
    • Isoniazid and para-aminosalicylic acid toxicity in 513 cases: A study including high doses of INH and gastrointestinal intolerance to PAS
    • Berte SJ, Dewlett HJ. 1959. Isoniazid and para-aminosalicylic acid toxicity in 513 cases: a study including high doses of INH and gastrointestinal intolerance to PAS. Dis. Chest 36:146-151. http://dx.doi.org/10.1378/chest.36.2.146 .
    • (1959) Dis. Chest , vol.36 , pp. 146-151
    • Berte, S.J.1    Dewlett, H.J.2
  • 10
    • 0006350559 scopus 로고
    • A five-year assessment of patients in a controlled trial of streptomycin, para-aminosalicylic acid, and streptomycin plus para-aminosalicylic acid, in pulmonary tuberculosis
    • Fox W, Sutherland I. 1956. A five-year assessment of patients in a controlled trial of streptomycin, para-aminosalicylic acid, and streptomycin plus para-aminosalicylic acid, in pulmonary tuberculosis. Q. J. Med. 25: 221-243.
    • (1956) Q. J. Med. , vol.25 , pp. 221-243
    • Fox, W.1    Sutherland, I.2
  • 14
    • 84875772699 scopus 로고    scopus 로고
    • Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation
    • Liwa AC, Schaaf HS, Rosenkranz B, Seifart HI, Diacon AH, Donald PR. 2013. Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation. J. Trop. Pediatr. 59:90-94. http://dx.doi.org/10.1093/tropej/fins053 .
    • (2013) J. Trop. Pediatr. , vol.59 , pp. 90-94
    • Liwa, A.C.1    Schaaf, H.S.2    Rosenkranz, B.3    Seifart, H.I.4    Diacon, A.H.5    Donald, P.R.6
  • 15
    • 34748854885 scopus 로고    scopus 로고
    • Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies
    • Savic RM, Jonker DM, Kerbusch T, Karlsson MO. 2007. Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies. J. Pharmacokinet. Pharmacodyn. 34:711-726. http://dx.doi.org/10.1007/sl0928-007-9066-0 .
    • (2007) J. Pharmacokinet. Pharmacodyn. , vol.34 , pp. 711-726
    • Savic, R.M.1    Jonker, D.M.2    Kerbusch, T.3    Karlsson, M.O.4
  • 16
    • 84891792560 scopus 로고    scopus 로고
    • Basic concepts in population modeling, simulation, and model-based drug development: Part 3-introduction to pharmacodynamic modeling methods
    • Upton RN, Mould DR. 2014. Basic concepts in population modeling, simulation, and model-based drug development: part 3-introduction to pharmacodynamic modeling methods. CPT Pharmacometrics Syst. Pharmacol. 3:e88. http://dx.doi.org/10.1038/psp.2013.71 .
    • (2014) CPT Pharmacometrics Syst. Pharmacol. , vol.3 , pp. e88
    • Upton, R.N.1    Mould, D.R.2
  • 17
    • 67749114556 scopus 로고    scopus 로고
    • New semiphysiological absorption model to assess the pharmacodynamic profile of cefuroxime axetil using nonparametric and parametric population pharmacokinetics
    • Bulitta JB, Landersdorfer CB, Kinzig M, Holzgrabe U, Sorgel F. 2009. New semiphysiological absorption model to assess the pharmacodynamic profile of cefuroxime axetil using nonparametric and parametric population pharmacokinetics. Antimicrob. Agents Chemother. 53:3462-3471. http://dx.doi.org/10.1128/AAC.00054-09 .
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 3462-3471
    • Bulitta, J.B.1    Landersdorfer, C.B.2    Kinzig, M.3    Holzgrabe, U.4    Sorgel, F.5
  • 18
    • 84860739324 scopus 로고    scopus 로고
    • Rapid sample size calculations for a defined likelihood ratio test-based power in mixedeffects models
    • Vong C, Bergstrand M, Nyberg J, Karlsson MO. 2012. Rapid sample size calculations for a defined likelihood ratio test-based power in mixedeffects models. AAPS J. 14:176-186. http://dx.doi.org/10.1208/s12248-012-9327-8 .
    • (2012) AAPS J. , vol.14 , pp. 176-186
    • Vong, C.1    Bergstrand, M.2    Nyberg, J.3    Karlsson, M.O.4
  • 24
    • 0036033914 scopus 로고    scopus 로고
    • Therapeutic drug monitoring in the treatment of tuberculosis
    • Peloquin CA. 2002. Therapeutic drug monitoring in the treatment of tuberculosis. Drugs 62:2169-2183. http://dx.doi.org/10.2165/00003495-20026215000001 .
    • (2002) Drugs , vol.62 , pp. 2169-2183
    • Peloquin, C.A.1
  • 25
    • 78751706488 scopus 로고    scopus 로고
    • HPLC analysis of paraaminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues
    • Hong L, Jiang W, Zheng W, Zeng S. 2011. HPLC analysis of paraaminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues. J. Pharm. Biomed. Anal. 54:1101-1109. http://dx.doi.org/10.1016/j.jpba.2010.11.031 .
    • (2011) J. Pharm. Biomed. Anal. , vol.54 , pp. 1101-1109
    • Hong, L.1    Jiang, W.2    Zheng, W.3    Zeng, S.4
  • 26
    • 0030986424 scopus 로고    scopus 로고
    • Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity
    • Cummins CL, O'Neil WM, Soo EC, Lloyd DK, Wainer IW. 1997. Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity. J. Chromatogr. B Biomed. Sci. Appl. 697: 283-288. http://dx.doi.org/10.1016/S037S-4347(97)00084-4 .
    • (1997) J. Chromatogr. B Biomed. Sci. Appl. , vol.697 , pp. 283-288
    • Cummins, C.L.1    O'neil, W.M.2    Soo, E.C.3    Lloyd, D.K.4    Wainer, I.W.5
  • 27
    • 0016252507 scopus 로고
    • Bioavailability of aminosalicylic acid and its various salts in humans. 3. Absorption from tablets
    • Wan SH, Pentikainen PJ, Azarnoff DL. 1974. Bioavailability of aminosalicylic acid and its various salts in humans. 3. Absorption from tablets. J. Pharm. Sci. 63:708-711.
    • (1974) J. Pharm. Sci. , vol.63 , pp. 708-711
    • Wan, S.H.1    Pentikainen, P.J.2    Azarnoff, D.L.3
  • 28
    • 84897452695 scopus 로고    scopus 로고
    • Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent
    • Michaud V, Kreutz Y, Skaar T, Ogburn E, Thong N, Flockhart DA, Desta Z. 2014. Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent. Pharmacogenomics J. 14:151-159. http: //dx.doi.org/10.1038/tpj,2013,17.
    • (2014) Pharmacogenomics J. , vol.14 , pp. 151-159
    • Michaud, V.1    Kreutz, Y.2    Skaar, T.3    Ogburn, E.4    Thong, N.5    Flockhart, D.A.6    Desta, Z.7
  • 29
    • 84877861235 scopus 로고    scopus 로고
    • Model-based estimates of the effects of efavirenz on bedaquiline pharmacokinetics and suggested dose adjustments for patients coinfected with HIV and tuberculosis
    • Svensson EM, Aweeka F, Park JG, Marzan F, Dooley KE, Karlsson MO. 2013. Model-based estimates of the effects of efavirenz on bedaquiline pharmacokinetics and suggested dose adjustments for patients coinfected with HIV and tuberculosis. Antimicrob. Agents Chemother. 57:2780-2787. http://dx.doi.org/10.1128/AAC.00191-13 .
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 2780-2787
    • Svensson, E.M.1    Aweeka, F.2    Park, J.G.3    Marzan, F.4    Dooley, K.E.5    Karlsson, M.O.6
  • 30
    • 84872175723 scopus 로고    scopus 로고
    • Unexpected drug-drug interactions in human immunodeficiency virus (HIV) therapy: Induction of UGT1A1 and bile efflux transporters by efavirenz
    • Lee LS, Pham P, Flexner C. 2012. Unexpected drug-drug interactions in human immunodeficiency virus (HIV) therapy: induction of UGT1A1 and bile efflux transporters by efavirenz. Ann. Acad. Med. Singapore 41: 559-562.
    • (2012) Ann. Acad. Med. Singapore , vol.41 , pp. 559-562
    • Lee, L.S.1    Pham, P.2    Flexner, C.3
  • 31
    • 84875872681 scopus 로고    scopus 로고
    • Cytochrome P450 2B6: Function, genetics, and clinical relevance
    • Turpeinen M, Zanger UM. 2012. Cytochrome P450 2B6: function, genetics, and clinical relevance. Drug Metab. Drug Interact. 27:185-197.
    • (2012) Drug Metab. Drug Interact. , vol.27 , pp. 185-197
    • Turpeinen, M.1    Zanger, U.M.2
  • 33
    • 84862916534 scopus 로고    scopus 로고
    • Effect of efavirenz on UDP-glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 activities in human liver microsomes
    • Ji HY, Lee H, Lim SR, Kim JH, Lee HS. 2012. Effect of efavirenz on UDP-glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 activities in human liver microsomes. Molecules 17:851-860. http://dx.doi.org/10.3390/molecules17010851.
    • (2012) Molecules , vol.17 , pp. 851-860
    • Ji, H.Y.1    Lee, H.2    Lim, S.R.3    Kim, J.H.4    Lee, H.S.5
  • 35
    • 6344240478 scopus 로고    scopus 로고
    • Induction of CYP3A4 by efavirenz in primary human hepatocytes: Comparison with rifampin and phenobarbital
    • Hariparsad N, Nallani SC, Sane RS, Buckley DJ, Buckley AR, Desai PB. 2004. Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J. Clin. Pharmacol. 44: 1273-1281. http://dx.doi.org/10.1177/0091270004269142 .
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 1273-1281
    • Hariparsad, N.1    Nallani, S.C.2    Sane, R.S.3    Buckley, D.J.4    Buckley, A.R.5    Desai, P.B.6
  • 36
    • 0034011272 scopus 로고    scopus 로고
    • Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: Pharmacokinetic drug interactions and antiviral activity
    • Falloon J, Piscitelli S, Vogel S, Sadler B, Mitsuya H, Kavlick MF, Yoshimura K, Rogers M, LaFon S, Manion DJ, Lane HC, Masur H. 2000. Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity. Clin. Infect. Dis. 30:313-318. http://dx.doi.org/10.1086/313667 .
    • (2000) Clin. Infect. Dis. , vol.30 , pp. 313-318
    • Falloon, J.1    Piscitelli, S.2    Vogel, S.3    Sadler, B.4    Mitsuya, H.5    Kavlick, M.F.6    Yoshimura, K.7    Rogers, M.8    LaFon, S.9    Manion, D.J.10    Lane, H.C.11    Masur, H.12
  • 37
  • 38
    • 0035034313 scopus 로고    scopus 로고
    • The pharmacokinetics of methadone in HIV-positive pa-tients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz
    • Clarke SM, Mulcahy FM, Tjia J, Reynolds HE, Gibbons SE, Barry MG, Back DJ. 2001. The pharmacokinetics of methadone in HIV-positive pa-tients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz. Br. J. Clin. Pharmacol. 51:213-217. http://dx.doi.Org/10.1046/j.13652125.2001.00342.x .
    • (2001) Br. J. Clin. Pharmacol. , vol.51 , pp. 213-217
    • Clarke, S.M.1    Mulcahy, F.M.2    Tjia, J.3    Reynolds, H.E.4    Gibbons, S.E.5    Barry, M.G.6    Back, D.J.7
  • 39
    • 82755165151 scopus 로고    scopus 로고
    • Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients
    • Yimer G, Ueda N, Habtewold A, Amogne W, Suda A, Riedel KD, Burhenne J, Aderaye G, Lindquist L, Makonnen E, Aklillu E. 2011. Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients. PLoS One 6:e27810. http://dx.doi.org/10.1371/journal.pone.0027830 .
    • (2011) PLoS One , vol.6 , pp. e27810
    • Yimer, G.1    Ueda, N.2    Habtewold, A.3    Amogne, W.4    Suda, A.5    Riedel, K.D.6    Burhenne, J.7    Aderaye, G.8    Lindquist, L.9    Makonnen, E.10    Aklillu, E.11
  • 40
    • 34547636549 scopus 로고    scopus 로고
    • Complications of antiretroviral therapy in patients with tuberculosis: Drug interactions, toxicity, and immune reconstitution inflammatory syndrome
    • Suppl 1
    • McIlleron H, Meintjes G, Burman WJ, Maartens G. 2007. Complications of antiretroviral therapy in patients with tuberculosis: drug interactions, toxicity, and immune reconstitution inflammatory syndrome. J. Infect. Dis. 196(Suppl 1):S63-S75. http://dx.doi.org/10.1086/518655 .
    • (2007) J. Infect. Dis. , vol.196 , pp. S63-S75
    • McIlleron, H.1    Meintjes, G.2    Burman, W.J.3    Maartens, G.4
  • 41
    • 0037015184 scopus 로고    scopus 로고
    • Guidelines for using antiretroviral agents among HIV-infected adults and adolescents
    • Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK. 2002. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann. Intern. Med. 137:381-433. http://dx.doi.org/10.7326/0003-4819-137-5> .,Part .,2-200209031-00001.
    • (2002) Ann. Intern. Med. , vol.137 , pp. 381-433
    • Dybul, M.1    Fauci, A.S.2    Bartlett, J.G.3    Kaplan, J.E.4    Pau, A.K.5
  • 42
    • 0002556014 scopus 로고    scopus 로고
    • Antimycobacterial agents: Paraaminosalicylic acid
    • Yu VL, Merigan TC, Barriere S, White NJ (ed) Williams and Wilkins, Baltimore, MD
    • Berning SE, Peloquin CA. 1998. Antimycobacterial agents: paraaminosalicylic acid, p 663-668. In Yu VL, Merigan TC, Barriere S, White NJ (ed), Antimicrobial chemotherapy. Williams and Wilkins, Baltimore, MD.
    • (1998) Antimicrobial Chemotherapy. , pp. 663-668
    • Berning, S.E.1    Peloquin, C.A.2
  • 44
    • 70449205306 scopus 로고
    • Clinical use of a single daily dose of paraaminosalicylic acid in association with isoniazid
    • Bridge EV, Carr DT. 1958. Clinical use of a single daily dose of paraaminosalicylic acid in association with isoniazid. Am. Rev. Tuberc. 78: 749-752.
    • (1958) Am. Rev. Tuberc. , vol.78 , pp. 749-752
    • Bridge, E.V.1    Carr, D.T.2
  • 46
    • 0014453675 scopus 로고
    • The role of the metabolism of p-aminosalicylic acid (PAS) in the treatment of tuberculosis. Interaction with the metabolism of isonicotinic acid hydrazide (INH) and the synthesis of cholesterol
    • Lehmann J. 1969. The role of the metabolism of p-aminosalicylic acid (PAS) in the treatment of tuberculosis. Interaction with the metabolism of isonicotinic acid hydrazide (INH) and the synthesis of cholesterol. Scand. J. Respir. Dis. 50:169-185.
    • (1969) Scand. J. Respir. Dis. , vol.50 , pp. 169-185
    • Lehmann, J.1
  • 47
    • 84875798265 scopus 로고
    • Effect of single and of double daily doses of para-aminosalicylic acid in tuberculosis of guinea pigs
    • Karslon AG, Carr DT. 1958. Effect of single and of double daily doses of para-aminosalicylic acid in tuberculosis of guinea pigs. Am. Rev. Tuberc. 78:753-759.
    • (1958) Am. Rev. Tuberc. , vol.78 , pp. 753-759
    • Karslon, A.G.1    Carr, D.T.2
  • 48
    • 0018902646 scopus 로고
    • The early bactericidal activity of drugs in patients with pulmonary tuberculosis
    • Jindani A, Aber VR, Edwards EA, Mitchison DA. 1980. The early bactericidal activity of drugs in patients with pulmonary tuberculosis. Am. Rev. Respir. Dis. 121:939-949.
    • (1980) Am. Rev. Respir. Dis. , vol.121 , pp. 939-949
    • Jindani, A.1    Aber, V.R.2    Edwards, E.A.3    Mitchison, D.A.4
  • 49
    • 0345436371 scopus 로고
    • Prevention of streptomycin resistance by combined chemotherapy
    • British Medical Journal
    • British Medical Journal. 1952. Prevention of streptomycin resistance by combined chemotherapy. Br Med. J. 1:1157-1162. http://dx.doi.org/10.1136/bmj.1.4769.1157 .
    • (1952) Br Med. J. , vol.1 , pp. 1157-1162
  • 50
    • 84965314501 scopus 로고
    • Isoniazid in combination with streptomycin or with P.A.S. In the treatment of pulmonary tuberculosis
    • British Medical Journal
    • British Medical Journal. 1953. Isoniazid in combination with streptomycin or with P.A.S. in the treatment of pulmonary tuberculosis. Br Med. J. 2:1005-1014. http://dx.doi.Org/10.1136/bmj.2.4844.I005 .
    • (1953) Br Med. J. , vol.2 , pp. 1005-1014
  • 51
    • 0344142719 scopus 로고
    • Bactericidal activity of streptomycin and isoniazid in combination with p-aminosalicylic acid against Mycobacterium tuberculosis
    • Singh B, Mitchison DA. 1955. Bactericidal activity of streptomycin and isoniazid in combination with p-aminosalicylic acid against Mycobacterium tuberculosis. J. Gen. Microbiol. 12:76-84. http://dx.doi.org/10.1099/00221287-12-1-76 .
    • (1955) J. Gen. Microbiol. , vol.12 , pp. 76-84
    • Singh, B.1    Mitchison, D.A.2
  • 53
    • 3142583521 scopus 로고    scopus 로고
    • The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria
    • Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ. 2004. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol. Microbiol. 53:275-282. http://dx.doi.Org/10.1111/j.1365-2958.2004.04120.x .
    • (2004) Mol. Microbiol. , vol.53 , pp. 275-282
    • Rengarajan, J.1    Sassetti, C.M.2    Naroditskaya, V.3    Sloutsky, A.4    Bloom, B.R.5    Rubin, E.J.6
  • 54
    • 0003235774 scopus 로고
    • Plasma concentrations of isoniazid in the treatment of tuberculosis
    • Davies D, Pritchard B (ed) Macmillan, London, United Kingdom
    • Mitchison D. 1973. Plasma concentrations of isoniazid in the treatment of tuberculosis, p 171-182. In Davies D, Pritchard B (ed), Biological effects of drugs in relation to their plasma concentrations. Macmillan, London, United Kingdom.
    • (1973) Biological Effects of Drugs in Relation to Their Plasma Concentrations. , pp. 171-182
    • Mitchison, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.