Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 34, Issue 5, 2007, Pages 711-726

  Savic, Radojka M ^a   Jonker, Daniël M ^a,b   Kerbusch, Thomas ^a,c   Karlsson, Mats O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NOVO NORDISK A S   (Denmark)

^c NV Organon ^*  (Netherlands)

Author keywords

Absorption delay; LAG model; NONMEM; Pharmacokinetics; TRANSIT model

Indexed keywords

AMILORIDE; FUROSEMIDE; GLIBENCLAMIDE; MOXONIDINE; PLACEBO;

ADULT; AGED; ARTICLE; COMPARTMENT MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DOSE ESCALATION; DRUG METABOLISM; FEMALE; HUMAN; INTERMETHOD COMPARISON; LAG TIME MODEL; MAJOR CLINICAL STUDY; MALE; PHARMACOLOGICAL PARAMETERS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL MODEL; TRANSIT COMPARTMENT MODEL;

ABSORPTION; ADULT; AGED; AGED, 80 AND OVER; AMILORIDE; FEMALE; FUROSEMIDE; GLYBURIDE; HUMANS; IMIDAZOLES; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS;

EID: 34748854885     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-007-9066-0     Document Type: Article

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