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Interactions between natural health products and antiretroviral drugs: Pharmacokinetic and pharmacodynamic effects
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Sustiva (efavirenz) Tablets
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Pharmacokinetics of indinavir at 800, 600, and 400 milligrams administered with ritonavir at 100 milligrams and efavirenz in ethnic chinese patients infected with human immunodeficiency virus
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Lee LS, Panchalingam A, Yap MC, Paton NI. Pharmacokinetics of indinavir at 800, 600, and 400 milligrams administered with ritonavir at 100 milligrams and efavirenz in ethnic chinese patients infected with human immunodeficiency virus. Antimicrob Agents Chemother 2004;48:4476-8.
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Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteers
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Soon GH, Shen P, Yong EL, Pham P, Flexner C, Lee L. Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteers. Antimicrob Agents Chemother 2010;54:2775-80.
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Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir
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Iwamoto M, Wenning LA, Petry AS, Laethem M, De Smet M, Kost JT et al. Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob Agents Chemother 2008;52:4338-43.
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Simultaneous determination of raltegravir and raltegravir glucuroniDe in human plasma by liquid chromatography-tandem mass spectrometric method
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Wang LZ, Lee LS, Thuya WL, Soon GH, Kong LR, Nye PL, et al. Simultaneous determination of raltegravir and raltegravir glucuroniDe in human plasma by liquid chromatography-tandem mass spectrometric method. J Mass Spectrom 2011;46:202-8.
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Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius
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Lee LS, Wise SD, Chan C, Parsons TL, Flexner C, Lietman PS. Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius. J Clin Pharmacol 2008;48:599-609.
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Induction of chemoprotective phase 2 enzymes by ginseng and its components
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Lee LS, Stephenson KK, Fahey JW, Parsons TL, Lietman PS, AndraDe AS, et al. Induction of chemoprotective phase 2 enzymes by ginseng and its components. Planta Med 2009;75:1129-33.
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Differential effects of tipranavir plus ritonavir on atorvastatin or rosuvastatin pharmacokinetics in healthy volunteers
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Pham PA, la Porte CJ, Lee LS, Van Heeswijk R, Sabo JP, Elgadi MM, et al. Differential effects of tipranavir plus ritonavir on atorvastatin or rosuvastatin pharmacokinetics in healthy volunteers. Antimicrob Agents Chemother 2009;53:4385-92.
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Pham, P.A.1
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Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes
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Jemnitz K, Veres Z, Tugyi R, Vereczkey L. Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes. Toxicol In Vitro 2010;24:605-10.
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Vlaming ML, Van Esch A, Van De Steeg E, Pala Z, Wagenaar E, Van Tellingen O, et al. Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate. Drug Metab Dispos 2011;39:1338-44.
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Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, et al. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther 2007;320:72-80.
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Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers
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Lee LS, Soon GH, Shen P, Yong EL, Flexner C, Pham P. Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers. Antivir Ther 2010;15:275-9.
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