-
1
-
-
0035891783
-
Remodeling of the airway epithelium in asthma
-
Fahy JV,. Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 2001; 164: S46-S51.
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. S46-S51
-
-
Fahy, J.V.1
-
2
-
-
4544274172
-
A critical role for eosinophils in allergic airways remodeling
-
Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, et al. A critical role for eosinophils in allergic airways remodeling. Science 2004; 305: 1776-1779.
-
(2004)
Science
, vol.305
, pp. 1776-1779
-
-
Humbles, A.A.1
Lloyd, C.M.2
McMillan, S.J.3
Friend, D.S.4
Xanthou, G.5
McKenna, E.E.6
-
3
-
-
75849142853
-
Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma
-
Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, et al. Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma. J Allergy Clin Immunol 2010; 125: 349-356.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 349-356
-
-
Kelly, M.M.1
O'Connor, T.M.2
Leigh, R.3
Otis, J.4
Gwozd, C.5
Gauvreau, G.M.6
-
4
-
-
79957512933
-
Effect of bronchoconstriction on airway remodeling in asthma
-
Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med 2011; 364: 2006-2015.
-
(2011)
N Engl J Med
, vol.364
, pp. 2006-2015
-
-
Grainge, C.L.1
Lau, L.C.2
Ward, J.A.3
Dulay, V.4
Lahiff, G.5
Wilson, S.6
-
5
-
-
2442457727
-
Mechanotransduction through growth-factor shedding into the extracellular space
-
Tschumperlin DJ, Dai G, Maly IV, Kikuchi T, Laiho LH, McVittie AK, et al. Mechanotransduction through growth-factor shedding into the extracellular space. Nature 2004; 429: 83-86.
-
(2004)
Nature
, vol.429
, pp. 83-86
-
-
Tschumperlin, D.J.1
Dai, G.2
Maly, I.V.3
Kikuchi, T.4
Laiho, L.H.5
McVittie, A.K.6
-
6
-
-
0038218405
-
Sphingosine-1-phosphate: An enigmatic signalling lipid
-
Spiegel S, Milstien S,. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003; 4: 397-407.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 397-407
-
-
Spiegel, S.1
Milstien, S.2
-
7
-
-
52949108813
-
The alliance of sphingosine-1-phosphate and its receptors in immunity
-
Rivera J, Proia RL, Olivera A,. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol 2008; 8: 753-763.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 753-763
-
-
Rivera, J.1
Proia, R.L.2
Olivera, A.3
-
8
-
-
84856066049
-
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
-
Milara J, Navarro R, Juan G, Peiro T, Serrano A, Ramon M, et al. Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. Thorax 2012; 67: 147-156.
-
(2012)
Thorax
, vol.67
, pp. 147-156
-
-
Milara, J.1
Navarro, R.2
Juan, G.3
Peiro, T.4
Serrano, A.5
Ramon, M.6
-
9
-
-
0026049696
-
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
-
Zhang H, Desai NN, Olivera A, Seki T, Brooker G, Spiegel S,. Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol 1991; 114: 155-167.
-
(1991)
J Cell Biol
, vol.114
, pp. 155-167
-
-
Zhang, H.1
Desai, N.N.2
Olivera, A.3
Seki, T.4
Brooker, G.5
Spiegel, S.6
-
10
-
-
84878240485
-
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling
-
Sobel K, Menyhart K, Killer N, Renault B, Bauer Y, Studer R, et al. Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem 2013; 288: 14839-14851.
-
(2013)
J Biol Chem
, vol.288
, pp. 14839-14851
-
-
Sobel, K.1
Menyhart, K.2
Killer, N.3
Renault, B.4
Bauer, Y.5
Studer, R.6
-
11
-
-
84883427602
-
Sphingolipids and susceptibility to asthma
-
Levy BD,. Sphingolipids and susceptibility to asthma. N Engl J Med 2013; 369: 976-978.
-
(2013)
N Engl J Med
, vol.369
, pp. 976-978
-
-
Levy, B.D.1
-
12
-
-
77957113600
-
A large-scale, consortium-based genomewide association study of asthma
-
Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-1221.
-
(2010)
N Engl J Med
, vol.363
, pp. 1211-1221
-
-
Moffatt, M.F.1
Gut, I.G.2
Demenais, F.3
Strachan, D.P.4
Bouzigon, E.5
Heath, S.6
-
13
-
-
77955921529
-
Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
-
Sun X, Ma SF, Wade MS, Flores C, Pino-Yanes M, Moitra J, et al. Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility. J Allergy Clin Immunol 2010; 126: 241-249.
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 241-249
-
-
Sun, X.1
Ma, S.F.2
Wade, M.S.3
Flores, C.4
Pino-Yanes, M.5
Moitra, J.6
-
14
-
-
0035348292
-
Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
-
Ammit AJ, Hastie AT, Edsall LC, Hoffman RK, Amrani Y, Krymskaya VP, et al. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J 2001; 15: 1212-1214.
-
(2001)
FASEB J
, vol.15
, pp. 1212-1214
-
-
Ammit, A.J.1
Hastie, A.T.2
Edsall, L.C.3
Hoffman, R.K.4
Amrani, Y.5
Krymskaya, V.P.6
-
15
-
-
84872389819
-
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model
-
Kleinjan A, van Nimwegen M, Leman K, Hoogsteden HC, Lambrecht BN,. Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. Allergy 2013; 68: 204-212.
-
(2013)
Allergy
, vol.68
, pp. 204-212
-
-
Kleinjan, A.1
Van Nimwegen, M.2
Leman, K.3
Hoogsteden, H.C.4
Lambrecht, B.N.5
-
16
-
-
84873409675
-
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma
-
Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, et al. A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. J Allergy Clin Immunol 2013; 131: 501-511.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 501-511
-
-
Price, M.M.1
Oskeritzian, C.A.2
Falanga, Y.T.3
Harikumar, K.B.4
Allegood, J.C.5
Alvarez, S.E.6
-
17
-
-
84858336829
-
Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma
-
Yick CY, Ferreira DS, Annoni R, von der Thusen JH, Kunst PW, Bel EH, et al. Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma. Allergy 2012; 67: 552-559.
-
(2012)
Allergy
, vol.67
, pp. 552-559
-
-
Yick, C.Y.1
Ferreira, D.S.2
Annoni, R.3
Von Der Thusen, J.H.4
Kunst, P.W.5
Bel, E.H.6
-
18
-
-
8544230635
-
Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis
-
Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997; 156: 591-599.
-
(1997)
Am J Respir Crit Care Med
, vol.156
, pp. 591-599
-
-
Vignola, A.M.1
Chanez, P.2
Chiappara, G.3
Merendino, A.4
Pace, E.5
Rizzo, A.6
-
19
-
-
77951695782
-
Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma
-
Hassan M, Jo T, Risse PA, Tolloczko B, Lemiere C, Olivenstein R, et al. Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma. J Allergy Clin Immunol 2010; 125: 1037-1045.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1037-1045
-
-
Hassan, M.1
Jo, T.2
Risse, P.A.3
Tolloczko, B.4
Lemiere, C.5
Olivenstein, R.6
-
20
-
-
0141780843
-
Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells
-
Rosenfeldt HM, Amrani Y, Watterson KR, Murthy KS, Panettieri RA Jr, Spiegel S,. Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB J 2003; 17: 1789-1799.
-
(2003)
FASEB J
, vol.17
, pp. 1789-1799
-
-
Rosenfeldt, H.M.1
Amrani, Y.2
Watterson, K.R.3
Murthy, K.S.4
Panettieri, R.A.5
Spiegel, S.6
-
21
-
-
79957610938
-
The outs and the ins of sphingosine-1-phosphate in immunity
-
Spiegel S, Milstien S,. The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol 2011; 11: 403-415.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 403-415
-
-
Spiegel, S.1
Milstien, S.2
-
22
-
-
67649771753
-
Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma
-
Mahn K, Hirst SJ, Ying S, Holt MR, Lavender P, Ojo OO, et al. Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma. Proc Natl Acad Sci USA 2009; 106: 10775-10780.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 10775-10780
-
-
Mahn, K.1
Hirst, S.J.2
Ying, S.3
Holt, M.R.4
Lavender, P.5
Ojo, O.O.6
-
23
-
-
33747132952
-
Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells
-
Chan V, Burgess JK, Ratoff JC, O'Connor BJ, Greenough A, Lee TH, et al. Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med 2006; 174: 379-385.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 379-385
-
-
Chan, V.1
Burgess, J.K.2
Ratoff, J.C.3
O'Connor, B.J.4
Greenough, A.5
Lee, T.H.6
-
24
-
-
84874632934
-
Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes
-
Foster HR, Fuerst E, Lee TH, Cousins DJ, Woszczek G,. Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes. PLoS One 2013; 8: e58305.
-
(2013)
PLoS One
, vol.8
, pp. e58305
-
-
Foster, H.R.1
Fuerst, E.2
Lee, T.H.3
Cousins, D.J.4
Woszczek, G.5
-
25
-
-
0025904265
-
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
-
Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M,. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 1991; 251: 936-939.
-
(1991)
Science
, vol.251
, pp. 936-939
-
-
Higashiyama, S.1
Abraham, J.A.2
Miller, J.3
Fiddes, J.C.4
Klagsbrun, M.5
-
26
-
-
84855791275
-
An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma
-
Damera G, Druey KM, Cooper PR, Krymskaya VP, Soberman RJ, Amrani Y, et al. An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma. PLoS One 2012; 7: e28504.
-
(2012)
PLoS One
, vol.7
, pp. e28504
-
-
Damera, G.1
Druey, K.M.2
Cooper, P.R.3
Krymskaya, V.P.4
Soberman, R.J.5
Amrani, Y.6
-
27
-
-
84861870816
-
UPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
-
Stewart CE, Nijmeh HS, Brightling CE, Sayers I,. uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium. Thorax 2012; 67: 477-487.
-
(2012)
Thorax
, vol.67
, pp. 477-487
-
-
Stewart, C.E.1
Nijmeh, H.S.2
Brightling, C.E.3
Sayers, I.4
-
28
-
-
0037130962
-
Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin
-
Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT,. Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin. Circ Res 2002; 91: 689-695.
-
(2002)
Circ Res
, vol.91
, pp. 689-695
-
-
Schulze, P.C.1
De Keulenaer, G.W.2
Yoshioka, J.3
Kassik, K.A.4
Lee, R.T.5
-
29
-
-
52149084591
-
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells
-
Chen LY, Woszczek G, Nagineni S, Logun C, Shelhamer JH,. Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008; 295: L326-L335.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.295
, pp. L326-L335
-
-
Chen, L.Y.1
Woszczek, G.2
Nagineni, S.3
Logun, C.4
Shelhamer, J.H.5
-
30
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
-
Rosen H, Goetzl EJ,. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat Rev Immunol 2005; 5: 560-570.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
31
-
-
1842682019
-
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis
-
Jolly PS, Bektas M, Olivera A, Gonzalez-Espinosa C, Proia RL, Rivera J, et al. Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 2004; 199: 959-970.
-
(2004)
J Exp Med
, vol.199
, pp. 959-970
-
-
Jolly, P.S.1
Bektas, M.2
Olivera, A.3
Gonzalez-Espinosa, C.4
Proia, R.L.5
Rivera, J.6
-
32
-
-
0037198418
-
Mast-cell infiltration of airway smooth muscle in asthma
-
Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID,. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002; 346: 1699-1705.
-
(2002)
N Engl J Med
, vol.346
, pp. 1699-1705
-
-
Brightling, C.E.1
Bradding, P.2
Symon, F.A.3
Holgate, S.T.4
Wardlaw, A.J.5
Pavord, I.D.6
-
33
-
-
79959369140
-
The sentinel role of the airway epithelium in asthma pathogenesis
-
Holgate ST,. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev 2011; 242: 205-219.
-
(2011)
Immunol Rev
, vol.242
, pp. 205-219
-
-
Holgate, S.T.1
-
34
-
-
0026606394
-
Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study
-
Jeffery PK, Godfrey RW, Adelroth E, Nelson F, Rogers A, Johansson SA,. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis 1992; 145: 890-899.
-
(1992)
Am Rev Respir Dis
, vol.145
, pp. 890-899
-
-
Jeffery, P.K.1
Godfrey, R.W.2
Adelroth, E.3
Nelson, F.4
Rogers, A.5
Johansson, S.A.6
-
35
-
-
3242680392
-
Modulation of adaptive immune responses by sphingosine-1-phosphate
-
Payne SG, Milstien S, Barbour SE, Spiegel S,. Modulation of adaptive immune responses by sphingosine-1-phosphate. Semin Cell Dev Biol 2004; 15: 521-527.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 521-527
-
-
Payne, S.G.1
Milstien, S.2
Barbour, S.E.3
Spiegel, S.4
-
36
-
-
15244350900
-
Regulation of immunity by lysosphingolipids and their G protein-coupled receptors
-
Goetzl EJ, Rosen H,. Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest 2004; 114: 1531-1537.
-
(2004)
J Clin Invest
, vol.114
, pp. 1531-1537
-
-
Goetzl, E.J.1
Rosen, H.2
-
37
-
-
0036551246
-
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses
-
Idzko M, Panther E, Corinti S, Morelli A, Ferrari D, Herouy Y, et al. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J 2002; 16: 625-627.
-
(2002)
FASEB J
, vol.16
, pp. 625-627
-
-
Idzko, M.1
Panther, E.2
Corinti, S.3
Morelli, A.4
Ferrari, D.5
Herouy, Y.6
|