Blood schizontocidal and gametocytocidal activity of 3-hydroxy- N -arylidenepropanehydrazonamides: A new class of antiplasmodial compounds

Journal of Medicinal Chemistry

Volumn 57, Issue 19, 2014, Pages 7971-7976

  Leven, Michael ^a   Held, Jana ^b   Duffy, Sandra ^c   Tschan, Serena ^b   Sax, Sibylle ^d,e   Kamber, Jolanda ^d,e   Frank, Walter ^a   Kuna, Krystina ^a   Geffken, Detlef ^f   Siethoff, Christoph ^g   Barth, Stéphane ^g   Avery, Vicky M ^c   Wittlin, Sergio ^d,e   Mordmüller, Benjamin ^b,h   Kurz, Thomas ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GRIFFITH UNIVERSITY   (Australia)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

^f UNIVERSITY OF HAMBURG   (Germany)

^g Institut für Pharmazie Universität Hamburg ^*  (Switzerland)

^h Centre de Recherches Médicales de Lambaréné HÔpital Albert Schweitzer   (Gabon)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY N' ARYLIDENEPROPANEHYDRAZONAMIDE DERIVATIVE; ANTIMALARIAL AGENT; PHENANTHRENE; UNCLASSIFIED DRUG; CHLOROQUINE; PHENANTHRENE DERIVATIVE;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; BLOOD SCHIZONTOCIDAL ACTIVITY; DRUG ACTIVITY; DRUG STRUCTURE; GAMETOCYTE; GAMETOCYTOCIDAL ACTIVITY; IN VIVO STUDY; MYOBLAST; NONHUMAN; PARASITE CLEARANCE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RAT; ANIMAL; DRUG EFFECTS; DRUG SENSITIVITY; MALARIA; MOUSE; PARASITEMIA; PARASITOLOGY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; MALARIA; MICE; PARASITEMIA; PARASITIC SENSITIVITY TESTS; PHENANTHRENES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907903684     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500811p     Document Type: Article

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