Genome-wide identification and expression analyses of cytochrome P450 genes in mulberry (Morus notabilis)

Journal of Integrative Plant Biology

Volumn 56, Issue 9, 2014, Pages 887-901

  Ma, Bi ^a   Luo, Yiwei ^a   Jia, Ling ^a   Qi, Xiwu ^a   Zeng, Qiwei ^a   Xiang, Zhonghuai ^a   He, Ningjia ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Cytochrome P450; Metabolism; Morus notabilis; Pathway; Silkworm

Indexed keywords

ANGIOSPERM; CYTOCHROME; METABOLISM; PHYSIOLOGY;

BOMBYX MORI; MORUS (PLANT);

CYTOCHROME P450;

ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MORUS; PHYLOGENY; PLANT GENOME; POLYMERASE CHAIN REACTION;

CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, PLANT; GENOME, PLANT; MORUS; PHYLOGENY; POLYMERASE CHAIN REACTION;

EID: 84907902606     PISSN: 16729072     EISSN: 17447909     Source Type: Journal    
DOI: 10.1111/jipb.12141     Document Type: Article

References (82)

1. Al-Mssallem IS, Hu S, Zhang X, Lin Q, Liu W, Tan J, Yu X, Liu J, Pan L, Zhang T, Yin Y, Xin C, Wu H, Zhang G, Ba Abdullah MM, Huang D, Fang Y, Alnakhli YO, Jia S, Yin A, Alhuzimi EM, Alsaihati BA, Al-Owayyed SA, Zhao D, Zhang S, Al-Otaibi NA, Sun G, Majrashi MA, Li F Tala Wang J, Yun Q, Alnassar NA, Wang L, Yang M, Al-Jelaify RF, Liu K, Gao S, Chen K, Alkhaldi SR, Liu G, Zhang M, Guo H, Yu J, (2013) Genome sequence of the date palm Phoenix dactylifera L. Nat Commun 4: 2274
2. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215: 403-410
3. Bae SH, Suh HJ (2007) Antioxidant activities of five different mulberry cultivars in Korea. Lwt-Food Sci Technol 40: 955-962
4. Bailey TL, Elkan C (1994) Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc Int Conf Intell Syst Mol Biol 2: 28-36
5. Bailey TL, Gribskov M (1998) Combining evidence using p-values: Application to sequence homology searches. Bioinformatics 14: 48-54
6. Bak S, Beisson F, Bishop G, Hamberger B, Höfer R, Paquette S, Werck-Reichhart D (2011) Cytochromes P450. In: Rob Last, ed. The Arabidopsis Book. American Society of Plant Biologists. Rockville. pp. e0144.
7. Barber EJW (1991) Prehistoric textiles: The development of cloth in the Neolithic and Bronze Ages. Princeton University Press, Princeton. pp. 587-592
8. Berenbaum MR (1990) Evolution of specialization in insect-umbellifer associations. Annu Rev Entomol 35: 319-343
9. Berg CC (2001) Moreae, Artocarpeae, and Dorstenia (Moraceae): With Introductions to the Family and Ficus and with Additions and Corrections to Flora Neotropica Monograph 7, Organization for Flora Neotropica, The New York Botanical Garden, New York.
10. Berg CC (2005) Moraceae diversity in a global perspective. In: Friis I, Balslev H, eds. Proceedings of an International Symposium on Plant Diversity and Complexity Patterns-Local, Regional and Global Dimensions. Biologiske Skrifter 55. Ejnar Munksgaard, Denmark. pp. 423-440
11. Burge CB, Karlin S (1998) Finding the genes in genomic DNA. Curr Opin Struct Biol 8: 346-354
12. Chang LW, Juang LJ, Wang BS, Wang MY, Tai HM, Hung WJ, Chen YJ,Huang MH (2011) Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark. Food Chem Toxicol 49: 785-790
13. Cheng AX, Lou YG, Mao YB, Lu S, Wang LJ, Chen XY (2007) Plant terpenoids: Biosynthesis and ecological functions. J Integr Plant Biol 49: 179-186
14. Cheng DW, Lin H, Takahashi Y, Walker MA, Civerolo EL, Stenger DC (2010) Transcriptional regulation of the grape cytochrome P450 monooxygenase gene CYP736B expression in response to Xylella fastidiosa infection. BMC Plant Biol 10: 135
15. Conesa A, Götz S (2008) Blast2GO: A comprehensive suite for functional analysis in plant genomics. Int J Plant Genomics 2008: 619832. doi: 10.1155/2008/619832
16. Daimon T, Taguchi T, Meng Y, Katsuma S, Mita K, Shimada T (2008) b-Fructofuranosidase Genes of the Silkworm, Bombyx mori: Insight into enzymatic adaptation of B. mor to toxic alkaloids in mulberry latex. J Biol Chem 283: 15271-15279
17. Darias-Martín J, Lobo-Rodrigo G, Hernández-Cordero J, Díaz-Díaz E,Díaz-Romero C (2003) Alcoholic beverages obtained from black mulberry. Food Technol Biotechnol 41: 173-176
18. Despres L, David JP, Gallet C (2007) The evolutionary ecology of insect resistance to plant chemicals. Trends Ecol Evol 22: 298-307
19. Doi K, Kojima T, Makino M, Kimura Y, Fujimoto Y (2001) Studies on the constituents of the leaves of Morus alba L. ChemPharmBull 49: 151-153
20. Durst F, Nelson DR (1995) Diversity and evolution of plant P450 and P450-reductases. Drug Metabol Drug Interact 12: 189-206
21. Eddy SR (2011) Accelerated profileHMMsearches. PLoS Comput Biol 7: e1002195
22. Ercisli S, Orhan E (2007) Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits. Food Chem 103: 1380-1384
23. Facchini PJ (2001) Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu Rev Plant Physiol Plant Mol Biol 52: 29-66
24. Gotoh O (1993) Structure of P-450 genes in cytochrome P-450. In: Omura T, Ishimura Y, Fujii-Kuriyama Y, eds. Cytochrome P-450, 2nd edition Kodansha, Tokyo. pp. 207-223
25. Gotoh O (1998) Divergent structures of Caenorhabditis elegans cytochrome P450 genes suggest the frequent loss and gain of introns during the evolution of nematodes.Mol Biol Evol 15: 1447-1459
26. Guo AY, Zhu QH, Chen X, Luo JC (2007) GSDS: A gene structure display server. Yi Chuan 29: 1023-1026
27. Guo S, Zhang J, Sun H, Salse J, Lucas WJ, Zhang H, Zheng Y, Mao L, Ren Y, Wang Z, Min J, Guo X, Murat F, Ham BK, Zhang Z, Gao S, Huang M, Xu Y, Zhong S, Bombarely A, Mueller LA, Zhao H, He H, Zhang Y, Zhang Z, Huang S, Tan T, Pang E, Lin K, Hu Q, Kuang H, Ni P, Wang B, Liu J, Kou Q, Hou W, Zou X, Jiang J, Gong G, Klee K, Schoof H, Huang Y, Hu X, Dong S, Liang D, Wang J, Wu K, Xia Y, Zhao X, Zheng Z, Xing M, Liang X, Huang B, Lv T, Wang J, Yin Y, Yi H, Li R, Wu M, Levi A, Zhang X, Giovannoni JJ, Wang J, Li Y, Fei Z, Xu Y (2013) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet 45: 51-58
28. Guttikonda SK, Trupti J, Bisht NC, Chen H, An YQ, Pandey S, Xu D, Yu O (2010) Whole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases. BMC Plant Biol 10: 243
29. Hahlbrock K, Scheel D (1989) Physiology and molecular-biology of phenylpropanoid metabolism. Annu Rev Plant Physiol Plant Mol Biol 40: 347-369
30. Hassimotto N, Genovese M, Lajolo F (2007) Identification and characterisation of anthocyanins from wild mulberry (Morus nigra L.) growing in Brazil. Food Sci Technol Int 13: 17-25
31. He N, Zhang C, Qi X, Zhao S, Tao Y, Yang G, Lee T.-H, Wang X, Cai Q, Li D, Lu M, Liao S, Luo G, He R, Tan X, Xu Y, Li T, Zhao A, Jia L, Fu Q, Gao C, Ma B, Liang J, Wang X, Shang J, Song P,WuH, Fan L, Wang Q, Shuai Q, Zhu J, Wei C, Zhu-Salzman K, Jin D, Wang J, Liu T, Yu M, Tang C, Wang Z, Dai F, Chen J, Liu Y, Zhao S, Lin T, Zhang S, Wang J, Wang J, Yang H, Yang G, Wang J, Paterson AH, Xia Q, Ji D, Xiang Z (2013) Draft genome sequence of the mulberry tree Morus notabilis. Nat Commun 4: 2445
32. Hirayama C, Konno K, Wasano N, Nakamura M (2007) Differential effects of sugar-mimic alkaloids in mulberry latex on sugar metabolism and disaccharidases of Eri and domesticated silkworms: Enzymatic adaptation of Bombyx mori to mulberry defense. Insect Biochem Mol Biol 37: 1348-1358
33. International Peach. Genome I, Verde I, Abbott AG, Scalabrin S, Jung S, Shu S, Marroni F, Zhebentyayeva T, Dettori MT, Grimwood J, Cattonaro F, Zuccolo A, Rossini L, Jenkins J, Vendramin E, Meisel LA, Decroocq V, Sosinski B, Prochnik S, Mitros T, Policriti A, Cipriani G, Dondini L, Ficklin S, Goodstein DM, Xuan P, Del Fabbro C, Aramini V, Copetti D, Gonzalez S, Horner DS, Falchi R, Lucas S, Mica E, Maldonado J, Lazzari B, Bielenberg D, Pirona R, Miculan M, Barakat A, Testolin R, Stella A, Tartarini S, Tonutti P, Arus P, Orellana A, Wells C, Main D, Vizzotto G, Silva H, Salamini F, Schmutz J, Morgante M, Rokhsar DS, (2013) The high-quality draft genome of peach (Prunus persica) identifies unique patterns of genetic diversity, domestication and genome evolution. Nat Genet 45: 487-494
34. Jensen NB, Zagrobelny M, Hjerno K, Olsen CE, Houghton-Larsen J, Borch J, Moller BL, Bak S (2011) Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects. Nat Commun 2: 273
35. Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, Katayama T, Kawashima S, Okuda S, Tokimatsu T, Yamanishi Y (2008) KEGG for linking genomes to life and the environment. Nucleic Acids Res 36: D480-D484
36. Kang JG, Yun J, Kim DH, Chung KS, Fujioka S, Kim JI, Dae HW, Yoshida S, Takatsuto S, Song PS, Park CM (2001) Light and brassinosteroid signals are integrated via a dark-induced small G protein in etiolated seedling growth. Cell 105: 625-636
37. Katsube T, Imawaka N, Kawano Y, Yamazaki Y, Shiwaku K, Yamane Y (2006) Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity. Food Chem 97: 25-31
38. Kim SY, Gao JJ, Lee WC, Ryu KS, Lee KR, Kim YC (1999) Antioxidative flavonoids from the leaves of Morus alba. Arch Pharm Res 22: 81-85
39. Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K, Oita S, Oikawa S, Miyazawa T (2007) Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 55: 5869-5874
40. Klein D (2002) Quantification using real-time PCR technology: Applications and limitations. Trends Mol Med 8: 257-260
41. Konno K, Ono H, Nakamura M, Tateishi K, Hirayama C, Tamura Y, Hattori M, Koyama A, Kohno K (2006) Mulberry latex rich in antidiabetic sugar-mimic alkaloids forces dieting on caterpillars. Proc Natl Acad Sci USA 103: 1337-1341
42. Kraus PF, Kutchan TM (1995) Molecular cloning and heterologous expression of a cDNA encoding berbamunine synthase, a C-O phenol-coupling cytochrome P450 from the higher plant Berberis stolonifera. Proc Natl Acad Sci USA 92: 2071-2075
43. Kutchan TM (1995) Alkaloid biosynthesis-the basis for metabolic engineering of medicinal plants. Plant Cell 7: 1059-1070
44. Lalitha S (2000) Primer premier 5. Biotech Softw Internet Rep 1: 270-272
45. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) ClustalWand Clustal X version 2.0. Bioinformatics 23: 2947-2948
46. Li L, Cheng H, Gai J, Yu D (2007) Genome-wide identification and characterization of putative cytochrome P450 genes in the model legume Medicago truncatula. Planta 226: 109-123
47. Mao W, Rupasinghe S, Zangerl AR, Schuler MA, Berenbaum MR (2006) Remarkable substrate-specificity of CYP6AB3 in Depressaria pastinacella, a highly specialized caterpillar. Insect Mol Biol 15: 169-179
48. McGarvey DJ, Croteau R (1995) Terpenoid metabolism. Plant Cell 7: 1015-1026
49. Mol J, Stuitje A, Gerats A, van der Krol A, Jorgensen R (1989) Saying it with genes: Molecular flower breeding. Trends Biotechnol 7: 148-153
50. Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5: 621-628
51. Murray RDH, Mendez J, Brown SA (1982) The natural coumarins. J. Wiley & Sons, Chicester, United Kingdom Nelson DR (2006) Plant cytochrome P450s from moss to poplar. Phytochem Rev 5: 193-204
52. Nelson DR (2011) Progress in tracing the evolutionary paths of cytochrome P450. Biochim Biophys Acta 1814: 14-18
53. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, Okuda K, Nebert DW (1993) The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12: 1-51
54. Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW (1996) P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6: 1-42
55. Nelson DR, Ming R, Alam M, Schuler MA (2008) Comparison of cytochrome P450 genes from six plant genomes. Tropical Plant Biology 1: 216-235
56. Nelson DR, Schuler MA, Paquette SM, Werck-Reichhart D, Bak S (2004a) Comparative genomics of rice and Arabidopsis. Analysis of 727 cytochrome P450 genes and pseudogenes from a monocot and a dicot. Plant Physiol 135: 756-772
57. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (2004b) Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenet Genomics 14: 1-18
58. Nepal MP, Ferguson CJ (2012) Phylogenetics of Morus (Moraceae) Inferred from ITS and trnL-trnF Sequence Data. Syst Bot 37: 442-450
59. Nicholas KB, Nicholas H, Deerfield D (1997) GeneDoc: Analysis and visualization of genetic variation. Embnew News 4: 14
60. Nystedt B, Street NR, Wetterbom A, Zuccolo A, Lin YC, Scofield DG, Vezzi F, Delhomme N, Giacomello S, Alexeyenko A, Vicedomini R, Sahlin K, Sherwood E, Elfstrand M, Gramzow L, Holmberg K, Hallman J, Keech O, Klasson L, Koriabine M, Kucukoglu M, Kaller M, Luthman J, Lysholm F, Niittyla T, Olson A, Rilakovic N, Ritland C, Rossello JA, Sena J, Svensson T, Talavera-Lopez C, Theissen G, Tuominen H, Vanneste K, Wu ZQ, Zhang B, Zerbe P, Arvestad L, Bhalerao R, Bohlmann J, Bousquet J, Garcia Gil R, Hvidsten TR, de Jong P, MacKay J, Morgante M, Ritland K, Sundberg B, Thompson SL, Van de Peer Y, Andersson B, Nilsson O, Ingvarsson PK, Lundeberg J, Jansson S (2013) The Norway spruce genome sequence and conifer genome evolution. Nature 497: 579-584
61. Paquette SM, Bak S, Feyereisen R (2000) Intron-exon organization and phylogeny in a large superfamily, the paralogous cytochrome P450 genes of Arabidopsis thaliana. DNA Cell Biol 19: 307-317
62. Paquette SM, Jensen K, Bak S (2009) A web-based resource for the Arabidopsis P450, cytochromes b5, NADPH-cytochrome P450 reductases, and family 1 glycosyltransferases (http://www.P450. kvl.dk). Phytochemistry 70: 1940-1947
63. Punta M, Coggill PC, Eberhardt RY, Mistry J, Tate J, Boursnell C, Pang N, Forslund K, Ceric G, Clements J, Heger A, Holm L, Sonnhammer EL, Eddy SR, Bateman A, Finn RD (2012) The Pfam protein families database. Nucleic Acids Res 40: D290-D301
64. Rosenthal GA, Berenbaum MR (1992) Herbivores: Their Interactions with Secondary Plant Metabolites. Ecological and Evolutionary Processes, Academic Press, London.
65. Rozman D, Stromstedt M, Tsui LC, Scherer SW, Waterman MR (1996) Structure and mapping of the human lanosterol 14alphademethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Genomics 38: 371-381
66. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, Quackenbush J (2006) TM4 microarray software suite. Methods Enzymol 411: 134-193
67. Saitou N, NeiM(1987) The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol Biol Evol 4: 406-425
68. Sato S, Tabata S, Hirakawa H, Asamizu E, Shirasawa K, Isobe S, Kaneko T, Nakamura Y, Shibata D, Aoki K, Egholm M, Knight J, Bogden R, Li CB, Shuang Y, Xu X, Pan SK, Cheng SF, Liu X, Ren YY, Wang J, Albiero A, Dal Pero F, Todesco S, Van Eck J, Buels RM, Bombarely A, Gosselin JR, Huang MY, Leto JA, Menda N, Strickler S, Mao LY, Gao S, Tecle IY, York T, Zheng Y, Vrebalov JT, Lee J, Zhong SL, Mueller LA, Stiekema WJ, Ribeca P, Alioto T, Yang WC, Huang SW, Du YC, Zhang ZH, Gao JC, Guo YM, Wang XX, Li Y, He J, Li CY, Cheng ZK, Zuo JR, Ren JF, Zhao JH, Yan LH, Jiang HL, Wang B, Li HS, Li ZJ, Fu FY, Chen BT, Han B, Feng Q, Fan DL, Wang Y, Ling HQ, Xue YBA, Ware D, McCombie WR, Lippman ZB, Chia JM, Jiang K, Pasternak S, Gelley L, Kramer M, Anderson LK, Chang SB, Royer SM, Shearer LA, Stack SM, Rose JKC, Xu YM, Eannetta N, Matas AJ, McQuinn R, Tanksley SD, Camara F, Guigo R, Rombauts S, Fawcett J, Van de Peer Y, Zamir D, Liang CB, Spannagl M, Gundlach H, Bruggmann R, Mayer K, Jia ZQ, Zhang JH, Ye ZBA, Bishop GJ, Butcher S, Lopez-Cobollo R, Buchan D, Filippis I, Abbott J, Dixit R, Singh M, Singh A, Pal JK, Pandit A, Singh PK, Mahato AK, Dogra V, Gaikwad K, Sharma TR, Mohapatra T, Singh NK, Causse M, Rothan C, Schiex T, Noirot C, Bellec A, Klopp C, Delalande C, Berges H, Mariette J, Frasse P, Vautrin S, Zouine M, Latche A, Rousseau C, Regad F, Pech JC, Philippot M, Bouzayen M, Pericard P, Osorio S, del Carmen AF, Monforte A, Granell A, Fernandez-Munoz R, Conte M, Lichtenstein G, Carrari F, De Bellis G, Fuligni F, Peano C, Grandillo S, Termolino P, Pietrella M, Fantini E, Falcone G, Fiore A, Giuliano G, Lopez L, Facella P, Perrotta G, Daddiego L, Bryan G, Orozco M, Pastor X, Torrents D, van Schriek KNVMGM, Feron RMC, van Oeveren J, de Heer P, daPonte L, Jacobs-Oomen S, Cariaso M, Prins M, van Eijk MJT, Janssen A, van Haaren MJJ, Jo SH, Kim J, Kwon SY, Kim S, Koo DH, Lee S, Hur CG, Clouser C, Rico A, Hallab A, Gebhardt C, Klee K, Jocker A, Warfsmann J, Gobel U, Kawamura S, Yano K, Sherman JD, Fukuoka H, Negoro S, Bhutty S, Chowdhury P, Chattopadhyay D, Datema E, Smit S, Schijlen EWM, van de Belt J, van Haarst JC, Peters SA, van Staveren MJ, Henkens MHC, Mooyman PJW, Hesselink T, van Ham RCHJ, Jiang GY, Droege M, Choi D, Kang BC, Kim BD, Park M, Kim S, Yeom SI, Lee YH, Choi YD, Li GC, Gao JW, Liu YS, Huang SX, Fernandez-Pedrosa V, Collado C, Zuniga S, Wang GP, Cade R, Dietrich RA, Rogers J, Knapp S, Fei ZJ, White RA, Thannhauser TW, Giovannoni JJ, Botella MA, Gilbert L, Gonzalez R, Goicoechea JL, Yu Y, Kudrna D, Collura K, Wissotski M, Wing R, Schoof H, Meyers BC, Gurazada AB, Green PJ, Mathur S, Vyas S, Solanke AU, Kumar R, Gupta V, Sharma AK, Khurana P, Khurana JP, Tyagi AK, Dalmay T, Mohorianu I, Walts B, Chamala S, Barbazuk WB, Li JP, Guo H, Lee TH, Wang YP, Zhang D, Paterson AH, Wang XY, Tang HB, Barone A, Chiusano ML, Ercolano MR, D'Agostino N, Di Filippo M, Traini A, Sanseverino W, Frusciante L, Seymour GB, Elharam M, Fu Y, Hua A, Kenton S, Lewis J, Lin SP, Najar F, Lai HS, Qin BF, Qu CM, Shi RH, White D, White J, Xing YB, Yang KQ, Yi J, Yao ZY, Zhou LP, Roe BA, Vezzi A, D'Angelo M, Zimbello R, Schiavon R, Caniato E, Rigobello C, Campagna D, Vitulo N, Valle G, Nelson DR, De Paoli E, Szinay D, de Jong HH, Bai YL, Visser RGF, Lankhorst RMK, Beasley H, McLaren K, Nicholson C, Riddle C, Gianese G, Consortium TG (2012) The tomato genome sequence provides insights into fleshy fruit evolution. Nature 485: 635-641
69. Schuhegger R, Nafisi M, Mansourova M, Petersen BL, Olsen CE, Svatos A, Halkier BA, Glawischnig E (2006) CYP71B15 (PAD3) catalyzes the final step in camalexin biosynthesis. Plant Physiol 141: 1248-1254
70. Singh R, Ong-Abdullah M, Low ET, Manaf MA, Rosli R, Nookiah R, Ooi LC, Ooi SE, Chan KL, Halim MA, Azizi N, Nagappan J, Bacher B, Lakey N, Smith SW, He D, Hogan M, Budiman MA, Lee EK, DeSalle R, Kudrna D, Goicoechea JL, Wing RA, Wilson RK, Fulton RS, Ordway JM, Martienssen RA, Sambanthamurthi R (2013) Oil palm genome sequence reveals divergence of interfertile species in Old and New worlds. Nature 500: 335-339
71. Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (2007) Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem 282: 31744-31754
72. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28: 2731-2739
73. Venkatesh Kumar R, Chauhan S (2008) Mulberry: Life enhancer. J Med Plants Res 2: 271-278
74. Werck-Reichhart D, Bak S, Paquette S (2002) Cytochromes P450. In: Somerville CR, Meyerowitz EM, eds. The Arabidopsis Book. American Society of Plant Biologists, Rockville. pp. e0028
75. Wilson TG (2001) Resistance of Drosophila to toxins. Annu Rev Entomol 46: 545-571
76. Wu J, Wang Z, Shi Z, Zhang S, Ming R, Zhu S, Khan MA, Tao S, Korban SS, Wang H, Chen NJ, Nishio T, Xu X, Cong L, Qi K, Huang X, Wang Y, Zhao X, Wu J, Deng C, Gou C, Zhou W, Yin H, Qin G, Sha Y, Tao Y, Chen H, Yang Y, Song Y, Zhan D, Wang J, Li L, Dai M, Gu C, Wang Y, Shi D, Wang X, Zhang H, Zeng L, Zheng D, Wang C, Chen M, Wang G, Xie L, Sovero V, Sha S, Huang W, Zhang S, Zhang M, Sun J, Xu L, Li Y, Liu X, Li Q, Shen J, Wang J, Paull RE, Bennetzen JL, Wang J, Zhang S (2013) The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res 23: 396-408
77. Wu S, Chappell J (2008) Metabolic engineering of natural products in plants; tools of the trade and challenges for the future. Curr Opin Biotechnol 19: 145-152
78. Yang CQ, Fang X, Wu XM, Mao YB, Wang LJ, Chen XY (2012) Transcriptional regulation of plant secondary metabolism. J Integr Plant Biol 54: 703-712
79. Zagrobelny M, Bak S, Rasmussen AV, Jorgensen B, Naumann CM, Lindberg Moller B (2004) Cyanogenic glucosides and plant-insect interactions. Phytochemistry 65: 293-306
80. Zhang G, Liu X, Quan Z, Cheng S, Xu X, Pan S, Xie M, Zeng P, Yue Z, Wang W (2012a) Genome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential. Nat Biotechnol 30: 549-554
81. Zhang Q, Chen W, Sun L, Zhao F, Huang B, Yang W, Tao Y, Wang J, Yuan Z, Fan G, Xing Z, Han C, Pan H, Zhong X, Shi W, Liang X, Du D, Sun F, Xu Z, Hao R, Lv T, Lv Y, Zheng Z, Sun M, Luo L, Cai M, Gao Y, Wang J, Yin Y, Xu X, Cheng T, Wang J (2012b) The genome of Prunus mume. Nat Commun 3: 1318
82. Zulak KG, Bohlmann J (2010) Terpenoid biosynthesis and specialized vascular cells of conifer defense. J Integr Plant Biol 52: 86-97