Vaccination against persistent viral infection exacerbates CD4+ T- cell-mediated immunopathological disease

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 9672-9678

  Hildeman, David ^a   Yañez, Deborah ^b   Pederson, Katrina ^b   Havighurst, Thomas ^a   Muller, Daniel ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL INFILTRATION; CEREBROSPINAL FLUID ANALYSIS; FLOW CYTOMETRY; HELPER CELL; IMMUNOPATHOLOGY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VACCINATION; VIRUS INFECTION;

EID: 1842301028     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.9672-9678.1997     Document Type: Article

References (48)

1. Ahmed, R., A. Salmi, L. Butler, J. Chiller, M. B. A. Oldstone. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 60:521-540.
2. Bishop, D. K., S. Chan, W. Li, R. D. Ensley, S. Xu, and E. Eichwald. 1993. CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes. Transplantation 56:892-897.
3. Bloom, B., and B. Rager-Zisman. 1975. Cell mediated immunity in viral infections, p. 113-136. In A. L. Notkins (ed.) Viral immunology and immunopathology. Academic Press, New York, N.Y.
4. + T cells. J. Virol. 66:7444-7451.
5. Dialynas, D. P., Z. S. Quan, K. A. Wall, A. Pierres, J. Quintans, M. R. Loken, M. Pierres, and F. Fitch. 1983. Characterization of the murine T cell surface marker L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu3/T4 molecule. J. Immunol. 131:2445-2451.
6. Dohert, P., S. Hou, and P. Southern. 1993. Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins. J. Neuroimmunol. 46:11-18.
7. Fleming, J., J. Y. P. Ting, S. Stohlman, and L. Weiner. 1983. Improvements in obtaining and characterizing mouse cerebrospinal fluid. J. Neuroimmunol. 4:129-140.
8. Gessner, A., R. Drjupin, J. Lohler, H. Lother, and F. Lehmann-Grube. 1990. IFN-γ production in tissues of mice during acute viral infection with lymphocytic choriomeningitis virus. J. Immunol. 144:3160-3165.
9. Gossmann, J., J. Lohler, O. Utermohlen, and F. Lehmann-Grube. 1995. Murine hepatitis caused by lymphocytic choriomeningitis virus. II. Cells involved in pathogenesis. Lab. Invest. 72:559-570.
10. Haughton, G., L. Arnold, G. Bishop, and T. Mercolino. 1986. The CH series of murine B cell lymphomas: neoplastic analogues of Ly-1+ normal B cells. Immunol. Rev. 93:35-51.
11. Hendricks, R. L., M. Janowicz, and T. Tumpey. 1992. Critical role of corneal langerhans cells in the CD4-but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas. J. Immunol. 148:2522-2529.
12. 11a. Hildeman, D., and D. Muller. Unpublished data.
13. Hildeman, D., M. Salvato, J. L. Whitton, and D. Muller. 1996. Vaccination protects β2 microglobulin deficient mice from immune-mediated mortality but not from persisting viral infection. Vaccine 14:1223-1229.
14. Huber, S., and B. Pfaeffle. 1994. Differential Th1 and Th2 responses in male and female BALB/c mice infected with coxsackievirus group B type 3. J. Virol. 68:5126-5132.
15. Kagi, D., B. Lederman, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
16. Klavinskis, L. S., R. Geckeler, and M. B. A. Oldstone. 1989. Cytotoxic T lymphocytes control of acute lymphocytic choriomeningitis virus infection: IFN-γ, but not TNF-α, displays antiviral activity in vivo. J. Gen. Virol. 70:3317-3325.
17. Koenig, S., A. Conley, Y. Brewah, G. Jones, S. Leath, L. Boots, V. Davey, G. Pantaleo, J. Demarest, C. Carter, C. Wannebo, J. Yannelli, S. Rosenberg, and H. C. Lane. 1995. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat. Med. 1:330-336.
18. Koller, B., P. Marrack, J. Kappler, and O. Smithies. 1990. Normal development of mice deficient in β2-microglobulin. Science 248:1227-1230.
19. Kundig, T., M. Bachmann, C. DiPaulo, J. Simard, M. Battegay, H. Lother, A. Gessner, K. Kuhlcke, P. Ohashi, H. Hengartner, and R. M. Zinkernagel. 1995. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268:1343-1347.
20. Latour, D., K. Latour, and R. D. Wolfinger. 1994. Getting started with PROC MIXED. Software sales and marketing department, SAS Institute Inc., Cary, N.C.
21. 2-microglobulin gene. J. Virol. 67:332-339.
22. Leist, T. P., M. Eppler, and R. M. Zinkernagel. 1989. Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice. J. Virol. 63:2813-2819.
23. Mackett, M., G. Smith, and B. Moss. 1984. General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J. Virol. 49:857-864.
24. Marusic-Galesic, S., K. Udaka, and P. Walden. 1993. Increased number of cytotoxic T cells within CD4+8-T cells in β2-microglobulin, major histocompatibility complex class I-deficient mice. Eur. J. Immunol. 23:3115-3119.
25. Missale, G. J. J. Brems, H. Takiff, P. J. Pockros, and F. Chisari. 1993. Human leukocyte antigen class I-independent pathways may contribute to hepatitis B virus induced liver disease after liver transplantation. Hepatology 18:491-496.
26. Moskophidis, D., U. Assmann-Wischer, M. Simon, and F. Lehmann-Grube. 1987. The immune response of the mouse to lymphocytic choriomeningitis virus. V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection. Eur. J. Immunol. 17:937-942.
27. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758-761.
28. Muller, D., B. Koller, J. L. Whitton, K. LaPan, K. Brigman, and J. Frelinger. 1992. LCMV specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice. Science 255:1576-1578.
29. Muller, D., M. Chen, A. Vikingsson, D. Hildeman, and K. Pederson. 1995. Oestrogen influences CD4+ T-lymphocyte activity in vivo and in vitro in β2-microglobulin-deficient mice. Immunology 86:162-167.
30. Nowak, M., and C. Bangham. 1996. Population dynamics of immune responses to persistent viruses. Science 272:74-79.
31. Oehen, S., H. Hengartner, and R. M. Zinkernagel. 1991. Vaccination for disease. Science 251:195-198.
32. Olsen, N., and W. Kovacs. 1996. Gonadal steroids and immunity. Endocrine Rev. 17:369-384.
33. Quinn, D., A. Zajac, J. Frelinger, and D. Muller. 1993. Transfer of lymphocytic choriomeningitis disease in β2-microglobulin-deficient mice by CD4+ T cells. Int. Immunol. 5:1193-1198.
34. Plata-Salaman, C. R. 1995. Cytokines and feeding suppression: an integrative view from neurologic to molecular levels. Nutrition 11(Suppl. 5):674-677.
35. Plata-Salaman, C. R. 1992. Interferons and central regulation of feeding. Am. J. Physiol. 263:R1222-R1227.
36. 4 integrin directs virus-activated CD8+ T cells to sites of infection. J. Immunol. 154:5293-5301.
37. Pravsgaard-Christensen, J., J. Stenvang, O. Marker, and A. Randrup Thomsen. 1996. Characterization of virus primed CD8+ T cells with a type 1 cytokine profile. Int. Immunol. 8:1453-1461.
38. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohasbi, C. Thompson, and T. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609-612.
39. Taswell, C. 1981. Limiting dilution assays for the determination of immunocompetent cell frequencies. J. Immunol. 126:1614-1619.
40. Thomsen, A. R., M. Volkert, and O. Marker. 1979. The timing of the immune response in relation to virus growth determines the outcome of the LCM infection. Acta Pathol. Microbiol. Scand. Sect. C 87:47-54.
41. Vikingsson, A., K. Pederson, and D. Muller. 1994. Enumeration of IFN-γ producing lymphocytes by flow cytometry and correlation with quantitative measurement of IFN-γ. J. Immunol. Methods 173:219-228.
42. Vikingsson, A., K. Pederson, and D. Muller. 1996. Altered kinetics of CD4+ T cell proliferation and interferon-γ production in the absence of CD8+ T lymphocytes in virus-infected β2-microglobulin-deficient mice. Cell. Immunol. 173:261-268.
43. Whitton, J. L., P. J. Southern, and M. B. A. Oldstone. 1988. Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus. Virology 162:321-327.
44. Wille, A., A. Gessner, H. Lother, and F. Lehmann-Grube. 1989. Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-IFN-γ monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination. Eur. J. Immunol. 19:1283-1288.
45. Zajac, A. J., D. G. Quinn, P. L. Cohen, and J. A. Frelinger. 1996. Fasdependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection. Proc. Natl. Acad. Sci. USA 93:14730-14735.
46. 2-Microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature 344: 742-746.
47. Zinkernagel, R. M. 1996. Immunology taught by viruses. Science 271:173-178.
48. Zinkernagel, R. M., and P. Doherty. 1973. Cytotoxic, thymus derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis. J. Exp. Med. 138:1266-1269.