Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 19, 2014, Pages 8026-8034

  Tang, Guozhi ^a   Wong, Jason C ^a   Zhang, Weixing ^a   Wang, Zhanguo ^a   Zhang, Nan ^a   Peng, Zhenghong ^a   Zhang, Zhenshan ^a   Rong, Yiping ^a   Li, Shijie ^a   Zhang, Meifang ^a   Yu, Lingjie ^a   Feng, Teng ^a   Zhang, Xiongwen ^a   Wu, Xihan ^a   Wu, Jim Z ^a   Chen, Li ^a  

^a Roche Innovation Center Shanghai   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[5 (3 NITROPHENYL) 2 FURYL]METHYL] 3,4 DIHYDRO 1H ISOQUINOLINE 7 CARBOHYDROXAMIC ACID; 3 (2 PYRIDYLAMINO)TETRALIN 6 CARBOHYDROXAMIC ACID; 3 (3 CHLORO 4 CYANOANILINO)TETRALIN 6 CARBOHYDROXAMIC ACID; 3 (4 FLUOROANILINO)TETRALIN 6 CARBOHYDROXAMIC ACID; 3 (PYRIMIDIN 2 YLAMINO)TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [(3 CHLOROPHENYL)SULFONYLAMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [(3 FLUOROPHENYL)SULFONYLAMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [(4 PHENYLPYRIMIDIN 2 YL)AMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [METHYL [4 (3 PYRIDYL)PYRIMIDIN 2 YL]AMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [[4 (2 CHLOROPHENYL)PYRIMIDIN 2 YL]AMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [[4 (3 CHLOROPHENYL)PYRIMIDIN 2 YL]AMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [[4 (3 PYRIDYL)PYRIMIDIN 2 YL]AMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; 3 [[4 (4 CHLOROPHENYL)PYRIMIDIN 2 YL]AMINO]TETRALIN 6 CARBOHYDROXAMIC ACID; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; ISOTRETINOIN; TETRAHYDROISOQUINOLINE; TUBULIN; UNCLASSIFIED DRUG; HDAC6 PROTEIN, HUMAN; HDAC8 PROTEIN, HUMAN; HISTONE DEACETYLASE; REPRESSOR PROTEIN; TETRALIN DERIVATIVE;

ACETYLATION; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC50; MOLECULAR DYNAMICS; MOLECULAR MODEL; MYELOMA; NERVE FIBER GROWTH; NEUROBLASTOMA; NEUROBLASTOMA CELL; PHENOTYPE; STEREOISOMERISM; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MICE; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 84907897779     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5008962     Document Type: Article

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