A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways

Neurochemistry International

Volumn 78, Issue , 2014, Pages 76-85

  Xu, Da Ping ^a,b   Zhang, Kun ^c   Zhang, Zai Jun ^a,b,c   Sun, Ye Wei ^c   Guo, Bao Jian ^c   Wang, Yu Qiang ^c   Hoi, Pui Man ^c   Han, Yi Fan ^b   Lee, Simon Ming Yuen ^a  

^a UNIVERSITY OF MACAU   (Macao)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c JINAN UNIVERSITY   (China)

Author keywords

6 Hydroxydopamine; Neuroinflammation; Neuroprotection; Tetramethylpyrazine derivative

Indexed keywords

6 HYDROXYLDOPAMINE; DOPAMINE DERIVATIVE; EOSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOXYLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MESSENGER RNA; NATURAL PRODUCT; NITRIC OXIDE; NITRONE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCAVENGER; TETRAMETHYLPYRAZINE; TETRAMETHYLPYRAZINE BIS NITRONE; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; OXIDOPAMINE; PROTEIN KINASE C ALPHA; PYRAZINE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL LOSS; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; ENZYME ACTIVITY; ENZYME RELEASE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROGLIA; MODULATION; MTT ASSAY; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PC12 CELL LINE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; CHEMISTRY; DRUG EFFECTS; MALE; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; MALE; NEUROPROTECTIVE AGENTS; NF-KAPPA B; OXIDOPAMINE; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; ZEBRAFISH;

EID: 84907886062     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.09.001     Document Type: Article

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