메뉴 건너뛰기




Volumn 9, Issue 10, 2014, Pages

A closed-loop model of the respiratory system: Focus on hypercapnia and active expiration

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; OXYGEN;

EID: 84907855750     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109894     Document Type: Article
Times cited : (57)

References (52)
  • 1
    • 0018580598 scopus 로고
    • Neurogenesis of respiratory rhythm in the mammal
    • Cohen MI (1979) Neurogenesis of respiratory rhythm in the mammal. Physiol Rev 59: 1105-1173.
    • (1979) Physiol Rev , vol.59 , pp. 1105-1173
    • Cohen, M.I.1
  • 2
    • 0028984595 scopus 로고
    • Central control of breathing in mammals: Neuronal circuitry, membrane properties, and neurotransmitters
    • Bianchi AL, Denavitsaubie M, Champagnat J (1995) Central control of breathing in mammals: Neuronal circuitry, membrane properties, and neurotransmitters. Physiological Reviews 75: 1-45.
    • (1995) Physiological Reviews , vol.75 , pp. 1-45
    • Bianchi, A.L.1    Denavitsaubie, M.2    Champagnat, J.3
  • 3
    • 34848893279 scopus 로고    scopus 로고
    • Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation
    • Rybak IA, Abdala AP, Markin SN, Paton JF, Smith JC (2007) Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation. Prog Brain Res 165: 201-220.
    • (2007) Prog Brain Res , vol.165 , pp. 201-220
    • Rybak, I.A.1    Abdala, A.P.2    Markin, S.N.3    Paton, J.F.4    Smith, J.C.5
  • 4
    • 37549055001 scopus 로고    scopus 로고
    • Spatial and functional architecture of the mammalian brain stem respiratory network: A hierarchy of three oscillatory mechanisms
    • Smith JC, Abdala AP, Koizumi H, Rybak IA, Paton JF (2007) Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms. J Neurophysiol 98: 3370-3387.
    • (2007) J Neurophysiol , vol.98 , pp. 3370-3387
    • Smith, J.C.1    Abdala, A.P.2    Koizumi, H.3    Rybak, I.A.4    Paton, J.F.5
  • 5
    • 69949091248 scopus 로고    scopus 로고
    • Structural and functional architecture of respiratory networks in the mammalian brainstem
    • Smith JC, Abdala AP, Rybak IA, Paton JF (2009) Structural and functional architecture of respiratory networks in the mammalian brainstem. Philos Trans R Soc Lond B Biol Sci 364: 2577-2587.
    • (2009) Philos Trans R Soc Lond B Biol Sci , vol.364 , pp. 2577-2587
    • Smith, J.C.1    Abdala, A.P.2    Rybak, I.A.3    Paton, J.F.4
  • 7
    • 0014057089 scopus 로고
    • Mathematical analysis and digital simulation of the respiratory control system
    • Grodins FS, Buell J, Bart AJ (1967) Mathematical analysis and digital simulation of the respiratory control system. J Appl Physiol 22: 260-276.
    • (1967) J Appl Physiol , vol.22 , pp. 260-276
    • Grodins, F.S.1    Buell, J.2    Bart, A.J.3
  • 10
    • 0030907928 scopus 로고    scopus 로고
    • Modeling neural mechanisms for genesis of respiratory rhythm and pattern. III. Comparison of model performances during afferent nerve stimulation
    • Rybak IA, Paton JF, Schwaber JS (1997) Modeling neural mechanisms for genesis of respiratory rhythm and pattern. III. Comparison of model performances during afferent nerve stimulation. J Neurophysiol 77: 2027-2039.
    • (1997) J Neurophysiol , vol.77 , pp. 2027-2039
    • Rybak, I.A.1    Paton, J.F.2    Schwaber, J.S.3
  • 11
    • 0034963567 scopus 로고    scopus 로고
    • An integrated model of the human ventilatory control system: The response to hypercapnia
    • Ursino M, Magosso E, Avanzolini G (2001) An integrated model of the human ventilatory control system: the response to hypercapnia. Clin Physiol 21: 447-464.
    • (2001) Clin Physiol , vol.21 , pp. 447-464
    • Ursino, M.1    Magosso, E.2    Avanzolini, G.3
  • 13
    • 11044235832 scopus 로고    scopus 로고
    • A computational model of the human respiratory control system: Responses to hypoxia and hypercapnia
    • Topor ZL, Pawlicki M, Remmers JE (2004) A computational model of the human respiratory control system: responses to hypoxia and hypercapnia. Ann Biomed Eng 32: 1530-1545.
    • (2004) Ann Biomed Eng , vol.32 , pp. 1530-1545
    • Topor, Z.L.1    Pawlicki, M.2    Remmers, J.E.3
  • 14
    • 24144487437 scopus 로고    scopus 로고
    • Introduction of respiratory pattern generators into models of respiratory control
    • Longobardo G, Evangelisti CJ, Cherniack NS (2005) Introduction of respiratory pattern generators into models of respiratory control. Respir Physiol Neurobiol 148: 285-301.
    • (2005) Respir Physiol Neurobiol , vol.148 , pp. 285-301
    • Longobardo, G.1    Evangelisti, C.J.2    Cherniack, N.S.3
  • 15
    • 40849088105 scopus 로고    scopus 로고
    • A model for control of breathing in mammals: Coupling neural dynamics to peripheral gas exchange and transport
    • Ben-Tal A, Smith JC (2008) A model for control of breathing in mammals: coupling neural dynamics to peripheral gas exchange and transport. J Theor Biol 251: 480-497.
    • (2008) J Theor Biol , vol.251 , pp. 480-497
    • Ben-Tal, A.1    Smith, J.C.2
  • 16
    • 74849105195 scopus 로고    scopus 로고
    • Control of breathing: Two types of delays studied in an integrated model of the respiratory system
    • Ben-Tal A, Smith JC (2010) Control of breathing: two types of delays studied in an integrated model of the respiratory system. Respir Physiol Neurobiol 170: 103-112.
    • (2010) Respir Physiol Neurobiol , vol.170 , pp. 103-112
    • Ben-Tal, A.1    Smith, J.C.2
  • 17
    • 78049411644 scopus 로고    scopus 로고
    • An integrative model of respiratory and cardiovascular control in sleep-disordered breathing
    • Cheng L, Ivanova O, Fan HH, Khoo MC (2010) An integrative model of respiratory and cardiovascular control in sleep-disordered breathing. Respir Physiol Neurobiol 174: 4-28.
    • (2010) Respir Physiol Neurobiol , vol.174 , pp. 4-28
    • Cheng, L.1    Ivanova, O.2    Fan, H.H.3    Khoo, M.C.4
  • 18
  • 19
    • 84866452063 scopus 로고    scopus 로고
    • A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors
    • O'Connor R, Segers LS, Morris KF, Nuding SC, Pitts T, et al. (2012) A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors. Front Physiol 3: 264.
    • (2012) Front Physiol , vol.3 , pp. 264
    • O'Connor, R.1    Segers, L.S.2    Morris, K.F.3    Nuding, S.C.4    Pitts, T.5
  • 20
    • 84885762348 scopus 로고    scopus 로고
    • Integrative approaches for modeling regulation and function of the respiratory system
    • Ben-Tal A, Tawhai MH (2013) Integrative approaches for modeling regulation and function of the respiratory system. Wiley Interdiscip Rev Syst Biol Med 5: 687-699.
    • (2013) Wiley Interdiscip Rev Syst Biol Med , vol.5 , pp. 687-699
    • Ben-Tal, A.1    Tawhai, M.H.2
  • 21
    • 0024581705 scopus 로고
    • Abdominal muscle use during breathing in unanesthetized dogs
    • De Troyer A, Gilmartin JJ, Ninane V (1989) Abdominal muscle use during breathing in unanesthetized dogs. J Appl Physiol (1985) 66: 20-27.
    • (1985) J Appl Physiol , vol.66 , pp. 20-27
    • De Troyer, A.1    Gilmartin, J.J.2    Ninane, V.3
  • 24
    • 0018541075 scopus 로고
    • The effect of carbon dioxide on the tonic and the rhythmic discharges of expiratory bulbospinal neurones
    • Bainton CR, Kirkwood PA (1979) The effect of carbon dioxide on the tonic and the rhythmic discharges of expiratory bulbospinal neurones. J Physiol 296: 291-314.
    • (1979) J Physiol , vol.296 , pp. 291-314
    • Bainton, C.R.1    Kirkwood, P.A.2
  • 25
    • 0017695212 scopus 로고
    • The respiratory motoneuron and apneusis
    • Sears TA (1977) The respiratory motoneuron and apneusis. Fed Proc 36: 2412-2420.
    • (1977) Fed Proc , vol.36 , pp. 2412-2420
    • Sears, T.A.1
  • 26
    • 33644559872 scopus 로고    scopus 로고
    • Distinct rhythm generators for inspiration and expiration in the juvenile rat
    • Janczewski WA, Feldman JL (2006) Distinct rhythm generators for inspiration and expiration in the juvenile rat. J Physiol 570: 407-420.
    • (2006) J Physiol , vol.570 , pp. 407-420
    • Janczewski, W.A.1    Feldman, J.L.2
  • 27
    • 33644558047 scopus 로고    scopus 로고
    • Looking for inspiration: New perspectives on respiratory rhythm
    • Feldman JL, Del Negro CA (2006) Looking for inspiration: new perspectives on respiratory rhythm. Nat Rev Neurosci 7: 232-242.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 232-242
    • Feldman, J.L.1    Del Negro, C.A.2
  • 28
    • 67651114060 scopus 로고    scopus 로고
    • Abdominal expiratory activity in the rat brainstem-spinal cord in situ: Patterns, origins and implications for respiratory rhythm generation
    • Abdala AP, Rybak IA, Smith JC, Paton JF (2009) Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation. J Physiol 587: 3539-3559.
    • (2009) J Physiol , vol.587 , pp. 3539-3559
    • Abdala, A.P.1    Rybak, I.A.2    Smith, J.C.3    Paton, J.F.4
  • 29
    • 78049507151 scopus 로고    scopus 로고
    • Lateexpiratory activity: Emergence and interactions with the respiratory CPG
    • Molkov YI, Abdala AP, Bacak BJ, Smith JC, Paton JF, et al. (2010) Lateexpiratory activity: emergence and interactions with the respiratory CPG. J Neurophysiol 104: 2713-2729.
    • (2010) J Neurophysiol , vol.104 , pp. 2713-2729
    • Molkov, Y.I.1    Abdala, A.P.2    Bacak, B.J.3    Smith, J.C.4    Paton, J.F.5
  • 30
    • 79951648674 scopus 로고    scopus 로고
    • Active expiration induced by excitation of ventral medulla in adult anesthetized rats
    • Pagliardini S, Janczewski WA, Tan W, Dickson CT, Deisseroth K, et al. (2011) Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J Neurosci 31: 2895-2905.
    • (2011) J Neurosci , vol.31 , pp. 2895-2905
    • Pagliardini, S.1    Janczewski, W.A.2    Tan, W.3    Dickson, C.T.4    Deisseroth, K.5
  • 31
    • 77956843436 scopus 로고    scopus 로고
    • Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration
    • Marina N, Abdala AP, Trapp S, Li A, Nattie EE, et al. (2010) Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J Neurosci 30: 12466-12473.
    • (2010) J Neurosci , vol.30 , pp. 12466-12473
    • Marina, N.1    Abdala, A.P.2    Trapp, S.3    Li, A.4    Nattie, E.E.5
  • 32
    • 79959354634 scopus 로고    scopus 로고
    • Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
    • Molkov YI, Zoccal DB, Moraes DJ, Paton JF, Machado BH, et al. (2011) Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats. J Neuropysiol 105: 3080-3091.
    • (2011) J Neuropysiol , vol.105 , pp. 3080-3091
    • Molkov, Y.I.1    Zoccal, D.B.2    Moraes, D.J.3    Paton, J.F.4    Machado, B.H.5
  • 34
    • 77954726334 scopus 로고    scopus 로고
    • Retrotrapezoid nucleus and parafacial respiratory group
    • Guyenet PG, Mulkey DK (2010) Retrotrapezoid nucleus and parafacial respiratory group. Respir Physiol Neurobiol 173: 244-255.
    • (2010) Respir Physiol Neurobiol , vol.173 , pp. 244-255
    • Guyenet, P.G.1    Mulkey, D.K.2
  • 37
    • 79960084124 scopus 로고    scopus 로고
    • Interacting oscillations in neural control of breathing: Modeling and qualitative analysis
    • Rubin JE, Bacak BJ, Molkov YI, Shevtsova NA, Smith JC, et al. (2011) Interacting oscillations in neural control of breathing: modeling and qualitative analysis. J Comput Neurosci 30: 607-632.
    • (2011) J Comput Neurosci , vol.30 , pp. 607-632
    • Rubin, J.E.1    Bacak, B.J.2    Molkov, Y.I.3    Shevtsova, N.A.4    Smith, J.C.5
  • 38
    • 0000650934 scopus 로고
    • Reduction of conductance-based models with slow synapses to neural nets
    • Ermentrout B (1994) Reduction of conductance-based models with slow synapses to neural nets. Neural Comput 6: 679-695.
    • (1994) Neural Comput , vol.6 , pp. 679-695
    • Ermentrout, B.1
  • 39
    • 29244437865 scopus 로고    scopus 로고
    • Simplified models for gas exchange in the human lungs
    • Ben-Tal A (2006) Simplified models for gas exchange in the human lungs. J Theor Biol 238: 474-495.
    • (2006) J Theor Biol , vol.238 , pp. 474-495
    • Ben-Tal, A.1
  • 40
    • 0015324122 scopus 로고
    • On the regulation of depth and rate of breathing
    • Clark FJ, von Euler C (1972) On the regulation of depth and rate of breathing. J Physiol 222: 267-295.
    • (1972) J Physiol , vol.222 , pp. 267-295
    • Clark, F.J.1    Von Euler, C.2
  • 41
    • 0029794367 scopus 로고    scopus 로고
    • Respiratory neurons mediating the Breuer-Hering reflex prolongation of expiration in rat
    • Hayashi F, Coles SK, McCrimmon DR (1996) Respiratory neurons mediating the Breuer-Hering reflex prolongation of expiration in rat. J Neurosci 16: 6526-6536.
    • (1996) J Neurosci , vol.16 , pp. 6526-6536
    • Hayashi, F.1    Coles, S.K.2    McCrimmon, D.R.3
  • 43
  • 44
    • 0031825741 scopus 로고    scopus 로고
    • Neurogenesis of patterns of automatic ventilatory activity
    • St-John WM (1998) Neurogenesis of patterns of automatic ventilatory activity. Prog Neurobiol 56: 97-117.
    • (1998) Prog Neurobiol , vol.56 , pp. 97-117
    • St-John, W.M.1
  • 45
    • 0019475319 scopus 로고
    • Prolonged central respiratory inhibition following reflex-induced apnea
    • Lawson EE (1981) Prolonged central respiratory inhibition following reflex-induced apnea. J Appl Physiol Respir Environ Exerc Physiol 50: 874-879.
    • (1981) J Appl Physiol Respir Environ Exerc Physiol , vol.50 , pp. 874-879
    • Lawson, E.E.1
  • 47
    • 0023228513 scopus 로고
    • Interaction of hypoxic and hypercapnic stimuli on breathing pattern in the newborn rat
    • Saetta M, Mortola JP (1987) Interaction of hypoxic and hypercapnic stimuli on breathing pattern in the newborn rat. J Appl Physiol (1985) 62: 506-512.
    • (1985) J Appl Physiol , vol.62 , pp. 506-512
    • Saetta, M.1    Mortola, J.P.2
  • 48
    • 0030131013 scopus 로고    scopus 로고
    • Phrenic response to hypercapnia in the unanesthetized, decerbrate, newborn rat
    • Zhou D, Huang Q, Fung ML, Li A, Darnall RA, et al. (1996) Phrenic response to hypercapnia in the unanesthetized, decerbrate, newborn rat. Respir Physiol 104: 11-22.
    • (1996) Respir Physiol , vol.104 , pp. 11-22
    • Zhou, D.1    Huang, Q.2    Fung, M.L.3    Li, A.4    Darnall, R.A.5
  • 50
    • 84857713288 scopus 로고    scopus 로고
    • Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats
    • Tin C, Song G, Poon CS (2012) Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats. Respir Physiol Neurobiol 181: 79-87.
    • (2012) Respir Physiol Neurobiol , vol.181 , pp. 79-87
    • Tin, C.1    Song, G.2    Poon, C.S.3
  • 51
    • 84895177698 scopus 로고    scopus 로고
    • Phox2b-expressing retrotrapezoid neurons and the integration of central and peripheral chemosensory control of breathing in conscious rats
    • Takakura AC, Barna BF, Cruz JC, Colombari E, Moreira TS (2014) Phox2b-expressing retrotrapezoid neurons and the integration of central and peripheral chemosensory control of breathing in conscious rats. Exp Physiol 99: 571-585.
    • (2014) Exp Physiol , vol.99 , pp. 571-585
    • Takakura, A.C.1    Barna, B.F.2    Cruz, J.C.3    Colombari, E.4    Moreira, T.S.5
  • 52
    • 80755127200 scopus 로고    scopus 로고
    • Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats
    • Abbott SB, Stornetta RL, Coates MB, Guyenet PG (2011) Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. J Neurosci 31: 16410-16422.
    • (2011) J Neurosci , vol.31 , pp. 16410-16422
    • Abbott, S.B.1    Stornetta, R.L.2    Coates, M.B.3    Guyenet, P.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.