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Volumn 32, Issue 11, 2004, Pages 1530-1545

A computational model of the human respiratory control system: Responses to hypoxia and hypercapnia

Author keywords

Central and peripheral ventilatory contributions; Computer simulation; Hypocapnic hypoxia; Hypoxic ventilatory decline (HVD); Open loop response to hypercapnic step

Indexed keywords

BLOOD; BODY FLUIDS; BRAIN; CARBON DIOXIDE; COMPUTER SIMULATION; MATHEMATICAL MODELS; PARTIAL PRESSURE; TISSUE; TRANSPORT PROPERTIES;

EID: 11044235832     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/B:ABME.0000049037.65204.4c     Document Type: Article
Times cited : (46)

References (65)
  • 2
  • 3
    • 0030041282 scopus 로고
    • Respiratory responses to hypoxia peripheral and central effects
    • Berkenbosch, A., C. N. Olievier, and J. DeGoede. Respiratory responses to hypoxia peripheral and central effects. Adv. Experim. Med. Biol. 393:251-256, 1995.
    • (1995) Adv. Experim. Med. Biol. , vol.393 , pp. 251-256
    • Berkenbosch, A.1    Olievier, C.N.2    Degoede, J.3
  • 4
    • 0020644378 scopus 로고
    • Mechanisms of hypoxia-induced periodic breathing during sleep in humans
    • Berssenbrugge, A., J. Dempsey, C. Iber, J. Skatrud, and P. Wilson. Mechanisms of hypoxia-induced periodic breathing during sleep in humans. J. Physiol. 343:507-524, 1983.
    • (1983) J. Physiol. , vol.343 , pp. 507-524
    • Berssenbrugge, A.1    Dempsey, J.2    Iber, C.3    Skatrud, J.4    Wilson, P.5
  • 5
    • 0014116349 scopus 로고
    • Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man
    • Cohen, P. J., S. C. Alexander, T. C. Smith, M. Reivich, and H. Wollman. Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J. Appl. Physiol. 23(2):183-189, 1967.
    • (1967) J. Appl. Physiol. , vol.23 , Issue.2 , pp. 183-189
    • Cohen, P.J.1    Alexander, S.C.2    Smith, T.C.3    Reivich, M.4    Wollman, H.5
  • 6
    • 0016178203 scopus 로고
    • Cardiovascular effects of carbon dioxide in man
    • Cullen, D. J., and E. I. Eger. Cardiovascular effects of carbon dioxide in man. Anesthesiology 41(4):345-349, 1974.
    • (1974) Anesthesiology , vol.41 , Issue.4 , pp. 345-349
    • Cullen, D.J.1    Eger, E.I.2
  • 7
    • 1542368740 scopus 로고
    • Integrative aspects of the regulation of breathing: A personal view
    • edited by J. G. Widdicombe. London: Butterworths
    • Cunningham, D. J. C. Integrative aspects of the regulation of breathing: A personal view. In: Respiratory Physiology, edited by J. G. Widdicombe. London: Butterworths, 1974, pp. 303-369.
    • (1974) Respiratory Physiology , pp. 303-369
    • Cunningham, D.J.C.1
  • 8
    • 0024887824 scopus 로고
    • Tidal volume change and gas mixing in the lung
    • Damato, S., and G. Gumming, Tidal volume change and gas mixing in the lung. Respiration 56:173-181, 1989.
    • (1989) Respiration , vol.56 , pp. 173-181
    • Damato, S.1    Gumming, G.2
  • 9
    • 0000740440 scopus 로고
    • Blood as physio-chemical system. XI. Man at rest
    • Dill, D. B., H. T. Edwards, and W. V. Consolazio. Blood as physio-chemical system. XI. Man at rest. J. Biol. Chem. 118:635-648, 1937.
    • (1937) J. Biol. Chem. , vol.118 , pp. 635-648
    • Dill, D.B.1    Edwards, H.T.2    Consolazio, W.V.3
  • 10
    • 0018841961 scopus 로고
    • Subthreshold central neural respiratory activity and afterdischarge
    • Eldridge, F. L. Subthreshold central neural respiratory activity and afterdischarge. Respir. Physiol. 39:327-343, 1980.
    • (1980) Respir. Physiol. , vol.39 , pp. 327-343
    • Eldridge, F.L.1
  • 11
    • 0026664052 scopus 로고
    • Human cerebrovascular response to oxygen and carbon dioxide as determined by internal carotid artery duplex scanning
    • Fortune, J. B., D. Bock, A. M. Kupinski, H. H. Stratton, D. M.Shah, and P. J. Feustel. Human cerebrovascular response to oxygen and carbon dioxide as determined by internal carotid artery duplex scanning. J. Trauma 32(5):618-628, 1992.
    • (1992) J. Trauma , vol.32 , Issue.5 , pp. 618-628
    • Fortune, J.B.1    Bock, D.2    Kupinski, A.M.3    Stratton, H.H.4    Shah, D.M.5    Feustel, P.J.6
  • 12
    • 49449092679 scopus 로고
    • Transforms and nonlinear regressions
    • San Rafael, CA: Jandel Corporation
    • Fox, E., and K. Shotton. Transforms and nonlinear regressions. User's manual. San Rafael, CA: Jandel Corporation, 1995.
    • (1995) User's Manual
    • Fox, E.1    Shotton, K.2
  • 13
    • 0025764697 scopus 로고
    • Short-term potentiation of breathing in humans
    • Fregosi, R. F. Short-term potentiation of breathing in humans. J. Appl. Physiol. 71(3):892-899, 1991.
    • (1991) J. Appl. Physiol. , vol.71 , Issue.3 , pp. 892-899
    • Fregosi, R.F.1
  • 14
    • 0018644897 scopus 로고
    • Effects of carotid body denervation on respiratory pattern of awake cats
    • Gautier, H., and M. Bonora. Effects of carotid body denervation on respiratory pattern of awake cats. J. Appl. Physiol. 46(6):1127-1131, 1979.
    • (1979) J. Appl. Physiol. , vol.46 , Issue.6 , pp. 1127-1131
    • Gautier, H.1    Bonora, M.2
  • 15
    • 0025113973 scopus 로고
    • Hypoxic exposure and activation of the after-discharge mechanism in conscious humans
    • Georgopoulos, D., Z. Bshouty, M. Younes, and N. R. Anthonisen. Hypoxic exposure and activation of the after-discharge mechanism in conscious humans. J. Appl. Physiol. 69(3):1159-1164, 1990.
    • (1990) J. Appl. Physiol. , vol.69 , Issue.3 , pp. 1159-1164
    • Georgopoulos, D.1    Bshouty, Z.2    Younes, M.3    Anthonisen, N.R.4
  • 16
    • 0011908914 scopus 로고
    • The multiple factor theory of the control of respiratory ventilation
    • Gray, J. S. The multiple factor theory of the control of respiratory ventilation. Science 103:739-744, 1946.
    • (1946) Science , vol.103 , pp. 739-744
    • Gray, J.S.1
  • 17
    • 11044225828 scopus 로고
    • A structural approach to respiratory control simulation
    • edited by J. P. Paul. London: McMillan
    • Greer, W., M. M. Jordan, and D. J. Murray-Smith. A structural approach to respiratory control simulation. In: Computing in Medicine, edited by J. P. Paul. London: McMillan, 1982, pp. 339-346.
    • (1982) Computing in Medicine , pp. 339-346
    • Greer, W.1    Jordan, M.M.2    Murray-Smith, D.J.3
  • 18
    • 0014057089 scopus 로고
    • Mathematical analysis and digital simulation of the respiratory control system
    • Grodins, F. S., J. Buell, and A. J. Bart. Mathematical analysis and digital simulation of the respiratory control system. J. Appl. Physiol. 22(2):260-276, 1967.
    • (1967) J. Appl. Physiol. , vol.22 , Issue.2 , pp. 260-276
    • Grodins, F.S.1    Buell, J.2    Bart, A.J.3
  • 20
    • 0013804409 scopus 로고
    • Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressure
    • Harper, M. A., and H. I. Glass. Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressure. J. Neurol. Neurosurg. Psychiatry 28:449-452, 1965.
    • (1965) J. Neurol. Neurosurg. Psychiatry , vol.28 , pp. 449-452
    • Harper, M.A.1    Glass, H.I.2
  • 22
    • 0004078226 scopus 로고
    • Blood as a physio-chemical system. X. the physio-chemical properties of oxygenated human blood
    • Henderson, L. J., D. B. Dill, H. T. Edwards, and W. P. O. Morgan. Blood as a physio-chemical system. X. The physio-chemical properties of oxygenated human blood. J. Biol. Chem. 90:697-724, 1931.
    • (1931) J. Biol. Chem. , vol.90 , pp. 697-724
    • Henderson, L.J.1    Dill, D.B.2    Edwards, H.T.3    Morgan, W.P.O.4
  • 23
    • 0002006835 scopus 로고
    • A rapid computer controlled binary gas mixing system for studies in respiratory control
    • Howson, M. G., S. Khamnei, M. E. McIntyre, D. F. O'Connor, and P. A. Robbins. A rapid computer controlled binary gas mixing system for studies in respiratory control. J. Physiol. 403:103P, 1987.
    • (1987) J. Physiol. , vol.403
    • Howson, M.G.1    Khamnei, S.2    McIntyre, M.E.3    O'Connor, D.F.4    Robbins, P.A.5
  • 24
    • 0029921042 scopus 로고    scopus 로고
    • Augmented hypoxic cerebral vasodilation in men during 5 days at 3,810 m altitude
    • Jensen, J. B., B. Sperling, J. W. Severinghaus, and N. A. Lassen. Augmented hypoxic cerebral vasodilation in men during 5 days at 3,810 m altitude. J. Appl. Physiol. 80(4): 1214-1428, 1996.
    • (1996) J. Appl. Physiol. , vol.80 , Issue.4 , pp. 1214-1428
    • Jensen, J.B.1    Sperling, B.2    Severinghaus, J.W.3    Lassen, N.A.4
  • 27
    • 0019979176 scopus 로고
    • Factors inducing periodic breathing in humans: A general model
    • Khoo, M. C. K., R. E. Kronauer, K. P. Strohl, and A. S. Slutsky. Factors inducing periodic breathing in humans: a general model. J. Appl. Physiol. 53(3):644-659, 1982.
    • (1982) J. Appl. Physiol. , vol.53 , Issue.3 , pp. 644-659
    • Khoo, M.C.K.1    Kronauer, R.E.2    Strohl, K.P.3    Slutsky, A.S.4
  • 28
    • 0029976199 scopus 로고    scopus 로고
    • Effects of hypercapnia on hemodynamic, inotropic, lusitropic, and electrophysiologic indices in humans
    • Kiely, D. G., R. I. Cargill, and B. J. Lipworth. Effects of hypercapnia on hemodynamic, inotropic, lusitropic, and electrophysiologic indices in humans. Chest 109(5):1215-1221, 1996.
    • (1996) Chest , vol.109 , Issue.5 , pp. 1215-1221
    • Kiely, D.G.1    Cargill, R.I.2    Lipworth, B.J.3
  • 29
    • 70449217048 scopus 로고
    • The interactions between hypoxia and other ventilatory stimuli
    • Lloyd, B. B., M. G. M. Jukes, and D. J. C. Cunningham. The interactions between hypoxia and other ventilatory stimuli. Quart. J. Exp. Physiol. 43:214-221, 1958.
    • (1958) Quart. J. Exp. Physiol. , vol.43 , pp. 214-221
    • Lloyd, B.B.1    Jukes, M.G.M.2    Cunningham, D.J.C.3
  • 30
    • 0013965115 scopus 로고
    • Cheyne-Stokes breathing produced by a model of the human respiratory system
    • Longobardo, G. S., N. S. Cherniack, and A. P. Fishman. Cheyne-Stokes breathing produced by a model of the human respiratory system. J. Appl. Physiol. 21(6):1839-1846, 1966.
    • (1966) J. Appl. Physiol. , vol.21 , Issue.6 , pp. 1839-1846
    • Longobardo, G.S.1    Cherniack, N.S.2    Fishman, A.P.3
  • 31
    • 0003016597 scopus 로고
    • A mathematical model of the human respiratory control system
    • Milhorn, H. T., H. Benton, H. Ross, and A. C. Guyton. A mathematical model of the human respiratory control system. Biophys. J. 5:27-46, 1965.
    • (1965) Biophys. J. , vol.5
    • Milhorn, H.T.1    Benton, H.2    Ross, H.3    Guyton, A.C.4
  • 32
    • 0014902932 scopus 로고
    • Steady-state simulation of the human respiratory system
    • Milhorn, H. T., and D. R. Brown. Steady-state simulation of the human respiratory system. Comput. Biomed. Res. 3:604-619, 1971.
    • (1971) Comput. Biomed. Res. , vol.3 , pp. 604-619
    • Milhorn, H.T.1    Brown, D.R.2
  • 35
    • 84958295282 scopus 로고
    • Studies on the regulation of respiration in acute hypoxia
    • Nielsen, M., and H. Smith. Studies on the regulation of respiration in acute hypoxia. Acta Physiol. Scand. 24:293-313, 1952.
    • (1952) Acta Physiol. Scand. , vol.24 , pp. 293-313
    • Nielsen, M.1    Smith, H.2
  • 37
    • 0014259276 scopus 로고
    • A system of digital computer subroutines for blood gas calculations
    • Olszowka, A. J., and L. E. Farhi. A system of digital computer subroutines for blood gas calculations. Respir. Physiol. 4:270-280, 1968.
    • (1968) Respir. Physiol. , vol.4 , pp. 270-280
    • Olszowka, A.J.1    Farhi, L.E.2
  • 38
    • 0027229960 scopus 로고
    • A mathematical model of the human ventilatory response to isocapnic hypoxia
    • Painter, R., S. Khamnei, and P. Robbins. A mathematical model of the human ventilatory response to isocapnic hypoxia. J. Appl. Physiol. 74(4):2007-2015, 1993.
    • (1993) J. Appl. Physiol. , vol.74 , Issue.4 , pp. 2007-2015
    • Painter, R.1    Khamnei, S.2    Robbins, P.3
  • 39
    • 4243773517 scopus 로고
    • Modelling the breath by breath variability in respiratory data
    • edited by G. D. Swanson, F. S. Grodins, and R. L. Hughson. New York: Plenum Press
    • Patil, C. P., K. B. Saunders, and B. M. Sayers. Modelling the breath by breath variability in respiratory data. In: Respiratory Control. A Modeling Perspective, edited by G. D. Swanson, F. S. Grodins, and R. L. Hughson. New York: Plenum Press, 1989, pp. 343-352.
    • (1989) Respiratory Control. A Modeling Perspective , pp. 343-352
    • Patil, C.P.1    Saunders, K.B.2    Sayers, B.M.3
  • 40
    • 0023969943 scopus 로고
    • The effects of hypoxemia on cardiac output. A dose-response curve
    • Phillips, B. A., J. W. McConelly, and M. D. Smith. The effects of hypoxemia on cardiac output. A dose-response curve. Chest 93(3):471-475, 1988.
    • (1988) Chest , vol.93 , Issue.3 , pp. 471-475
    • Phillips, B.A.1    McConelly, J.W.2    Smith, M.D.3
  • 41
    • 0345051248 scopus 로고
    • Central mechanism of interaction between sympathetic preganglionic neurons and the respiratory oscillator
    • edited by H. P. Koepchen, S. M. Hilton, and A. Trzebski. Berlin: Springer-Verlag
    • Polosa, C., U. Gerber, and R. Schondorf. Central mechanism of interaction between sympathetic preganglionic neurons and the respiratory oscillator. In: Central Interactions Between Respiratory and Cardiovascular Control Systems, edited by H. P. Koepchen, S. M. Hilton, and A. Trzebski. Berlin: Springer-Verlag, 1980, pp. 137-143.
    • (1980) Central Interactions between Respiratory and Cardiovascular Control Systems , pp. 137-143
    • Polosa, C.1    Gerber, U.2    Schondorf, R.3
  • 42
    • 0031964207 scopus 로고    scopus 로고
    • Influence of cerebral blood flow on the ventilatory response to hypoxia in humans
    • Poulin, M. J., and P. A. Robbins. Influence of cerebral blood flow on the ventilatory response to hypoxia in humans. Exp. Physiol. 83:95-106, 1998.
    • (1998) Exp. Physiol. , vol.83 , pp. 95-106
    • Poulin, M.J.1    Robbins, P.A.2
  • 44
    • 0030455702 scopus 로고    scopus 로고
    • Indices of flow and cross-sectional area of the middle cerebral artery using Doppler ultrasound during hypoxia and hypercapnia in humans
    • Poulin, M. J., and P. A. Robbins. Indices of flow and cross-sectional area of the middle cerebral artery using Doppler ultrasound during hypoxia and hypercapnia in humans. Stroke 27:2244-2250, 1996.
    • (1996) Stroke , vol.27 , pp. 2244-2250
    • Poulin, M.J.1    Robbins, P.A.2
  • 45
    • 0002646229 scopus 로고
    • Ventilation, perfusion, and gas exchange-The VA/Q concept
    • edited by W. O. Fenn and H. Rahn. Washington, DC: American Physiological Society
    • Rahn, H., and L. E. Farhi. Ventilation, perfusion, and gas exchange-The VA/Q concept. In: Handbook of Physiology. Section 3: Respiration. Volume I, edited by W. O. Fenn and H. Rahn. Washington, DC: American Physiological Society, 1964, pp. 735-766.
    • (1964) Handbook of Physiology. Section 3: Respiration , vol.1 , pp. 735-766
    • Rahn, H.1    Farhi, L.E.2
  • 46
    • 0027333009 scopus 로고
    • 2 homeostasis during periodic breathing: Predictions from a computer model
    • 2 homeostasis during periodic breathing: Predictions from a computer model. J. Appl. Physiol. 75(5):2302-2309, 1993.
    • (1993) J. Appl. Physiol. , vol.75 , Issue.5 , pp. 2302-2309
    • Rapoport, D.M.1    Norman, R.G.2    Goldring, R.M.3
  • 47
    • 78651161246 scopus 로고
    • CO2 and cerebral hemodynamics
    • CO2 and cerebral hemodynamics. Am. J. Physiol. 206(1):25-35, 1964.
    • (1964) Am. J. Physiol. , vol.206 , Issue.1 , pp. 25-35
    • Reivich, M.1
  • 49
    • 0019958152 scopus 로고
    • A prediction-correction scheme for forcing alveolar gases along certain time courses
    • Robbins, P. A., G. D. Swanson, and M. G. Howson. A prediction-correction scheme for forcing alveolar gases along certain time courses. J. Appl. Physiol. 52:1353-1357, 1982.
    • (1982) J. Appl. Physiol. , vol.52 , pp. 1353-1357
    • Robbins, P.A.1    Swanson, G.D.2    Howson, M.G.3
  • 50
    • 0019152711 scopus 로고
    • A breathing model of the respiratory system: The controlled system
    • Saunders, K. B., H. N. Bali, and E. R. Carson. A breathing model of the respiratory system: The controlled system. J. Theor. Biol. 84:135-161, 1980.
    • (1980) J. Theor. Biol. , vol.84 , pp. 135-161
    • Saunders, K.B.1    Bali, H.N.2    Carson, E.R.3
  • 51
    • 0026484654 scopus 로고
    • Comparison of respiratory and circulatory human responses to progressive hypoxia and hypercapnia
    • Serebrovskaya, T. V. Comparison of respiratory and circulatory human responses to progressive hypoxia and hypercapnia. Respiration 59:35-41, 1992.
    • (1992) Respiration , vol.59 , pp. 35-41
    • Serebrovskaya, T.V.1
  • 52
    • 0018399378 scopus 로고
    • 2 dissociation computations
    • 2 dissociation computations. J. Appl. Physiol. 46(3):599-602, 1979.
    • (1979) J. Appl. Physiol. , vol.46 , Issue.3 , pp. 599-602
    • Severinghaus, J.W.1
  • 53
    • 0017136480 scopus 로고
    • Proposed standard determination of ventilatory responses to hypoxia and hypercapnia in man
    • Severinghaus, J. W. Proposed standard determination of ventilatory responses to hypoxia and hypercapnia in man. Chest 70(1):129-131, 1976.
    • (1976) Chest , vol.70 , Issue.1 , pp. 129-131
    • Severinghaus, J.W.1
  • 54
    • 0013910907 scopus 로고
    • Blood gas calculator
    • Severinghaus, J. W. Blood gas calculator. J. Appl. Physiol. 21(3):1108-1116, 1966.
    • (1966) J. Appl. Physiol. , vol.21 , Issue.3 , pp. 1108-1116
    • Severinghaus, J.W.1
  • 56
    • 0014900277 scopus 로고
    • Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man
    • Shapiro, W., A. J. Wasserman, J. P. Baker, and J. L. Patterson, Jr. Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man. J. Clin. Invest. 49:2362-2368, 1970.
    • (1970) J. Clin. Invest. , vol.49 , pp. 2362-2368
    • Shapiro, W.1    Wasserman, A.J.2    Baker, J.P.3    Patterson Jr., J.L.4
  • 57
    • 0342410609 scopus 로고
    • New computational models of the respiratory oscillator in mammals
    • edited by S. J. G. Semple, L. Adams, and B. J. Whipp. New York: Plenum Press
    • Smith, J. C. New computational models of the respiratory oscillator in mammals. In: Modeling and Control of ventiLation, edited by S. J. G. Semple, L. Adams, and B. J. Whipp. New York: Plenum Press, 1995, pp. 7-13.
    • (1995) Modeling and Control of VentiLation , pp. 7-13
    • Smith, J.C.1
  • 59
    • 0027134764 scopus 로고
    • Destabilization of the respiratory control by hypoxic ventilatory depression: A model analysis
    • Takahashi, E., and K. Doi. Destabilization of the respiratory control by hypoxic ventilatory depression: A model analysis. Jap. J. Physiol. 43:599-612, 1993.
    • (1993) Jap. J. Physiol. , vol.43 , pp. 599-612
    • Takahashi, E.1    Doi, K.2
  • 60
    • 0015371480 scopus 로고
    • Algorithms for selected blood acid-base and blood gas calculations
    • Thomas, L. J. Algorithms for selected blood acid-base and blood gas calculations. J. Appl. Physiol. 33(1):154-158, 1972.
    • (1972) J. Appl. Physiol. , vol.33 , Issue.1 , pp. 154-158
    • Thomas, L.J.1
  • 61
    • 0019793791 scopus 로고
    • CO2 dependent drive of the sympathetic discharge?
    • CO2 dependent drive of the sympathetic discharge? J. Auton. Nerv. Syst. 3:401-420, 1981.
    • (1981) J. Auton. Nerv. Syst. , vol.3 , pp. 401-420
    • Trzebski, A.1    Kubin, L.2
  • 62
    • 0034963567 scopus 로고    scopus 로고
    • An integrated model of the human ventilatory control system: The response to hypercapnia
    • Ursino, M., E. Magosso, and G. Avanzolini. An integrated model of the human ventilatory control system: The response to hypercapnia. Clin. Physiol. 21(4):447-464, 2001.
    • (2001) Clin. Physiol. , vol.21 , Issue.4 , pp. 447-464
    • Ursino, M.1    Magosso, E.2    Avanzolini, G.3
  • 63
    • 0034953393 scopus 로고    scopus 로고
    • An integrated model of the human ventilatory control system: The response to hypoxia
    • Ursino, M., E. Magosso, and G. Avanzolini. An integrated model of the human ventilatory control system: The response to hypoxia. Clin. Physiol. 21(4):465-477, 2001.
    • (2001) Clin. Physiol. , vol.21 , Issue.4 , pp. 465-477
    • Ursino, M.1    Magosso, E.2    Avanzolini, G.3
  • 64
    • 0025957469 scopus 로고
    • Development of short-term potentiation of respiration
    • Wagner, P. G., and F. L. Eldridge. Development of short-term potentiation of respiration. Respir. Physiol. 83:129-140, 1991.
    • (1991) Respir. Physiol. , vol.83 , pp. 129-140
    • Wagner, P.G.1    Eldridge, F.L.2
  • 65
    • 0028826299 scopus 로고
    • Effect of venous oxygenation on arterial desaturation rate during repetitive apneas in lambs
    • Wilkinson, M. H., P. J. Berger, N. Blanch, and V. Brodecky. Effect of venous oxygenation on arterial desaturation rate during repetitive apneas in lambs. Respir. Physiol. 101:321-331, 1995.
    • (1995) Respir. Physiol. , vol.101 , pp. 321-331
    • Wilkinson, M.H.1    Berger, P.J.2    Blanch, N.3    Brodecky, V.4


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