메뉴 건너뛰기




Volumn 19, Issue 9, 2014, Pages 1465-1470

Reversal of target-specific oral anticoagulants

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; ANDEXANET ALFA; ANTICOAGULANT AGENT; APIXABAN; BETRIXABAN; DABIGATRAN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; ANTIDOTE; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A INHIBITOR;

EID: 84907813416     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.05.013     Document Type: Review
Times cited : (34)

References (42)
  • 1
    • 84869236631 scopus 로고    scopus 로고
    • Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis of the literature
    • F. Dentali Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature Circulation 126 2012 2381 2391
    • (2012) Circulation , vol.126 , pp. 2381-2391
    • Dentali, F.1
  • 2
    • 84869838484 scopus 로고    scopus 로고
    • Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials
    • B.D. Fox Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials BMJ 345 2012 e7498
    • (2012) BMJ , vol.345 , pp. 7498
    • Fox, B.D.1
  • 3
    • 84861137106 scopus 로고    scopus 로고
    • Oral direct factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: A systematic review and meta-analysis
    • I. Neumann Oral direct factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: a systematic review and meta-analysis Ann. Intern. Med. 156 2012 710 719
    • (2012) Ann. Intern. Med. , vol.156 , pp. 710-719
    • Neumann, I.1
  • 4
    • 84861117312 scopus 로고    scopus 로고
    • Adverse effects of plasma transfusion
    • S. Pandey, and G.N. Vyas Adverse effects of plasma transfusion Transfusion 52 Suppl. 1 2012 65 79
    • (2012) Transfusion , vol.52 , Issue.SUPPL. 1 , pp. 65-79
    • Pandey, S.1    Vyas, G.N.2
  • 5
    • 80052332326 scopus 로고    scopus 로고
    • Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis
    • F. Dentali Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis Thromb. Haemost. 106 2011 429 438
    • (2011) Thromb. Haemost. , vol.106 , pp. 429-438
    • Dentali, F.1
  • 6
    • 34547436844 scopus 로고    scopus 로고
    • Coagulation factor concentrates: Past, present, and future
    • N.S. Key, and C. Negrier Coagulation factor concentrates: past, present, and future Lancet 370 2007 439 448
    • (2007) Lancet , vol.370 , pp. 439-448
    • Key, N.S.1    Negrier, C.2
  • 7
    • 0036489638 scopus 로고    scopus 로고
    • Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events
    • H.J. Ehrlich Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events Haemophilia 8 2002 83 90
    • (2002) Haemophilia , vol.8 , pp. 83-90
    • Ehrlich, H.J.1
  • 8
    • 13244262642 scopus 로고    scopus 로고
    • Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity
    • L.M. Aledort Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity J. Thromb. Haemost. 2 2004 1700 1708
    • (2004) J. Thromb. Haemost. , vol.2 , pp. 1700-1708
    • Aledort, L.M.1
  • 9
    • 78049498149 scopus 로고    scopus 로고
    • Safety of recombinant activated factor VII in randomized clinical trials
    • M. Levi Safety of recombinant activated factor VII in randomized clinical trials N. Engl. J. Med. 363 2010 1791 1800
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1791-1800
    • Levi, M.1
  • 10
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Functional and structural characterization
    • F. Schiele A specific antidote for dabigatran: functional and structural characterization Blood 121 2013 3554 3562
    • (2013) Blood , vol.121 , pp. 3554-3562
    • Schiele, F.1
  • 11
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
    • G. Lu A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa Nat. Med. 19 2013 446 451
    • (2013) Nat. Med. , vol.19 , pp. 446-451
    • Lu, G.1
  • 12
    • 84907816852 scopus 로고    scopus 로고
    • Reversal for factor Xa inhibitors using factor Xa zymogen-like variants
    • N. Thalji Reversal for factor Xa inhibitors using factor Xa zymogen-like variants J. Thromb. Haemost. 11 2013 167
    • (2013) J. Thromb. Haemost. , vol.11 , pp. 167
    • Thalji, N.1
  • 13
    • 84897877156 scopus 로고    scopus 로고
    • Antidote for new oral anticoagulants: Mechanism of action and binding specificity of PER977
    • B. Laulicht Antidote for new oral anticoagulants: mechanism of action and binding specificity of PER977 J. Thromb. Haemost. 11 2013 75
    • (2013) J. Thromb. Haemost. , vol.11 , pp. 75
    • Laulicht, B.1
  • 14
    • 84873544394 scopus 로고    scopus 로고
    • Laboratory assessment of the anticoagulant effects of the next generation of oral anticoagulants
    • D. Garcia Laboratory assessment of the anticoagulant effects of the next generation of oral anticoagulants J. Thromb. Haemost. 11 2013 245 252
    • (2013) J. Thromb. Haemost. , vol.11 , pp. 245-252
    • Garcia, D.1
  • 15
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • E.S. Eerenberg Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects Circulation 124 2011 1573 1579
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1
  • 16
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers
    • R. Marlu Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers Thromb. Haemost. 108 2012 217 224
    • (2012) Thromb. Haemost. , vol.108 , pp. 217-224
    • Marlu, R.1
  • 17
    • 84875053456 scopus 로고    scopus 로고
    • The use of FEIBA(R) in the correction of coagulation abnormalities induced by dabigatran
    • T.L. Khoo The use of FEIBA(R) in the correction of coagulation abnormalities induced by dabigatran Int. J. Lab. Hematol. 35 2013 222 224
    • (2013) Int. J. Lab. Hematol. , vol.35 , pp. 222-224
    • Khoo, T.L.1
  • 18
    • 84899721137 scopus 로고    scopus 로고
    • Thrombin generation using the calibrated automated thrombinoscope to assess reversibility of dabigatran and rivaroxaban
    • R. Herrmann Thrombin generation using the calibrated automated thrombinoscope to assess reversibility of dabigatran and rivaroxaban Thromb. Haemost. 111 2014 989 995
    • (2014) Thromb. Haemost. , vol.111 , pp. 989-995
    • Herrmann, R.1
  • 19
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • J. Stangier, and M. Feuring Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran Blood Coagul. Fibrinolysis 23 2012 138 143
    • (2012) Blood Coagul. Fibrinolysis , vol.23 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 20
    • 84876681877 scopus 로고    scopus 로고
    • Prothrombin complex concentrates reduce blood loss in mice rendered coagulopathic by warfarin but not dabigatran etexilate
    • M.D. Lambourne Prothrombin complex concentrates reduce blood loss in mice rendered coagulopathic by warfarin but not dabigatran etexilate Transfusion 52 2012 56A 57A
    • (2012) Transfusion , vol.52 , pp. 56A-57A
    • Lambourne, M.D.1
  • 21
    • 84856214360 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    • W. Zhou Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran Stroke 42 2011 3594 3599
    • (2011) Stroke , vol.42 , pp. 3594-3599
    • Zhou, W.1
  • 22
    • 84865773023 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model
    • I. Pragst Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model J. Thromb. Haemost. 10 2012 1841 1848
    • (2012) J. Thromb. Haemost. , vol.10 , pp. 1841-1848
    • Pragst, I.1
  • 23
    • 84876684507 scopus 로고    scopus 로고
    • In vitro characterization, pharmacokinetics and reversal of supratherapeutic doses of dabigtran-induced bleeding in rats by a specific antibody fragment antidote to dabigtran
    • meeting abstract 3418
    • J. van Ryn In vitro characterization, pharmacokinetics and reversal of supratherapeutic doses of dabigtran-induced bleeding in rats by a specific antibody fragment antidote to dabigtran Blood 120 2012 meeting abstract 3418
    • (2012) Blood , vol.120
    • Van Ryn, J.1
  • 24
    • 84876675451 scopus 로고    scopus 로고
    • Reversal of dabigtran's anticoagulant activity in the monkey by a specific antidote and pharmacokinetic and pharmacodynamic modeling
    • meeting abstract 22
    • J. Toth Reversal of dabigtran's anticoagulant activity in the monkey by a specific antidote and pharmacokinetic and pharmacodynamic modeling Blood 120 2012 meeting abstract 22
    • (2012) Blood , vol.120
    • Toth, J.1
  • 25
    • 84883812030 scopus 로고    scopus 로고
    • In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for rivaroxaban
    • J. Dinkelaar In vitro assessment, using thrombin generation, of the applicability of prothrombin complex concentrate as an antidote for rivaroxaban J. Thromb. Haemost. 11 2013 1111 1118
    • (2013) J. Thromb. Haemost. , vol.11 , pp. 1111-1118
    • Dinkelaar, J.1
  • 26
    • 84922565475 scopus 로고    scopus 로고
    • Measurement and reversal of prophylactic and therapeutic peak levels of rivaroxaban: An in vitro study
    • M.K. Korber Measurement and reversal of prophylactic and therapeutic peak levels of rivaroxaban: an in vitro study Clin. Appl. Thromb. Hemost. 2013 10.1177/1076029613494468
    • (2013) Clin. Appl. Thromb. Hemost.
    • Korber, M.K.1
  • 27
    • 84892921288 scopus 로고    scopus 로고
    • Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: Significance of studies in vitro with circulating human blood
    • G. Escolar Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: significance of studies in vitro with circulating human blood PLoS One 8 2013 e78696
    • (2013) PLoS One , vol.8 , pp. 78696
    • Escolar, G.1
  • 28
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents
    • T. Fukuda Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents Thromb. Haemost. 107 2012 253 259
    • (2012) Thromb. Haemost. , vol.107 , pp. 253-259
    • Fukuda, T.1
  • 29
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    • A. Godier Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model Anesthesiology 116 2012 94 102
    • (2012) Anesthesiology , vol.116 , pp. 94-102
    • Godier, A.1
  • 30
    • 84879671176 scopus 로고    scopus 로고
    • Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates
    • E. Perzborn Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates Thromb. Haemost. 110 2013 162 172
    • (2013) Thromb. Haemost. , vol.110 , pp. 162-172
    • Perzborn, E.1
  • 31
    • 84885203373 scopus 로고    scopus 로고
    • A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect factor Xa inhibitors
    • M. Crowther A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect factor Xa inhibitors J. Thromb. Haemost. 11 2013 30
    • (2013) J. Thromb. Haemost. , vol.11 , pp. 30
    • Crowther, M.1
  • 32
    • 84876681725 scopus 로고    scopus 로고
    • Reversal of novel oral anticoagulants in patients with major bleeding
    • D.M. Siegal, and A. Cuker Reversal of novel oral anticoagulants in patients with major bleeding J. Thromb. Thrombolysis 35 2013 391 398
    • (2013) J. Thromb. Thrombolysis , vol.35 , pp. 391-398
    • Siegal, D.M.1    Cuker, A.2
  • 33
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • J. Stangier The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects Br. J. Clin. Pharmacol. 64 2007 292 303
    • (2007) Br. J. Clin. Pharmacol. , vol.64 , pp. 292-303
    • Stangier, J.1
  • 34
    • 38749131205 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
    • S. Blech The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans Drug Metab. Dispos. 36 2008 386 399
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 386-399
    • Blech, S.1
  • 35
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor
    • D. Kubitza Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor Clin. Pharmacol. Ther. 78 2005 412 421
    • (2005) Clin. Pharmacol. Ther. , vol.78 , pp. 412-421
    • Kubitza, D.1
  • 36
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - An oral, direct factor Xa inhibitor - After multiple dosing in healthy male subjects
    • D. Kubitza Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - an oral, direct factor Xa inhibitor - after multiple dosing in healthy male subjects Eur. J. Clin. Pharmacol. 61 2005 873 880
    • (2005) Eur. J. Clin. Pharmacol. , vol.61 , pp. 873-880
    • Kubitza, D.1
  • 37
    • 66449099711 scopus 로고    scopus 로고
    • Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans
    • C. Weinz Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans Drug Metab. Dispos. 37 2009 1056 1064
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 1056-1064
    • Weinz, C.1
  • 38
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • N. Raghavan Apixaban metabolism and pharmacokinetics after oral administration to humans Drug Metab. Dispos. 37 2009 74 81
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 74-81
    • Raghavan, N.1
  • 39
    • 84872260247 scopus 로고    scopus 로고
    • Apixaban, an oral, direct factor Xa inhibitor: Single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
    • C. Frost Apixaban, an oral, direct factor Xa inhibitor: single-dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects Br. J. Clin. Pharmacol. 75 2013 476 487
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 476-487
    • Frost, C.1
  • 40
    • 84860511290 scopus 로고    scopus 로고
    • A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects
    • Y.C. Barrett A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects Thromb. Haemost. 107 2012 916 924
    • (2012) Thromb. Haemost. , vol.107 , pp. 916-924
    • Barrett, Y.C.1
  • 41
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
    • B.I. Eriksson Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development Clin. Pharmacokinet. 48 2009 1 22
    • (2009) Clin. Pharmacokinet. , vol.48 , pp. 1-22
    • Eriksson, B.I.1
  • 42
    • 84885772245 scopus 로고    scopus 로고
    • Evaluation of the oral direct factor Xa inhibitor - Betrixaban
    • M. Palladino Evaluation of the oral direct factor Xa inhibitor - betrixaban Expert Opin. Investig. Drugs 22 2013 1465 1472
    • (2013) Expert Opin. Investig. Drugs , vol.22 , pp. 1465-1472
    • Palladino, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.